269
Views
24
CrossRef citations to date
0
Altmetric
Research Article

A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse

, , , , , & show all
Pages 1325-1332 | Received 30 May 2011, Accepted 25 Aug 2011, Published online: 26 Sep 2011

References

  • Burr M, Koshland DE Jr. Use of “reporter groups” in structure-function studies of proteins. Proc Natl Acad Sci USA 1964;52:1017–1024.
  • Berliner LJ, ed. 1976. Spin labeling. NewYork: Academic Press.
  • Eaton GR, Eaton SS, Ohno K, eds. 1991 EPR imaging and in vivo EPR. Florida: CRC Press.
  • Hyodo F, Matsumoto K, Matsumoto A, Mitchell JB, Krishna MC. Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents. Cancer Res 2006;66:9921–9928.
  • Kulkarni AC, Bratasz A, Rivera A, Krishna MC, Kuppusamy P. Redox mapping of biological samples using EPR imaging. Israel J Chem 2008;47:27–31.
  • Hyodo F, Chuang KH, Goloshevsky AG, Sulima A, Griffiths GL, Mitchell JB, . Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. J Cereb Blood Flow Metab 2008;28:1165–1174.
  • Yamato M, Shiba T, Yamada K, Watanabe T, Utsumi H. Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging. J Cereb Blood Flow Metab 2009;29:1655–1664.
  • Fujii H, Sato-Akaba H, Kawanishi K, Hirata H. Mapping of redox status in a brain-disease mouse model by three-dimensional EPR imaging. Magn Reson Med 2011;65:295–303.
  • Bellin MF. MR contrast agents, the old and the new. Eur J Radiol 2006;60:314–323.
  • Marx L, Chiarelli R, Guiberteau T, Rassat A. A comparative study of the reduction by ascorbate of 1,1,3,3-tetraethylisoindolin-2-yloxyl and of 1,1,3,3-tetramethylisoindolin-2-yloxyl. J Chem Soc Perkin Trans 2000;1:1181–1182.
  • Kirilyuk IA, Bobko AA, Grigor'ev IA, Khramtsov VV. Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction. Org Biomol Chem 2004;2:1025–1030.
  • Kinoshita Y, Yamada K, Yamasaki T, Sadasue H, Sakai K, Utsumi H. Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid. Free Radic Res 2009;43: 565–571.
  • Kinoshita Y, Yamada K, Yamasaki T, Mito F, Yamato M, Kosem N, . In vivo evaluation of novel nitroxyl radicals with reduction stability. Free Radic Biol Med 2010;49:1703–1709.
  • Yamasaki T, Mito F, Ito Y, Pandian S, Kinoshita Y, Nakano K, . Structure-reactivity relationship of piperidine nitroxide: electrochemical, ESR and computational studies. J Org Chem 2011;76:435–440.
  • Gregoriadis G. Drug entrapment in liposomes. FEBS Lett 1973;36:292–296.
  • Charlier N, Préat V, Gallez B. Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems. Magn Reson Med 2006;55:215–218.
  • Gregoriadis G, Florence AT. Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential. Drugs 1993;45:15–28.
  • Sato-Akaba H, Kuwahara Y, Fujii H, Hirata H. Half-life mapping of nitroxyl radicals with three-dimensional electron paramagnetic resonance imaging at an interval of 3.6 seconds. Anal Chem 2009;81:7501–7506.
  • Kawada Y, Hirata H, Fujii H. Use of multi-coil parallel-gap resonators for co-registration EPR/NMR imaging. J Magn Reson 2007;184:29–38.
  • Kocherginsky N, Swartz HM. 1995. Chemical reactivity of nitroxides. In: Kocherginsky N, Swartz HM, editors. Nitroxide spin labels: Reactions in biology and chemistry. Boca Raton: CRC Press; p 27–66.
  • Sato-Akaba H, Fujii H, Hirata H. Development and testing of a CW-EPR apparatus for imaging of short-lifetime nitroxyl radicals in mouse head. J Magn Reson 2008;193:191–198.
  • Yokoyama H, Itoh O, Aoyama M, Obara H, Ohya H, Kamada H. In vivo temporal EPR imaging of the brain of rats by using two types of blood-brain barrier-permeable nitroxide radicals. Magn Reson Imaging 2002;20:277–284.
  • Chan HC, Magin RL, Swartz HM. Rapid assessment of liposomal stability in blood by an aqueous nitroxide spin label. J Biochem Biophys Methods 1989;18:271–276.
  • Honzak L, Sentjurc M, Swartz HM. In vivo EPR of topical delivery of a hydrophilic substance encapsulated in multilamellar liposomes applied to the skin of hairless and normal mice. J Control Release 2000;66:221–228.
  • Kuppusamy P, Wang P, Zweier JL, Krishna MC, Mitchell JB, Ma L, . Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl-albumin. Biochemistry 1996;35:7051–7057.
  • Kazama S, Takashige G, Yoshioka H, Tanizawa H, Ogata T, Koscielniak J, Berliner LJ. Dynamic electron spin resonance (ESR) imaging of the distribution of spin labeled dextran in a mouse. Magn Reson Med 1996;36:547–550.
  • Kuppusamy P, Li H, Ilangovan G, Cardounel AJ, Zweier JL, Yamada K, . Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Res 2002;62:307–312.
  • De la Fuente M, Hernanz A, Vallejo MC. The immune system in the oxidative stress conditions of aging and hypertension: favorable effects of antioxidants and physical exercise. Antioxid. Redox Signal 2005;7:1356–1366.
  • Anzai K, Saito K, Takeshita K, Takahashi S, Miyazaki H, Shoji H, . Assessment of ESR-CT imaging by comparison with autoradiography for the distribution of a blood-brain-barrier permeable spin probe, MC-PROXYL, to rodent brain. Magn Reson Imaging 2003;21:765–772.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.