Chronic uranium exposure dose-dependently induces glutathione in rats without any nephrotoxicity

References

• La Touche YD, Willis DL, Dawydiak OI. Absorption and biokinetics of U in rats following an oral administration of uranyl nitrate solution. Health Phys 1987;53:147–162.
   PubMed Web of Science ®Google Scholar
• Leggett RW. The behavior and chemical toxicity of U in the kidney: a reassessment. Health Phys 1989;57:365–383.
   PubMed Web of Science ®Google Scholar
• Domingo JL, Llobet JM, Tomas JM, Corbella J. Acute toxicity of uranium in rats and mice. Bull Environ Contam Toxicol 1987;39:168–174.
   PubMed Web of Science ®Google Scholar
• Gilman AP, Villeneuve DC, Secours VE, Yagminas AP, Tracy BL, Quinn JM, et al. Uranyl nitrate: 28-day and 91-day toxicity studies in the Sprague-Dawley rat. Toxicol Sci 1998; 41:117–128.
   PubMed Web of Science ®Google Scholar
• Taulan M, Paquet F, Maubert C, Delissen O, Demaille J, Romey MC. Renal toxicogenomic response to chronic uranyl nitrate insult in mice. Environ Health Perspect 2004;112: 1628–1635.
   PubMed Web of Science ®Google Scholar
• Berradi H, Bertho JM, Dudoignon N, Mazur A, Grandcolas L, Baudelin C, et al. Renal anemia induced by chronic ingestion of depleted uranium in rats. Toxicol Sci 2008;103:397–408.
   PubMed Web of Science ®Google Scholar
• Linares V, Belles M, Albina ML, Sirvent JJ, Sanchez DJ, Domingo JL. Assessment of the pro-oxidant activity of uranium in kidney and testis of rats. Toxicol Lett 2006;167:152–161.
   PubMed Web of Science ®Google Scholar
• Gueguen Y, Rouas C, Monin A, Manens L, Stefani J, Delissen O, Grison S, Dublineau I. Molecular, cellular, and tissue impact of depleted uranium on xenobiotic-metabolizing enzymes. Arch Toxicol 2014;88(2):227–39.
   PubMedGoogle Scholar
• Yapar K, Cavusoglu K, Oruc E, Yalcin E. Protective role of Ginkgo biloba against hepatotoxicity and nephrotoxicity in uranium-treated mice. J Med Food 2010;13:179–188.
   PubMed Web of Science ®Google Scholar
• Pourahmad J, Ghashang M, Ettehadi HA, Ghalandari R. A search for cellular and molecular mechanisms involved in depleted uranium (DU) toxicity. Environ Toxicol 2006;21: 349–354.
   PubMed Web of Science ®Google Scholar
• Pourahmad J, Shaki F, Tanbakosazan F, Ghalandari R, Ettehadi HA, Dahaghin E. Protective effects of fungal beta- (1--> 3)-D-glucan against oxidative stress cytotoxicity induced by depleted uranium in isolated rat hepatocytes. Hum Exp Toxicol 2011;30:173–181.
   PubMed Web of Science ®Google Scholar
• Thiebault C, Carriere M, Milgram S, Simon A, Avoscan L, Gouget B. Uranium induces apoptosis and is genotoxic to normal rat kidney (NRK-52E) proximal cells. Toxicol Sci 2007;98:479–487.
   PubMed Web of Science ®Google Scholar
• Gueguen Y, Grandcolas L, Baudelin C, Grison S, Tissandie E, Jourdain JR, et al. Effect of acetaminophen administration to rats chronically exposed to depleted uranium. Toxicology 2007;229:62–72.
   PubMed Web of Science ®Google Scholar
• Lestaevel P, Romero E, Dhieux B, Ben Soussan H, Berradi H, Dublineau I, et al. Different pattern of brain pro-/anti-oxidant activity between depleted and enriched uranium in chronically exposed rats. Toxicology 2009;258:1–9.
   PubMedGoogle Scholar
• Racine R, Grandcolas L, Blanchardon E, Gourmelon P, Veyssiere G, Souidi M. Hepatic cholesterol metabolism following a chronic ingestion of cesium-137 starting at fetal stage in rats. J Radiat Res 2010;51:37–45.
   PubMedGoogle Scholar
• Rouas C, Stefani J, Grison S, Grandcolas L, Baudelin C, Dublineau I, et al. Effect of nephrotoxic treatment with gentamicin on rats chronically exposed to uranium. Toxicology 2011;279:27–35.
   PubMedGoogle Scholar
• Clerc J, Fourre C, Fragu P. SIMS microscopy: methodology, problems and perspectives in mapping drugs and nuclear medicine compounds. Cell Biol Int 1997;21:619–633.
   PubMedGoogle Scholar
• Chen CF, Tsai SY, Ma MC, Wu MS. Hypoxic preconditioning enhances renal superoxide dismutase levels in rats. J Physiol 2003;552:561–569.
   PubMedGoogle Scholar
• Itoh M, Oh-Ishi S, Hatao H, Leeuwenburgh C, Selman C, Ohno H, et al. Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm. Am J Physiol Regul Integr Comp Physiol 2004;287:R33–R38.
