7
Views
19
CrossRef citations to date
0
Altmetric
Original Article

α-Phenyl N-Tert-Butyl Nitrone (PBN) Increases the Cortical Cerebral Blood Flow by Inhibiting the Breakdown of Nitric Oxide in Anesthetized Rats

&
Pages 33-39 | Received 11 Aug 1993, Published online: 07 Jul 2009

References

  • Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends in Neuroscience 1991; 14: 60–67
  • Palmer R. M.J., Ferrige A. G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–526
  • Palmer R. M.J., Ashton D. S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664–666
  • Adachi T., Inanami O., Sato A. Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats. Neuroscience Letters 1992; 139: 201–204
  • Koniewska E., Osgka M., Stys T. Effects of endothelium-derived nitric oxide on cerebral circulation during normoxia and hypoxia in the rat. Journal of Cerebral Blood Flow and Metabolism 1992; 12: 311–317
  • Brown L P., Thompson C. I., Belloni F. L. Role of nitric oxide in hypoxic coronary vasodilatation in isolated guinea pig heart. American Journal of Physiology 1993; 264: H821–H829
  • Walder C. E., Thiemermann C., Vane J. R. The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat. British Journal of Pharmacology 1991; 102: 967–973
  • Gryglewski R. J., Palmer R. M.J., Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived relaxing factor. Nature 1986; 320: 454–456
  • Rubaniyi G. M., Vanhoutte P. M. Oxygen-derived free radicals, endothelium and responsiveness of vascular smooth muscle. American Journal of Physiology 1986b; 250: H815–H821
  • Rubaniyi G. M., Vanhoutte P. M. Superoxide anions and hypoxia inactivate endothelium-derived relaxing factor. American Journal of Physiology 1986a; 250: H822–H827
  • Halliwell B., Gutteridge J. M. Free Radicals in Biology and Medicine. Clarendon Press, Oxford 1989
  • Rosen G. M., Freeman B. A. Detection of super-oxide generated by endothelial cells. Proceedings of National Academy of Sciences USA 1984; 81: 7269–7273
  • Carney J. M., Starke-Reed P. E., Oliver C. N., Landum R. W., Cheng M. S., Wu J. F., Floyd R. A. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-a-phenyl nitrone. Proceedings of National Academy of Sciences USA 1991; 88: 3633–3636
  • Biesold D., Inanami O., Sato A., Sato Y. Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats. Neuroscience Letters 1989; 98: 39–44
  • Bonner R., Nossal R. Model for laser Doppler measurement of blood flow in tissue. Applied Optics 1981; 20: 2097–2107
  • Paxinos G., Watson C. The Rat Brain. Stereotaxic Coordinates, 2nd ed. Academic Press., Sydney 1986
  • Mayer B., John M., Heinzel B., Klatt P., Werner E. R., Bohme E. Properties of Ca +-regulated brain nitric oxide synthase. The Biology of Nitric Oxide, 2 Enzymology, Biochemistry and Immunology, S. Moncada, M. A. Marietta, J. B. Hibbs, Jr., E. A. Higgs. Portland Press, London and Chapel Hill 1992; 4–6
  • Moncada S., Palmer R. M.J., Higgs E. A. Biosynthesis of nitric oxide from L-arginine. Biochemical Pharmacology 1989; 38: 1709–1715
  • Chen G., Griffin M., Poyer J. L., McCay P. B. HPLC procedure for the pharmacokinetic study of the spin-trapping agent, α-phenyl-N-tert-butylnitrone (PBN). Free Radical Biology and medicine 1990; 8: 93–98
  • Lai E. K., Crossley R., Sridhar H. P., Misra E. G., Janzen E. G., McCay P. B. In vivo spin trapping of free radicals generated in brain, spleen, and liver during -γ-radiation of mice. Archives of Biochemistry and Biophysics 1986; 244: 156–160
  • Janzen E. G. Spin-trapping. Methods in Enzymology 105, L. Packer. Academic Press, London 1984; 188–209
  • Prónai L., Ichimori K., Nozaki H., Nakazawa H., Okino H., Carmichael A. J., Arroyo C M. Investigation of the existence and biological role of L-arginine/nitric oxide pathway in human platelets by spin-trapping/EPR studies. European Journal of Biochemistry 1991; 202: 923–930
  • Li X.-Y., Sun J.-Z., Bradamonte S., Piccinini F., Bolli R. Effects of the spin trap α-phenyl N-tert-buthyl nitrone on myocardial function and flow: A dose-response response study in the open-chest dog and in the isolated rat heart. Free Radical Biology and medicine 1993; 14: 277–285
  • Konorev E. A., Baker J. E., Joseph J., Karyanaraman B. Vasodilatory and toxic effects of spin-traps on aerobic cardiac function. Free Radical Biology and Medicine 1993; 14: 127–137
  • Anderson D. E., Yuan X.-J., Tseng C.-M., Rubin L. J., Rosen G. M., Tod M. L. Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals. Biochemistry and Biophysical Research Communications 1993; 193: 878–885

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.