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Original Article

Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells

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Pages 1346-1360 | Received 23 Apr 2012, Accepted 24 Aug 2012, Published online: 05 Sep 2012

References

  • Post-White J, Ladas EJ, Kelly KM. Advances in the use of milk thistle (Silybum marianum). Integr Cancer Ther 2007; 6:104–109.
  • Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, . Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res 2010;207:387–393.
  • Lu P, Mamiya T, Lu LL, Mouri A, Niwa M, Hiramatsu M, . Silibinin attenuates amyloid beta(25–35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice. J Pharmacol Exp Ther 2009;331:319–326.
  • Mokhtari MJ, Motamed N, Shokrgozar MA. Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line. Cell Biol Int 2008;32:888–892.
  • Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res 2007;143: 58–65.
  • Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Bio Ther 2005;4:139–163.
  • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305–1308.
  • Chi S, Kitanaka C, Noguchi K, Mochizuki T, Nagashima Y, Shirouzu M, . Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell deathprogram in human cancer cells. Oncogene 1999;18:2281–2290.
  • Butler R, Mitchell SH, Tindall DJ, Young CY. Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. Cell Growth Differ 2000;11:49–61.
  • Crack J, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 2005;38:1433–1444.
  • Fiers W, Beyaert R, Declercq W, Vandenabeele P. More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 1999;18:7719–7730.
  • Chakraborti T, Das S, Mondal M, Roychoudhury S, Chakraborti S. Oxidant, mitochondria and calcium: an overview. Cell Signal 1999;11:77–85.
  • Choi WY, Kim GY, Lee WH, Choi YH. Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA‐MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway. Chemotherapy 2008;54:279–287.
  • Pryor WA, Houk KN, Foote CS, Fukuto JM, Ignarro LJ, Squadrito GL, . Free radical biology and medicine: it's a gas, man!Am J Physiol Regul Integr Comp Physiol 2006;291:R491–R511.
  • Rotilio G, Aquilano K, Ciriolo MR. Interplay of Cu, Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes. IUBMB Life 2003;55:629–634.
  • Brüne B. The intimate relation between nitric oxide and superoxide in apoptosis and cell survival. Antioxid Redox Signal 2005;7:497–507.
  • Azad N, Iyer A, Vallyathan V, Wang L, Castranova V, Stehlik C, . Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation. Ann N Y Acad Sci 2010;1203:1–6.
  • Swanlund JM, Kregel KC, Oberley TD. Autophagy following heat stress: the role of aging and protein nitration. Autophagy 2008;4:936–939.
  • Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 2004;287:C817–C833.
  • Li LH, Wu LJ, Tashiro S, Onodera S, Uchiumi F, Ikejima T. Silibinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway. Biol Pharm Bull 2006;29:1096–1101.
  • Jiang YY, Wang HJ, Wang J, Tashiro S, Onodera S, Ikejima T. The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells. J Pharmacol Sci 2009;111:137–146.
  • Zhou B, Wu LJ, Li LH, Tashiro S, Onodera S, Uchiumi F, . Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up‐regulation of SIRT1. J Pharmacol Sci 2006;102:387–395.
  • Liu B, Yang P, Ye Y, Zhou Y, Li L, Tashiro S, . Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells. Free Radic Res 2011;45:835–847.
  • Lu P, Mamiya T, Lu LL, Mouri A, Zou L, Nagai T, . Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice. Br J Pharmacol 2009;157:1270–1277.
  • Wang Q, Zou L, Liu W, Hao W, Tashiro S, Onodera S, . Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence. Pharmacol Biochem Behav 2011;98:140–149.
  • Duan W, Jin X, Li Q, Tashiro S, Onodera S, Ikejima T. Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. J Pharmacol Sci 2010;113:48–56.
  • Wang HJ, Jiang YY, Wei XF, Huang H, Tashiro S, Onodera S, . Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells. Free Radic Res 2010;44:90–100.
  • Kauntz H, Bousserouel S, Gossé F, Raul F. Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis 2011;16:1042–1053.
  • Jiang YY, Yang R, Wang HJ, Huang H, Wu D, Tashiro SI, . Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells. Eur J Pharmacol. 2011. [Epub ahead of print].
  • Fan S, Li L, Chen S, Yu Y, Qi M, Tashiro S, . Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells. Free Radic Res 2011;45:1307–1324.
  • Zhao Y, Li R, Xia W, Neuzil J, Lu Y, Zhang H, . Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. Cancer Lett 2010;288:42–49.
  • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007;8:741–752.
  • González-Polo RA, Niso-Santano M, Ortíz-Ortíz MA, Gómez-Martín A, Morán JM, García-Rubio L, . Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells. Toxicol Sci 2007; 97:448–458.
  • Ohtani S, Iwamaru A, Deng W, Ueda K, Wu G, Jayachandran G, . Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy. Cancer Res 2007;67:6293–6303.
  • McBride HM, Neuspiel M, Wasiak S. Mitochondria: more than just a powerhouse. Biol 2006;16:R551–R560.
  • Chen Y, Gibson SB. Is mitochondrial generation of reactive oxygen species a trigger for autophagy?Autophagy 2008;2: 246–248.
  • Ricci JE. Gottlieb RA. Green DR. Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol 2003;160:65–75.
  • Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000;279: L1005–L1028.
  • Huang H, Manton KG. The role of oxidative damage in mitochondria during aging: a review. Front Biosci 2004;9: 1100–1117.
  • Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 2003;66:1499–1503.
  • Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005;15:316–328.
  • Kiruthiga P, Karutha Pandian S, Pandima Devi K. Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: An in vitro study. Environ Toxicol 2011. [Epub ahead of print]
  • Naso LG, Ferrer EG, Butenko N, Cavaco I, Lezama L, Rojo T, . Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium (IV)/silibinin complex. J Biol Inorg Chem 2011;16:653–668.
  • Tsai MJ, Liao JF, Lin DY, Huang MC, Liou DY, Yang HC, . Silymarin protects spinal cord and cortical cells against oxidative stress and lipopolysaccharide stimulation. Neurochem Int 2010;57:867–875.
  • Wang F, Liu J, Robbins D, Morris K, Sit A, Liu YY, . Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells. Apoptosis 2011;16:301–310.
  • Wanka C, Brucker DP, Bähr O, Ronellenfitsch M, Weller M, Steinbach JP, . Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Oncogene 2011 [Epub ahead of print]
  • Fan S, Qi M, Yu Y, Li L, Yao G, Tashiro SI, . P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. Free Radic Res 2012;46:310–319.
  • Ahmad N, Adhami VM, Afaq F, Feyes DK, Mukhtar H. Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res 2001;7:1466–1473.
  • Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M. Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways. Exp Dermatol 2006;15:538–546.
  • Lass A, Sohal BH, Weindruch R, Forster MJ, Sohal RS. Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med 1998;25:1089–1097.
  • Zou Y, Jung KJ, Kim JW, Yu BP, Chung HY. Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. FASEB J 2004;18:320–322.
  • Sumien N, Forster MJ, Sohal RS. Supplementation with vitamin E fails to attenuate oxidative damage in aged mice. Exp Gerontol 2003;38:699–704.

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