Redox-sensitive mechanisms underlying vascular dysfunction in heart failure

References

• Go AS, Mozaffarian D, Roger VL, Benjaamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 2014;129:e28–e292.
   PubMed Web of Science ®Google Scholar
• Fonarow GC, Peterson ED. Heart failure performance measures and outcomes: real or illusory gains. JAMA 2009;302:792–794.
   PubMed Web of Science ®Google Scholar
• Bueno H, Ross JS, Wang Y, Chen J, Vidán MT, Normand SL, et al. Trends in length of stay and short-term outcomes among Medicare patients hospitalized for heart failure, 1993–2006. JAMA 2010;303:2141–2147.
   PubMed Web of Science ®Google Scholar
• Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004;109:III27–III32.
   Web of Science ®Google Scholar
• Heitzer T, Baldus S, von Kodolitsch Y, Rudolph V, Meinertz T. Systemic endothelial dysfunction as an early predictor of adverse outcome in heart failure. Arterioscler Thromb Vasc Biol 2005;25:1174–1179.
   PubMed Web of Science ®Google Scholar
• Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A, Yasskiy A. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation 2005;111:310–314.
   PubMed Web of Science ®Google Scholar
• Tousoulis D, Charakida M, Stefanadis C. Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure. Int J Cardiol 2005;100:347–353.
   PubMed Web of Science ®Google Scholar
• Vita JA. Endothelial function and clinical outcome. Heart 2005;91:1278–1279.
   PubMed Web of Science ®Google Scholar
• Parodi O, De Maria R, Roubina E. Redox state, oxidative stress and endothelial dysfunction in heart failure: the puzzle of nitrate-thiol interaction. J Cardiovasc Med (Hagerstown) 2007;8:765–774.
   PubMedGoogle Scholar
• Touyz RM, Briones AM, Sedeek M, Burger D, Montezano AC. NOX isoforms and reactive oxygen species in vascular health. Mol Interv 2011;11:27–35.
   PubMedGoogle Scholar
• Konior A, Schramm A, Czesnikiewicz-Guzik M, Guzik TJ. NADPH oxidases in vascular pathology. Antioxid Redox Signal 2014;20:2794–2814.
   PubMed Web of Science ®Google Scholar
• Leto TL, Morand S, Hurt D, Ueyama T. Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal 2009;11:2607–2619.
   PubMed Web of Science ®Google Scholar
• Petry A, Weitnauer M, Gorlach A. Receptor activation of NADPH oxidases. Antioxid Redox Signal 2010;13: 467–487.
   PubMed Web of Science ®Google Scholar
• Schulz E, Munzel T. NOX5, a new “radical” player in human atherosclerosis? J Am Coll Cardiol 2008;52:1810–1812.
   PubMed Web of Science ®Google Scholar
• Geiszt M. NADPH oxidases: new kids on the block. Cardiovasc Res 2006;71:289–299.
   PubMed Web of Science ®Google Scholar
• Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007;87:245–313.
   PubMed Web of Science ®Google Scholar
• Lassegue B, Sorescu D, Szocs K, Yin Q, Akers M, Zhang Y, Grant SL, et al. Novel gp91(phox) homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res 2001;88:888–894.
   PubMed Web of Science ®Google Scholar
• Wingler K, Wünsch S, Kreutz R, Rothermund L, Paul M, Schmidt HH. Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Free Radic Biol Med 2001;31:1456–1464.
   PubMed Web of Science ®Google Scholar
• Katsuyama M, Fan C, Yabe-Nishimura C. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. J Biol Chem 2002;277:13438–13442.
   PubMed Web of Science ®Google Scholar
• Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 1999;401:79–82.
   PubMed Web of Science ®Google Scholar
• Valente AJ, Yoshida T, Murthy SN, Sakamuri SS, Katsuyama M, Clark RA, et al. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Am J Physiol Heart Circ Physiol 2012;303:H282–H296.
   PubMed Web of Science ®Google Scholar
• Rivera J, Sobey CG, Walduck AK, Drummond GR. Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Rep 2010;15:50–63.
   PubMed Web of Science ®Google Scholar
• MacMicking JD.Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol 2012;12: 367–382.
   PubMed Web of Science ®Google Scholar
• Murdoch CE, Alom-Ruiz SP, Wang M, Zhang M, Walker S, Yu B, et al. Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol 2011;106:527–538.
   PubMed Web of Science ®Google Scholar
• Chan SL, Baumbach GL. Nox2 deficiency prevents hypertension-induced vascular dysfunction and hypertrophy in cerebral arterioles. Int J Hypertens 2013;2013:793630.
   PubMedGoogle Scholar
• Lynch CM, Kinzenbaw DA, Chen X, Zhan S, Mezzetti E, Filosa J, et al. Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke 2013;44:3195–3201.
   PubMed Web of Science ®Google Scholar
• Chabrashvili T, Tojo A, Onozato ML, Kitiyakara C, Quinn MT, Fujita T, et al. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 2002;39:269–274.
   PubMed Web of Science ®Google Scholar
• Violi F, Sanguigni V, Carnevale R, Plebani A, Rossi P, Finocchi A, et al. Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study. Circulation 2009;120:1616–1622.
   PubMed Web of Science ®Google Scholar
• Dikalov SI, Dikalova AE, Bikineyeva AT, Schmidt HH, Harrison DG, Griendling KK. Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med 2008;45: 1340–1351.
   PubMed Web of Science ®Google Scholar
• Wu RF, Ma Z, Liu Z, Terada LS. Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation. Mol Cell Biol 2010;30:3553–3568.
   PubMed Web of Science ®Google Scholar
• Szocs K, Lassègue B, Sorescu D, Hilenski LL, Valppu L, Couse TL, et al. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol 2002;22:21–27.
   PubMed Web of Science ®Google Scholar
• Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, et al. Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ Res 2003;93:767–775.
   PubMed Web of Science ®Google Scholar
• Hwang J, Ing MH, Salazar A, Lassègue B, Griendling K, et al. Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Circ Res 2003;93:1225–1232.
   PubMed Web of Science ®Google Scholar
• Suliman HB, Ali M, Piantadosi CA. Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 2004;104:43–50.
   PubMed Web of Science ®Google Scholar
• Vallet P, Charnay Y, Steger K, Ogier-Denis E, Kovari E, Herrmann F, et al. Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Neuroscience 2005;132:233–238.
   PubMed Web of Science ®Google Scholar
• Moe KT, Aulia S, Jiang F, Chua YL, Koh TH, Wong MC, Dusting GJ. Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells. J Cell Mol Med 2006;10:231–239.
   PubMed Web of Science ®Google Scholar
• Schroder K, Wandzioch K, Helmcke I, Brandes RP. Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol 2009;29:239–245.
   PubMed Web of Science ®Google Scholar
• Lener B, Kozieł R, Pircher H, Hütter E, Greussing R, Herndler-Brandstetter D, et al. The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. Biochem J 2009;423:363–374.
