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Research Article

Colon-targeted celecoxib-loaded Eudragit® S100-coated poly-ϵ-caprolactone microparticles: Preparation, characterization and in vivo evaluation in rats

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Pages 523-535 | Received 23 Jan 2011, Accepted 27 May 2011, Published online: 28 Jul 2011

References

  • Abdallah M, Yuichi T, Hirofumi T. (2009). pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model. Eur J Pharm Biopharm, 72, 1–8.
  • Abdelbary GA, Tadros MI. (2008). Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer. Eur J Pharm Biopharm, 69, 1019–28.
  • Ali J, Tyagi P, Ahuja A, Baboota S, Hasan S. (2007). Development and evaluation of a gastroretentive drug delivery system for the low-absorption-window drug celecoxib. PDA J Pharm Sci Technol, 61(2), 88–96.
  • Ardizzone S, Bianchi Porro G. (1998). A practical guide to the management of distal ulcerative colitis. Drugs, 55, 519–42.
  • Ashford M, Fell JT, Attwood D, Woodhead PJ. (1993). An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting. Int J Pharm, 91, 241–45.
  • Barbato F, Rotonda MI, Maglio G, Palumo R, Quaglia F. (2001). Biodegradable microspheres of a novel segmented polyether-ester-amides based on poly-ϵ-caprolactone for the delivery of bioactive compounds. Biomaterials, 22, 1371–78.
  • Campieri M, Ferguson A, Doe W, Persson T, Nilsson LG. (1997). Oral budesonide is as effective as oral prednisolone in active Crohn’s disease. The Global Budesonide Study Group. Gut, 41, 209–14.
  • Castellanos IJ, Carrasquillo KG, de Jesus Lopez J, Alvarez M, Griebenow K. (2001). Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique. J Pharm Pharmacol, 53, 167–78.
  • Cheng SY, Yuen MC, Lam PL, Gambari R, Wong RS, Cheng GY, Lai PB, Tong SW, Chan KW, Lau FY, Kok SH, Lam KH, Chui CH. (2010). Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules. Bioorg Med Chem Lett, 20(14), 4147–4151.
  • Chourasia MK, Jain SK. (2003). Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Sci, 6(1), 33–66.
  • de Heer P, Sandel MH, Guertens G, de Boeck G, Koudijs MM, Nagelkerke JF, Junggeburt JM, de Bruijn EA, van de Velde CJ, Kuppen PJ. (2008). Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer. Cancer Chemother Pharmacol, 62(5), 811–19.
  • Fu X, Ping Q, Gao Y. (2005). Effects of formulation factors on encapsulation efficiency and release behavior in vitro of huperzine A-PLGA microspheres. J Microencapsul, 22, 705–14.
  • Higuchi T. (1963). Mechanism of sustained action medication. J Pharm Sci, 52, 1145–49.
  • Homar M, Ubrich N, El Ghazouani F, Kristl J, Kerc J, Maincent P. (2007). Influence of polymers on the bioavailability of microencapsulated celecoxib. J Microencapsul, 24(7), 621–633.
  • Hu LD, Liu Y, Tang X, Zhang Q. (2006). Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets. Eur J Pharm Biopharm, 64, 185–92.
  • Imaly JA, Linn S. (1988). DNA damage and oxygen radical toxicity. Science, 240, 1302–9.
  • Kondo H, Sharma RK, Mishra AK, Chuttani K, Murthy RR. (2005). Albumin microspheres as carriers for the antiarthritic drug celecoxib. AAPS PharmSciTech, 6 (1), E65–73.
  • Kondo N, Iwao T, Hirai K, Fukuda M, Yamanouchi K, Yokoyama K, Miyaji M, Ishihara Y, Kon K, Ogawa Y, Mayumi T. (1994). Improved oral absorption of enteric coprecipitates of a poorly soluble drug. J Pharm Sci, 4(83), 566–70.
