246
Views
14
CrossRef citations to date
0
Altmetric
Research Article

DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16

, , , , &
Pages 316-324 | Received 06 Aug 2012, Accepted 03 Feb 2013, Published online: 08 Mar 2013

References

  • Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000;408:255–262.
  • Finch CE, Ruvkun G. The genetics of aging. Annu Rev Genomics Hum Genet 2001;2:435–462.
  • Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005;120:449–460.
  • Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 2001;11:1975–1980.
  • Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 2001;11:1950–1957.
  • Lin K, Hsin H, Libina N, Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 2001;28:139–145.
  • Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that ontrol C. elegans life-span and metabolism. Science 2003;300:644–647.
  • McElwee J, Bubb K, Thomas JH. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2003;2:111–121.
  • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, . Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003;424:77–283.
  • Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA. A new DAF-16 isoform regulates longevity. Nature 2010;466: 498–502.
  • Honda Y, Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J 1999;13:1385–1393.
  • Murakami S, Johnson TE. The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Curr Biol 2001;11:1517–1523.
  • Barsyte D, Lovejoy DA, Lithgow GJ. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J 2001;15:627–634.
  • Ookuma S, Fukuda M, Nishida E. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr Biol 2003;13:427–431.
  • Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131:3897–3906.
  • Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 2003;300:1142–1145.
  • Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet 2006;38:251–257.
  • Rine J, Herskowitz I. Four genes responsible for a position effect on expression from HML and HMR in Sac-charomyces cerevisiae. Genetics 1987;116:9–22.
  • Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999; 13:2570–2580.
  • Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 2004;101:15998–16003.
  • Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001; 410:227–230.
  • Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 2006;125:1165–1177.
  • Guan S, Li P, Wang L. A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans. Free Radic Res 2010;44:813–820.
  • Yali L, Lili G, Roger WR, Wei L. The method improvement of synthyesis and purification of deuterohemin. Acta Sci Nat Univ Jilin 2001;1:91–92.
  • Liping W, Yali L, Wei L. Synthesis and anti-cataract activity of a novel peroxidase mimetics. Chem J Chin Univ 2004; 25:2171–2173.
  • Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974;77:71–94.
  • Kamath R, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, . Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 2003;421:231–237.
  • Dixon TJ, Taggart JB, George SG. Application of real time PCR determination to assess interanimal variabilities in CYP1A induction in the European flounder (Platichthys flesus). Mar Environ Res 2002;54:267–270.
  • Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S, Hahn K. Localized Rac activation dynamics visualized in living cells. Science 2000;290:333–337.
  • Strayer A, Wu Z, Christen Y, Link CD, Luo Y. Expression of the small heatshock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J 2004;17:2305–2307.
  • Kampko¨tter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wa¨tjen W, Kahl R. Investigations of protective effects of the flavonoids quercetin and rutin onstress resistance the in model organism Caenorhabditis elegans. Toxicology 2007;234:113–123.
  • Shi YC, Yu CW, Liao VH, Pan TM. Monascus-Fermented dioscorea enhances oxidative stress resistance via DAF- 16/FOXO in Caenorhabditis elegans. PLoS One 2012;7: e39515.
  • Friedman DB, Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 1988;118:75–86.
  • Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 2002;161:1101–1112.
  • Furuyama T, Nakazawa T, Nakano I, Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 2000;349:629–634.
  • Giglio AM, Hunter T, Bannister JV, Bannister WH, Hunter GJ. The copper/zinc superoxide dismutase gene of Caenorhabditis elegans. Biochem Mol Biol Int 1994;33: 41–44.
  • Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev 2006;127:741–747.
  • Mukhopadhyay A, Oh SW, Tissenbaum HA. Worming pathways to and from DAF-16/FOXO. Exp Gerontol 2006;41:928–934.
  • Hileman EO, Liu J, Albitar M, Keating MJ, Huang P. Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol 2004;53:209–219.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.