1,969
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Brain targeting by intranasal drug delivery (INDD): a combined effect of trans-neural and para-neuronal pathway

, , , , &
Pages 923-929 | Received 30 Mar 2014, Accepted 07 May 2014, Published online: 24 Jun 2014

References

  • Aceto A, DiIlio C, Angelucci S, et al. (1989). Glutathione transferases in human nasal mucosa. Arch Toxicol 63:427–31
  • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. (2004). Recent advances on chitosan based micro-and nanoparticles in drug delivery. J Control Rel 100:5–28
  • Balin BJ, Broadwell RD, Salcman M, El-Kalliny M. (1986). Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251:260–80
  • Brittebo EB, Eriksson C. (1995). Taurine in the olfactory system: effects of the olfactory toxicant dichlobenil. Neurotoxicology 16:271–80
  • Brunton LL, Lazo JS, Parker EL. (2008). Local anaesthetic. Goodman & Gilman’s the pharmacological basis of therapeutics. 11th ed. OH, USA: The MacGraW-Hill Companies
  • Calvo P, Remunan C, VilaJato JL, Alonso MJ. (1997). Development of positively charged colloidal drug carriers: chitosan-coated polyester nanocapsule and submicron emulsions. Colloid Polym Sci 275:46–53
  • Chou KJ, Donovan MD. (1998). The distribution of local anaesthetics into the CSF following intranasal administration. Int J Pharm 168:137–45
  • Eriksson C, Bergman U, Franzen A, et al. (1999). Transfer of some carboxylic acids in the olfactory system following intranasal administration. J Drug Target 7:131–42
  • Felt O, Buri P, Gurny R. (1998). Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm 24:979–93
  • Frey WH, Liu J, Chen X, et al. (1997). Delivery of 125I-NGF to the brain via the olfactory route. Drug Deliv 4:87–2
  • Henriksson J, Tjalve H. (1998). Uptake of inorganic mercury in the olfactory bulbs via olfactory pathways in rats. Environ Res 77:130–40
  • Illum L. (1998). Chitosan and its use as a pharmaceutical excipient. Pharm Res 15:1326–31
  • Illum L. (2000). Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 11:1–18
  • Kumar TCA, David GF, Sankaranarayanan A, et al. (1982). Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying. Proc Natl Acad Sci USA 79:4185–9
  • Levin VA. (1980). Relationship of octanol/water partition coefficients and molecular weight to rat brain capillary permeability. J Med Chem 23:682–4
  • Lewis JL, Nikula KJ, Novak R, Dahl AR. (1994). Comparative localization of carboxyl esterase in F344 rat, beagle dog and human nasal tissue. Anat Rec 239:55–64
  • Mathison S, Nagilla R, Kompella UB. (1998). Nasal route for direct delivery of solutes to the central nervous system: fact or fiction. J Drug Target 5:415–41
  • Merkus FW, van den Berg MP. (2007). Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory. Drugs R D 8:133–44
  • Mustafa G, Ahmad N, Baboota S, et al. (2012b). Stressed kinetics of nanoemulsion formulation encapsulated ropinirole with a validated ultra high performance liquid chromatography–synapt mass spectrometry (UPLC-MS/MS ESI-Q-TOF). J Chin Chem Soc 59:1021–30
  • Mustafa G, Baboota S, Ahuja A, Ali J. (2012c). formulation development of chitosan coated intra nasal ropinirole nanoemulsion for better management option of parkinson: an in vitro ex vivo evaluation. Current Nanoscience 8:348–60
  • Mustafa G, Baboota S, Ali J, et al. (2013) Nose to Brain targeting potential of a chitosan coated nanoformulation: Pharmacodynamic and Pharmacoscintigraphic evaluation. Sci Adv Mat 5:1236–49
  • Mustafa G, Khan ZI, Bansal T, Talegaonkar S. (2009). Preparation and characterization of oil in water nano-reservoir systems for improved oral delivery of atorvastatin. Curr Nano Sci 5:428–40
  • Mustafa G, Kumar N, Singh T, Baboota et al. (2012a) Effect of homogenization on the fate of true nanoemulsion in brain translocation: a gamma scintigraphic evaluation. Sci Ad Material 4:739–48
  • Nattel S, Gagne G, Pineau M. (1987). The pharmacokinetics of lignocaine and -adrenoceptor antagonists in patients with acute myocardial infarction. Clin Pharmacokinet 13:293–316
  • Sakane T, Akizuki M, Yamashita S, et al. (1991). The transport of a drug to the cerebrospinal fluid directly from the nasal cavity: the relation to the lipophilicity of the drug. Chem Pharm Bull 39:2456–8
  • Shipley MT. (1985). Transport of molecules from nose to brain: transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium. Brain Res Bull 15:129–42
  • Singla AK, Chawla M. (2001). Chitosan: some pharmaceutical and biological aspects-an update. J Pharm Pharmacol 53:1047–67
  • Stakic J, Suchanek JM, Ziegler GP, Griff ER. (2011). The source of spontaneous activity in the main olfactory bulb of the rat. PLoS ONE 6:e23990
  • Stevens J, Ploeger BA, van der Graaf PH, et al. (2011). Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration. Drug Metab Dispos 39:2275–82
  • Talegaonkar S, Mustafa G, Akhter S, Iqbal ZI. (2009). Design and development of oral oil-in-water nanoemulsion formulation bearing atorvastatin: in vitro assessment. J Disp Sci Tech 30:1–12
  • Thorne RG, Frey WH. (2001). Delivery of neurotrophic factors to the central nervous system. Clin Pharma 40:907–46
  • Turker S, Onur E, Ozer Y. (2004). Nasal route and drug delivery systems. Pharm World Sci 26:137–42
  • Wang Y, Aun R, Tse FLS. (1998). Brain uptake of dihydroergotamine after intravenous and nasal administration in the rat. Biopharm Drug Dispos 19:571–5
  • Wen MM. (2011). Olfactory targeting through intranasal delivery of biopharmaceutical drugs to the brain: current development. Discov Med 11:497–503
  • Wils P, Warnery A, Phung-Ba V, et al. (1994). High lipophilicity decreases drug transport across intestinal epithelial cells. J Pharmacol Exp Ther 269:654–8
  • Yajima T, Juni K, Saneyoshi M, et al. (1998). Direct transport of 2′,3′-didehydro-3′-deoxythymidine (D4T) and its ester derivatives to the cerebrospinal fluid via the nasal mucous membrane in rats. Biol Pharm Bull 21:272–7
  • Yao J, Zhou JP, Ping QN, et al. (2008). Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice. Int J Pharm 352:256–62
  • Yu CR, Power J, Barnea G, et al. (2004). Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron 42:553–66

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.