   PubMed Web of Science ®Google Scholar
• McCrann DJ, Yang D, Chen H, Carroll S, Ravid K. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle 2009;8:902–908.
   PubMed Web of Science ®Google Scholar
• Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, et al. Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways. Arterioscler Thromb Vasc Biol 2006;26:801–807.
   PubMed Web of Science ®Google Scholar
• Petry A, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, et al. NOX2 and NOX4 mediate proliferative response in endothelial cells. Antioxid Redox Signal 2006;8:1473–1484.
   PubMed Web of Science ®Google Scholar
• Peshavariya H, Dusting GJ, Jiang F, Halmos LR, Sobey CG, Drummond GR, Selemidis S. NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn Schmiedebergs Arch Pharmacol 2009;380: 193–204.
   PubMed Web of Science ®Google Scholar
• Kuroda J, Nakagawa K, Yamasaki T, Nakamura K, Takeya R, Kuribayashi F, et al. The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells 2005;10:1139–1151.
   PubMed Web of Science ®Google Scholar
• Schroder K, Zhang M, Benkhoff S, Mieth A, Pliquett R, Kosowski J, et al. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res 2012;110:1217–1225.
   PubMed Web of Science ®Google Scholar
• Li J, Stouffs M, Serrander L, Banfi B, Bettiol E, Charnay Y, et al. The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell 2006;17:3978–3988.
   PubMed Web of Science ®Google Scholar
• Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 2005;97:900–907.
   PubMed Web of Science ®Google Scholar
• Banfi B, Tirone F, Durussel I, Knisz J, Moskwa P, Molnár GZ, et al. Mechanism of Ca2 + activation of the NADPH oxidase 5 (NOX5). J Biol Chem 2004;279:18583–18591.
   PubMed Web of Science ®Google Scholar
• Jay DB, Papaharalambus CA, Seidel-Rogol B, Dikalova AE, Lassègue B, Griendling KK. Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radic Biol Med 2008;45:329–335.
   PubMed Web of Science ®Google Scholar
• Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D, et al. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J Am Coll Cardiol 2008;52:1803–1809.
   PubMed Web of Science ®Google Scholar
• Fulton DJ. Nox5 and the regulation of cellular function. Antioxid Redox Signal 2009;11:2443–2452.
   PubMed Web of Science ®Google Scholar
• BelAiba RS, Djordjevic T, Petry A, Diemer K, Bonello S, Banfi B, et al. NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med 2007;42:446–459.
   PubMed Web of Science ®Google Scholar
• Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, et al. Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells. Circ Res 2010;106:1363–1373.
   PubMed Web of Science ®Google Scholar
• Pandey D, Patel A, Patel V, Chen F, Qian J, Wang Y, et al. Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels. Am J Physiol Heart Circ Physiol 2012;302:H1919–1928.
   Web of Science ®Google Scholar
• McBride HM, Neuspiel M, Wasiak S. Mitochondria: more than just a powerhouse. Curr Biol 2006;16:R551–560.
   PubMed Web of Science ®Google Scholar
• Dromparis P, Michelakis ED. Mitochondria in vascular health and disease. Annu Rev Physiol 2013;75:95–126.
   PubMed Web of Science ®Google Scholar
• Frazier AE, Kiu C, Stojanovski D, Hoogenraad NJ, Ryan MT. Mitochondrial morphology and distribution in mammalian cells. Biol Chem 2006;387:1551–1558.
   PubMedGoogle Scholar
• Tang X, Luo YX, Chen HZ, Liu DP. Mitochondria, endothelial cell function, and vascular diseases. Front Physiol 2014;5:175.
   PubMed Web of Science ®Google Scholar
• Quintero M, Colombo SL, Godfrey A, Moncada S. Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A 2006;103:5379–5384.
   PubMed Web of Science ®Google Scholar
• Brand MD. The sites and topology of mitochondrial superoxide production. Exp Gerontol 2010;45:466–472.
   PubMed Web of Science ®Google Scholar
• Luo S, Lei H, Qin H, Xia Y. Molecular mechanisms of endothelial NO synthase uncoupling. Curr Pharm Des 2014;20:3548–3553.
   PubMed Web of Science ®Google Scholar
• Forstermann U, Sessa WC.Nitric oxide synthases: regulation and function. Eur Heart J 2012;33:829–837, 837a–837d.
   PubMed Web of Science ®Google Scholar
• Hemmens B, Mayer B.Enzymology of nitric oxide synthases. Methods Mol Biol 1998;100:1–32.
   PubMedGoogle Scholar
• Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC, et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 1998;392:821–824.
   PubMed Web of Science ®Google Scholar
• Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, et al. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem 2001;276:17621–17624.
   PubMed Web of Science ®Google Scholar
• Song Y, Cardounel AJ, Zweier JL, Xia Y. Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation. Biochemistry 2002;41:10616–10622.
   PubMed Web of Science ®Google Scholar
• Sowa G, Pypaert M, Sessa WC. Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc Natl Acad Sci U S A 2001;98:14072–14077.
   PubMed Web of Science ®Google Scholar
• Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399: 597–601.
   PubMed Web of Science ®Google Scholar
• McCabe TJ, Fulton D, Roman LJ, Sessa WC. Enhanced electron flux and reduced calmodulin dissociation may explain “calcium-independent” eNOS activation by phosphorylation. J Biol Chem 2000;275:6123–6128.
   PubMed Web of Science ®Google Scholar
• Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003;284:R1–R12.
   PubMed Web of Science ®Google Scholar
• Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal 2009;2:ra41.
   Web of Science ®Google Scholar
• Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res 1999;43:521–531.
   PubMed Web of Science ®Google Scholar
• Sullivan JC, Pollock JS. Coupled and uncoupled NOS: separate but equal? Uncoupled NOS in endothelial cells is a critical pathway for intracellular signaling. Circ Res 2006;98:717–719.
   PubMed Web of Science ®Google Scholar
• Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006;113:1708–1714.
   PubMed Web of Science ®Google Scholar
• Chen DD, Chen LY, Xie JB, Shu C, Yang T, Zhou S, et al. Tetrahydrobiopterin regulation of eNOS redox function. Curr Pharm Des 2014;20:3554–3562.
   PubMed Web of Science ®Google Scholar
• Zweier JL, Chen CA, Druhan LJ. S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling. Antioxid Redox Signal 2011;14: 1769–1775.
   PubMed Web of Science ®Google Scholar
• Fleming I, Mohamed A, Galle J, Turchanowa L, Brandes RP, Fisslthaler B, Busse R. Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha. Cardiovasc Res 2005;65:897–906.
   PubMed Web of Science ®Google Scholar
• Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H, et al. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A 1998;95:9220–9225.
   PubMed Web of Science ®Google Scholar
• Milstien S, Katusic Z. Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function. Biochem Biophys Res Commun 1999;263:681–684.
   PubMed Web of Science ®Google Scholar
• Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 2002;109:817–826.
   PubMed Web of Science ®Google Scholar
• Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 2003;111:1201–1209.
