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Original Article

Antioxidant Activity of Diethyldithiocarbamate

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Pages 461-472 | Received 09 Nov 1995, Published online: 07 Jul 2009

References

  • Heikkila R. E., Cabbat F. S., Cohen G. In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate. Journal of Biological Chemistry 1976; 251: 2182–2185
  • Bynoe L. A., Gottsch J. D., Pou S., Rosen G. M. Light-dependent generation of superoxide from human erythrocytes. Photochemistry and Photobiology 1992; 56: 353–356
  • Faiman M. D., Meld R. G., Oehme F. W. Protection with disulfiram from central and pulmonary oxygen toxicity. Biochemical Pharmacology 1971; 20: 3059–3067
  • Frank L., Wood D. L., Roberts R. J. Effect of DDC on oxygen toxicity and lung enzyme activity in immature and adult rats. Biochemical Pharmacology 1978; 27: 251–254
  • Deneke S. M., Bemstein S. P., Fanburg B. L. Enhancement by disulfiram (Antabuse) of toxic effects of 95 and 97% O2 on the rat lung. Journal of Pharmacology and Experimental Therapy 1979; 208: 377–380
  • Kaminsky L. S., Fraser J. M., Seaman M., Dunbar D. Rat liver metabolism and toxicity of 2, 2, 2-trifluoroethanol. Biochemical Pharmacology 1992; 44: 1829–1837
  • Puccini P., Menicagli S., Longo V., Santucci A., Gervasi P. G. Purification and characterization of an acetone-inducible cytochrome P450 from hamster liver microsomes. Biochemical Journal 1992; 287: 863–870
  • Kharasch E. D., Thummel K. E., Mhyre J., Lillibridge J. H. Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. Clinical Pharmacology and Therapy 1993; 53: 643–650
  • Pan J., Hong J. Y., Li D., Schuetz E.G., Guzelian P. S., Huang W., Yang C. S. Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes. Biochemical Pharmacology 1993; 45: 2323–2329
  • Broner C. W., Sheneep J. L., Stokes D. C., Fairclough D., Hildner W. K., Storgion S. A., Rehg J. E. Reversal of dopamine-refractory septic shock by diethyldithiocarbamate, an inhibitor of endothelium-derived relaxing factor. Journal of Infective Disease 1993; 167: 141–147
  • East C. J., Borch R. F. The importance of schedule on diethyldithiocarbamate modulation of drug-induced myelosuppression. Cancer Cheinatheropy and Pharmacology 1992; 31: 123–126
  • Schuchter L. M., Luginbuhl W. E., Meropol N. J. The current status of toxicity protectants in cancer therapy. Seminars in Oncology 1992; 19: 742–751
  • Dufour P., Lang J. M., Giron C., Duclos B., Haehnel P., Jaeck D., Jung J. M., Oberling F. Sodium dithiocarb as adjuvant immunotherapy for high risk breast cancer: a randomized study. Biothrerapy 1993; 6: 9–12
  • Hersh E. M., Funk C. Y., Petersen E. A., Mosier D. E. Biological activity of diethyldithiocarbamate (Dithiocarb, Imuthiol) in an animal model of retrovirus-induced immunodeficiency disease and in clinical trials in patients with HIV infection: The Dithiocarb Study Group. Developmental Biology and Standardazation 1990; 72: 355–363
  • Coutellier A., Bonnefont-Rousselot D., Delattre J., Lopez O., Jaudon M. C., Herson S., Emerit J. Oxidative stress in 29 HIV seropositive patients: two-year results of a double-blind trial of diethyldithiocarbamate versus placebo. Presse Medicine 1992; 21: 1809–1812
  • Vanham L., Kestens L., Van-Hoof J., Penne G., Colebunders R., Giolav C., Vandenbruaene M., El-Habib R., Gigase P. Immunological parameters during treatment with dithiocarb (Imuthiol). AIDS 1993; 7G: 525–530
  • Evans R. E., Engel C. R., Wheatly C. L., Nielsen J. R., Ciborowski L. J. An in vitro study of the radio-protective effect of diethyldithiocarbamate (DTC). International journal of Rad. Onc. Biol. Phys 1983; 9: 1635–1640
  • Bartoli G., Muller A., Cadenas E., Sies H. Anti-oxidant effect of diethyldithiocarbamate on microsomal lipid peroxidation assessed by low-level chemilumines-cence and alkane production. FEBS. Letters 1983; 164: 371–374
  • Zanocco A. L., Pavez R., Videla A., Lissi E. A. Antioxidant capacity of diethyldithiocarbamate in a metal independent lipid peroxidative process. Free Radical Biology and Medicine 1989; 7: 151–156
  • Mankhetkom S., Abedinzadeh Z., Houee-Levin C. Antioxidant action of sodium diethyldithiocarbamate: reaction with hydrogen peroxide and superoxide radical. Free Radical Biology and Medicine 1994; 17: 517–527
