Doxorubicin Resistance Conferred by Selective Enhancement of Intracellular Glutathione Peroxidase or Superoxide Dismutase Content in Human MCF-7 Breast Cancer Cells

J. H. Doroshow Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA

S. Akman Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA

S. Esworthy Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA

F. F. Chu Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA

T. Burke Department of Medical Oncology and Therapeutics Research., City of Hope National Medical Center, Duarte, California, 91010, USA

References

Batist G., Tulpule A., Sinha B. K., Katki A. G., Myers C. E., Cowan K. H. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. Journal of Biological Chemistry 1986; 261: 15544–15549
PubMed Web of Science ®Google Scholar
Sinha B. K., Katki A. G., Batist G., Cowan K. H., Myers C. E. Differential formation of hydroxyl radicals by Adriamycin in sensitive and resistant MCF-7 human breast tumor cells: Implications for the mechanism of action. Biochemistry 1987; 26: 3776–3781
PubMed Web of Science ®Google Scholar
Fairchild C. R., Ivy S. P., Kao-Shan C. S., Whang-Peng J., Rosen N., Israel M. A., Melera P. W., Cowan K. H., Goldsmith M. E. Isolation of amplified and overexpressed DNA sequences from Adriamycin-resistant human breast cancer cells. Cancer Research. 1987; 47: 5141–5148
PubMed Web of Science ®Google Scholar
Doroshow J. H. Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents. Biochemical and Biophysical Research Communicutions. 1986; 135: 330–335
PubMed Web of Science ®Google Scholar
McNeil P. L., Murphy R. F., Lanni F., Taylor D. L. A method for incorporating macro-molecules into adherent cells. Journal of Cell Biology. 1984; 98: 1556–1564
PubMed Web of Science ®Google Scholar
Doroshow J. H., Locker G. Y., Myers C. E. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: Alterations produced by doxorubicin. Journal of Clinical Investigation. 1980; 65: 128–135
PubMed Web of Science ®Google Scholar

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Doxorubicin Resistance Conferred by Selective Enhancement of Intracellular Glutathione Peroxidase or Superoxide Dismutase Content in Human MCF-7 Breast Cancer Cells

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Doxorubicin Resistance Conferred by Selective Enhancement of Intracellular Glutathione Peroxidase or Superoxide Dismutase Content in Human MCF-7 Breast Cancer Cells

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