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Review Article

Oxidative stress associated to dysfunctional adipose tissue: a potential link between obesity, type 2 diabetes mellitus and breast cancer

, , , &
Pages 243-256 | Received 25 Oct 2012, Accepted 30 Jan 2013, Published online: 26 Feb 2013

References

  • Lorincz AM, Sukumar S. Molecular links between obesity and breast cancer. Endocr Relat Cancer 2006;13:279–292.
  • Pollan M. Epidemiology of breast cancer in young women. Breast Cancer Res Treat 2010;123:3–6.
  • Hankinson SE, Colditz GA, Willett WC. Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res 2004;6:213–218.
  • Larsson SC, Mantzoros CS, Wolk A. Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer 2007;121: 856–862.
  • Abdullah A, Peeters A, de Courten M, Stoelwinder J. The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies. Diabetes Res Clin Pract 2011;89:309–319.
  • Casanueva FF, Moreno B, Rodriguez-Azeredo R, Massien C, Conthe P, Formiguera X, . Relationship of abdominal obesity with cardiovascular disease, diabetes and hyperlipidaemia in Spain. Clin Endocrinol (Oxf) 2010;73:35–40.
  • Zou C, Shao J. Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem 2008;19:277–286.
  • Cusi K. The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes. Curr Diab Rep 2011;10:306–315.
  • Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, Smith SR. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 2004;89: 1844–1848.
  • Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R. Diabetes and cancer. Endocr Relat Cancer 2009;16:1103–1123.
  • Crujeiras AB, Cueva J, Vieito M, Curiel T, Lopez-Lopez R, Pollan M, Casanueva FF. Association of breast cancer and obesity in a homogeneous population from Spain. J Endocrinol Invest 2012;35:681–685.
  • Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR,. Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials. Cancer Prev Res (Phila) 2012;5:583–592.
  • Carmichael AR. Obesity as a risk factor for development and poor prognosis of breast cancer. BJOG 2006;113: 1160–1166.
  • Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL, . Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst 2011; 103:250–263.
  • Anderson GL, Neuhouser ML. Obesity and the risk for premenopausal and postmenopausal breast cancer. Cancer Prev Res (Phila) 2012;5:515–521.
  • Prieto-Hontoria PL, Perez-Matute P, Fernandez-Galilea M, Bustos M, Martinez JA, Moreno-Aliaga MJ. Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach. Biochim Biophys Acta 2011;1807: 664–678.
  • Dizdar O, Alyamac E. Obesity: an endocrine tumor?Med Hypotheses 2004;63:790–792.
  • Fang J, Seki T, Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009;61:290–302.
  • Kundu JK, Surh YJ. Inflammation: gearing the journey to cancer. Mutat Res 2008;659:15–30.
  • Kaplan MA, Pekkolay Z, Kucukoner M, Inal A, Urakci Z, Ertugrul H, . Type 2 diabetes mellitus and prognosis in early stage breast cancer women. Med Oncol 2012;29:1576–1580.
  • Gouveri E, Papanas N, Maltezos E. The female breast and diabetes. Breast 2011;20:205–211.
  • Liao S, Li J, Wei W, Wang L, Zhang Y, Li J, . Association between Diabetes Mellitus and Breast Cancer Risk: a meta-analysis of the literature. Asian Pac J Cancer Prev 2011;12:1061–1065.
  • Barone BB, Yeh HC, Snyder CF, Peairs KS, Stein KB, Derr RL, . Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA 2008;300:2754–2764.
  • He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2 + breast cancer. Ann Oncol 2012;23:1771–1780.
  • Chakraborty A, Chowdhury S, Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract 2011;93:56–62.
  • Holbro T, Hynes NE. ErbB receptors: directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol 2004;44:195–217.
  • Gallagher EJ, Fierz Y, Vijayakumar A, Haddad N, Yakar S, LeRoith D. Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia. Oncogene 2012;31: 3213–3222.
  • Fernandez-Real JM, Menendez JA, Fruhbeck G, Moreno- Navarrete JM, Vazquez-Martin A, Ricart W. Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss. Nutr Metab (Lond) 2010;7:14.
  • van Kruijsdijk RC, van der Wall E, Visseren FL. Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev 2009;18:2569–2578.
  • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008;454:436–444.
  • Gilbert CA, Slingerland JM. Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression. Annu Rev Med 2013;64:45–47.
  • Goldberg JE, Schwertfeger KL. Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Curr Drug Targets 2010;11:1133–1146.
  • Nicolini A, Carpi A, Rossi G. Cytokines in breast cancer. Cytokine Growth Factor Rev 2006;17:325–337.
