983
Views
69
CrossRef citations to date
0
Altmetric
Research Article

Abnormal mitochondrial fusion–fission balance contributes to the progression of experimental sepsis

, , , , , , , & show all
Pages 769-783 | Received 22 Oct 2013, Accepted 17 Mar 2014, Published online: 10 Apr 2014

References

  • Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165–228.
  • Dyson A, Singer M. Why does preclinical efficacy fail to translate to the clinical setting?Crit Care Med 2009;37: S30–S37.
  • Bathia M, He M, Zhang H, Moochhala S. Sepsis as a model of SIRS. Frontiers Biosci 2009;14:4703–4711.
  • Opal SM. The host response to endotoxin, anti- lipopolysaccharide strategies, and the management of severe sepsis. Int J Med Microbiol 2007;297:365–377.
  • Remick DG, Ward PA. Evaluation of endotoxin models for the study of sepsis. Shock 2005;24:7–11.
  • Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue LW III, Bland KI, Chaudry IH. Cecal ligation and puncture. Shock 2005;24:52–57.
  • Beal AL, Cerra FB. Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction. JAMA 1991;271:226–233.
  • Kurose I, Miura S, Higuchi H, Watanabe N, Kamegaya Y, Takaishi M, et al. Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor alpha. Hepatology 1996;24: 1185–1192.
  • Cawels A. Nitric oxide in shock. Kidney Int 2007;72: 557–565.
  • Hauser B, Bracht H, Matejovi M, Radermacher P, Venkatesh B. Nitric oxide synthase inhibition in sepsis?Lessons learned from large-animal studies. Anesth Analg 2005;101:488–498.
  • Fredriksson K, Tjader I, Keller P, Petrovic N, Ahlman B, Schéele C, et al. Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PLoS One 2008;3:e3686. doi:10.1371/journal.pone.0003686.
  • Brown GC, Borutaite V. Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochem Biophys Acta 2004;1658:44–49.
  • Lee HC, Wei YH. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol 2005;37:822–834.
  • Rasbach KA, Schnellmann RG. Signaling of mitochondrial biogenesis following oxidative injury. J Biol Chem 2007;282:2355–2362.
  • Choumar A, Tarhuni A, Lettéron P, Reyl-Desmars F, Dauhoo N, Damasse J, et al. Lypopolysaccharide-induced mitochondrial DNA depletion. Antioxid Redox Signal 2011; 15:2837–2854.
  • Antico Arciuch VG, Elguero ME, Poderoso JJ, Carreras MC. Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal 2012;16:1150–1180.
  • Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes Dev 2008;22:1577–1590.
  • Chan DC. Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 2012;46: 265–287.
  • Palmer CS, Osellame LD, Stojanovski D, Ryan MT. The regulation of mitochondrial morphology: intrincate mechanisms and dynamic machinery. Cell Signal 2011; 23:1534–1545.
  • Brooks C, Wei Q, Cho SG, Donq Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 2009;119:1275–1285.
  • Carreras MC, Converso DP, Lorente AS, Barbich MR, Levisman DM, Jaitovich A, et al. Mitochondrial nitric oxide synthase drives redox signals from proliferation and quiescence in rat liver development. Hepatology 2004; 40:157–166.
  • Poderoso JJ, Lisdero C, Schöpfer F, Riobó N, Carreras MC, Cadenas E, Boveris A. The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol. J Biol Chem 1999;274:37709–37716.
  • Berry MN, Friend DS. High-yield preparation of isolated rat parenchymal cells: a biochemical and fine structural study. J Cell Biol 1969;43:506–520.
  • López-Figueroa M, Caamaño C, Morano MI, Ronn LC, Akil H, Watson SJ. Direct evidence of nitric oxide presence within mitochondria. Biochem Biophys Res Commun 2000;272:129–133.
  • Morais Cardoso S, Pereira C, Resende Oliveira C. Mitochondrial function is differentially affected upon oxidative stress. Free Rad Biol Med 1999;26:3–13.
  • Escames G, León J, Macías M, Khaldy H, Acuña-Castroviejo D. Melatonin counteracts lipopolysaccaride-induced expression and activity of mitochondrial nitric oxide synthase in rats. FASEB J 2003;17:932–934.
