634
Views
21
CrossRef citations to date
0
Altmetric
Review Article

Oxidative and non-oxidative DNA damage and cardiovascular disease

&
Pages 554-564 | Received 28 Oct 2011, Accepted 01 Feb 2012, Published online: 27 Feb 2012

References

  • Masetti S, Botto N, Manfredi S, Colombo MG, Rizza A, Vassalle C, . Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk. J Mol Med 2003;81:488–494.
  • Nair J, De Flora S, Izzotti A, Bartsch H. Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions. Mutat Res 2007;621:95–105.
  • von Sonntag C. New aspects in the free-radical chemistry of pyrimidine nucleobases. Free Radic Res Commun 1987;2: 217–224.
  • Cooke MS, Evans MD, Dizdaroglu M, Lunec J. Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J 2003;17:1195–1214.
  • Melvin T, Bothe E, Schulte-Frohlinde D. The reaction of triplet 2-methyl-1,4-naphthoquinone (menadione) with DNA and polynucleotides. Photochem Photobiol 1996;64: 769–776.
  • Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer. FEBS Lett 1995;358:1–3.
  • Croteau DL, Bohr VA. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem 1997;272:25409–25412.
  • Costa RA, Romagna CD, Pereira JL, Souza-Pinto NC. The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species. J Bioenerg Biomembr 2011;43: 25–29.
  • Spelbrink JN. Functional organization of mammalian mitochondrial DNA in nucleoids: History, recent developments, and future challenges. IUBMB Life 2010;62:19–32.
  • Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A 1988;85:6465–6467.
  • Trapp C, McCullough AK, Epe B. The basal levels of 8-oxoG and other oxidative modifications in intact mitochondrial DNA are low even in repair-deficient (Ogg1(-/-)/Csb(-/-)) mice. Mutat Res 2007;625:155–163.
  • Gredilla R, Bohr VA, Stevnsner T. Mitochondrial DNA repair and association with aging-an update. Exp Gerontol 2010;45:478–488.
  • Kaneto H, Fujii J, Myint T, Miyazawa N, Islam KN, Kawasaki Y, . Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochem J 1996; 320:855–863.
  • Farhangkhoee H, Khan ZA, Barbin Y, Chakrabarti S. Glucose-induced up-regulation of CD36 mediates oxidative stress and microvascular endothelial cell dysfunction. Diabetologia 2005;48:1401–1410.
  • Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, . Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: The distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005;183:259–267.
  • Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M, . Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the akt site. J Clin Invest 2001;108:1341–1348.
  • Madsen-Bouterse SA, Zhong Q, Mohammad G, Ho YS, Kowluru RA. Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. Free Radic Res 2010;44:313–321.
  • Medikayala S, Piteo B, Zhao X, Edwards JG. Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function. Am J Physiol Cell Physiol 2011;300: C338–C348.
  • Li TK, Chen AY, Yu C, Mao Y, Wang H, Liu LF, . Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev 1999;13:1553–1560.
  • Sun J, Xu Y, Sun S, Sun Y, Wang X. Intermittent high glucose enhances cell proliferation and VEGF expression in retinal endothelial cells: The role of mitochondrial reactive oxygen species. Mol Cell Biochem 2010;343:27–35.
  • Mehta PK, Griendling KK. Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007;292:C82–C97.
  • Mazza F, Goodman A, Lombardo G, Vanella A, Abraham NG. Heme oxygenase-1 gene expression attenuates angiotensin II-mediated DNA damage in endothelial cells. Exp Biol Med 2003;228:576–583.
  • Herbert KE, Mistry Y, Hastings R, Poolman T, Niklason L, Williams B, . Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere- dependent and independent pathways. Circ Res 2008; 102:201–208.
  • Schupp N, Schmid U, Rutkowski P, Lakner U, Kanase N, Heidland A, . Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging. Am J Physiol Renal Physiol 2007;292:F1427–F1434.
  • Liu Q, Wang G, Zhou G, Tan Y, Wang X, Wei W, . Angiotensin II-induced p53-dependent cardiac apoptotic cell death: Its prevention by metallothionein. Toxicol Lett 2009;191:314–320.
  • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273: 5858–5868.
  • Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, . Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 2003;107:1418–1423.
  • Bhatnagar A. Environmental cardiology: Studying mechanistic links between pollution and heart disease. Circ Res 2006;99:692–705.
  • Tellez-Plaza M, Navas-Acien A, Crainiceanu CM, Guallar E. Cadmium exposure and hypertension in the 1999–2004 national health and nutrition examination survey (NHANES). Environ Health Perspect 2008;116:51–56.
  • Houtman JP. Prolonged low-level cadmium intake and atherosclerosis. Sci Total Environ 1993;138:31–36.
  • Messner B, Knoflach M, Seubert A, Ritsch A, Pfaller K, Henderson B, . Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance. Arterioscler Thromb Vasc Biol 2009;29: 1392–1398.
  • Yang MS, Li D, Lin T, Zheng JJ, Zheng W, Qu JY, . Increase in intracellular free/bound NAD[P]H as a cause of cd-induced oxidative stress in the HepG(2) cells. Toxicology 2008;247:6–10.
  • Pathak N, Khandelwal S. Impact of cadmium in T lymphocyte subsets and cytokine expression: Differential regulation by oxidative stress and apoptosis. Biometals 2008;21:179–187.
  • Liu F, Jan KY. DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells. Free Radic Biol Med 2000;28:55–63.
  • Lynn S, Gurr JR, Lai HT, Jan KY. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Circ Res 2000;86: 514–519.
  • Martinet W, Knaapen MW, De Meyer GR, Herman AG, Kockx MM. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res 2001;88:733–739.
  • Oumouna-Benachour K, Hans CP, Suzuki Y, Naura A, Datta R, Belmadani S, . Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: Effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation 2007;115:2442–2450.
  • Shall S. The function of poly (ADP-ribosylation) in DNA breakage and rejoining. Mol Cell Biochem 1994;138:7175.
  • Folkmann JK, Loft S, Moller P. Oxidatively damaged DNA in aging dyslipidemic ApoE-/- and wild-type mice. Mutagenesis 2007;22:105–110.
  • Godschalk RW, Albrecht C, Curfs DM, Schins RP, Bartsch H, van Schooten FJ, . Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice. Mutat Res 2007;621: 87–94.
  • Cakir Y, Yang Z, Knight CA, Pompilius M, Westbrook D, Bailey SM, . Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis. Free Radic Biol Med 2007;43:1279–1288.
  • Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, . Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol 2009;297: L209–L216.
  • Kang GS, Gillespie PA, Gunnison A, Moreira AL, Tchou-Wong KM, Chen LC, . Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model. Environ Health Perspect 2011; 119:176–181.
  • Andreassi MG. DNA damage, vascular senescence and atherosclerosis. J Mol Med 2008;86:1033–1043.
  • Costopoulos C, Liew TV, Bennett M. Ageing and atherosclerosis: Mechanisms and therapeutic options. Biochem Pharmacol 2008;75:1251–1261.
  • Khan SJ, Pham S, Wei Y, Mateo D, St-Pierre M, Fletcher TM, . Stress-induced senescence exaggerates postinjury neointimal formation in the old vasculature. Am J Physiol Heart Circ Physiol 2010;298:H66–H74.
  • Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, . DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res 2010;107:1021–1031.
  • De Flora S, Izzotti A, Randerath K, Randerath E, Bartsch H, Nair J, . DNA adducts and chronic degenerative disease. pathogenetic relevance and implications in preventive medicine. Mutat Res 1996;366:197–238.
  • De Flora S, Izzotti A, Walsh D, Degan P, Petrilli GL, Lewtas J, . Molecular epidemiology of atherosclerosis. FASEB J 1997;11:1021–1031.
  • Izzotti A, De Flora S, Petrilli GL, Gallagher J, Rojas M, Alexandrov K, . Cancer biomarkers in human atherosclerotic lesions: Detection of DNA adducts. Cancer Epidemiol Biomarkers Prev 1995;4:105–110.