   PubMed Web of Science ®Google Scholar
• Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991;338:1546–1550.
   PubMed Web of Science ®Google Scholar
• Rossitch E, Jr., Alexander E 3rd, Black PM, Cooke JP. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J Clin Invest 1991;87: 1295–1299.
   PubMed Web of Science ®Google Scholar
• Imaizumi T, Hirooka Y, Masaki H, Harada S, Momohara M, Tagawa T, Takeshita A. Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension 1992;20: 511–517.
   Google Scholar
• Hishikawa K, Nakaki T, Suzuki H, Kato R, Saruta T. Role of L-arginine-nitric oxide pathway in hypertension. J Hypertens 1993;11:639–645.
   PubMed Web of Science ®Google Scholar
• Gorren AC, List BM, Schrammel A, Pitters E, Hemmens B, Werner ER, et al. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 1996;35:16735–16745.
   PubMed Web of Science ®Google Scholar
• Martasek P, Miller RT, Liu Q, Roman LJ, Salerno JC, Migita CT, et al. The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding. J Biol Chem 1998;273:34799–34805.
   PubMedGoogle Scholar
• Sydow K, Munzel T. ADMA and oxidative stress. Atheroscler Suppl 2003;4:41–51.
   PubMed Web of Science ®Google Scholar
• Antoniades C, Shirodaria C, Leeson P, Antonopoulos A, Warrick N, Van-Assche T, et al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. Eur Heart J 2009;30:1142–1150.
   PubMed Web of Science ®Google Scholar
• Boger RH, Sullivan LM, Schwedhelm E, Wang TJ, Maas R, Benjamin EJ, et al. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 2009;119:1592–1600.
   PubMed Web of Science ®Google Scholar
• Boger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, et al. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. Circ Res 2000;87:99–105.
   PubMed Web of Science ®Google Scholar
• Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, et al. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002;106:987–992.
   PubMed Web of Science ®Google Scholar
• von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, et al. Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. Circulation 2011;124:2735–2745.
   PubMed Web of Science ®Google Scholar
• Chen CA, Wang TY, Varadharaj S, Reyes LA, Hemann C, Talukder MA, et al. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 2010;468:1115–1118.
   PubMed Web of Science ®Google Scholar
• Meneshian A, Bulkley GB. The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction. Microcirculation 2002;9:161–175.
   PubMed Web of Science ®Google Scholar
• Battelli MG, Bolognesi A, Polito L. Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme. Biochim Biophys Acta 2014; 1842:1502–1517.
   PubMed Web of Science ®Google Scholar
• Pacher P, Nivorozhkin A, Szabo C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 2006;58: 87–114.
   PubMed Web of Science ®Google Scholar
• Chung HY, Baek BS, Song SH, Kim MS, Huh JI, Shim KH, Kim WK, Lee KH, et al. Xanthine dehydrogenase/xanthine oxidase and oxidative stress. Age (Omaha).1997;20: 127–140.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Blake DR, Stevens CR, Kanczler JM, Winyard PG, Symons MC, et al. A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor. Free Radic Res 1998;28:151–164.
   PubMed Web of Science ®Google Scholar
• George J, Struthers AD. Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vasc Health Risk Manag 2009;5:265–272.
   PubMedGoogle Scholar
• Pritsos CA. Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system. Chem Biol Interact 2000;129:195–208.
   PubMed Web of Science ®Google Scholar
• Alp NJ, Channon KM. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol 2004;24:413–420.
   PubMed Web of Science ®Google Scholar
• Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P, et al. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol 2001;158:879–891.
   PubMed Web of Science ®Google Scholar
• van der Veen BS, de Winther MP, Heeringa P. Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease. Antioxid Redox Signal 2009;11:2899–2937.
   PubMed Web of Science ®Google Scholar
• Davies MJ, Hawkins CL, Pattison DI, Rees MD. Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxid Redox Signal 2008;10:1199–1234.
   PubMed Web of Science ®Google Scholar
• Eiserich JP, Baldus S, Brennan ML, Ma W, Zhang C, Tousson A, et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science 2002;296:2391–2394.
   PubMed Web of Science ®Google Scholar
• Vita JA, Brennan ML, Gokce N, Mann SA, Goormastic M, Shishehbor MH, et al. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation 2004;110:1134–1139.
   PubMed Web of Science ®Google Scholar
• Tang WH, Brennan ML, Philip K, Tong W, Mann S, van Lente F, Hazen SL. Plasma myeloperoxidase levels in patients with chronic heart failure. Am J Cardiol 2006;98:796–799.
   PubMed Web of Science ®Google Scholar
• Michowitz Y, Kisil S, Guzner-Gur H, Rubinstein A, Wexler D, Sheps D, et al. Usefulness of serum myeloperoxidase in prediction of mortality in patients with severe heart failure. Isr Med Assoc J 2008;10:884–888.
   PubMedGoogle Scholar
• Van Antwerpen P, Boudjeltia KZ, Babar S, Legssyer I, Moreau P, Moguilevsky N, et al. Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation. Biochem Biophys Res Commun 2005;337:82–88.
   PubMed Web of Science ®Google Scholar
• Malle E, Furtmulller, Sattler W, Obinger C. Myeloperoxidase: a target for new drug development? Br J Pharmacol 2007;152:838–854.
   PubMed Web of Science ®Google Scholar
• Van Antwerpen P, Dufrasne F, Lequeux M, Boudjeltia KZ, Lessgyer I, Babar S, et al. Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid. Eur J Pharmacol 2007;570:235–243.
   PubMed Web of Science ®Google Scholar
• Van Antwerpen P, Prévost M, Zouaoui-Boudjeltia K, Babar S, Legssyer I, Moreau P, et al. Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification. Bioorg Med Chem 2008;16:1702–1720.
   PubMed Web of Science ®Google Scholar
• Zuurbier KW, Bakkenist AR, Fokkens RH, Nibbering NM, Wever R, Muijsers AO. Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase. Biochem Pharmacol 1990;40:1801–1808.
   PubMed Web of Science ®Google Scholar
• Cuperus RA, Muijsers AO, Wever R. Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes. A therapeutic mechanism of these drugs in rheumatoid arthritis? Arthritis Rheum 1985;28:1228–1233.
   PubMed Web of Science ®Google Scholar
• Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res 2000;86:347–354.
   PubMed Web of Science ®Google Scholar
• Thomas SR, Chen K, Keaney JF, Jr. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem 2002;277:6017–6024.
   PubMed Web of Science ®Google Scholar
• Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 2003;278:22546–22554.
   PubMed Web of Science ®Google Scholar
• Forstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions Hypertension 1994;23:1121–1131.
   PubMed Web of Science ®Google Scholar
• Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 2008;5:338–349.
   PubMed Web of Science ®Google Scholar
• Forstermann U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch 2010;459:923–939.
   PubMed Web of Science ®Google Scholar
• Abu-Soud HM, Hazen SL. Nitric oxide modulates the catalytic activity of myeloperoxidase. J Biol Chem 2000;275: 5425–5430.
