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Review Article

Stimuli-responsive hydrogels in drug delivery and tissue engineering

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Pages 748-770 | Received 28 Apr 2014, Accepted 26 Jun 2014, Published online: 21 Jul 2014

References

  • Alarcon CLH, Pennadam S, Alexander C. (2005). Stimuli responsive polymers for biomedical applications. Chem Soc Rev 34:276–85
  • Albin GW, Horbett TA, Miller SR, Ricker NL. (1987). Theoretical and experimental studies of glucose sensitive membranes. J Control Release 6:267–91
  • Almarza A, Athanasiou K. (2004). Design characteristics for the tissue engineering of cartilaginous tissues. Ann Biomed Eng 32:2–17
  • Amsden B. (1998). Solute diffusion within hydrogels. Mechanisms and models. Macromolecules 31:8382–95
  • Arndt KF, Schmidt T, Richter A, Kuckling D. (2004). High response smart gels: synthesis and application. Macromol Symp 207:257–68
  • Aroca AS, Ribelles JL, Pradas MM, et al. (2007). Characterization of macroporouspolymethyl methacrylate coated with plasma polymerized poly 2-hydroxyethyl acrylate. Eur Polym J 43:4552–64
  • Bae YH, Okano T, Kim SW. (1991). On–off’ thermo control of solute transport. I. Temperature dependence of swelling of N-isopropyl acrylamide networks modified with hydrophobic components in water. Pharm Res 8:531–7
  • Bajpai SK, Saggu SS. (2007). Insulin release behaviour of poly (methacrylamide-co-N-vinyl-2-pyrrolidone–co-itaconic acid) hydrogel, an interesting probe. J Macromol Sci A Pure Appl Chem 44:153–7
  • Balasubramaniam J, Kant S, Pandit JK. (2003). In vitro and in vivo evaluation of the Gelrite® gellan gum-based ocular delivery system for indomethacin. Acta Pharm 53:251–61
  • Bawa P, Pillay V, Choonara YE, du Toit LC. (2009). Stimuli-responsive polymers and their applications in drug deliver. Biomed Mater 4:022001
  • Beckert WH, Al E. (1970). Mitogenic activity of the jack bean with rabbit peripheral blood lymphocytes. Int Arch Allergy Appl Immunol 30:337–41
  • Berger J, Reist M, Mayer JM, et al. (2004). Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm 57:19–34
  • Betancourt T, Pardo J, Soo K, Peppas NA. (2010). Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents. J Biomed Mater Res A 93:175–88
  • Beyssac E, Bregni C, Aiache JM, et al. (1996). Hydrogel implants for methotrexate obtained by ionizing radiation. Drug Dev Ind Pharm 2:439–44
  • Bhattarai N, Gunn J, Zhang M. (2010). Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliver Rev 62:83–99
  • Blanco MD, Gomez CO, Teijoan JM. (1998). Ara-C release from poly(acrylamide-co-monomethylitaconate) hydrogels: in vitro and in vivo studies. Polym Gels Netw 6:57–69
  • Blumenstein I, Borger D, Loitsch S, et al. (2012). A glycerin hydrogel-based wound dressing prevents peristomal infections after percutaneous endoscopic gastrostomy (PEG). Nutr Clin Pract 27:422–5
  • Borenstein JT, Terai H, King KR, et al. (2002). Microfabrication technology for vascularized tissue engineering. Biomed Microdev 4:167–75
  • Brannon L, Peppas NA. (1991). Equilibrium swelling behavior of pH-sensitive hydrogels. Chem Eng Sci 46:715–22
  • Brannon-Peppas L, Peppas NA. (1990). Dynamic and equilibrium swelling behaviour of pH-sensitive hydrogels containing 2-hydroxyethyl methacrylate. Biomaterials 11:635–44
  • Bromberg LE, Ron ES. (1998). Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv Drug Deliv Rev 31:197–221
  • Brownlee M, Cerami A. (1979). Glucose-controlled insulin delivery system: semisynthetic insulin bound to lectin. Science 206:1190–1
  • Bruguerolle B. (1998). Chronopharmacokinetics current status. Clin Pharmacokinet 35:83–94
  • Cahalan PT, Coury AJ, Jevne AH, Kallok MJ. (1988). Hydrogel adhesive. US Patent US4768523A
