Nrf2-ARE signals mediated the anti-oxidative action of electroacupuncture in an MPTP mouse model of Parkinson's disease

References

• Hornykiewicz O, Kish SJ. Biochemical pathophysiology of Parkinson's disease. Adv Neurol 1987;45:19–34.
   PubMedGoogle Scholar
• Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003;39:889–909.
   PubMed Web of Science ®Google Scholar
• Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003;302:819–822.
   PubMed Web of Science ®Google Scholar
• Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006;443:787–795.
   PubMed Web of Science ®Google Scholar
• Wang B, Williamson G. Detection of a nuclear protein which binds specifically to the antioxidant responsive element (ARE) of the human NAD(P)H:quinone oxidoreductase gene. Biochim Biophys Acta 1994;1219:645–652.
   PubMed Web of Science ®Google Scholar
• Prestera T, Talalay P, Alam J, Ahn YI, Lee PJ, Choi AM. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1995;1:827–837.
   PubMed Web of Science ®Google Scholar
• Favreau LV, Pickett CB. Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. J Biol Chem 1991;266:4556–4561.
   PubMed Web of Science ®Google Scholar
• Mulcahy RT, Gipp JJ. Identification of a putative antioxidant response element in the 5’-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene. Biochem Biophys Res Commun 1995;209:227–233.
   PubMed Web of Science ®Google Scholar
• Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, et al. Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol 2007;66:75–85.
   PubMed Web of Science ®Google Scholar
• von Otter M, Landgren S, Nilsson S, Celojevic D, Bergstrom P, Hakansson A, et al. Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease. BMC Med Genet 2010;11:36.
   PubMed Web of Science ®Google Scholar
• Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, et al. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxid Redox Signal 2013; 18:139–157.
   PubMed Web of Science ®Google Scholar
• Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, Johnson JA. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A 2009;106:2933–2938.
   PubMed Web of Science ®Google Scholar
• Kumar H, Koppula S, Kim IS, More SV, Kim BW, Choi DK. Nuclear factor erythroid 2-related factor 2 signaling in Parkinson disease: a promising multi therapeutic target against oxidative stress, neuroinflammation and cell death. CNS Neurol Disord Drug Targets 2012;11:1015–1029.
   PubMed Web of Science ®Google Scholar
• Zhuang X, Wang L. Acupuncture treatment of Parkinson's disease–a report of 29 cases. J Tradit Chin Med 2000;20: 265–267.
   PubMedGoogle Scholar
• Eng ML, Lyons KE, Greene MS, Pahwa R. Open-label trial regarding the use of acupuncture and yin tui na in Parkinson's disease outpatients: a pilot study on efficacy, tolerability, and quality of life. J Altern Complement Med 2006;12:395–399.
   PubMed Web of Science ®Google Scholar
• Shulman LM, Wen X, Weiner WJ, Bateman D, Minagar A, Duncan R, Konefal J. Acupuncture therapy for the symptoms of Parkinson's disease. Mov Disord 2002;17:799–802.
   PubMed Web of Science ®Google Scholar
• Zeng BY, Salvage S, Jenner P. Current development of acupuncture research in Parkinson's disease. Int Rev Neurobiol 2013;111:141–158.
   PubMed Web of Science ®Google Scholar
• Zeng XH, Li QQ, Xu Q, Li F, Liu CZ. Acupuncture mechanism and redox equilibrium. Evid Based Complement Alternat Med 2014;2014:483294.
   PubMedGoogle Scholar
• Wattanathorn J, Sutalangka C. Laser Acupuncture at HT7 Acupoint Improves Cognitive Deficit, Neuronal Loss, Oxidative Stress, and Functions of Cholinergic and Dopaminergic Systems in Animal Model of Parkinson's Disease. Evid Based Complement Alternat Med 2014;2014:937601.
   PubMed Web of Science ®Google Scholar
• Yu YP, Ju WP, Li ZG, Wang DZ, Wang YC, Xie AM. Acupuncture inhibits oxidative stress and rotational behavior in 6-hydroxydopamine lesioned rat. Brain Res 2010;1336: 58–65.
   PubMed Web of Science ®Google Scholar
• Kim ST, Moon W, Chae Y, Kim YJ, Lee H, Park HJ. The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum. J Physiol Sci 2010;60:27–34.
   PubMed Web of Science ®Google Scholar
• Wang H, Liang X, Wang X, Luo D, Jia J, Wang X. Electro-acupuncture stimulation improves spontaneous locomotor hyperactivity in MPTP intoxicated mice. PLoS One 2013;8:e64403.
