PKCδ phosphorylation is an upstream event of GSK3 inactivation-mediated ROS generation in TGF-β1-induced senescence

References

• Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614–636.
   PubMed Web of Science ®Google Scholar
• Cristofalo VJ, Lorenzini A, Allen RG, Torres C, Tresini M. Replicative senescence: a critical review. Mech Ageing Dev 2004;125:827–848.
   PubMed Web of Science ®Google Scholar
• Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000;408:239–247.
   PubMed Web of Science ®Google Scholar
• Das D, Holmes A, Murphy GA, Mishra K, Rosenkranz AC, Horowitz JD, Kennedy JA. TGF-beta1-Induced MAPK activation promotes collagen synthesis, nodule formation, redox stress and cellular senescence in porcine aortic valve interstitial cells. J Heart Valve Dis 2013;22:621–630.
   PubMed Web of Science ®Google Scholar
• Untergasser G, Gander R, Rumpold H, Heinrich E, Plas E, Berger P. TGF-beta cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence. Exp Gerontol 2003;38:1179–1188.
   PubMed Web of Science ®Google Scholar
• Fabregat I, Fernando J, Mainez J, Sancho P. TGF-beta signaling in cancer treatment. Curr Pharm Des 2013.
   Web of Science ®Google Scholar
• Massagué J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753–791.
   PubMed Web of Science ®Google Scholar
• Massagué J, Chen YG. Controlling TGF-beta signaling. Genes Dev 2000;14:627–644.
   PubMed Web of Science ®Google Scholar
• Pardali K, Moustakas A. Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta 2007;1775:21–62.
   PubMed Web of Science ®Google Scholar
• Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 1994;371: 257–261.
   PubMed Web of Science ®Google Scholar
• Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577–584.
   PubMed Web of Science ®Google Scholar
• Pardali K, Kurisaki A, Moren A, ten Dijke P, Kardassis D, Moustakas A. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem 2000;275:29244–29256.
   PubMed Web of Science ®Google Scholar
• Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003;3:807–821.
   PubMed Web of Science ®Google Scholar
• Li CY, Suardet L, Little JB. Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. J Biol Chem 1995;270:4971–4974.
   PubMed Web of Science ®Google Scholar
• Zhao H, Patra A, Tanaka Y, Li LC, Dahiya R. Transforming growth factor-beta(s) and their receptors in aging rat prostate. Biochem Biophys Res Commun 2002;294:464–469.
   PubMed Web of Science ®Google Scholar
• Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O. Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 2001;276:2531–2537.
   PubMed Web of Science ®Google Scholar
• Katakura Y, Nakata E, Miura T, Shirahata S. Transforming growth factor beta triggers two independent-senescence programs in cancer cells. Biochem Biophys Res Commun 1999;255:110–115.
   PubMed Web of Science ®Google Scholar
• Kordon EC, McKnight RA, Jhappan C, Hennighausen L, Merlino G, Smith GH. Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol 1995;168: 47–61.
   PubMed Web of Science ®Google Scholar
• Rahimi RA, Leof EB. TGF-beta signaling: a tale of two responses. J Cell Biochem 2007;102:593–608.
   PubMed Web of Science ®Google Scholar
• Buday A, Orsy P, Godo M, Mozes M, Kokeny G, Lacza Z, et al. Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice. Am J Physiol Heart Circ Physiol 2010;299: H386–H395.
   PubMed Web of Science ®Google Scholar
• Hu T, Ramachandrarao SP, Siva S, Valancius C, Zhu Y, Mahadev K, et al. Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells. Am J Physiol Renal Physiol 2005;289:F816–F825.
   PubMed Web of Science ®Google Scholar
• Nam HJ, Park YY, Yoon G, Cho H, Lee JH. Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation. Exp Mol Med 2010;42:270–279.
   PubMed Web of Science ®Google Scholar
• Xia L, Wang H, Munk S, Kwan J, Goldberg HJ, Fantus IG, Whiteside CI. High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF-beta1 signaling in mesangial cells. Am J Physiol Renal Physiol 2008;295:F1705–F1714.
   PubMed Web of Science ®Google Scholar
• Herrera B, Alvarez AM, Sanchez A, Fernandez M, Roncero C, Benito M, et al. Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J 2001;15:741–751.
   PubMed Web of Science ®Google Scholar
• Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology 2010;52:966–974.
