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Original Articles

Enhanced effectiveness of tocotrienol-based nano-emulsified system for topical delivery against skin carcinomas

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Pages 1514-1524 | Received 12 Sep 2014, Accepted 15 Sep 2014, Published online: 08 Oct 2014

References

  • Abuasal BS, Lucas C, Peyton B, et al. (2012). Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases gamma-tocotrienol oral bioavailability. Lipids 47:461–9
  • Aggarwal B, Nesaretnam K. (2012). Vitamin E tocotrienols: life beyond tocopherols. Genes Nutr 7:1
  • Alayoubi A, Alqahtani S, Kaddoumi A, Nazzal S. (2013a). Effect of PEG surface conformation on anticancer activity and blood circulation of nanoemulsions loaded with tocotrienol-rich fraction of palm oil. AAPS J 15:1168–79
  • Alayoubi A, Ayoub NM, Malaviya A, et al. (2014). Entrapment into nanoemulsions potentiates the anticancer activity of tocotrienols against the highly malignant (+SA) mouse mammary epithelial cells. J Nanosci Nanotechnol 14:4002–5
  • Alayoubi A, Kanthala S, Satyanarayanajois SD, et al. (2013b). Stability and in vitro antiproliferative activity of bioactive “Vitamin E” fortified parenteral lipid emulsions. Colloids Surf B Biointerfaces 103:23–30
  • Ali H, El-Sayed K, Sylvester PW, Nazzal S. (2010). Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR). Colloids Surf B Biointerfaces 77:286–97
  • Anton N, Gayet P, Benoit JP, Saulnier P. (2007). Nano-emulsions and nanocapsules by the PIT method: an investigation on the role of the temperature cycling on the emulsion phase inversion. Int J Pharm 344:44–52
  • Bose S, Du Y, Takhistov P, Michniak-Kohn B. (2013). Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. Int J Pharm 441:56–66
  • Chen H, Chang X, Du D, et al. (2006). Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int J Pharm 315:52–8
  • Chen J, Ruczinski I, Jorgensen TJ, et al. (2008). Nonmelanoma skin cancer and risk for subsequent malignancy. J Natl Cancer Inst 100:1215–22
  • Cichewicz A, Pacleb C, Connors A, et al. (2013). Cutaneous delivery of alpha-tocopherol and lipoic acid using microemulsions: influence of composition and charge. J Pharm Pharmacol 65:817–26
  • Das S, Ng WK, Kanaujia P, et al. (2011). Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables. Colloids Surf B Biointerfaces 88:483–9
  • Date AA, Desai N, Dixit R, Nagarsenker M. (2010). Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine (Lond) 5:1595–616
  • Izquierdo P, Esquena J, Tadros TF, et al. (2004). Phase behavior and nano-emulsion formation by the phase inversion temperature method. Langmuir 20:6594–8
  • Jordan M, Nayel A, Brownlow B, Elbayoumi T. (2012). Development and evaluation of tocopherol-rich argan oil-based nanoemulsions as vehicles possessing anticancer activity. J Biomed Nanotechnol 8:944–56
  • Kakumanu S, Tagne JB, Wilson TA, Nicolosi RJ. (2011). A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension. Nanomedicine 7:277–83
  • Kannappan R, Yadav VR, Aggarwal BB. (2010). Gamma-Tocotrienol but not gamma-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. J Biol Chem 285:33520–8
  • Karadzovska D, Riviere JE. (2013). Assessing vehicle effects on skin absorption using artificial membrane assays. Eur J Pharm Sci 50:569–76
  • Kuo F, Timothy K, Wilson TA, et al. (2007). A nanoemulsion of an anti-oxidant synergy formulation reduces tumor growth rate in neuroblastoma-bearing nude mice. J Exp Ther Oncol 6:129–35
  • McClements DJ, Decker EA, Weiss J. (2007). Emulsion-based delivery systems for lipophilic bioactive components. J Food Sci 72:R109–24
  • Mostafa DM, Ammar NM, Abd El-Alim SH, El-anssary AA. (2014). Transdermal microemulsions of Glycyrrhiza glabra L.: characterization, stability and evaluation of antioxidant potential. Drug Deliv 21:130–9
  • Muller L, Theile K, Bohm V. (2010). In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma. Mol Nutr Food Res 54:731–42
  • Muller RH, Petersen RD, Hommoss A, Pardeike J. (2007). Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv Drug Deliv Rev 59:522–30
  • Ng SH, Woi PM, Basri M, Ismail Z. (2013). Characterization of structural stability of palm oil esters-based nanocosmeceuticals loaded with tocotrienol. J Nanobiotechnol 11:1–7
  • Patacsil D, Tran AT, Cho YS, et al. (2012). Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells. J Nutr Biochem 23:93–100
  • Pham J, Brownlow B, Elbayoumi T. (2013). Mitochondria-specific pro-apoptotic activity of genistein lipidic nanocarriers. Mol Pharm 10:3789–800
  • Phan V, Walters J, Brownlow B, Elbayoumi T. (2013). Enhanced cytotoxicity of optimized liposomal genistein via specific induction of apoptosis in breast, ovarian and prostate carcinomas. J Drug Target 21:1001–11
  • Rajendran P, Li F, Manu KA, et al. (2011). Gamma-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. Brit J Pharmacol 163:283–98
  • Rass K, Tilgen W. (2008). Treatment of melanoma and nonmelanoma skin cancer. Adv Exp Med Biol 624:296–318
  • Saberi AH, Fang Y, McClements DJ. (2013a). Effect of glycerol on formation, stability, and properties of vitamin-E enriched nanoemulsions produced using spontaneous emulsification. J Colloid Interface Sci 411:105–13
  • Saberi AH, Fang Y, McClements DJ. (2013b). Fabrication of vitamin E-enriched nanoemulsions: factors affecting particle size using spontaneous emulsification. J Colloid Interface Sci 391:95–102
  • Sarker DK. (2005). Engineering of nanoemulsions for drug delivery. Curr Drug Deliv 2:297–310
  • Sen CK, Khanna S, Roy S. (2006). Tocotrienols: vitamin E beyond tocopherols. Life Sci 78:2088–98
  • Sylvester PW, Kaddoumi A, Nazzal S, El Sayed KA. (2010). The value of tocotrienols in the prevention and treatment of cancer. J Am Coll Nutr 29:324S–33S
  • Tadros T, Izquierdo P, Esquena J, Solans C. (2004). Formation and stability of nano-emulsions. Adv Colloid Interface Sci 108–109:303–18
  • Thaipong K, Boonprako U, Crosby K, et al. (2006). Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts. J Food Comp Anal 19:669–75
  • Zhang J, Michniak-Kohn B. (2011). Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine. Int J Pharm 421:34–44

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