   PubMed Web of Science ®Google Scholar
• Rudolph TK, Wipper S, Reiter B, Rudolph V, Coym A, Detter C, et al. Myeloperoxidase deficiency preserves vasomotor function in humans. Eur Heart J 2012;33:1625–1634.
   PubMed Web of Science ®Google Scholar
• Zhang C, Patel R, Eiserich JP, Zhou F, Kelpke S, Ma W, et al. Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid. Am J Physiol Heart Circ Physiol 2001;281:H1469–1475.
   Web of Science ®Google Scholar
• Zhang C, Reiter C, Eiserich JP, Boersma B, Parks DA, Beckman JS, et al. L-arginine chlorination products inhibit endothelial nitric oxide production. J Biol Chem 2001;276: 27159–27165.
   PubMed Web of Science ®Google Scholar
• Bienert GP, Schjoerring JK, Jahn TP. Membrane transport of hydrogen peroxide. Biochim Biophys Acta 2006;1758: 994–1003.
   PubMed Web of Science ®Google Scholar
• Solaini G, Harris DA. Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion. Biochem J 2005;390:377–394.
   PubMed Web of Science ®Google Scholar
• Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006;3:187–197.
   PubMed Web of Science ®Google Scholar
• Solaini G, Baracca A, Lenaz G, Sgarbi G. Hypoxia and mitochondrial oxidative metabolism. Biochim Biophys Acta 2010;1797:1171–1177.
   PubMed Web of Science ®Google Scholar
• Halestrap AP, Woodfield KY, Connern CP. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem 1997;272:3346–3354.
   PubMed Web of Science ®Google Scholar
• Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2001;2: 67–71.
   PubMed Web of Science ®Google Scholar
• Lynch RM, Paul RJ. Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle. Science 1983;222:1344–1346.
   PubMed Web of Science ®Google Scholar
• Krutzfeldt A, Spahr R, Mertens S, Siegmund B, Piper HM. Metabolism of exogenous substrates by coronary endothelial cells in culture. J Mol Cell Cardiol 1990;22:1393–1404.
   PubMed Web of Science ®Google Scholar
• Culic O, Gruwel ML, Schrader J. Energy turnover of vascular endothelial cells. Am J Physiol 1997;273:C205–C213.
   PubMed Web of Science ®Google Scholar
• Barron JT, Bárány M, Gu L, Parrillo JE. Metabolic fate of glucose in vascular smooth muscle during contraction induced by norepinephrine. J Mol Cell Cardiol 1998;30:709–719.
   PubMedGoogle Scholar
• Barron JT, Kopp SJ, Tow JP, Messer JV. Effects of altering carbohydrate metabolism on energy status and contractile function of vascular smooth muscle. Biochim Biophys Acta 1989;976:42–52.
   PubMedGoogle Scholar
• Barron JT, Kopp SJ, Tow J, Parrillo JE. Fatty acid, tricarboxylic acid cycle metabolites, and energy metabolism in vascular smooth muscle. Am J Physiol 1994;267:H764–769.
   Google Scholar
• Cleeter MW, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AH. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases FEBS Lett 1994;345:50–54.
   PubMed Web of Science ®Google Scholar
• Clementi E, Brown GC, Foxwell N, Moncada S. On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc Natl Acad Sci U S A 1999;96:1559–1562.
   PubMed Web of Science ®Google Scholar
• Jornot L, Maechler P, Wollheim CB, Junod AF. Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger. J Cell Sci 1999;112:1013–1022.
   PubMed Web of Science ®Google Scholar
• Hirano T. Molecular basis underlying functional pleiotropy of cytokines and growth factors. Biochem Biophys Res Commun 1999;260:303–308.
   PubMed Web of Science ®Google Scholar
• Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 2002;277: 29355–29358.
   PubMed Web of Science ®Google Scholar
• Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009;78:539–552.
   PubMed Web of Science ®Google Scholar
• Paulus WJ. Cytokines and heart failure. Heart Fail Monit 2000;1:50–56.
   PubMedGoogle Scholar
• Hedayat M, Mahmoudi MJ, Rose NR, Rezaei N. Proinflammatory cytokines in heart failure: double-edged swords. Heart Fail Rev 2010;15:543–562.
   PubMed Web of Science ®Google Scholar
• Gullestad L, Ueland T, Vinge LE, Finsen A, Yndestad A, Aukrust P. Inflammatory cytokines in heart failure: mediators and markers. Cardiology 2012;122:23–35.
   PubMed Web of Science ®Google Scholar
• Deswal A, Petersen NJ, Feldman AM, Young JB, White BG, Mann DL. Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 2001;103: 2055–2059.
   PubMed Web of Science ®Google Scholar
• Lo YY, Cruz TF. Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes. J Biol Chem 1995;270:11727–11730.
   PubMed Web of Science ®Google Scholar
• Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462–472.
   PubMed Web of Science ®Google Scholar
• Meier B, Radeke HH, Selle S, Younes M, Sies H, Resch K, Habermehl GG. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J 1989;263:539–545.
   PubMed Web of Science ®Google Scholar
• Shoji Y, Uedono Y, Ishikura H, Takeyama N, Tanaka T. DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation. Immunology 1995;84:543–548.
   PubMed Web of Science ®Google Scholar
• Corda S, Laplace C, Vicaut E, Duranteau J. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol 2001;24:762–768.
   PubMed Web of Science ®Google Scholar
• Kim YS, Morgan MJ, Choksi S, Liu ZG. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 2007;26:675–687.
   PubMed Web of Science ®Google Scholar
• Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011;208:519–533.
   PubMed Web of Science ®Google Scholar
• Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med 2011;208:417–420.
   PubMed Web of Science ®Google Scholar
• Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 1989;86:2863–2867.
   PubMed Web of Science ®Google Scholar
• Kedzierski RM, Yanagisawa M. Endothelin system: the double-edged sword in health and disease. Annu Rev Pharmacol Toxicol 2001;41:851–876.
   PubMed Web of Science ®Google Scholar
• Bohm F, Pernow J. The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. Cardiovasc Res 2007;76:8–18.
   PubMed Web of Science ®Google Scholar
• Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, et al. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 2004;110:2233–2240.
   PubMed Web of Science ®Google Scholar
• Chen HC, Guh JY, Shin SJ, Tsai JH, Lai YH. Reactive oxygen species enhances endothelin-1 production of diabetic rat glomeruli in vitro and in vivo. J Lab Clin Med 2000;135: 309–315.
   PubMed Web of Science ®Google Scholar
• Cheng TH, Cheng PY, Shih NL, Chen IB, Wang DL, Chen JJ. Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts. J Am Coll Cardiol 2003;42:1845–1854.
   PubMed Web of Science ®Google Scholar
• Cheng TH, Shih NL, Chen SY, Loh SH, Cheng PY, Tsai CS, et al. Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. J Mol Cell Cardiol 2001;33:1805–1814.
