298
Views
6
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

17α-Estradiol down-regulates glutathione synthesis in serum deprived PC-12 cells

, , , , &
Pages 1170-1178 | Received 18 Dec 2013, Accepted 29 May 2014, Published online: 01 Jul 2014

References

  • Scott E, Zhang QG, Wang RM, Vadlamudi R, Brann D. Estrogen neuroprotection and the critical period hypothesis. Front Neuroendocrinol 2012;33:85–104.
  • Fallgren AB, Mathisen GH, Maehlen J, Blomhoff R, Paulsen RE. Preconditioning with estradiol abolishes its neuroprotection in cerebellar neurons. Biochem Biophys Res Commun 2007;352:966–972.
  • Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994;77: 817–827.
  • Jenner P, Schapira AH, Marsden CD. New insights into the cause of Parkinson's disease. Neurology 1992;42:2241–2250.
  • Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997;138:863–870.
  • Behl C, Skutella T, Lezoualch F, Post A, Widmann M, Newton CJ, Holsboer F. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship. Mol Pharmacol 1997;51:535–541.
  • Dykens JA, Moos WH, Howell N. Development of 17alpha-estradiol as a neuroprotective therapeutic agent: rationale and results from a phase I clinical study. Ann NY Acad Sci 2005;1052:116–135.
  • Santanam N, Shern-Brewer R, McClatchey R, Castellano PZ, Murphy AA, Voelkel S, Parthasarathy S. Estradiol as an antioxidant: incompatible with its physiological concentrations and function. J Lipid Res 1998;39:2111–2118.
  • Moosmann B, Behl C. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci U S A 1999; 96:8867–8872.
  • Borras C, Gambini J, Lopez-Grueso R, Pallardo FV, Vina J. Direct antioxidant and protective effect of estradiol on isolated mitochondria. Biochim Biophys Acta 2010;1802:205–211.
  • Satoh T, Sakai N, Enokido Y, Uchiyama Y, Hatanaka H. Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells. Brain Res 1996;733:9–14.
  • Calderon FH, Bonnefont A, Munoz FJ, Fernandez V, Videla LA, Inestrosa NC. PC12 and neuro 2a cells have different susceptibilities to acetylcholinesterase-amyloid complexes, amyloid(25–35) fragment, glutamate, and hydrogen peroxide. J Neurosci Res 1999;56:620–631.
  • Gollapudi L, Oblinger MM. Stable transfection of PC12 cells with estrogen receptor (ERalpha): protective effects of estrogen on cell survival after serum deprivation. J Neurosci Res 1999;56:99–108.
  • Gelinas S, Bureau G, Valastro B, Massicotte G, Cicchetti F, Chiasson K, et al. Alpha and beta estradiol protect neuronal but not native PC12 cells from paraquat-induced oxidative stress. Neurotox Res 2004;6:141–148.
  • Dickinson DA, Forman HJ. Cellular glutathione and thiols metabolism. Biochem Pharmacol 2002;64:1019–1026.
  • Morales A, GarciaRuiz C, Miranda M, Mari M, Colell A, Ardite E, Fernández-Checa JC. Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase. J Biol Chem 1997;272:30371–30379.
  • Myhrstad MC, Carlsen H, Nordstrom O, Blomhoff R, Moskaug JO. Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med 2002;32:386–393.
  • Yao KS, Godwin AK, Johnson SW, Ozols RF, O’Dwyer PJ, Hamilton TC. Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res 1995;55:4367–4374.
  • Huang CS, Anderson ME, Meister A. Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem 1993;268:20578–20583.
  • Huang CS, Chang LS, Anderson ME, Meister A. Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem 1993; 268:19675–19680.
  • Chan JY, Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta-Gene Struct Expression 2000;1517:19–26.
  • Kwong M, Kan YW, Chan JY. The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents - Role for Nrf1 in gamma-gcs(L) and g(ss) expression in mouse fibroblasts. J Biol Chem 1999;274:37491–37498.
  • Morales A, Miranda M, Sanchez-Reyes A, Colell A, Biete A, Fernandez-Checa JC. Transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase by ionizing radiation. FEBS Lett 1998;427:15–20.
  • Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991;1072:129–157.
  • Gridley KE, Green PS, Simpkins JW. A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25–35-induced toxicity in vitro. Mol Pharmacol 1998;54:874–880.
  • Paulsen RE, Weaver CA, Fahrner TJ, Milbrandt J. Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B. J Biol Chem 1992;267:16491–16496.
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680–685.
  • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350–4354.
  • Green PS, Gridley KE, Simpkins JW. Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione. Neuroscience 1998;84:7–10.
  • Froissard P, Monrocq H, Duval D. Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells. Eur J Pharmacol 1997;326: 93–99.
  • Jurma OP, Hom DG, Andersen JK. Decreased glutathione results in calcium-mediated cell death in PC12. Free Radic Biol Med 1997;23:1055–1066.
  • Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976;73:2424–2428.
  • Andersen JK, Mo JQ, Hom DG, Lee FY, Harnish P, Hamill RW, McNeill TH. Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons. J Neurochem 1996;67:2164–2171.
  • Alexaki VI, Charalampopoulos I, Kampa M, Vassalou H, Theodoropoulos P, Stathopoulos EN, et al. Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt/NOS activation. FASEB J 2004;18:1594–1596.
  • Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 1991;14:421–451.
  • Pan Z, Perez-Polo R. Role of nerve growth factor in oxidant homeostasis: glutathione metabolism. J Neurochem 1993; 61:1713–1721.
  • Tong L, Perez-Polo JR. Effect of nerve growth factor on AP-1, NF-kappa B, and Oct DNA binding activity in apoptotic PC12 cells: extrinsic and intrinsic elements. J Neurosci Res 1996; 45:1–12.
  • Tong L, Werrbach-Perez K, Perez-Polo JR. Prolonged activation of transcription factor AP-1 during NGF-mediated rescue from apoptotic cell death in PC12 cells. Neurochem Res 1999; 24:1431–1441.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.