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Research Article

Neuroprotection by mefenamic acid against d-serine: Involvement of oxidative stress, inflammation and apoptosis

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Pages 726-739 | Received 10 Feb 2012, Accepted 22 Feb 2012, Published online: 16 Mar 2012

References

  • Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993;262:689–695.
  • Schulz JB, Henshaw DR, Siwek D, Jenkins BG, Ferrante RJ, Cipolloni PB, . Involvement of free radicals in excitotoxicity in vivo. J Neurochem 1995;64:2239–2247.
  • Nakao N, Brundin P. Neurodegeneration and glutamate induced oxidative stress. Prog Brain Res 1998;116:245–263.
  • Mothet JP, Parent AT, Wolosker H, Brady RO Jr, Linden DJ, Ferris CD, . d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor. Proc Natl Acad Sci USA 2000;97:4926–4931.
  • Katsuki H, Nonaka M, Shirakawa H, Kume T, Akaike A. Endogenous d-serine is involved in induction of neuronal death by N-methyl-d-aspartate and simulated ischemia in rat cerebrocortical slices. J Pharm Exp Ther 2004;311:836–844.
  • Wolosker H. NMDA receptor regulation by d-serine: new findings and perspectives. Mol Neurobiol 2007;36:152–164.
  • Wu SZ, Bodles AM, Porter MM, Griffin WST, Basile AS, Barger SW, . Induction of serine rasemase expression and d-serine release from microglia by amyloid β-peptide. J Neuroinf 2004;1:2.
  • Brito-Moreira J, Paula-Lima AC, Bomfim TR, Oliveira FB, Sepúlveda FJ, De Mello FG, . Aβ oligomers induce glutamate release from hippocampal neurons. Curr Alzheimer Res 2011;8:552–562.
  • Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994;330:613–622.
  • Ho L, Purohit D, Haroutunian V, Luterman JD, Willis F, Naslund J, . Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch Neurol 2001;58:487–492.
  • Hoozemans JJ, Rozemuller AJ, Janssen I, De Groot CJ, Veerhuis R, Eikelenboom P, . Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain. Acta Neuropathol 2001;101:2–8.
  • Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley P, Fisakson P, Markowska AL, . Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci 2001;21:8198–8209.
  • Asanuma M, Nishibayashi-Asanuma S, Miyazzaki I, Kohno M, Ogawa N. Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals. J Neurochem 2001;76:1895–1904.
  • Khansari PS, Halliwell RF. Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int 2009;55: 683–688.
  • Armagan G, Kanit L, Yalcin A. d-Serine induces oxidative stres in rat brain. Drug Chem Toxicol 2011;34:129–138.
  • Armagan G, Kanit L, Yalcin A. Effects of non-steroidal antiinflammatory drugs on d-serine-induced oxidative stress in vitro. Drug Chem Toxicol. doi:10.3109/01480545.2011.633086.
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the folin-phenol reagent. J Biol Chem 1951;193:265–375.
  • Driver AS, Kodavanti PRS, Mundy WR. Age-related changes in reactive oxygen species production in rat brain homogenates. Neurotox Teratol 2000;22:175–181.
  • Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990;186: 421–431.
  • Reznick AZ, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay, Methods Enzymol 1994;233:357–363.
  • Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 1993;15:532–537.
  • Yalcin A, Kanit L, Sozmen EY. Altered gene expressions in the rat hippocampus after kainic acid with or without melatonin pre-treatment. Neurosci Lett 2004;359;65–68.
  • Rozen S, Skaletsky HJ. Primers on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132: 365–386.
  • Livak KJ, Schmittengen TD. Analysis of relative gene expression data using realtime quantitative PCR and the 2 − ΔΔCT method. Methods 2001;25:402–408.
  • Levine RL. Carbonyl modified proteins in cellular regulation, aging, and disease. Free Radic Biol Med 2002;2:790–796.
  • Rosi S, Vazdarjanova A, Ramirez-Amaya V, Worley PF, Barnes CA, Wenk GL, . Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience 2006;142:1303–1315.
  • Tilleux S, Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 2007;85:2059–2070.
  • Chang YC, Kim HW, Rapoport SI, Rao JS. Chronic NMDA administration increases neuroinflammatory markers in rat frontal cortex: cross-talk between excitotoxicity and neuroinflammation. Neurochem Res 2008;33:2318–2323.
  • Rao JS, Ertley RN, Rapoport SI, Bazinet RP, Lee HJ. Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2. J Neurochem 2007;102:1918–1927.
  • Thommesen L, Sjursen W, Gåsvik K, Hanssen W, Brekke OL, Skattebøl L, . Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1. J Immunol 1998;161:3421–3430.
  • Suyama K, Kabuyama Y, Suzuki S, Kawasaki Y, Suzuki J, Suzuki H, . Induction of transcription factor AP-2 by cytokines and prostaglandins in cultured mesangial cells. Am J Nephrol 2001;21:307–314.
  • Pearson VL, Rothwell NJ, Toulmond S. Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia 1999;25:311–323.
  • Minami M, Kuraishi Y, Satoh M. Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain. Biochem Biophys Res Commun 1991;176:593–598.
  • Rockwell NJ. Cytokines-killer in the brain? J Physiol 1999; 514:3–17.
  • Hu S, Sheng WS, Ehrlich LC, Peterson PK, Chao CC. Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation 2000;7:153–159.