  • Wasil M., Halliwell B., Hutchison D. C.S., Baum H. The antioxidant action of human extracellular fluids. Biochemical Journal 1987; 243: 219–223
  • Halliwell B. Drug antioxidant effects—a basis for drug selection. Drugs 1991; 42: 569–605
  • Gutteridge J. M.C., Maidt L., Poyer L. Super-oxide dismutase and Fenton chemistry: reaction of ferric-EDTA complex and ferric-bipyridyl complex with hydrogen peroxide without the apparent formation of iron(II). Biochemical Journal 1990; 269: 169–174
  • Hogg N., Darley-Usmar V. M., Wilson M. T., Moncada S. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochemical Journal 1992; 281: 419–424
  • Gutteridge J. M.C., Fu X. C. Enhancement of bleomycin-iron free radical damage to DNA by anti-oxidants and their inhibition of lipid peroxidation. FEBS. Letters 1981; 123: 71–74
  • Paya M., Halliwell B., Hoult J. R.S. Interaction of a series of coumarins with reactive oxygen species: scavenging of superoxide, hypochlorous acid and hydroxyl radicals. Biochemical Pharmacology 1992; 44: 205–214
  • Liu J., Mori A. Monoamine metabolism provides an antioxidant defense in the brain against oxidant-and free radical-induced damage. Archives of Biochemistry and Biophysics 1993; 302: 118–127
  • Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979; 95: 351–358
  • Oliver C. N., Ah B-W., Mwrman E. J., Goldstein S., Stadtman E. R. Age-related changes in oxidized proteins. Journal of Biological Chemistry 1987; 262: 5488–5491
  • Wagner J. R., Hu C-C., Ames B. N. Endogenous oxidative damage of deoxycytidine in DNA. Proceedings of National Academy of Sciences of USA 1992; 89: 3380–3384
  • Shigenaga M. K., Aboujaoude E. N., Chen Q., Ames B. N. Assays of oxidative DNA damage biomarkers 8-oxo-2-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Methods in Enzymology 1994; 234: 16–33
  • Gutteridge J. M.C., Halliwell B. Radical promoting loosely-bound iron in biological fluids and the bleomycin assay. Life Chemistry Reports 1987; 4: 113–142
  • Wiseman H., Paganga G., Rice-Evans C., Halliwell 8. Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?. Biochemical Journal 1993; 292: 438–635
  • Aruoma O. I., Halliwell B. The iron-binding and hydroxyl radical scavenging action of anti-inflammatory drugs. Xenobiotica 1988; 18: 459–470
  • Fay R. C., Weir J. R., Bruder A. H. Nuclear magnetic resonance studies of stereochemical rearrangements in pentagonal-bipyramidal. Inorganic Chemistry 1984; 23: 1079–1089
  • McCormick B. J. Monothio- and monoseleno-carbamate complexes. Coordination Chemistry Reviews 1984; 54: 99–130
  • Bond A. M. Electrochemistry and redox behavior of transition metal dithiocarbamates. Coordination Chemistry Reviews 1984; 54: 23–98
  • Okada S., Minamiyama Y., Hamazaki S., Toyokuni S., Sotomatsu A. Glutathione cycle dependency of ferric nitrilotriacetate-induced lipid peroxidation in mouse proximal renal tubules. Archives of Biochemistry and Biophysics 1993; 301: 138–142
  • Gutteridge J. M.C., Qwnlan GJ. Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidizing proteins. Biochimica et Biophysica Acta 1993; 1156: 144–150
  • Halliwell B. Oxidants and the central nervous system: some fundamental questions. Acta Neurologica Scandinavica 1989; 126: 23–33
  • Vanin A. F., Mordvintcev P. I., Hauschildt S., Mulsch A. The relationship between L-arginine-dependent nitric oxide synthesis, nitrite release and dinitrosyl-iron complex formation by activated macrophages. Biochimica et Biophysica Acta 1993; 1177: 37–42
  • Sato S., Tominaga T., Ohnishi T., Ohnishi S. T. EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat. Biochimica et Biophysica Acta 1993; 1181: 195–197
  • Gutteridge J. M.C., Quinlan G. J., Swain J., Cox J. Ferrous ion formation by ferrioxamine prepared from aged desferrioxamine: a potential prooxidant property. Free Radical Biology and Medicine 1994; 16: 733–739
  • Howard J. A., Chemier J. H.B. Metal complexes as antioxidant II. Reaction of nickel di-n-butyldithiocarbamate and nickel diisopropyl-dithiophosphate with alkyl peroxy radicals. Canadian Journal of Chemistry 1976; 54: 382–389
  • Gessner T., Jakubowski M. Diethyldithio-carbamic acid methyl ester: a metabolite of disulfiram. Biochemical Pharmacology 1972; 21: 219–230
  • Narayanaswami V., Sies H. Oxidative damage to mitochondria and protection by ebselen and other anti-oxidants. Biochemical Pharmacology 1990; 40: 1623–1629

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