   PubMed Web of Science ®Google Scholar
• Lund AK, Peterson SL, Timmins GS, Walker MK. Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice. Toxicol Sci 2005;88:265–273.
   PubMed Web of Science ®Google Scholar
• Parker JD, Thiessen JJ. Increased endothelin-1 production in patients with chronic heart failure. Am J Physiol Heart Circ Physiol 2004;286:H1141–H1145.
   Web of Science ®Google Scholar
• Masson S, Latini R, Anand IS, Barlera S, Judd D, Salio M, et al. The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). J Card Fail 2006;12:375–380.
   PubMed Web of Science ®Google Scholar
• Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006;69:562–573.
   PubMed Web of Science ®Google Scholar
• Verma RP, Hansch C. Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem 2007;15:2223–2268.
   PubMed Web of Science ®Google Scholar
• Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999;274:21491–21494.
   PubMed Web of Science ®Google Scholar
• Shah PK. Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm. Circulation 1997;96:2115–2117.
   PubMed Web of Science ®Google Scholar
• Spinale FG. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 2002;90:520–530.
   PubMed Web of Science ®Google Scholar
• Newby AC Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 2005;85:1–31.
   PubMed Web of Science ®Google Scholar
• Zaragoza C, Balbín M, López-Otín C, Lamas S. Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium. Kidney Int 2002;61:804–808.
   PubMed Web of Science ®Google Scholar
• Upchurch GR Jr, Ford JW, Weiss SJ, Knipp BS, Peterson DA, Thompson RW, et al. Nitric oxide inhibition increases matrix metalloproteinase-9 expression by rat aortic smooth muscle cells in vitro. J Vasc Surg 2001;34:76–83.
   PubMed Web of Science ®Google Scholar
• Fan LM, Douglas G, Bendall JK, McNeill E, Crabtree MJ, Hale AB, Mai A, et al. Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. Circulation 2014;129:2661–2672.
   PubMed Web of Science ®Google Scholar
• Chung AW, Yang HH, Sigrist MK, Brin G, Chum E, Gourlay WA, Levin A. Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease. Cardiovasc Res 2009;84:494–504.
   PubMed Web of Science ®Google Scholar
• Guimaraes DA, Rizzi E, Ceron CS, Oliveira AM, Gerlach RF, Tanus-Santos J. Atorvastatin and Sildenafil Reduce Oxidative Stress, MMP-2 And MMP-9 Levels, TGF-beta Expression and Prevent Vascular Remodeling in 2 K1C-hypertension. Hypertension 2013;62:A645.
   Web of Science ®Google Scholar
• Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Biol Chem 2001;276:41279–41287.
   PubMed Web of Science ®Google Scholar
• Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, et al. Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nat Med 2010;16: 470–474.
   PubMed Web of Science ®Google Scholar
• Baum J, Duffy HS. Fibroblasts and myofibroblasts: what are we talking about? J Cardiovasc Pharmacol 2011;57: 376–379.
   PubMed Web of Science ®Google Scholar
• Clayton A, Evans RA, Pettit E, Hallett M, Williams JD, Steadman R, et al. Cellular activation through the ligation of intercellular adhesion molecule-1. J Cell Sci 1998;111: 443–453.
   PubMed Web of Science ®Google Scholar
• Helmdach M, Thielitz A, Röpke EM, Gollnick H. Age and sex variation in lipid composition of human fingernail plates. Skin Pharmacol Appl Skin Physiol 2000;13:111–119.
   PubMedGoogle Scholar
• Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6:392–401.
   PubMed Web of Science ®Google Scholar
• Rodemann HP, Muller GA. Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. Am J Kidney Dis 1991;17:684–686.
   PubMedGoogle Scholar
• Haurani MJ, Pagano PJ. Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease? Cardiovasc Res 2007;75:679–689.
   PubMed Web of Science ®Google Scholar
• Wang HD, Xu S, Johns DG, Du Y, Quinn MT, Cayatte AJ, Cohen RA. Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice. Circ Res 2001;88:947–953.
   PubMed Web of Science ®Google Scholar
• Bush E, Maeda N, Kuziel WA, Dawson TC, Wilcox JN, DeLeon H, Taylor WR. CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension. Hypertension 2000;36: 360–363.
   PubMed Web of Science ®Google Scholar
• Liu J, Yang F, Yang XP, Jankowski M, Pagano PJ. NAD(P)H oxidase mediates angiotensin II-induced vascular macrophage infiltration and medial hypertrophy. Arterioscler Thromb Vasc Biol 2003;23:776–782.
   PubMed Web of Science ®Google Scholar
• Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quinn MT, Brecher P, Cohen RA. Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide. Circ Res 1998;82:810–818.
   PubMed Web of Science ®Google Scholar
• Di Wang H, Hope S, Du Y, Quinn MT, Cayatte A, Pagano PJ, Cohen RA, et al. Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. Hypertension 1999;33:1225–1232.
   PubMed Web of Science ®Google Scholar
• Cifuentes ME, Rey FE, Carretero OA, Pagano PJ. Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice. Am J Physiol Heart Circ Physiol 2000;279:H2234–2240.
   PubMed Web of Science ®Google Scholar
• Rey FE, Pagano PJ.The reactive adventitia: fibroblast oxidase in vascular function. Arterioscler Thromb Vasc Biol 2002;22:1962–1971.
   PubMed Web of Science ®Google Scholar
• Chamseddine AH, Miller FJ, Jr. Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. Am J Physiol Heart Circ Physiol 2003;285:H2284–H2289.
   Web of Science ®Google Scholar
• Pagano PJ, Clark JK, Cifuentes-Pagano ME, Clark SM, Callis GM, Quinn MT. Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II. Proc Natl Acad Sci U S A 1997;94:14483–14488.
   PubMed Web of Science ®Google Scholar
• Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen RA, et al. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med 2013;45: 17–36.
   PubMed Web of Science ®Google Scholar
• Baas AS, Berk BC.Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells. Circ Res 1995;77:29–36.
   PubMed Web of Science ®Google Scholar
• Touyz RM, Schiffrin EL.Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 2004;122:339–352.
   PubMed Web of Science ®Google Scholar
• Yu H, Payne TJ, Mohanty DK.Effects of slow, sustained, and rate-tunable nitric oxide donors on human aortic smooth muscle cells proliferation. Chem Biol Drug Des 2011;78: 527–534.
   PubMed Web of Science ®Google Scholar
• Yokoyama M, Inoue N, Kawashima S.Role of the vascular NADH/NADPH oxidase system in atherosclerosis. Ann N Y Acad Sci 2000;902:241–247; discussion 247–248.
   PubMed Web of Science ®Google Scholar
• West N, Guzik T, Black E, Channon K. Enhanced superoxide production in experimental venous bypass graft intimal hyperplasia: role of NAD(P)H oxidase. Arterioscler Thromb Vasc Biol 2001;21:189–194.
   PubMed Web of Science ®Google Scholar
• Panchenko MP, Silva N, Stone JR. Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia. Cardiovasc Pathol 2009;18:167–172.
