Edta Differentially and Incompletely Inhibits Components of Prolonged Cell-Mediated Oxidation of Low-Density Lipoprotein

References

• Steinberg D., Parthasarathy S., Carew T. E., Khoo J. C., Witztum J. L. Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity. New England Journal of Medicine 1989; 320: 915–924
   PubMed Web of Science ®Google Scholar
• Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801–809
   PubMed Web of Science ®Google Scholar
• Steinbrecher U. P., Parthasarathy S., Leake D. S., Witztum J. L., Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proceedings of the National Academy of Sciences USA 1984; 81: 3882–3887
   Web of Science ®Google Scholar
• Henriksen T., Mahoney E. M., Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: Recognition by receptors for acetylated low density lipoproteins. Proceedings of the National Academy of Sciences USA 1981; 78: 6499–6503
   PubMed Web of Science ®Google Scholar
• Heinecke J. W., Rosen H., Chait A. Iron and copper promote modification of low density lipoprotein in vitro by free radical oxidation. Journal of Clinical Investigation 1984; 74: 1890–1894
   PubMed Web of Science ®Google Scholar
• Esterbauer H., Gebicki J., Puhl H., Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radicals in Biology and Medicine 1992; 13: 341–390
   PubMed Web of Science ®Google Scholar
• Bedwell S., Dean R. T., Jessup W. The action of defined oxygen-centred free radicals on human low-density lipoprotein. Biochemical Journal 1989; 262: 707–712
   PubMed Web of Science ®Google Scholar
• Stocker R., Bowry V., Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National Academy of Sciences USA 1991; 88: 1646–1650
   PubMed Web of Science ®Google Scholar
• Berliner J., Territo M. C., Sevanian A., et al. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. Journal of Clinical Investigation 1990; 85: 1260–1266
   PubMed Web of Science ®Google Scholar
• Sparrow C. P., Parthasarathy S., Steinberg D. Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification. Proceedings of the National Academy of Sciences USA 1988; 29: 745–753
   Google Scholar
• Lenz M. L., Hughes H., Mitchell J. R., et al. Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. Journal of Lipid Research 1990; 31: 1043–1050
   PubMed Web of Science ®Google Scholar
• Wang T., We-gui Y., Powell W. S. Formation of monohydroxy derivatives of arachidonic acid, linoleic acid and oleic acid during oxidation of low density lipoprotein by copper ions and endothelial cells. Journal of Lipid Research 1992; 33: 525–537
   PubMed Web of Science ®Google Scholar
• Zhang H., Basra H. J.K., Steinbrecher U. P. Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages. Journal of Lipid Research 1990; 31: 1361–1369
   PubMed Web of Science ®Google Scholar
• Jialal I., Freeman D. A., Grundy S. M. Varying susceptibilities of different low density lipoproteins to oxidative modification. Arteriosclerosis and Thrombosis 1991; 11: 482–488
   PubMed Web of Science ®Google Scholar
• Warner G. J., Addis P. B., Emanuel H. A., Wolfbauer G., Chait A. Cholesterol oxidation products in oxidatively modified low density lipoproteins. Federation American Society Experimental Biology Journal 1990; 4: A368
   Google Scholar
• Esterbauer H., Cheeseman K. H. Determination of aldehydic lipid peroxidation products: malondialdehyde and 4-hydroxynonenal. Methods in Enzymology. 1990; 186: 407–421
   PubMed Web of Science ®Google Scholar
• Pryor W. A., Castle L. Chemical methods for the detection of lipid hydroperoxides. Methods in Enzymology. 1984; 105: 293–299
   PubMed Web of Science ®Google Scholar