  • Lisdero CL, Carreras MC, Meulemans A, Melani M, Aubier M, Boczkowski J, Poderoso JJ. The mitochondrial interplay of ubiquinol and nitric oxide in endotoxemia. Methods Enzymol 2004;382:67–81.
  • López LC, Escames G, Tapias V, Utrilla P, León J, Acuña-Castroviejo D. Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin. Int J Biochem Cell Biol 2006;38:267–278.
  • Jagnandan D, Sessa WC, Fulton D. Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am J Physiol Cell Physiol 2005;289:C1024–C1033.
  • Piantadosi SA, Suliman HG. Redox regulation of mitochondrial biogenesis. Free Rad Biol Med 2012;53: 2043–2053.
  • Brealey D, Karyampudi S, Jacques TS, Novelli M, Stidwill R, Taylor V, et al. Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol 2003;286:R491–497.
  • Franco MC, Antico Arciuch VG, Peralta JG, Galli S, Levisman D, López LM, et al. Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric oxide synthase. J Biol Chem 2006;281:4779–4786.
  • Beltran B, Orsi A, Clementi E, Moncada S. Oxidative stress and S-nitrosylation of proteins in cells. Br J Pharmacol 2000;129:953–960.
  • Borutaite V, Budriunaite A, Brown GC. Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols. Biochim Biophys Acta 2000;1459:405–412.
  • Riobo NA, Clementi E, Melani M, Boveris A, Cadenas E, Moncada S, Poderoso JJ. Nitric oxide inhibits mitochondrial NADH: ubiquinone reductase activity through peroxynitrite formation. Biochem J 2001;359:139–145.
  • Carreras MC, Franco MC, Peralta JG, Poderoso JJ. Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease. Mol Aspects Med 2004;25:125–139.
  • Carreras MC, Poderoso JJ. Mitochondrial nitric oxide in the signaling of cell integrated responses. Am J Physiol Cell Physiol 2007;292:1569–1580.
  • Dalle-Donne I, Aldini G, Carini M, Colombo R, Rossi R, Milzani A. Protein carbonylation, cellular dysfunction, and disease progression. J Cell Mol Med 2006;10:389–406.
  • Boczkowski J, Lisdero C, Lanone S, Carreras MC, Boveris A, Aubier M, Poderoso JJ. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia. FASEB J 1999;13:1637–1646.
  • Alvarez S, Boveris A. Mitochondrial nitric oxide metabolism in rat muscle during endotoxemia. Free Rad Biol Med 2004;37:1472–1478.
  • Protti A, Carré J, Frost MT, Taylor V, Stidwill R, Rudiger A, Singer M. Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle. Crit Care Med 2007;35:2150–2155.
  • Hock MB, Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol 2009;71: 177–203.
  • Crouser ED, Julian MW, Huff JE, Struck J, Cook CD. Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis. Crit Care Med 2006;34:2439–2446.
  • Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 2010;141:280–289.
  • Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA. S-nitrosylation of Drp1 mediates β-amyloid- related mitochondrial fission and neuronal injury. Science 2009;324:102–105.
  • Foster MW, Hess DT, Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 2009;15:391–404.
  • Wu S, Zhou F, Zhang Z, Xing D. Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins. FEBS J 2011;278:941–954.
  • Chen H, Chan DC. Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 2005; 14:R283–289.
  • Campello S, Scorrano L. Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep 2010;11: 678–684.
  • Muster B, Kohl W, Wittig I, Strecker V, Joos F, Haase W, et al. Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells. PLoS One 2010;5:e11910. doi:10.1371/journal.pone.0011910
  • Westermann B. Bioenergetics role of mitochondrial fusion and fission. Biochim Biophys Acta 2012;1817: 1833–1838.
  • Westermann B. Mitochondrial fusion and fission in cell life and death. Nature Rev Mol Cell Biol 2010;11: 872–884.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.