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Research Article

The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress

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Pages 1393-1405 | Received 17 May 2012, Accepted 07 Aug 2012, Published online: 05 Sep 2012

References

  • Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis. Biol Pharm Bull 2005;28:2068–2074.
  • Osawa K, Yasuda H, Maruyama T, Morita H, Takeya K, Itokawa H, . An investigation of diterpenes from the leaves of Rabdosia trichocarpa and their antibacterial activity against oral microorganisms. Chem Pharm Bull (Tokyo) 1994;42:922–925.
  • Cheng Y, Qiu F, Ikejima T. Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells. Autophagy 2009;5:430–431.
  • Debatin K. Activation of apoptosis pathways by anticancer treatment. Toxicol Lett 2000;15:41–48.
  • Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, . The role of autophagy during the early neonatal starvation period. Nature 2004;432:1032–1036.
  • Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004;23:2891–2906.
  • Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 2004;59:21–26.
  • Okamoto I. Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy. FEBS J 2010;277:309–315.
  • Kang N, Zhang JH, Qiu F, Tashiro S, Onodera S, Ikejima T. Inhibition of EGFR signalling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Lett 2010;294: 147–158.
  • Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells. Biol Pharm Bull 2007;30:254–260.
  • Crack PJ, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 2005;38:1433–1444.
  • Oyagbemi AA, Azeez OI, Saba AB. Interactions between reactive oxygen species and cancer: the roles of natural dietary antioxidants and their molecular mechanisms of action. Asian Pac J Cancer Prev 2009;10:535–544.
  • Cheng Y, Qiu F, Ye YC, Tashiro S, Onodera S, Ikejima T. Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch Biochem Biophys 2009;490:70–75.
  • Yang J, Wu LJ, Tashino S, Onodera S, Ikejima T. Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis. Free Radic Res 2007;41:1099–1108.
  • Fan S, Li L, Chen S, Yu Y, Qi M, Tashiro S, . Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells. Free Radic Res 2011;45:1307–1324.
  • Suzuki K, Hino M, Kutsuna H, Hato F, Sakamoto C, Takahashi T, . Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1beta. J Immunol 2001;167:5940–5947.
  • Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway. J Asian Nat Prod Res 2008;10:77–87.
  • Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway. J Pharmacol Sci 2007;103: 56–66.
  • Nagane M, Narita Y, Mishima K, Levitzki A, Burgess AW, Cavenee WK, . Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor. J Neurosurg 2001;95:472–479.
  • Ellis AG, Doherty MM, Walker F, Weinstock J, Nerrie M, Vitali A, . Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochem Pharmacol 2006;71:1422–1434.
  • Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 1999;274:5053–5060.
  • Mitsiades CS, Poulaki V, Fanourakis G, Sozopoulos E, McMillin D, Wen Z, . Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation. Clin Cancer Res 2006;12:3705–3712.
  • Ricci JE, Gottlieb RA, Green DR. Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol 2003;160:65–75.
  • Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signalling pathways. J Pharmacol Sci 2008;107:370–379.
  • Ahmad N, Adhami VM, Afaq F, Feyes DK, Mukhtar H. Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res 2001;7: 1466–1473.
  • Li FC, Li YH, Zhao X, Fu WN, Xu ZM, Li ZG, . Association of homozygous deletion of p15 and p16 gene and amplification of EGFR gene in laryngeal squamous cell carcinoma. Yi Chuan Xue Bao 2004;31:109–113.
  • Li F, Kang N, Fu W, Sun X, Gao H, Sun K. Detection of epidermal growth factor receptor gene amplification in human laryngeal carcinomas by means of fluorescence in situ hybridization. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000;17:278–280.
  • Efferth T, Ramirez T, Gebhart E, Halatsch ME. Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774. Biochem Pharmacol 2004;67:1689–1700.
  • Pu YS, Hsieh MW, Wang CW, Liu GY, Huang CY, Lin CC, . Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells. Biochem Pharmacol 2006;71:751–760.
  • Lee HY, Crawley S, Hokari R, Kwon S, Kim YS. Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Int J Oncol 2010;36: 941–953.
  • Dhanasekaran DN, Reddy EP. JNK signalling in apoptosis. Oncogene 2008;27:6245–6251.
  • Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, . Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 2011;475:231–234.
  • Wong KK. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK pathway. Recent Pat Anticancer Drug Discov 2009;4:28–35.
  • Cui Q, Tashiro S, Onodera S, Minami M, Ikejima T. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 2007;30: 859–864.
  • Joo SS, Yoo YM. Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. J Pineal Res 2009;47:8–14.
  • Heasley LE, Han SY. JNK regulation of oncogenesis. Mol Cells 2006;21:167–173.
  • Bode AM, Dong Z. The functional contrariety of JNK. Mol Carcinog 2007;46:591–598.
  • Schramek D, Kotsinas A, Meixner A, Penninger JM. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet 2011;43:212–219.
  • Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu Rev Pathol 2008;3:427–455.
  • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007;8:741–752.
  • Cui Q, Tashiro S, Onodera S, Minami M, Ikejima T. Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. J Pharmacol Sci 2007;105:317–325.
  • Li D, Cui Q, Chen SG, Wu LJ, Tashiro S, Onodera S, . Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. J Pharmacol Sci 2007;105:22–33.
  • Zhang Y, Wu Y, Cheng Y, Zhao Z, Tashiro S, Onodera S, . Fas-mediated autophagy requires JNK activation in HeLa cells. Biochem Biophys Res Commun 2008;377: 1205–1210.
  • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007;8:741–752.

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