  • Korsmeyer RW, Peppas NA. (1981). Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs. J Membr Sci, (9), 211–27.
  • Krishnamachari Y, Madan P, Lin S. (2007). Development of pH- and time dependent oral microparticles to optimize budesonide delivery to ileum and colon. Int J Pharm, 348, 238–47.
  • Lamprecht A, Schafer U, Lehr CM. (2001). Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res, 18, 788–93.
  • Mahadevan U, Loftus EV Jr, Tremaine WJ, Sandborn WJ. (2002). Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease. Am J Gastroenterol, 97(4), 910–14.
  • Meissner Y, Pellequer Y, Lamprecht A. (2006). Nanoparticles in inflammatory bowel disease: particle targeting versus pH-sensitive delivery. Int J Pharm, 316, 138–43.
  • Nakase H, Okazaki K, Tabata Y, Uose S, Ohana M, Uchida K, Matsushima Y, Kawanami C, Oshima C, Ikada Y, Chiba T. (2000). Development of an oral drug delivery system targeting immune-regulating cells in experimental inflammatory bowel disease: a new therapeutic strategy. J Pharmacol Exp Ther, 292, 15–21.
  • Niederberger E, Tegeder I, Vetter G, Schmidtko A, Schmidt H, Euchenhofer C, Bräutigam L, Grösch S, Geisslinger G. (2001). Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-κB. The FASEB J, 15, 1622–24.
  • Paulson SK, Vaughn MB, Jessen SM, Lawal Y, Gresk CJ, Yan B, Maziasz TJ, Cook CS, Karim A. (2001). Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption. J Pharmacol Exp Ther, 297 (2), 638–645.
  • Passerini N, Perissutti B, Albertini B, Voinovich D, Moneghini M, Rodriguez L. (2003). Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing. J Control Release, 88(2), 263–275.
  • Raffin RP, Colomé LM, Guterres SS, Pohlmann AR. (2007). Enteric Controlled-Release Pantoprazole-Loaded Microparticles Prepared by Using Eudragit S100 and Poly(ε-caprolactone) Blend. Pharm Dev Technology, 12(5), 463–71.
  • Rodriguez M, Vila-Jato JL, Torres D. (1998). Design of new multiparticulate system for potential site specific and controlled drug delivery to the colonic region. J Control Rel, 55, 67–77.
  • Simmonds NJ, Rampton DS. (1994). Inflammatory bowel disease: a radical view. Gut, 34, 861–5.
  • Sinha VR, Bhinge JR, Kumria R, Kumar M. (2006). Development of pulsatile systems for targeted drug delivery of celecoxib for prophylaxis of colorectal cancer. Drug Deliv, 13(3), 221–5.
  • Sinha VR, Bansal K, Kaushik R, Kumria R, Trehan A. (2004). Poly-ϵ-caprolactone microspheres and nanospheres: an overview. Int J Pharm, 278, 1–23.
  • Tan A, Simovic S, Davey AK, Rades T, Prestidge CA. (2009). Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs. J Control Rel, 134, 62–70.
  • Thakkar H, Sharma RK, Mishra AK, Chuttani K, Murthy RR. (2005). Albumin microspheres as carriers for the antiarthritic drug celecoxib. AAPS PharmSciTech, 20;6(1), E65–73.
  • Thakkar H, Sharma RK, Mishra AK, Chuttani K, Murthy RS. (2004). Celecoxib incorporated chitosan microspheres: in vitro and in vivo evaluation. J Drug Target, 12(9-10), 549–557.
  • Yehia SA, Elshafeey AH, Sayed I, Shehata AH. (2009). Optimization of budesonide compression-coated tablets for colonic delivery. AAPS PharmSciTech, 10(1), 147–57.
  • Zvonar A, Kristl J, Kerc J, Grabnar PA.(2009). High celecoxib-loaded nanoparticles prepared by a vibrating nozzle device. J Microencapsul, 26(8), 748–759.

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