• Yamamoto Y., Brodsky M. H., Baker J. C., Ames B. N. Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography. Analytical Biochemistry 1987; 160: 7–13
   PubMed Web of Science ®Google Scholar
• Gutteridge J. M.C., Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. Trends In Biochemical Science 1990; 15: 129–135
   PubMed Web of Science ®Google Scholar
• Noguchi N., Gotoh N., Niki E. Dynamics of the oxidation of low density lipoprotein induced by free radicals. Biochimica Biophysica Acta 1993; 1168: 348–357
   PubMed Web of Science ®Google Scholar
• Esterbauer H., Striegel G., Puhl H., Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radical Research Communications 1989; 6: 67–75
   PubMed Web of Science ®Google Scholar
• Kritharides L., Jessup W., Gifford J., Dean R. T. A method for defining the stages of low-density lipoprotein oxidation by the separation of cholesterol- and cholesteryl ester-oxidation products using HPLC. Analytical Biochemistry 1993; 213: 79–89
   PubMed Web of Science ®Google Scholar
• Bhadra S., Arshad M. A.Q., Rymaszewski Z., Norman E., Wherley R., Subbiah M. T.R. Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu2+ ions: identification of major products and their effects. Biochemical Biophysical Research Communications 1991; 176: 431–440
   PubMed Web of Science ®Google Scholar
• Hodis H. N., Crawford D. W., Sevanian A. Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis. Atherosclerosis 1991; 89: 117–126
   PubMed Web of Science ®Google Scholar
• Chung B. H., Segrest J. P., Ray M. J., et al. Single vertical spin density gradient ultracentrifugation. Methods in enzymology 1986; 128: 181–209
   PubMed Web of Science ®Google Scholar
• Cathcart M. K., Chisolm G. M., McNally A. K., Morel D. W. Oxidative modification of low density lipoprotein (LDL) by activated human monocytes and the cell lines U937 and HL60. In vitro cellular and developmental biology 1988; 24: 1001–1008
   PubMed Web of Science ®Google Scholar
• Van Hinsberg V. W.M., Scheffer M., Havekes L., Kempen H. J.M. Role of endothelial cells and their products in the modification of low-density lipoproteins. Biochimica Biophysica Acta 1986; 878: 49–64
   PubMedGoogle Scholar
• Jessup W., Rankin S. M., De Whalley C. V., Hoult J. R.S., Scott J., Leake D. S. Alpha-tocopherol consumption during low-density-lipoprotein oxidation. Biochemical Journal 1990; 265: 399–405
   PubMed Web of Science ®Google Scholar
• Kuzuya M., Yamada K., Hayashi T., et al. Role of lipoprotein-copper complex in copper-catalyzed peroxidation of low-density lipoprotein. Biochimica Biophysica Acta 1992; 1123: 334–41
   PubMed Web of Science ®Google Scholar
• Steinbrecher U. P. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxidation decomposition products. Journal of Biological Chemistry 1987; 262: 3603–3608
   PubMed Web of Science ®Google Scholar
• Cheng K. L., Ueno K., Imamura T. EDTA and other complexanes. CRC handbook of organic analytical reagents., K. L. Cheng. CRC Press, Boca Raton, Fla.USA 1978; 213–220
   Google Scholar
• Sattler W., Stocker R. Greater selective uptake by Hep G2 cells of high-density lipoprotein cholesteryl ester hydroperoxides than of unoxidized cholesteryl esters. Biochemical Journal 1993; 294: 771–778
   PubMed Web of Science ®Google Scholar
• Halliwell B., Gutteridge J. M.C. Free Radicals in Biology and Medicine. (2nd ed.). Clarendon Press, Oxford 1989
   Google Scholar
• Bors W., Erben-Russ M., Michel C., Saran M. Radical mechanisms in fatty acid and lipid peroxidation. Free Radicals, lipoproteins, and membrane lipids, A. Crastes de Paulet. Plenum Press, New York 1990; 1–16
   Google Scholar
• Jessup W., Mander E. L., Dean R. The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages. Biochimica Biophysica Acta 1992; 1126: 167–177