   PubMed Web of Science ®Google Scholar
• Yoon YS, Lee JH, Hwang SC, Choi KS, Yoon G. TGF beta1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells. Oncogene 2005;24:1895–1903.
   PubMed Web of Science ®Google Scholar
• Byun HO, Jung HJ, Seo YH, Lee YK, Hwang SC, Hwang ES, Yoon G. GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence. Exp Cell Res 2012;318:1808–1819.
   PubMed Web of Science ®Google Scholar
• Wheaton K, Riabowol K. Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Mol Cell Biol 2004;24:7298–7311.
   PubMed Web of Science ®Google Scholar
• Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 2006;8:1291–1297.
   PubMed Web of Science ®Google Scholar
• Katakura Y, Udono M, Katsuki K, Nishide H, Tabira Y, Ikei T, et al. Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells. J Biochem 2009;146:87–93.
   PubMed Web of Science ®Google Scholar
• Hayashida T, Schnaper HW. High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal–regulated kinase and protein kinase Cdelta activities in human mesangial cells. J Am Soc Nephrol 2004;15:2032–2041.
   PubMed Web of Science ®Google Scholar
• Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E, Strieter RM, et al. Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. J Biol Chem 2004;279:28315–28319.
   PubMed Web of Science ®Google Scholar
• Seo YH, Jung HJ, Shin HT, Kim YM, Yim H, Chung HY, et al. Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell 2008;7:894–907.
   PubMed Web of Science ®Google Scholar
• Pascal T, Debacq-Chainiaux F, Chretien A, Bastin C, Dabee AF, Bertholet V, et al. Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett 2005;579:3651–3659.
   PubMed Web of Science ®Google Scholar
• Ksiazek K, Korybalska K, Jorres A, Witowski J. Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1. Lab Invest 2007;87: 345–356.
   PubMed Web of Science ®Google Scholar
• Yoon G, Kim HJ, Yoon YS, Cho H, Lim IK, Lee JH. Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. Biochem J 2002;366:613–621.
   PubMed Web of Science ®Google Scholar
• Bouin AP, Grandvaux N, Vignais PV, Fuchs A. p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. J Biol Chem 1998;273:30097–30103.
   PubMed Web of Science ®Google Scholar
• Fontayne A, Dang PM, Gougerot-Pocidalo MA, El-Benna J. Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry 2002;41:7743–7750.
   PubMed Web of Science ®Google Scholar
• Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C–dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 2000;49:1939–1945.
   PubMed Web of Science ®Google Scholar
• Bankers-Fulbright JL, Kita H, Gleich GJ, O’Grady SM. Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. J Cell Physiol 2001;189:306–315.
   PubMed Web of Science ®Google Scholar
• Saito S, Frank GD, Mifune M, Ohba M, Utsunomiya H, Motley ED, et al. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem 2002;277:44695–44700.
   PubMed Web of Science ®Google Scholar
• Talior I, Tennenbaum T, Kuroki T, Eldar-Finkelman H. PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase. Am J Physiol Endocrinol Metab 2005;288:E405–E411.
   PubMed Web of Science ®Google Scholar
• Embi N, Rylatt DB, Cohen P. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 1980;107:519–527.
   PubMedGoogle Scholar
• Rylatt DB, Aitken A, Bilham T, Condon GD, Embi N, Cohen P. Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur J Biochem 1980;107:529–537.
   PubMedGoogle Scholar
• Forde JE, Dale TC. Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 2007;64:1930–1944.
   PubMed Web of Science ®Google Scholar
• Kaidanovich O, Eldar-Finkelman H. The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Expert Opin Ther Targets 2002;6:555–561.
   PubMedGoogle Scholar
• Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A. Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol 2009;156:885–898.
   PubMed Web of Science ®Google Scholar
• Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I. Dual regulation of glycogen synthase kinase 3 (GSK3)alpha/beta by protein kinase C (PKC) alpha and Akt promotes thrombin-mediated integrin alphaIIbbeta3 activation and granule secretion in platelets. J Biol Chem 2013;288:3918–3928.
   PubMed Web of Science ®Google Scholar
• Baluch DP, Capco DG. GSK3 beta mediates acentromeric spindle stabilization by activated PKC zeta. Dev Biol 2008;317:46–58.
   PubMed Web of Science ®Google Scholar