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Free Radical Research Communications Volume 19, 1993 - Issue sup1: Third International Symposium on Spin Trapping and Aminoxyl Radical Chemistry
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Original Article

EPR Spin Trapping of Free Radicals Produced by Bleomycin and Ascorbate

Garry R. Buettner ESR Center, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
&
Pope L. Moseley Department of Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Pages s89-s93 | Published online: 07 Jun 2011

References

  • S.M. Hechi (1986) The chemistry of activated bleomycin. Accounts of Chemical Research, 19, 383 391.
  • J. Slubbc and J.W. Kozarich (1987) Mechanisms of blcomycin-induccd DNA degradation. Chemical Reviews, 87, 1107 1136.
  • D.H. Petering. R. Byrnes and W.F., Antholinel 1990) The role of redoxactive metals in the mechanism of action of bleomycin. Chemico-Biological Interactions. 73, 133–182.
  • L.W. Obcrley and Ci.R. Bucttner (1979) The production of hydroxyl radical by bleomycin and Ìron(ll). FEBS Letters, 97, 47–49.
  • D. Solaiman, E.R. Kao. D.H. Petering, R.C. Scaly and W.E. Antholine (1979) Chemical, biochemical, and cellular properties of copper and iron bleomycins. International Journal Radiation Oncology & Biology Physiology, 5. 1519–1521.
  • Y. Sugiura and T. Kikuchi (1978) Formation of superoxide and hydroxy radicals in iron(II). bleomycin -oxygen system. Electron spin resonance detection by spin trapping. Journal of Antibiotics, 31, 1310–1312.
  • W.E. Antholine, B. Kalyanaraman, J.A. Templin. R.W. Byrnes and DM. Petering (1991) Spin. trapping studies of the oxidation-reduction reactions of iron bleomycin in lhe presence of thiols and buffer. Free Radical Biology A Medicine, 10, 119–123.
  • C. Padbury, S.G. Sugar. R. Labcquc and I.J. Mameli (1988) Ferric bleomycin catalyzed reduction of 10-hydroperoxy-8, 12-octadecadienoic acid: evidence for homolylic 0-0 bond scission. Biochemistry, 27. 7846–7852.
  • W.E. Antholine and D.H. Petering (1979) On the reaction of iron bleomycin with ihiols and oxygen. Biochemical Biophysical Research Communications, 90, 384–389.
  • P.L. Moseleyaud R. Chalklcy (1987) Bleomycin-induced DNA élevage: Studies in vitro and in intact cells. Journal Laboratory and Clinical Medicine, 110, 618–623.
  • E.A. Sausvillc, J. Pcisach and S.B. Horwitz (1978) Effect of chelating agents and metal ions on the degradation of DNA by bleomycin. Biochemistry, 17, 2740–2746.
  • A. Nairajan, S.M. Hccht, G.A. van der Marel and J.H. van Boom (1990) A study of 02-versus nonsupported activation of Fc-Bleomycin. Journal of the American Chemical Society, 112, 3997–4002.
  • G.R. Bucttner (1988) In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals. Journal of Biochemical A Biophysical Methods, 16, 27–40.
  • G.R. Buettncr and I.,W. Oberlcy (1978) Considerations in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5.5 dimethyl-1-pyrroltne-N-oxide. Biochemical Biophysical Research Communications, 87. 69–74.
  • G.R. Bucttner (1990) On the reaction of superoxide with DMPO/-OOH. Free Radical Research Cornimi nicat ions, 10, 11–13.
  • G.R. Bucttner (1990) Ascorbate oxidation: UVabsorbance of ascorbate and EPR spectroscopy of the ascorbate radical as assays for iron. Free Radical Research Communications, 10, 1–2:5–9.
  • R.M. Burger, S.B. Horwitz and J. Pcisach (1985) Stimulation of iron(ll) bleomycin activity by phosphate-containing compounds. Biochemistry. 24, 3623–3629.
  • G.R. Buetiner and P.L. Moseley (1991) Ascorbate both activates and inactivates bleomycin by free radical generation. Biochemistry, 31, 9784–9788.
  • G.R. Bucttner (1982) The spin trapping of superoxide and hydroxyl radicals. Superoxide Disimilase, 2. 2–63. edited by L.W. Oberlcy. CRC Press, Inc., Boca Raton. FL.
  • G.R. Buetiner and R.P. Mason (Í990) Spin-trapping methods for detecting superoxide and hydroxyl free radicals In Vitro and in Vivo. Methods in F.nzymology. 186, 127–133.
  • G.R. Buetiner (1987) Spin trapping: EPR parameters of spin adducis. Free Radiation Biology Medicine, 3, 259–303.
  • Li A.S.W., Cummings K.B.. Rocthling, II.P. Bueitncr G.R., Chignell and Colin F. (1988) A spin-trapping database implemented on the IBM PC/AT. Journal of Magnetic Resonance, 79, 140–142.
  • A.S.W. Li and C.F. Chignell (1991)The NoH value in EPR spin trapping: anew parameier for the identification oT 5,5-dimelhyl-l-pyrrolinc-N-oxide spin adducts. Journal Biochemical A Biophysical Methods. 22, 83–87.
  • A.S.W. Li and C.F. Chignell (1987) Spectroscopic studies of cutaneous photosensitizing agents-X, A spin-trapping and direct electron spin resonance study of the photochemical pathways of daunomycin and adriamycin. Photochemistry Photobiohgy, 45, 565–570.

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