  • Calejo MT, Kjoniksen AL, Pinazo A, et al. (2012). Thermoresponsive hydrogels with low toxicity from mixtures of ethyl (hydroxyethyl) cellulose and arginine-based surfactants. Int J Pharm 436:454–62
  • Chang CS. (1988). Measuring density and porosity of grain kernels using a gas pycnometer. Cereal Chem 65:13–5
  • Chao P, Grayson W, Vunjak-Novakovic G. (2007). Engineering cartilage and bone using human mesenchymal stem cells. J Orthop Res 12:398–404
  • Chen CC, Fang CL, Suwayeh AS, et al. (2011a). Transdermal delivery of selegiline from alginate-Pluronic composite thermogels. Int J Pharm 415:119–28
  • Chen G, Ushida T, Tateishi T. (2002). Development of biodegradable porous scaffolds for tissue engineering. J Mater Sci Eng C 17:63–9
  • Chen J, Blevins WE, Park H, Park K. (2000). Gastric retention properties of superporous hydrogel composites. J Control Release 55:12–5
  • Chen X, Guo Z, Xin J, Li J. (2011b). Modulated insulin release from glucose-sensitive multilayer films. J Control Release 152:152–4
  • Chen X, Li W, Zhong W, et al. (1997). Ion sensitivity of hydrogels based on complex-forming chitosan/silk fibroin interpenetrating polymer network. J Appl Polym Sci 65:2257–62
  • Chiu HC, Hsiue GH, Lee YP, Huang LW. (1999). Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system. J Biomater Sci Polym 10:591–608
  • Chiu YC, Kocagoz S, Larson JC, Brey EM. (2013). Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation. PLoS One 9:607–28
  • Choi JS, Park JS. (2005). Design elements of polymeric gene carrier. In: Mahato R, ed. Biomaterials for delivery and targeting of proteins and nucleic acids. Boca Raton: CRC Press, 643–62
  • Chudzik SJ. (2012). Hydrogel-based joint repair system and method. US Patent US8242179 B2
  • Chung HJ, Lee Y, Park TG. (2008). Thermo-sensitive and biodegradable hydrogels based on stereocomplexed pluronic multi-block copolymers for controlled protein delivery. J Control Release 127:22–30
  • Cohen S, Lobel E, Trevgoda A, Peled T. (1997). A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. J Control Release 44:201–8
  • Crabbe A, Thompson P. (2001). Clinical trial of a patient-operated microwave care system for hydrogel contact lenses. Optom Vis Sci 78:605–9
  • Creque HM, Langer R, Folkman J. (1980). One month of sustained release of insulin from a polymer implant. Diabetes 29:37–40
  • Dagani R. (1997). Intelligent gels. Chem Eng News 75:26–36
  • Dong LC, Allan S, Hoffman A. (1991). Novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery. J Control Release 15:141–52
  • Drury JL, Mooney DJ. (2003). Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 24:4337–51
  • Dufresne MH, Garrec DL, Sant V, et al. (2004). Preparation and characterization of water-soluble pH sensitive nanocarriers for drug delivery. Int J Pharm 277:81–90
  • Dumbleton K, Woods C, Jones L, et al. (2010). Comfort and vision with silicone hydrogel lenses: effect of compliance. Optom Vis Sci 87:131–9
  • Falamarzian M, Varshosaz J. (1998). The effect of structural changes on swelling kinetics of polybasic/hydrophobic pH sensitive hydrogels. Drug Dev Ind Pharm 24:667–9
  • Fernandes R, Gracias DH. (2012). Self-folding polymeric containers for encapsulation and delivery of drugs. Adv Drug Deliv Rev 64:1579–89
  • Fei B, Wach RA, Mitomo H, et al. (2000). Hydrogel of biodegradable cellulose derivatives. I. Radiation-induced crosslinking of CMC. J Appl Polym Sci 78:278–83
  • Feil H, Bae YH, Kim SW. (1992). Mutual influence of pH and temperature on the swelling of ionizable and thermosensitive hydrogels. Macromolecules 25:5528–30
  • Fidkowski C, Mofrad MRK, Borenstein J, et al. (2005). Endothelialized microvasculature based on a biodegradable elastomer. Tissue Eng 11:302–9
  • Firestone BA, Siegel RA. (1991). Kinetics and mechanisms of water sorption in hydrophobic, ionizable copolymer gels. J Appl Polym Sci 42:901–14