   PubMed Web of Science ®Google Scholar
• Lougheed M., Zhang H., Steinbrecher U. P. Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages. Journal of Biological Chemistry 1991; 266: 14519–14525
   PubMed Web of Science ®Google Scholar
• Goldstein J. L., Ho Y. K., Basu S. K., Brown M. S. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein producing massive cholesterol deposition. Proceedings of the National Academy of Sciences USA 1979; 76: 333–337
   PubMed Web of Science ®Google Scholar
• Heinecke J. W., Baker L., Rosen H., Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J. Clin. Invest. 1986; 77: 757–761
   PubMed Web of Science ®Google Scholar
• Steinbrecher U. P., Lougheed M. Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima. Arterioscerosis and Thrombosis 1992; 12: 608–625
   PubMedGoogle Scholar
• Brooks C. J.W., Harland W. A., Steel G. Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. Biochimica Biophysica Acta 1966; 125: 620–622
   PubMed Web of Science ®Google Scholar
• Morgan J., Smith J. A., Wilkins G. M., Leake D. S. Oxidation of low density lipoprotein by bovine and porcine aortic endothelial cells and porcine endocardial cells in culture. Atherosclerosis 1993; 102: 209–216
   PubMed Web of Science ®Google Scholar
• Smith L. L., Johnson B. H. Biological effects of oxysterols. Free Radicals in Biology and Medicine 1989; 7: 285–332
   PubMed Web of Science ®Google Scholar
• Minotti G., Aust S. D. Redox cycling of iron and lipid peroxidation. Lipids 1992; 27: 219–26
   PubMed Web of Science ®Google Scholar
• Lamb D. J., Leake D. S. The effect of EDTA on the oxidation of low density lipoprotein. Atherosclerosis 1992; 94: 35–42
   PubMed Web of Science ®Google Scholar
• Nakagawara A., Nathan C. F., Cohn Z. A. Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. Journal of Clinical Investigation 1981; 68: 1243–1252
   PubMed Web of Science ®Google Scholar
• Jessup W., Mohr D., Gieseg S. P., Dean R. T., Stocker R. The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein. Biochimica Biophysica Acta 1992
   Google Scholar
• Jessup W., Dean R. T. Autoinhibition of murine macrophage-mediated oxidation of low-density lipoprotein by nitric oxide synthesis. Atherosclerosis 1993; 101: 145–155
   PubMed Web of Science ®Google Scholar
• Parthasarathy S., Wieland E., Steinberg D. A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proceedings of the National Academy of Sciences USA 1989; 86: 1046–1050
   PubMed Web of Science ®Google Scholar
• Rankin S. M., Parthasarathy S., Steinberg D. Evidence for a dominant roleoflipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. Journal of Lipid Research 1991; 32: 449–456
   PubMed Web of Science ®Google Scholar
• Jessup W., Darley-Usmar V., O'Leary V., Bedwell S. 5-Lipoxygenase is not essential in macro-phage-mediated oxidation of low-density lipoprotein. Biochemical Journal 1991; 278: 163–169
   PubMed Web of Science ®Google Scholar
• Sparrow C. P., Olszewski J. Cellular oxidative modification of low density lipoprotein does not require lipoxygenases. Proceedings of the National Academy of Sciences USA 1992; 89: 128–131
   PubMed Web of Science ®Google Scholar
• Barclay L. R.C., Baskin K. A., Locke S. J., Vinquist M. R. Absolute rate constants for lipid peroxidation for lipid peroxidation and inhibition in model biomembranes. Canadian Journal of Chemistry 1989; 67: 1366–1369
   Web of Science ®Google Scholar
• Barclay L. R.C., Cameron R. C., Forrest B. J., Locke S. J., Nigam R., Vinqvist M. R. Choles-terol:free radical peroxidation and transfer into phospholipid membranes. Biochimica Biophysica Act 1990; 1047: 255–263
   PubMedGoogle Scholar