   PubMed Web of Science ®Google Scholar
• Wang H, Pan Y, Xue B, Wang X, Zhao F, Jia J, Liang X, Wang X. The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease. PLoS One 2011;6:e19790.
   PubMed Web of Science ®Google Scholar
• Chandran JS, Lin X, Zapata A, Hoke A, Shimoji M, Moore SO, et al. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis 2008;29:505–514.
   PubMed Web of Science ®Google Scholar
• Liang XB, Liu XY, Li FQ, Luo Y, Lu J, Zhang WM, et al. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Brain Res Mol Brain Res 2002;108:51–59.
   PubMedGoogle Scholar
• Calkins MJ, Vargas MR, Johnson DA, Johnson JA. Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition. Toxicol Sci 2010;115:557–568.
   PubMed Web of Science ®Google Scholar
• Beraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, et al. Microglial activation and antioxidant responses induced by the Parkinson's disease protein alpha-synuclein. J Neuroimmune Pharmacol 2013;8:94–117.
   PubMed Web of Science ®Google Scholar
• Tillerson JL, Caudle WM, Reveron ME, Miller GW. Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Exp Neurol 2002;178:80–90.
   PubMed Web of Science ®Google Scholar
• Sconce MD, Churchill MJ, Greene RE, Meshul CK. Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease. Neuroscience 2015;299:156–274.
   PubMed Web of Science ®Google Scholar
• Fredriksson A, Plaznik A, Sundstrom E, Archer T. Effects of D1 and D2 agonists on spontaneous motor activity in MPTP treated mice. Pharmacol Toxicol 1994;75:36–41.
   PubMedGoogle Scholar
• Schwarting RK, Sedelis M, Hofele K, Auburger GW, Huston JP. Strain-dependent recovery of open-field behavior and striatal dopamine deficiency in the mouse MPTP model of Parkinson's disease. Neurotox Res 1999;1:41–56.
   PubMedGoogle Scholar
• Hofele K, Sedelis M, Auburger GW, Morgan S, Huston JP, Schwarting RK. Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility. Exp Neurol 2001;168:116–122.
   PubMed Web of Science ®Google Scholar
• Sedelis M, Schwarting RK, Huston JP. Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behav Brain Res 2001;125:109–125.
   PubMed Web of Science ®Google Scholar
• Nakabeppu Y, Tsuchimoto D, Yamaguchi H, Sakumi K. Oxidative damage in nucleic acids and Parkinson's disease. J Neurosci Res 2007;85:919–934.
   PubMed Web of Science ®Google Scholar
• Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth PJ, et al. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol 2006;2:249–253.
   PubMed Web of Science ®Google Scholar
• Niranjan R. The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes. Mol Neurobiol 2014;49:28–38.
   PubMed Web of Science ®Google Scholar
• Zhou C, Huang Y, Przedborski S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 2008;1147: 93–104.
   PubMed Web of Science ®Google Scholar
• Chun HS, Gibson GE, DeGiorgio LA, Zhang H, Kidd VJ, Son JH. Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem 2001;76:1010–1021.
   PubMed Web of Science ®Google Scholar
• McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglial are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38:1285–1291.
   PubMed Web of Science ®Google Scholar
• O’Callaghan JP, Miller DB, Reinhard JJ. Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res 1990;521:73–80.
   PubMed Web of Science ®Google Scholar
• Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol 2009;8:382–397.
   PubMed Web of Science ®Google Scholar
• Zafar KS, Inayat-Hussain SH, Ross D. A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. J Neurochem 2007;102:913–921.
   PubMed Web of Science ®Google Scholar
• van Muiswinkel FL, de Vos RA, Bol JG, Andringa G, Jansen SE, Ross D, et al. Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra. Neurobiol Aging 2004;25:1253–1262.
   PubMed Web of Science ®Google Scholar
• Han JM, Lee YJ, Lee SY, Kim EM, Moon Y, Kim HW, Hwang O. Protective effect of sulforaphane against dopaminergic cell death. J Pharmacol Exp Ther 2007;321:249–256.
   PubMed Web of Science ®Google Scholar
• Hwang O. Role of oxidative stress in Parkinson's disease. Exp Neurobiol 2013;22:11–17.
   PubMedGoogle Scholar
• Schipper HM, Liberman A, Stopa EG. Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp Neurol 1998;150:60–68.
   PubMed Web of Science ®Google Scholar
• Schipper HM, Song W, Zukor H, Hascalovici JR, Zeligman D. Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J Neurochem 2009;110:469–485.
   PubMed Web of Science ®Google Scholar