  • Gayet JC, Fortier G. (1996). High water content BSA-PEG hydrogel for controlled release device: evaluation of the drug release properties. J Control Release 38:177–84
  • Geisse NA. (2009). AFM and Combined Optical Techniques. Mater Today 12:40–5
  • Gong J, Osada Y. (2004). Low friction hydrogel having straight chain polymers and method for preparation. US Patent US20040116305 A1
  • Gorgieva S, Kokol V. (2012). Preparation, characterization and in-vitro enzymatic degradation of chitosan-gelatine hydrogel scaffolds as potential biomaterials. J Biomed Mater Res A 100:1655–67
  • Graham NB, Mc-Neil M. (1984). Hydrogels for controlled drug delivery. Biomaterials 5:27–36
  • Gupta AK, Maurya SD, Dhakkar RC, Singh RD. (2010). pH sensitive interpenetrating hydrogel for eradication of Helicobacter pylori. Int J Pharm Sci 3:924–32
  • Harasaki A, Schmit J, Wyant JC. (2001). Offset of coherent envelope position due to phase change on reflection. Appl Optics 40:2102–6
  • Hejazi R, Amiji M. (2003). Chitosan-based gastrointestinal delivery systems. J Control Release 89:151–65
  • Hench LL, Jones JR. (2005). Biomaterials, artificial organs and tissue engineering. 2nd ed. Cambridge, UK: Woodhead Publishing Limited, 227
  • Hennink WE, Nostrum CF. (2002). Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 54:13–36
  • Hinrichs WL, Suhuurmans NM. (1999). Thermosensitive polymers as carrier for DNA delivery. J Control Release 60:249–59
  • Hirotsu S. (1993). Coexistence of phases and the nature of first-order phase transition in poly (N-isopropylacrylamide) gels. Adv Polym Sci 110:1–26
  • Hoffman AS. (2002). Hydrogels for biomedical applications. Adv Drug Deliv Rev 54:3–12
  • Hoffman AS. (2013). Stimuli-responsive polymers: biomedical applications and challenges for clinical translation. Adv Drug Deliv Rev 65:10–6
  • Irie M. (1993). Stimuli-responsive poly (N-isopropylacrylamide). Photo and chemical-induced phase transitions. Adv Polym Sci 110:49–65
  • Ishihara K, Matsui K. (1986). Glucose-responsive insulin release from polymer capsule. J Polym Sci Polym Lett 24:413–7
  • Iskakov RM, Kikuchi A, Okano T. (2002). Time-programmed pulsatile release of dextran from calcium alginate gel beads coated with carboxy-n-propylacrylamide copolymers. J Control Release 80:57–68
  • Jaiswal M, Koul V. (2011). Assessment of multicomponent hydrogel scaffolds of poly(acrylic acid-2-hydroxy ethyl methacrylate)/gelatin for tissue engineering applications. J Biomater Appl 1:1–14
  • Janshoff A, Neitzert M, Obersofer Y, Fuchs H. (2002). Force spectroscopy of molecular systems, single molecular spectroscopy of polymers and macromolecules. Angew Chem Int Ed 39:3212–37
  • Jen AC, Wake MC, Mikos AG. (1996). Review: hydrogels for cell immobilization. Biotechnol Bioeng 50:357–64
  • Junginger HE. (1991). Mucoadhesive hydrogels. Pharm Ind 53:1056–65
  • Kang SI, Bae YH. (2003). A sulfonamide based glucose-responsive hydrogel with covalently immobilized glucose oxidase and catalase. J Control Release 86:115–21
  • Kataoka K, Matsumoto A. (1998). Total synthetic polymer gels responding to external glucose concentration: their preparation and applications to on-off regulation of insulin release. J Am Chem Soc 120:12694
  • Katchalsky A, Michaeli I. (1955). Polyelectrolyte gels in salt solution. J Polym Sci 15:69–86
  • Katono H, Maruyama A, Sanui K, et al. (1991). Thermo-responsive swelling and drug release switching of interpenetrating polymer networks composed of poly-butyl methacrylate) and poly(acrylic acid). J Control Release 16:215–27
  • Kazakia GJ, Nauman EA, Ebenstein DM, et al. (2006). Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone Substitute. J Biomed Mater Res A 77:688–99