   PubMed Web of Science ®Google Scholar
• Bird A. Perceptions of epigenetics. Nature 2007;447:396–398.
   PubMed Web of Science ®Google Scholar
• Matouk CC, Marsden PA. Epigenetic regulation of vascular endothelial gene expression. Circ Res 2008;102:873–887.
   PubMed Web of Science ®Google Scholar
• Schleithoff C, Voelter-Mahlknecht S, Dahmke IN, Mahlknecht U. On the epigenetics of vascular regulation and disease. Clin Epigenetics 2012;4:7.
   PubMed Web of Science ®Google Scholar
• Pons D, de Vries FR, van den Elsen PJ, Heijmans BT, Quax PH, Jukema JW. Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease. Eur Heart J 2009;30:266–277.
   PubMed Web of Science ®Google Scholar
• Graff J, Kim D, Dobbin MM, Tsai LH. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev 2011;91:603–649.
   PubMed Web of Science ®Google Scholar
• Ziech D, Franco R, Pappa A, Panayiotidis MI. Reactive oxygen species (ROS) –induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res 2011;711: 167–173.
   PubMed Web of Science ®Google Scholar
• Kang KA, Zhang R, Kim GY, Bae SC, Hyun JW. Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. Tumour Biol 2012;33:403–412.
   PubMedGoogle Scholar
• Afanas'ev I. New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer. Aging Dis 2013;5:52–62.
   PubMed Web of Science ®Google Scholar
• Won KJ, Jung SH, Jung SH, Lee KP, Lee HM, Lee DY, et al. DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase. Cardiovasc Res 2014;101:473–481.
   PubMed Web of Science ®Google Scholar
• Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 2006;25:176–185.
   PubMed Web of Science ®Google Scholar
• Ota H, Akishita M, Eto M, Iijima K, Kaneki M, Ouchi Y. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol 2007;43:571–579.
   PubMed Web of Science ®Google Scholar
• Cencioni C, Spallotta F, Martelli F, Valente S, Mai A, Zeiher AM, Gaetano C. Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci 2013;14:17643–17663.
   PubMed Web of Science ®Google Scholar
• Chronic Heart Failure: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care: Partial Update. London 2010.
   Google Scholar
• Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol 1993;22:6A–13A.
   PubMed Web of Science ®Google Scholar
• Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA 1996;275:1557–1562.
   PubMed Web of Science ®Google Scholar
• He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med 2001;161:996–1002.
   PubMed Web of Science ®Google Scholar
• Mahmood SS, Wang TJ. The epidemiology of congestive heart failure: the Framingham Heart Study perspective. Glob Heart2013;8:77–82.
   Google Scholar
• Komajda M, Pousset F, Isnard R, Lechat P. The role of the neurohormonal system in heart failure. Heart 1998;79: S17–23.
   Web of Science ®Google Scholar
• Fang ZY, Marwick TH. Vascular dysfunction and heart failure: epiphenomenon or etiologic agent? Am Heart J 2002;143:383–390.
   PubMed Web of Science ®Google Scholar
• Laskey WK, Kussmaul WG. Arterial wave reflection in heart failure. Circulation 1987;75:711–722.
   PubMed Web of Science ®Google Scholar
• White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 1987;76:44–51.
   PubMed Web of Science ®Google Scholar
• Ramsey MW, Goodfellow J, Jones CJ, Luddington LA, Lewis MJ, Henderson AH. Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation 1995;92:3212–3219.
   PubMed Web of Science ®Google Scholar
• Mitchell GF, Tardif JC, Arnold MO, Marchiori G, O’Brein TX, Dunlap ME, Pfeffer MA, et al. Pulsatile hemodynamics in congestive heart failure. Hypertension 2001;38:1433–1439.
   PubMed Web of Science ®Google Scholar
• Bauersachs J, Widder JD.Endothelial dysfunction in heart failure. Pharmacol Rep 2008;60:119–126.
   PubMed Web of Science ®Google Scholar
• Treasure CB, Vita JA, Cox DA, Fish RD, Gordon JB, Mudge GH, et al. Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation 1990;81:772–779.
   PubMed Web of Science ®Google Scholar
• Ben Driss A, Devaux C, Henrion D, Duriez M, Thuillez C, Levy BI, et al. Hemodynamic stresses induce endothelial dysfunction and remodeling of pulmonary artery in experimental compensated heart failure. Circulation 2000;101:2764–2770.
   PubMed Web of Science ®Google Scholar
• Moraes DL, Colucci WS, Givertz MM.Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management. Circulation 2000;102:1718–1723.
   PubMed Web of Science ®Google Scholar
• Varin R, Mulder P, Tamino F, Richard V, Henry JP, Lallemand F, et al. Improvement of endothelial function by chronic angiotensin-converting enzyme inhibition in heart failure: role of nitric oxide, prostanoids, oxidant stress, and bradykinin. Circulation 2000;102:351–356.
   PubMed Web of Science ®Google Scholar
• Blair JE, Manuchehry A, Chana A, Rossi J, Schrier RW, Burnett JC, Gheorghiade M. Prognostic markers in heart failure–congestion, neurohormones, and the cardiorenal syndrome. Acute Card Care 2007;9:207–213.
   PubMedGoogle Scholar
• Hare JM, Stamler JS.NO/redox disequilibrium in the failing heart, cardiovascular system. J Clin Invest 2005;115: 509–517.
   PubMed Web of Science ®Google Scholar
• Marti CN, Gheorghiade M, Kalogeropoulos AP, Georgiopoulou VV, Quyyumi AA, Butler J. Endothelial dysfunction, arterial stiffness, and heart failure. J Am Coll Cardiol 2012;60:1455–1469.
   PubMed Web of Science ®Google Scholar
• Chow MS.Assessing the treatment of congestive heart failure: diuretics, vasodilators, and angiotensin-converting enzyme inhibitors. Pharmacotherapy 1993;13:82S–87S.
   Web of Science ®Google Scholar
• Klapholz M. Beta-blocker use for the stages of heart failure. Mayo Clin Proc 2009;84:718–729.
   PubMed Web of Science ®Google Scholar
• Fischer D, Rossa S, Landmesser U, Spiekermann S, Engberding N, Hornig B, Drexler H. Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death. Eur Heart J 2005;26: 65–69.
   PubMed Web of Science ®Google Scholar
• Meyer B, Mörtl D, Strecker K, Hülsmann M, Kulemann V, Neunteufl T, Pacher R, Berger R. Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide. J Am Coll Cardiol 2005;46:1011–1018.
   PubMed Web of Science ®Google Scholar
• Shechter M, Matetzky S, Arad M, Feinberg MS, Freimark D. Vascular endothelial function predicts mortality risk in patients with advanced ischaemic chronic heart failure. Eur J Heart Fail 2009;11:588–593.