  • Zhang YJ, Weksler BB, Wang L, Schwartz J, Santella RM. Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers. Atherosclerosis 1998;140:325–331.
  • Binkova B, Smerhovsky Z, Strejc P, Boubelik O, Stavkova Z, Chvatalova I, . DNA-adducts and atherosclerosis: A study of accidental and sudden death males in the czech republic. Mutat Res 2002;501:115–128.
  • Leadon SA, Stampfer MR, Bartley J. Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing. Proc Natl Acad Sci U S A 1988;85:4365–4368.
  • Gur M, Yilmaz R, Demirbag R, Yildiz A, Kocyigit A, Celik H, . Lymphocyte DNA damage is associated with increased aortic intima-media thickness. Mutat Res 2007;617:111–118.
  • Pernice F, Floccari F, Caccamo C, Belghity N, Mantuano S, Pacile ME, . Chromosomal damage and atherosclerosis. A protective effect from simvastatin. Eur J Pharmacol 2006;532:223–229.
  • Botto N, Rizza A, Colombo MG, Mazzone AM, Manfredi S, Masetti S, . Evidence for DNA damage in patients with coronary artery disease. Mutat Res 2001;493:23–30.
  • Andreassi MG, Botto N, Cocci F, Battaglia D, Antonioli E, Masetti S, . Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease. Hum Genet 2003;112:171–177.
  • Shen YH, Utama B, Wang J, Raveendran M, Senthil D, Waldman WJ, . Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways. Circ Res 2004;94: 1310–1317.
  • Martinet W, Knaapen MW, De Meyer GR, Herman AG, Kockx MM. Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation 2002;106:927–932.
  • Botto N, Masetti S, Petrozzi L, Vassalle C, Manfredi S, Biagini A, . Elevated levels of oxidative DNA damage in patients with coronary artery disease. Coron Artery Dis 2002;13:269–274.
  • Izzotti A, Piana A, Minniti G, Vercelli M, Perrone L, De Flora S, . Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms. Mutat Res 2007;621:119–128.
  • Izzotti A, Cartiglia C, Lewtas J, De Flora S. Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype. FASEB J 2001;15:752–757.
  • Satoh M, Ishikawa Y, Takahashi Y, Itoh T, Minami Y, Nakamura M, . Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease. Atherosclerosis 2008;198: 347–353.
  • Martinet W, de Meyer GR, Herman AG, Kockx MM. Reactive oxygen species induce RNA damage in human atherosclerosis. Eur J Clin Invest 2004;34:323–327.
  • Ballinger SW, Patterson C, Knight-Lozano CA, Burow DL, Conklin CA, Hu Z, . Mitochondrial integrity and function in atherogenesis. Circulation 2002;106:544–549.
  • Meissner C, Bruse P, Mohamed SA, Schulz A, Warnk H, Storm T, . The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more? Exp Gerontol 2008;43:645–652.
  • Wei YH. Mitochondrial DNA alterations as ageing-associated molecular events. Mutat Res 1992;275:145–155.
  • Corral-Debrinski M, Shoffner JM, Lott MT, Wallace DC. Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res 1992; 275:169–180.
  • Lai LP, Tsai CC, Su MJ, Lin JL, Chen YS, Tseng YZ, . Atrial fibrillation is associated with accumulation of aging-related common type mitochondrial DNA deletion mutation in human atrial tissue. Chest 2003;123: 539–544.
  • Lin PH, Lee SH, Su CP, Wei YH. Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation. Free Radic Biol Med 2003;35:1310–1318.
  • Bogliolo M, Izzotti A, De Flora S, Carli C, Abbondandolo A, Degan P, . Detection of the ‘4977 bp’ mitochondrial DNA deletion in human atherosclerotic lesions. Mutagenesis 1999;14:77–82.
  • Botto N, Berti S, Manfredi S, Al-Jabri A, Federici C, Clerico A, . Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease. Mutat Res 2005; 570:81–88.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.