  • Kheirandish S, Guybaidullin I, Wohlleben W, Willenbacher N. (2009). Shear and elongational flow behavior of acrylic thickener solutions. Part I: effect of intermolecular aggregation. Rheol Acta 4:397–407
  • Khoylou F, Naimian F. (2009). Radiation synthesis of superabsorbent polyethylene oxide/tragacanth hydrogel. Radiat Phys Chem 78:195–8
  • Kidd EM, Shin S, Shea DL. (2011). Fibrin hydrogel for lentiviral gene delivery in vitro and in vivo. J Control Release 157:80–5
  • Kikuchi A, Kawabuchi M, Sugihara M, et al. (1997). Pulsed dextran release from calcium-alginate gel beads. J Control Release 47:21–9
  • Kim JJ, Park K. (2001). Modulated insulin delivery from glucose-sensitive hydrogel dosage forms. J Control Release 77:39–47
  • Kim SW, Bae YH, Okano T. (1992). Hydrogels: swelling, drug loading and release. Pharm Res 9:283–90
  • Kim SW, Pai CM, Makino K, et al. (1990). Self-regulated glycosylated insulin delivery. J Control Release 11:193–201
  • Kitano S, Kataoka K, Koyama Y, et al. (1991). Glucose-responsive complex formation between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with pendent phenylboronic acid moieties. Makromol Chem Rapid Commun 12:227–33
  • Kitano S, Koyama Y, Kataoka K, et al. (1992). A novel drug delivery system utilizing a glucose responsive polymer complex between poly (vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with a phenylboronic acid moiety. J Control Release 19:162–170
  • Kou JH, Amidon GL, Lee PI. (1988). pH-dependent swelling and solute diffusion characteristics of poly (hydroxyethyl methacrylate-co-methacrylic acid) hydrogels. Pharm Res 5:592–7
  • Kumar A, Srivastava A, Galaev IY, Mattiasson B. (2007). Smart polymers: physical forms and bioengineering applications. Prog Polym Sci 32:1205–37
  • Kuo CK, Ma PX. (2001). Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties. Biomaterials 22:511–21
  • Kuzma P, Young AJM, Mora D, et al. (2011). Subcutaneous hydrogel reservoir system for controlled drug delivery. Macromol Symp 109:15–26
  • Langer R. (1998). Drug delivery and targeting. Nature 392:5–10
  • Lee KY, Mooney DJ. (2001). Hydrogels for tissue engineering. Chem Rev 101:1869–77
  • Lee PY, Li Z, Huang L. (2003). Thermosensitive hydrogel as a Tgf-beta 1 gene delivery vehicle enhances diabetic wound healing. Pharm Res 20:1995–2000
  • Lee SC, Kwon K, Park K. (2013). Hydrogels for delivery of bioactive agents: a historical perspective. Adv Drug Deliv Rev 65:17–20
  • Li AA, Shen F, Zhang T, et al. (2006). Enhancement of myoblast microencapsulation for gene therapy. J Biomed Mater Res B 77:296–306
  • Li W, Cai X, Kim C, et al. (2011). Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound. Nanoscale 3:1724–30
  • Liu P, Zhai M, Li J, et al. (2002). Radiation preparation and swelling behavior of sodium carboxymethyl cellulose hydrogels. Radiat Phys Chem 63:525–8
  • Liu Q, Hedberg EL, Liu Z, et al. (2000). Preparation of macroporous poly 2-hydroxyethylmethacrylate hydrogels by enhanced phase separation. Biomaterials 21:2163–9
  • Liu Y, Liu J, Zhang X, et al. (2010). In situ gelling gelrite/alginate formulations as vehicles for ophthalmic drug delivery. AAPS PharmSciTech 11:610–20
  • Lopez CR, Bodmeier R. (1997). Mechanical water uptake and permeability of crosslinked chitosan glutamate and alginate films. J Control Release 44:215–25
  • Lowman AM, Peppas NA. (1991). Hydrogels. In: Mathiowitz E, ed. Encyclopedia of controlled drug delivery. New York: Wiley, 397–418
  • Lugao AB, Malmonge SM. (2001). Use of radiation in the production of hydrogels. Nucl Instrum Methods Phys Res Set B 185:37–42
  • Mageed Z, Haider M, Li D, et al. (2004). In vitro and in vivo evaluation of recombinant silk-elastin like hydrogels for cancer gene therapy. J Control Release 94:33–45