  • Russell L, Blaylock MD. Chronic microglial activation and excitotoxicity secondary to excessive immune stimulation: possible factors in Gulf War syndrome and autism. J Am Physici Surgeons 2004;9:46–51.
  • Heyes MP, Saito K, Lackner A, Wiley CA, Achim CL, Markey SP, . Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques. FASEB J 1998;12:881–896.
  • Berdichevsky E, Riveros N, Sánchez-Armáss S, Orrego F. Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro. Neurosci Lett 1983;36:75–80.
  • Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003;34:325–337.
  • Filbert M, Levine E, Ballough G. Neuroprotection for nerve agent-induced brain damage by blocking delayed calcium overload: a review. J Med CBR Def 2004;3:1–21.
  • Zhivotovsky B, Orrenius S. Cell death mechanisms: cross-talk and role in disease. Exp Cell Res 2010;316:1374–1383.
  • Choi DW. Excitotoxic cell death. J Neurobiol 1992;23: 1261–1276.
  • Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995;92:7162–7166.
  • Kure S, Tominaga T, Yoshimoto T, Tada K, Narisawa K. Glutamate triggers internucleosomal DNA cleavage in neuronal cells. Biochem Biophys Res Commun 1991;179:39–45.
  • Zhong LT, Kane DJ, Bredesen DE. BCL-2 blocks glutamate toxicity in neural cell lines. Brain Res Mol Brain Res 1993; 19:353–355.
  • Figiel I, Kaczmarek L. Cellular and molecular correlates of glutamate-evoked neuronal programmed cell death in the in vitro cultures of rat hippocampal dentate gyrus. Neurochem Int 1997;31:229–240.
  • Tenneti L, D'Emilia DM, Troy CM, Lipton SA. Role of caspases in N-methyl-d-aspartate-induced apoptosis in cerebrocortical neurons. J Neurochem 1998;71:946–959.
  • Jiang Q, Gu Z, Zhang G, Jing G. N-methyl-d-aspartate receptor activation results in regulation of extracellular signal-regulated kinases by protein kinases and phosphatases in glutamate-induced neuronal apototic-like death. Brain Res 2000;887:285–292.
  • Soto A, DelRaso NJ, Schlager JJ, Chan VT. d-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response. Toxicology 2008;243: 177–192.
  • Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, . Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995;15:961–973.
  • Schelman WR, Andres RD, Sipe KJ, Kang E, Weyhenmeyer JA. Glutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line. Brain Res Mol Brain Res 2004;128:160–169.
  • Montpied P, Weller M, Paul SM. N-methyl-d-aspartate receptor agonists decrease protooncogene bcl-2 mRNA expression in cultured rat cerebellar granule neurons. Biochem Biophys Res Commun 1993;195:623–629.
  • Hughes PE, Alexi T, Yoshida T, Schreiber SS, Knusel B. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation. Neuroscience 1996;74:1143–1160.
  • Chen J, Marsh T, Zhang JS, Graham SH. Expression of cyclo-oxygenase 2 in rat brain following kainate treatment. Neuroreport 1995;6:245–248.
  • Adams J, Collaco-Moraes Y, de Belleroche J. Cyclooxygenase 2 induction in cerebral cortex: an intracellular response to synaptic excitation. J Neurochem 1996;66:6–13.
  • Miettinen S, Fusco FR, Yrjänheikki J, Keinänen R, Hirvonen T, Roivainen R, . Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-d-aspartic acid-receptors and phospholipase A2. Proc Natl Acad Sci USA 1997;94:6500–6505.
  • Hewett SJ, Uliasz TF, Vidwans AS, Hewett JA. Cyclooxygenase-2 contributes to N-methyl-d-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther 2000;293:417–425.
  • Strauss KI, Marini AM. Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death. J Neurotrauma 2002;19:627–638.
  • Strauss KI. Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain. Brain Behav Immun 2008;22:285–298.
  • Ramos CL, Pou S, Rosen GM. Effect of anti-inflammatory drugs on myeloperoxidase-dependent hydroxyl radical generation by human neutrophils. Biochem Pharmacol 1993;49: 1079–1084.
  • Halliwell RF, Thomas P, Patten D, James CH, Martinez-Torres A, Miledi R, . Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. Eur J Neurosci 1999;11:2897–2905.
  • Coyne L, Su J, Patten D, Halliwell RF. Characterization of the interaction between fenamates and hippocampal neuron GABA(A) receptors. Neurochem Int 2007;51:440–446.
  • Leipnitz G, da Silva Lde B, Fernandes CG, Seminotti B, Amaral AU, Dutra-Filho CS, . d-Serine administration provokes lipid oxidation and decreases the antioxidant defenses in rat striatum. Int J Dev Neurosci 2010;28:297–301.
  • Ikonomidou-Turski C, Cavalheiro EA, Turski L, Bortolotto ZA, Kleinrok Z, Calderazzo-Filho LS, . Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. Brain Res 1988;462:275–285.
  • Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Beas-Zarate C, . An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders. Expert Opin Investig Drugs 2010;19:587–604.
  • Sanz-Blasco S, Valero RA, Rodríguez-Crespo I, Villalobos C, Núñez L. Mitochondrial Ca2 + overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs. PLoS One 2008;3:e2718.
  • Woo DH, Han IS, Jung G. Mefenamic acid-induced apoptosis in human liver cancer cell-lines through caspase-3 pathway. Life Sci 2004;75:2439–2449.

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