   PubMed Web of Science ®Google Scholar
• de Berrazueta JR, Guerra-Ruiz A, García-Unzueta MT, Toca GM, Laso RS, de Adana MS, et al. Endothelial dysfunction, measured by reactive hyperaemia using strain-gauge plethysmography, is an independent predictor of adverse outcome in heart failure. Eur J Heart Fail 2010;12:477–483.
   PubMed Web of Science ®Google Scholar
• Mathier MA, Rose GA, Fifer MA, Miyamoto MI, Dinsmore RE, Castaño HH, et al. Coronary endothelial dysfunction in patients with acute-onset idiopathic dilated cardiomyopathy. J Am Coll Cardiol 1998;32:216–224.
   PubMed Web of Science ®Google Scholar
• Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998;98: 2709–2715.
   PubMed Web of Science ®Google Scholar
• Tousoulis D, Simopoulou C, Papageorgiou N, Oikonomou E, Hatzis G, Siasos G, et al. Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches Pharmacol Ther 2014;144:253–267.
   PubMed Web of Science ®Google Scholar
• Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6: 1004–1010.
   PubMed Web of Science ®Google Scholar
• Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy JY. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation 2006;114:2655–2662.
   PubMed Web of Science ®Google Scholar
• Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998;273:24266–24271.
   PubMed Web of Science ®Google Scholar
• Pelat M, Dessy C, Massion P, Desager JP, Feron O, Balligand JL. Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo. Circulation 2003;107:2480–2486.
   PubMed Web of Science ®Google Scholar
• Wassmann S, Laufs U, Bäumer AT, Müller K, Konkol C, Sauer H, et al. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol 2001;59:646–654.
   PubMed Web of Science ®Google Scholar
• Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 2000;20:61–69.
   PubMed Web of Science ®Google Scholar
• Antoniades C, Bakogiannis C, Leeson P, Guzik TJ, Zhang MH, Tousoulis D, et al. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. Circulation 2011;124:335–345.
   PubMed Web of Science ®Google Scholar
• Kumar AP, Reynolds WF. Statins downregulate myeloperoxidase gene expression in macrophages. Biochem Biophys Res Commun 2005;331:442–451.
   PubMed Web of Science ®Google Scholar
• Stenvinkel P, Rodríguez-Ayala E, Massy ZA, Qureshi AR, Barany P, Fellström B et al. Statin treatment and diabetes affect myeloperoxidase activity in maintenance hemodialysis patients. Clin J Am Soc Nephrol 2006;1:281–287.
   PubMed Web of Science ®Google Scholar
• Zhou T, Zhou SH, Qi SS, Shen XQ, Zeng GF, Zhou HN. The effect of atorvastatin on serum myeloperoxidase and CRP levels in patients with acute coronary syndrome. Clin Chim Acta 2006;368:168–172.
   PubMed Web of Science ®Google Scholar
• Andreou I, Tousoulis D, Miliou A, Tentolouris C, Zisimos K, Gounari P, et al. Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study. Atherosclerosis 2010;210: 194–198.
   PubMed Web of Science ®Google Scholar
• Hornig B, Landmesser U, Kohler C, Ahlersmann D, Spiekermann S, Christoph A, et al. Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation 2001;103:799–805.
   PubMed Web of Science ®Google Scholar
• Faggiotto A, Paoletti R. State-of-the-Art lecture. Statins and blockers of the renin-angiotensin system: vascular protection beyond their primary mode of action. Hypertension 1999;34:987–996.
   PubMed Web of Science ®Google Scholar
• Warnholtz A, Nickenig G, Schulz E, Macharzina R, Bräsen JH, Skatchkov M, et al. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation 1999;99:2027–2033.
   PubMed Web of Science ®Google Scholar
• Liu X, Engelman RM, Rousou JA, Cordis GA, Das DK. Attenuation of myocardial reperfusion injury by sulfhydryl-containing angiotensin converting enzyme inhibitors. Cardiovasc Drugs Ther 1992;6:437–443.
   PubMed Web of Science ®Google Scholar
• Mak IT, Freedman AM, Dickens BF, Weglicki WB. Protective effects of sulfhydryl-containing angiotensin converting enzyme inhibitors against free radical injury in endothelial cells. Biochem Pharmacol 1990;40:2169–2175.
   PubMed Web of Science ®Google Scholar
• Imanishi T, Tsujioka H, Ikejima H, Kuroi A, Takarada S, Kitabata H, et al. Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. Hypertension 2008;52:563–572.
   PubMed Web of Science ®Google Scholar
• Nussberger J, Aubert JF, Bouzourene K, Pellegrin M, Hayoz D, Mazzolai L, et al. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine. Hypertension 2008;51: 1306–1311.
   PubMed Web of Science ®Google Scholar
• Evangelista S, Garbin U, Pasini AF, Stranieri C, Boccioletti V, Cominacini L, et al. Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells. Pharmacol Res 2007;55:303–309.
   PubMed Web of Science ®Google Scholar
• Oelze M, Daiber A, Brandes RP, Hortmann M, Wenzel P, Hink U, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 2006;48:677–684.
   PubMed Web of Science ®Google Scholar
• Cominacini L, Fratta Pasini A, Garbin U, Nava C, Davoli A, Criscuoli M, et al. Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. J Am Coll Cardiol 2003;42:1838–1844.
   PubMed Web of Science ®Google Scholar
• Fratta Pasini A, Garbin U, Nava MC, Stranieri C, Davoli A, Sawamura T, et al. Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens 2005;23: 589–596.
   PubMed Web of Science ®Google Scholar
• Mason RP, Kalinowski L, Jacob RF, Jacoby AM, Malinski T. Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans. Circulation 2005;112:3795–3801.
   PubMed Web of Science ®Google Scholar
• Pasini AF, Garbin U, Stranieri C, Boccioletti V, Mozzini C, Manfro S, et al. Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients. Am J Hypertens 2008;21:1251–1257.
   PubMed Web of Science ®Google Scholar
• Dessy C, Moniotte S, Ghisdal P, Havaux X, Noirhomme P, Balligand JL. Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization. Circulation 2004;110:948–954.
   PubMed Web of Science ®Google Scholar
• Dessy C, Saliez J, Ghisdal P, Daneau G, Lobysheva II, Frérart F, et al. Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol. Circulation 2005;112:1198–1205.
   PubMed Web of Science ®Google Scholar
• Bank AJ, Kelly AS, Thelen AM, Kaiser DR, Gonzalez-Campoy JM. Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. Am J Hypertens 2007;20:777–783.
   PubMed Web of Science ®Google Scholar
• Nishioka K, Nakagawa K, Umemura T, Jitsuiki D, Ueda K, Goto C. Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy. Heart 2007;93:247–248.
   PubMed Web of Science ®Google Scholar
• Neunteufl T, Priglinger U, Heher S, Zehetgruber M, Söregi G, Lehr S, et al. Effects of vitamin E on chronic and acute endothelial dysfunction in smokers. J Am Coll Cardiol 2000;35:277–283.