  • Malachowski K, Breger J, Kwag HR, et al. (2014). Stimuli-responsive theragrippers for chemomechanical controlled release. Angew Chem Int Ed Engl. doi: 10.1002/anie.201311047. [Epub ahead of print]
  • Mansur HS, Sadahira CM, Souza AN, Mansur AP. (2008). FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Mater Sci Eng 28:539–48
  • Mason MN, Metters AT, Bowman CN, Anseth KS. (2001). Predicting controlled-release behaviour of degradable PLA-b-PLZ hydrogels. Macromolecules 34:4630–5
  • Matsumoto A, Ishii T, Nishida J, et al. (2012). A synthetic approach toward a self-regulated insulin delivery system. Angew Chem Int Ed Engl 51:2124–8
  • Mauck RL, Yuan X, Tuan RS. (2006). Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthr Cartil 14:179–89
  • McGuigan AP, Sefton MV. (2006). Vascularized organoid engineered by modular assembly enables blood perfusion. Proc Natl Acad Sci USA 11:461–6
  • McMullan D. (2005). Scanning electron microscopy 1928–1965. Scanning 3:175
  • Mironov V, Boland T, Trusk T, et al. (2003). Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol 10:157–61
  • Morishta M, Lowman AM, Takayama K, et al. (2002). Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers. J Control Release 81:25–32
  • Nagai T, Machida Y. (1993). Buccal delivery systems using hydrogels. Adv Drug Deliver Rev 11:179–91
  • Nazar H, Fatouros DG, Merwe SM, et al. (2011). Thermosensitive hydrogels for nasal drug delivery: the formulation and characterisation of systems based on N-trimethyl chitosan chloride. Eur J Pharm Biopharm 77:225–32
  • Nicodemus GD, Bryant SJ. (2008). Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng B Rev 14:149–65
  • Noble L, Gray AI, Sadiq L, Uchegbu IF. (1999). Chitosan and sodium alginate-based bioadhesive vaginal tablets. Int J Pharm 192:173–82
  • Obaidat AA, Park K. (1996). Characterization of glucose dependant gel-sol phase transition of the polymeric glucose-concanvalin A hydrogel system. Pharm Res 13:989–5
  • Okor RS, Otimenyin S, Ijeh I. (1991). Coating of certain matrix cores with aqueous-based systems of acrylate methacrylate, a water-insoluble copolymer and drug release profiles. J Control Release 16:349–54
  • Omidian H, Rocca JG, Park K. (2005). Advances in super porous hydrogels. J Control Release 102:3–12
  • Onuki Y, Nishikawa M, Morishita M, Takayama K. (2008). Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: involvement of formulation factors in physical properties and pharmacological effects. Int J Pharm 349:47–52
  • Pal K, Bag S, Pal S. (2008). Development of porous ultra high molecular weight polyethylene scaffolds for the fabrication of orbital implant. J Porous Mater 15:53–9
  • Palumbo FS, Pitarresi G, Mandracchia D, et al. (2006). New graft copolymers of hyaluronic acid and polylactic acid: synthesis and characterization. Carbohydr Polym 66:379–85
  • Pan L, Yu G, Zhai D, et al. (2012). Hierarchical nanostructured conducting polymer hydrogel with high electrochemical activity. Cambridge, MA: Harvard University Press, 1–6
  • Park H, Park K. (1996). Biocompatibility issues of implantable drug delivery systems. Pharm Res 13:1770–6
  • Park TG, Hoffman AS. (1993). Sodium chloride-induced phase transition in non-ionic Poly (N-isopropylacrlyamide) gel. Macromolecules 26:5045–8
  • Patel VR, Amiji MM. (1996). Preparation and characterization of freeze dried Chitosan-poly(ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach. Pharm Res 13:588–93
  • Patil SA, Rane BR, Bakliwal SR, Pawar SP. (2011). Pragmatic hydrogels. IJRAP 2:758–66
  • Peppas NA, Colombo P. (1997). Analysis of drug release behaviour from swellable polymer carriers using the dimensionality index. J Control Release 45:35–40
  • Peppas NA, Khare AR. (1993). Preparation, structure and diffusional behavior of hydrogels in controlled-release. Adv Drug Deliver Rev 11:1–35