  • Soria G, Ofri-Shahak M, Haas I, Yaal-Hahoshen N, Leider-Trejo L, Leibovich-Rivkin T, . Inflammatory mediators in breast cancer: coordinated expression of TNFalpha & IL-1beta with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer 2011;11:130.
  • Kamel M, Shouman S, El-Merzebany M, Kilic G, Veenstra T, Saeed M, . Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells. J Cancer 2012;3:310–321.
  • Diaz-Lagares A, Alegre E, Gonzalez A. Detection of 3-nitrotyrosine-modified human leukocyte antigen-G in biological fluids. Hum Immunol 2009;70:976–980.
  • Diaz-Lagares A, Alegre E, LeMaoult J, Carosella ED, Gonzalez A. Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu. Immunology 2009;126:436–445.
  • Kim JM, Lee EK, Park G, Kim MK, Yokozawa T, Yu BP, Chung HY. Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity. Free Radic Res 2010;44:454–461.
  • Halliwell B, Gutteridge JM. Free radicals in biology and medicine. Oxford, UK: Clarendon Press; 2007.
  • Perez-Matute P, Zulet MA, Martinez JA. Reactive species and diabetes: counteracting oxidative stress to improve health. Curr Opin Pharmacol 2009;9:771–779.
  • Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39: 44–84.
  • Diaz-Lagares A, Alegre E, Arroyo A, Corrales FJ, Gonzalez A. Tyrosine nitration in the human leucocyte antigen-G-binding domain of the Ig-like transcript 2 protein. Febs J 2009;276: 4233–4243.
  • Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked?Free Radic Biol Med 2010;49:1603–1616.
  • Kundu JK, Surh YJ. Emerging avenues linking inflammation and cancer. Free Radic Biol Med 2012;52:2013–2037.
  • Cortes DF, Sha W, Hower V, Blekherman G, Laubenbacher R, Akman S, . Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress. Free Radic Biol Med 2011;50:1565–1574.
  • Panis C, Victorino VJ, Herrera AC, Freitas LF, De Rossi T, Campos FC, . Differential oxidative status and immune characterization of the early and advanced stages of human breast cancer. Breast Cancer Res Treat 2012;133:881–888.
  • Peluso M, Munnia A, Risso GG, Catarzi S, Piro S, Ceppi M, . Breast fine-needle aspiration malondialdehyde deoxyguanosine adduct in breast cancer. Free Radic Res 2011;45: 477–482.
  • Vera-Ramirez L, Sanchez-Rovira P, Ramirez-Tortosa MC, Ramirez-Tortosa CL, Granados-Principal S, Lorente JA, Quiles JL. Oxidative stress status in metastatic breast cancer patients receiving palliative chemotherapy and its impact on survival rates. Free Radic Res 2011;46:2–10.
  • Gago-Dominguez M, Castelao JE, Pike MC, Sevanian A, Haile RW. Role of lipid peroxidation in the epidemiology and prevention of breast cancer. Cancer Epidemiol Biomarkers Prev 2005;14:2829–2839.
  • Vera-Ramirez L, Ramirez-Tortosa M, Perez-Lopez P, Granados-Principal S, Battino M, Quiles JL. Long-term effects of systemic cancer treatment on DNA oxidative damage: the potential for targeted therapies. Cancer Lett 2012;327: 134–141.
  • Vera-Ramirez L, Sanchez-Rovira P, Ramirez-Tortosa MC, Ramirez-Tortosa CL, Granados-Principal S, Lorente JA, Quiles JL. Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. Biological bases to develop oxidative-based therapies. Crit Rev Oncol Hematol 2011;80:347–368.
  • Hamdy SM, Latif AK, Drees EA, Soliman SM. Prevention of rat breast cancer by genistin and selenium. Toxicol Ind Health 2012;28:746–757.
  • Al-Malki AL, Moselhy SS, Refai MY. Synergistic effect of lycopene and tocopherol against oxidative stress and mammary tumorigenesis induced by 7,12-dimethyl[a]benzanthracene in female rats. Toxicol Ind Health 2012;28:542–548.
  • Escrich E, Solanas M, Moral R, Escrich R. Modulatory effects and molecular mechanisms of olive oil and other dietary lipids in breast cancer. Curr Pharm Des 2011;17: 813–830.
  • Gonzalez CA, Riboli E. Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Cancer 2010;46:2555–2562.
  • Trichopoulou A, Bamia C, Lagiou P, Trichopoulos D. Conformity to traditional Mediterranean diet and breast cancer risk in the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohort. Am J Clin Nutr 2010; 92:620–625.
  • Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics. Genes Dev 2009;23:781–783.
  • Holliday R. The inheritance of epigenetic defects. Science 1987;238:163–170.
  • Herceg Z, Vaissiere T. Epigenetic mechanisms and cancer: an interface between the environment and the genome. Epigenetics 2011;6:804–819.
  • Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010;28:1057–1068.
  • Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med 2011;17:330–339.
  • Taby R, Issa JP. Cancer epigenetics. CA Cancer J Clin 2010;60:376–392.
  • Esteller M. Epigenetics in cancer. N Engl J Med 2008;358: 1148–1159.
  • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683–692.
  • Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, . Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007;67:1424–1429.
  • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011;12:861–874.
  • Taft RJ, Pang KC, Mercer TR, Dinger M, Mattick JS. Non-coding RNAs: regulators of disease. J Pathol 2010;220:126–139.
  • Lee SK, Calin GA. Non-coding RNAs and cancer: new paradigms in oncology. Discov Med 2011;11:245–254.
  • Garzon R, Calin GA, Croce CM. MicroRNAs in Cancer. Annu Rev Med 2009;60:167–179.
  • Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell 2010;19: 698–711.
  • Campion J, Milagro F, Martinez JA. Epigenetics and obesity. Prog Mol Biol Transl Sci 2010;94:291–347.
  • Toperoff G, Aran D, Kark JD, Rosenberg M, Dubnikov T, Nissan B, . Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet 2011;21:371–83.
  • Ballestar E. Epigenetic alterations in autoimmune rheumatic diseases. Nat Rev Rheumatol 2011;7:263–271.
  • Nimmo ER, Prendergast JG, Aldhous MC, Kennedy NA, Henderson P, Drummond HE, . Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis 2011;18:889–899.
  • Sharma G, Mirza S, Yang YH, Parshad R, Hazrah P, Datta Gupta S, Ralhan R. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. Cell Oncol 2009;31:487–500.
  • Huang Y, Nayak S, Jankowitz R, Davidson NE, Oesterreich S. Epigenetics in breast cancer: what's new?Breast Cancer Res 2011;13:225.
  • Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, . MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65:7065–7070.
  • Hill VK, Hesson LB, Dansranjavin T, Dallol A, Bieche I, Vacher S, . Identification of 5 novel genes methylated in breast and other epithelial cancers. Mol Cancer 2010;9:51.
  • Hill VK, Ricketts C, Bieche I, Vacher S, Gentle D, Lewis C, . Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity. Cancer Res 2011;71:2988–2999.
  • Hamilton JP. Epigenetics: principles and practice. Dig Dis 2011;29:130–135.
  • Ziech D, Franco R, Pappa A, Panayiotidis MI. Reactive oxygen species (ROS) –induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res 2011;711:167–173.
  • O’Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, . Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands. Cancer Cell 2011;20: 606–619.
  • Franco R, Schoneveld O, Georgakilas AG, Panayiotidis MI. Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett 2008;266:6–11.
  • Wachsman JT. DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis. Mutat Res 1997;375:1–8.
  • Govindarajan B, Klafter R, Miller MS, Mansur C, Mizesko M, Bai X, . Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase. Mol Med 2002;8:1–8.
  • Lim SO, Gu JM, Kim MS, Kim HS, Park YN, Park CK, . Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 2008;135:2128–2140, 2140.e2121–2128.
  • Rajendran R, Garva R, Krstic-Demonacos M, Demonacos C. Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol 2011;2011:368276.
  • Mateescu B, Batista L, Cardon M, Gruosso T, de Feraudy Y, Mariani O, . miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med 2011;17:1627–1635.
  • Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, . Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One 2009;4:e6377.
  • Castilla MA, Diaz-Martin J, Sarrio D, Romero-Perez L, Lopez-Garcia MA, Vieites B, . MicroRNA-200 family modulation in distinct breast cancer phenotypes. PLoS One 2012;7:e47709.
  • Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548–2556.
  • Catalan V, Gomez-Ambrosi J, Rodriguez A, Salvador J, Fruhbeck G. Adipokines in the treatment of diabetes mellitus and obesity. Expert Opin Pharmacother 2009;10:239–254.
  • Roca-Rivada A, Alonso J, Al-Massadi O, Castelao C, Peinado JR, Seoane LM, . Secretome analysis of rat adipose tissues shows location-specific roles for each depot type. J Proteomics 2011;74:1068–1079.
  • Crujeiras AB, Parra D, Goyenechea E, Abete I, Gonzalez-Muniesa P, Martinez JA. Energy restriction in obese subjects impact differently two mitochondrial function markers. J Physiol Biochem 2008;64:211–219.
  • Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 2006;30:400–418.
  • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579–591.
  • Grossmann ME, Cleary MP. The balance between leptin and adiponectin in the control of carcinogenesis - focus on mammary tumorigenesis. Biochimie 2012;94:2164–2171.
  • Ray A. Adipokine leptin in obesity-related pathology of breast cancer. J Biosci 2012;37:289–294.
  • Konstantinidis D, Paletas K, Koliakos G, Kaloyianni M. The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes. Cell Stress Chaperones 2009;14:591–601.
  • Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001;276:25096–25100.
  • Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel-Soto J, Morales-Gonzalez A, Esquivel-Chirino C, . Inflammation, oxidative stress, and obesity. Int J Mol Sci 2011;12:3117–3132.
  • Cleary MP, Grossmann ME. Minireview: obesity and breast cancer: the estrogen connection. Endocrinology 2009;150: 2537–2542.
  • Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, . Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res (Phila) 2011;4:1021–1029.
  • Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, . Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila) 2011;4:329–346.
  • Hou J, Wang X, Li Y, Liu X, Wang Z, An J, . 17beta-estradiol induces both up-regulation and processing of cyclin E in a calpain-dependent manner in MCF-7 breast cancer cells. FEBS Lett 2012;586:892–896.
  • Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, . Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monogr 2000: 95–112.
  • Arcidiacono B, Iiritano S, Nocera A, Possidente K, Nevolo MT, Ventura V, . Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms. Exp Diabetes Res 2012;2012:789174.
  • Weichhaus M, Broom J, Wahle K, Bermano G. A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer. Int J Oncol 2012;41:745–752.
  • Martin EC, Bratton MR, Zhu Y, Rhodes LV, Tilghman SL, Collins-Burow BM, Burow ME. Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line. PLoS One 2012;7:e49067.
  • D’Esposito V, Passaretti F, Hammarstedt A, Liguoro D, Terracciano D, Molea G, . Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia 2012;55:2811–2822.
  • Krieger-Brauer HI, Medda PK, Kather H. Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. J Biol Chem 1997;272:10135–10143.
  • Aggeli IK, Theofilatos D, Beis I, Gaitanaki C. Insulin-induced oxidative stress up-regulates heme oxygenase-1 via diverse signaling cascades in the C2 skeletal myoblast cell line. Endocrinology 2011;152:1274–1283.
  • Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, . Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114: 1752–1761.
  • Suhail N, Bilal N, Khan HY, Hasan S, Sharma S, Khan F, . Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy. J Clin Pharm Ther 2011;37:22–26.
  • Chen YC, Sosnoski DM, Gandhi UH, Novinger LJ, Prabhu KS, Mastro AM. Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. Carcinogenesis 2009;30:1941–1948.
  • Hauner H, Hauner D. The impact of nutrition on the development and prognosis of breast cancer. Breast Care (Basel) 2010;5:377–381.
  • Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist 2010;15:556–565.
  • Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE. Adult weight change and risk of postmenopausal breast cancer. JAMA 2006;296:193–201.
  • Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA. Physical activity and survival after breast cancer diagnosis. JAMA 2005;293:2479–2486.
  • Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, . Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst 2006;98: 1767–1776.
  • Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007;9: 813–839.
  • Crujeiras AB, Parra MD, Rodriguez MC, Martinez de Morentin BE, Martinez JA. A role for fruit content in energy-restricted diets in improving antioxidant status in obese women during weight loss. Nutrition 2006;22:593–599.
  • Crujeiras AB, Parra D, Abete I, Martinez JA. A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects. Free Radic Res 2007;41: 498–506.
  • Crujeiras AB, Parra D, Goyenechea E, Abete I, Martinez JA. Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction. Eur J Nutr 2009;48:341–347.
  • Crujeiras AB, Parra D, Milagro FI, Goyenechea E, Larrarte E, Margareto J, Martinez JA. Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study. Omics 2008;12:251–261.
  • Crujeiras AB, Parra D, Goyenechea E, Martinez JA. Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction. Eur J Clin Invest 2008;38:672–678.
  • Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 2011;11:886–895.
  • Luo T, Yan HM, He P, Luo Y, Yang YF, Zheng H. Aspirin use and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 2011;131:581–587.
  • Ararat E, Sahin I, Altundag K. Mechanisms behind the aspirin use and decreased breast cancer incidence. J Buon 2011;16:180.
  • Cuzick J, DeCensi A, Arun B, Brown PH, Castiglione M, Dunn B, . Preventive therapy for breast cancer: a consensus statement. Lancet Oncol 2011;12:496–503.

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