   PubMed Web of Science ®Google Scholar
• Pullin CH, Bonham JR, McDowell IF, Lee PJ, Powers HJ, Wilson J, et al. Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria. J Inherit Metab Dis 2002;25:107–118.
   PubMed Web of Science ®Google Scholar
• Antoniades C, Tousoulis D, Tentolouris C, Toutouza M, Marinou K, Goumas G, et al. Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers. Thromb Haemost 2003;89:990–995.
   PubMed Web of Science ®Google Scholar
• Tousoulis D, Antoniades C, Tentolouris C, Tsioufis C, Toutouza M, Toutouzas P, Stefanadis C. Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers. Atherosclerosis 2003;170:261–267.
   PubMed Web of Science ®Google Scholar
• Erbs S, Antoniades C, Tentolouris C, Tsioufis C, Toutouza M, Toutouzas P, Stefanadis C. Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy. Am Heart J 2003;146:280–285.
   PubMed Web of Science ®Google Scholar
• Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico. Lancet 1999;354:447–455.
   PubMed Web of Science ®Google Scholar
• Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet 2000;355: 253–259.
   PubMed Web of Science ®Google Scholar
• Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360:23–33.
   PubMed Web of Science ®Google Scholar
• Saremi A, Arora R. Vitamin E and cardiovascular disease. Am J Ther 2010;17:e56–65.
   PubMed Web of Science ®Google Scholar
• McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 2014;371: 993–1004.
   PubMed Web of Science ®Google Scholar
• Turner AJ. Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries. Biochem Soc Trans 2003;31:723–727.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick PA, Guinan AF, Walsh TG, Murphy RP, Killeen MT, Tobin NP, et al. Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production. Int J Biochem Cell Biol 2009;41: 2287–2294.
   PubMed Web of Science ®Google Scholar
• Rademaker MT, Charles CJ, Espiner EA, Nicholls MG, Richards AM, Kosoglou T. Neutral endopeptidase inhibition: augmented atrial and brain natriuretic peptide, haemodynamic and natriuretic responses in ovine heart failure. Clin Sci (Lond) 1996;91:283–291.
   PubMed Web of Science ®Google Scholar
• Wilkinson IB, McEniery CM, Bongaerts KH, MacCallum H, Webb DJ, Cockcroft JR. Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP). Br J Clin Pharmacol 2001;52:159–164.
   PubMed Web of Science ®Google Scholar
• Cruden NL, Fox KA, Ludlam CA, Johnston NR, Newby DE. Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition. Hypertension 2004;44:913–918.
   PubMed Web of Science ®Google Scholar
• Kuhn M.Molecular physiology of natriuretic peptide signalling. Basic Res Cardiol 2004;99:76–82.
   PubMed Web of Science ®Google Scholar
• Maric C, Zheng W, Walther T. Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase. Nephron Physiol 2006;103:149–156.
   Google Scholar
• von Lueder TG, Wang BH, Kompa AR, Huang L, Webb R, Jordaan P, et al. Angiotensin Receptor Neprilysin Inhibitor LCZ696 Attenuates Cardiac Remodeling and Dysfunction After Myocardial Infarction by Reducing Cardiac Fibrosis and Hypertrophy. Circ Heart Fail 2015;8:71–78.
   PubMed Web of Science ®Google Scholar
• Izumiya Y, Araki S, Usuku H, Rokutanda T, Hanatani S, Ogawa H. Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling. Int J Vasc Med 2012;2012:246058.
   PubMedGoogle Scholar
• Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, et al. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 2003;167:327–334.
   PubMed Web of Science ®Google Scholar
• Fatouros IG, Jamurtas AZ, Villiotou V, Pouliopoulou S, Fotinakis P, Taxildaris K, Deliconstantinos G. Oxidative stress responses in older men during endurance training and detraining. Med Sci Sports Exerc 2004;36:2065–2072.
   PubMed Web of Science ®Google Scholar
• Fisher-Wellman K, Bloomer RJ.Acute exercise and oxidative stress: a 30 year history. Dyn Med 2009;8:1.
   PubMedGoogle Scholar
• Radak Z, Chung HY, Koltai E, Taylor AW, Goto S.Exercise, oxidative stress and hormesis. Ageing Res Rev 2008;7: 34–42.
   PubMed Web of Science ®Google Scholar
• O’Keefe JH, Patil HR, Lavie CJ, Magalski A, Vogel RA, McCullough PA. Potential adverse cardiovascular effects from excessive endurance exercise. Mayo Clin Proc 2012; 87:587–595.
   PubMed Web of Science ®Google Scholar
• Kanter MM, Lesmes GR, Kaminsky LA, La Ham-Saeger J, Nequin ND. Serum creatine kinase and lactate dehydrogenase changes following an eighty kilometer race. Relationship to lipid peroxidation Eur J Appl Physiol Occup Physiol 1988;57:60–63.
   PubMed Web of Science ®Google Scholar
• Sanchez-Quesada JL, Homs-Serradesanferm R, Serrat-Serrat J, Serra-Grima JR, González-Sastre F, Ordóñez-Llanos J. Increase of LDL susceptibility to oxidation occurring after intense, long duration aerobic exercise. Atherosclerosis 1995;118:297–305.
   PubMed Web of Science ®Google Scholar
• Ginsburg GS, Agil A, O’Toole M, Rimm E, Douglas PS, Rifai N. Effects of a single bout of ultraendurance exercise on lipid levels and susceptibility of lipids to peroxidation in triathletes. JAMA 1996;276:221–225.
   PubMed Web of Science ®Google Scholar
• Margaritis I, Tessier F, Richard MJ, Marconnet P. No evidence of oxidative stress after a triathlon race in highly trained competitors. Int J Sports Med 1997;18:186–190.
   PubMed Web of Science ®Google Scholar
• Liu ML, Bergholm R, Mäkimattila S, Lahdenperä S, Valkonen M, Hilden H, et al. A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. Am J Physiol 1999;276: E1083–1091.
   PubMed Web of Science ®Google Scholar
• Nieman DC, Henson DA, McAnulty SR, McAnulty LS, Morrow JD, Ahmed A, Heward CB. Vitamin E and immunity after the Kona Triathlon World Championshi. Med Sci Sports Exerc 2004;36:1328–1335.
   PubMed Web of Science ®Google Scholar
• Knez WL, Jenkins DG, Coombes JS. Oxidative stress in half and full Ironman triathletes. Med Sci Sports Exerc 2007;39:283–288.
   PubMed Web of Science ®Google Scholar
• Quinn TJ, Sprague HA, Van Huss WD, Olson HW. Caloric expenditure, life status, and disease in former male athletes and non-athletes. Med Sci Sports Exerc 1990;22:742–750.
   PubMed Web of Science ®Google Scholar
• Lee IM, Hsieh CC, Paffenbarger RS, Jr. Exercise intensity and longevity in men. The Harvard Alumni Health Study. JAMA 1995;273:1179–1184.
   Google Scholar
• Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47–95.
   PubMed Web of Science ®Google Scholar