  • Peppas NA, Mikos AG, Peppas NA. (1986). Preparation methods and structure of hydrogels. In: Peppas NA, Mikos AG, eds. Hydrogels in medicine and pharmacy. Volume I. Boca Raton, FL: CRC Press, 2–23
  • Podual K, Doyle FJ, Peppas NA. (2000a). Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly (ethylene glycol) grafts. J Control Release 67:9–17
  • Podual K, Doyle FJ, Peppas NA. (2000b). Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidase. Polymer 41:3975–83
  • Polnok A, Verhoef JC, Borchard G, et al. (2004). In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels. Int J Pharm 269:303–10
  • Qiu Y, Park K. (2001). Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev 53:321–39
  • Rao SS, Ha N, Winter JO. (2011). Polylysine-modified PEG-based hydrogels to enhance the neuro-electrode interface. J Biomater Sci Polym 22:611–25
  • Razzak MT, Darwis D, Sukirno Z. (2001). Irradiation of polyvinyl alcohol and polyvinyl pyrrolidone blended hydrogel for wound dressing. Radiat Phys Chem 62:107–13
  • Rossi DD, Kanjiwara K, Osada Y, Yamauchi A. (1991). Polymer gels-fundamentals and biomedical applications. J Adhesion 37:271–2
  • Rowley J, Madlambayan G, Faulkner J, Mooney DJ. (1999). Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 20:45–53
  • Said HM, Alla SG, Naggar WMEL. (2004). Synthesis and characterization of novel gels based on carboxymethyl cellulose/acrylic acid prepared by electron beam irradiation. React Funct Polym 61:397–404
  • Schild HG. (1992). Poly (N-isopropylacrylamide): experiment, theory and application. Prog Polym Sci 17:163–249
  • Seminoff LA, Olsen GB, Kim SW. (1989). A self-regulating insulin delivery system. I. Characterization of a synthetic glycosylated insulin derivative. Int J Pharm 54:241–9
  • Serafim A, Dragusin DM, Zecheru T, et al. (2013). Gelatin hydrogels: effect of ethylene oxide based synthetic crosslinking agents on the physico-chemical properties. Dig J Nanomater Bios 8:101–10
  • Shi GX, Cai Q, Wang CY, et al. (2002). Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid). Polym Adv Technol 13:227
  • Shu XZ, Zhu KJ. (2002). Controlled drug release properties of ionically cross-linked chitosan beads: influence of anion structure. Int J Pharm 233:217–25
  • Singh B, Vashishth M. (2008). Development of novel hydrogels by modification of sterculia gum through radiation cross-linking polymerization for use in drug delivery. Nucl Instrum Methods B 266:2009–20
  • Sinha VR, Khosla L. (1998). Bioabsorbable polymers for implantable therapeutic systems. Drug Dev Ind Pharm 24:1129–38
  • Soppimath KS, Aminabhavi TM, Dave AM, et al. (2002). Stimulus-responsive “smart” hydrogels as novel drug delivery systems. Drug Dev Ind Pharm 28:957–74
  • Spinelli LS, Aquino AS, Lucas E, et al. (2008). Adsorption of polymers used in drilling fluids on the inner surfaces of carbon steel pipes. Polym Eng Sci 48:1885–91
  • Stapleton F, Stretton S, Papas E, et al. (2006). Silicon hydrogel contact lenses and the ocular surface. Ocul Surf 4:24–43
  • Stastny M, Plocova D, Etrych T, et al. (2002). HPMA-hydrogels containing static drugs. Kinetics of the drug release and in-vivo efficacy. J Control Release 81:101–11
  • Sultana Y, Aqil M, Ali A. (2006). Ion-Activated, Gelrite based in situ ophthalmic gels of pefloxacin mesylate: comparison with conventional eye drops. Drug Deliv 13:215–9
  • Sun G, Zhang X, Shen YI, et al. (2011). Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during wound healing. Annu Rev 108:26976–81
  • Svensson A, Nicklasson E, Harrah T, et al. (2005). Bacterial cellulose as a potential scaffold for tissue engineering of cartilage. Biomaterials 26:419–31
  • Takemoto Y, Ajiro H, Asoh TA, Akashi M. (2010). Fabrication of surface-modified hydrogels with polyion complex for controlled release. Chem Mater 22:2923
  • Tanaka T, Fillmore D, Sun ST, et al. (1980). Phase transitiononic gels. Phys Rev Lett 45:1636–9