   Google Scholar
• Ropenga A, Chapel A, Vandamme M, Griffiths NM. Use of reference gene expression in rat distal colon after radiation exposure: a caveat. Radiat Res 2004;161:597–602.
   PubMed Web of Science ®Google Scholar
• Singh P, Jain A, Kaur G. Impact of hypoglycemia and diabetes on CNS: correlation of mitochondrial oxidative stress with DNA damage. Mol Cell Biochem 2004;260:153–159.
   PubMed Web of Science ®Google Scholar
• Wierinckx A, Breve J, Mercier D, Schultzberg M, Drukarch B, Van Dam AM. Detoxication enzyme inducers modify cytokine production in rat mixed glial cells. J Neuroimmunol 2005; 166:132–143.
   PubMed Web of Science ®Google Scholar
• Poisson C, Rouas C, Manens L, Dublineau I, Gueguen Y. Antioxidant status in rat kidneys after coexposure to uranium and gentamicin. Hum Exp Toxicol 2014;33:136–147.
   PubMedGoogle Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351–358.
   PubMed Web of Science ®Google Scholar
• ATSDR. Toxicological Profile for Uranium Public health service Atlanta 2013.
   Google Scholar
• Paquet F, Houpert P, Blanchardon E, Delissen O, Maubert C, Dhieux B, et al. Accumulation and distribution of uranium in rats after chronic exposure by ingestion. Health Phys 2006; 90:139–147.
   PubMed Web of Science ®Google Scholar
• Zhu G, Tan M, Li Y, Xiang X, Hu H, Zhao S. Accumulation and distribution of uranium in rats after implantation with depleted uranium fragments. J Radiat Res (Tokyo) 2009; 50:183–192.
   PubMedGoogle Scholar
• Tessier C, Suhard D, Rebiere F, Souidi M, Dublineau I, Agarande M. Uranium microdistribution in renal cortex of rats after chronic exposure: a study by secondary ion mass spectrometry microscopy. Microsc Microanal 2012;18:123–133.
   PubMedGoogle Scholar
• Rouas C, Bensoussan H, Suhard D, Tessier C, Grandcolas L, Rebiere F, et al. Distribution of soluble uranium in the nuclear cell compartment at subtoxic concentrations. Chem Res Toxicol 2010;23:1883–1889.
   PubMed Web of Science ®Google Scholar
• Sun DF, Fujigaki Y, Fujimoto T, Goto T, Yonemura K, Hishida A. Relation of distal nephron changes to proximal tubular damage in uranyl acetate-induced acute renal failure in rats. Am J Nephrol 2002;22:405–416.
   PubMedGoogle Scholar
• Taulan M, Paquet F, Argiles A, Demaille J, Romey MC. Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure. BMC Genomics 2006;7:2.
   PubMed Web of Science ®Google Scholar
• Zimmerman KL, Barber DS, Ehrich MF, Tobias L, Hancock S, Hinckley J, et al. Temporal clinical chemistry and microscopic renal effects following acute uranyl acetate exposure. Toxicol Pathol 2007;35:1000–1009.
   PubMedGoogle Scholar
• Diamond GL, Morrow PE, Panner BJ, Gelein RM, Baggs RB. Reversible uranyl fluoride nephrotoxicity in the Long Evans rat. Fundam Appl Toxicol 1989;13: 65–78.
   PubMedGoogle Scholar
• Zhu G, Xiang X, Chen X, Wang L, Hu H, Weng S. Renal dysfunction induced by long-term exposure to depleted uranium in rats. Arch Toxicol 2009;83:37–46.
   PubMed Web of Science ®Google Scholar
• Sabath E, Robles-Osorio ML. Renal health and the environment: heavy metal nephrotoxicity. Nefrologia 2012;32: 279–286.
   PubMed Web of Science ®Google Scholar
• Sabolic I. Common mechanisms in nephropathy induced by toxic metals. Nephron Physiol 2006;104:107–114.
   Web of Science ®Google Scholar
• Periyakaruppan A, Kumar F, Sarkar S, Sharma CS, Ramesh GT. Uranium induces oxidative stress in lung epithelial cells. Arch Toxicol 2007;81:389–395.
   PubMed Web of Science ®Google Scholar
• Mendieta-Wejebe JE, Miliar-Garcia A, Correa-Basurto J, Sanchez-Rico C, Ramirez-Rosales D, Trujillo-Ferrara J, Rosales-Hernandez MC. Comparison of the effect of chronic cadmium exposure on the antioxidant defense systems of kidney and brain in rat. Toxicol Mech Methods 2013;23:329–336.
   PubMed Web of Science ®Google Scholar
• Shaki F, Hosseini MJ, Ghazi-Khansari M, Pourahmad J. Toxicity of depleted uranium on isolated rat kidney mitochondria. Biochim Biophys Acta 2012;1820:1940–1950.
   PubMed Web of Science ®Google Scholar
• Al Kaddissi S, Legeay A, Elia AC, Gonzalez P, Camilleri V, Gilbin R, Simon O. Effects of uranium on crayfish Procambarus clarkii mitochondria and antioxidants responses after chronic exposure: what have we learned? Ecotoxicol Environ Saf 2012;78:218–224.
   PubMed Web of Science ®Google Scholar
• Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 2009;238:209–214.
   PubMed Web of Science ®Google Scholar