  • Tang C, Yin L, Yu JC, Pei Y. (2007). Swelling behavior and biocompatibility of carbopol-containing superporous hydrogel composites. J Appl Polym Sci 104:2785–91
  • Teijon JM, Trigo RM, Garco O, Blanco MD. (1997). Cytarabine trapping in poly(2-hydroxyethyl methacrylate) hydrogels: drug delivery studies. Biomaterials 18:383–8
  • Torre PM, Enobakhre Y, Torrado G, Torrado S. (2003). Release of amoxicillin from polyionic complexes of chitosan and poly (acrylic acid). Study of polymer/polymer and polymer/drug interactions within the network structure. Biomaterials 24:1499
  • Ueno H, Mori T, Fujinaga T. (2001). Topical formulation and wound healing applications of chitosan. Adv Drug Deliv Rev 52:105–15
  • Vernon B, Kim SW, Bae YH. (2000). Thermoreversible copolymer gels for extracellular matrix. J Biomed Mater Res 51:69–79
  • Vodithala S, Khatry S, Shastri N, Sadanandam M. (2010). Formulation and evaluation of ion activated ocular gels of ketorolac tromethamine. Int J Curr Pharm Res 2:33–8
  • Wang K, Li WF, Xing JF, et al. (2012). Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel. Eur J Pharm Biopharm 82:332–9
  • Wang Q, Mynar JL, Yoshida M, et al. (2010). High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder. Nature 21:339–43
  • Weng L, Chen X, Chen W. (2007). Rheological characterization of in situ crosslinkable hydrogels formulated from oxidized dextran and N-carboxyethyl chitosan. Biomacromolecules 8:1109–15
  • Witchterle O, Lim D. (1960). Hydrophilic gels for biological use. Nature 185:117
  • Yan C, Altunbas A, Yucel T, et al. (2010). Injectable solid hydrogel: mechanism of shear-thinning and immediate recovery of injectable hairpin peptide hydrogels. Soft Matter 6:5143–56
  • Yang D, Zhang JZ, Fu S, et al. (2009). Evolution process of polymethacrylate hydrogels investigated by rheological and dynamic light scattering techniques. Colloids Surf A 355:197–203
  • Yang P, Li D, Jin S, et al. (2014). Stimuli-responsive biodegradable poly(methacrylic acid) based nanocapsules for ultrasound traced and triggered drug delivery system. Biomaterials 35:2079–88
  • Yin R, Tong Z, Yang D, Nie J. (2011). Glucose-responsive microhydrogels based on methacrylate modified dextran/concanavalin A for insulin delivery. J Control Release 152:e163–5
  • Yin X, Stayton PS, Hoffman AS. (2006). Temperature- and pH-responsiveness of poly(Nisopropylacrylamide-co-propylacrylic acid) copolymers prepared by RAFT polymerization. Biomacromolecules 7:1381–5
  • Yong-Hee K, Bae YH, Kim SW. (1994). pH/temperature-sensitive polymers for macromolecular drug loading and release. J Control Release 28:143–52
  • Yoshii F, Kume T. (2003). Process for producing gross linked starch derivatives and cross linked starch derivatives produced by the same. US Patent US 6617448 B2
  • Zha L, Banik B, Alexis F. (2011). Stimulus responsive nanogels for drug delivery. Soft Matter 7:5908–16
  • Zhang K, Wu XY. (2002). Modulated insulin permeation across a glucose-sensitive polymeric composite membrane. J Control Release 80:169–78
  • Zhang L, Chen J, Han C. (2009). A multicenter clinical trial of recombinant human GM-CSF hydrogel for the treatment of deep second-degree burns. Wound Repair Regen 17:685–9
  • Zhang L, Li K, Xiao W, et al. (2011). Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro. Carbohydr Polym 84:118–25
  • Zhang R, Ma PX. (1999). Poly(hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering preparation and morphology. J Biomed Mater Res 44:446
  • Zhang Y, Tang Y, Wang Y, Zhang L. (2011). Nanomaterials for cardiac tissue engineering application. Nano-Micro Lett 3:270–7
  • Zworykin VA, Hillier J, Snyder RL. (1942). A scanning electron microscope. ASTM Bull 117:15–23

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