Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy of curcumin both in vitro and in vivo

References

• Alam MI, Baboota S, Ahuja A, Ali M, et al. (2013). Intranasal infusion of nanostructured lipid carriers (NLC) containing CNS acting drug and estimation in brain and blood. Drug Deliv 20:247–51
   PubMed Web of Science ®Google Scholar
• Alizadeh AM, Sadeghizadeh M, Najafi F, et al. (2015). Encapsulation of curcumin in diblock copolymer micelles for cancer therapy. Biomed Res Int 2015:824746
   PubMed Web of Science ®Google Scholar
• Bandyopadhyay D. (2014). Farmer to pharmacist: curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer. Front Chem 2:113. doi: http://dx.doi.org/10.3389/fchem.2014.00113
   PubMed Web of Science ®Google Scholar
• Bondì ML, Craparo EF, Giammona G, et al. (2007). Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies. Drug Deliv 14:61–7
   PubMed Web of Science ®Google Scholar
• Cairncross JG, Wang M, Jenkins RB, et al. (2014). Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol 32:783–90
   PubMed Web of Science ®Google Scholar
• Chen QY, Jiao DM, Wang LF, et al. (2015). Curcumin inhibits proliferation-migration of NSCLC by steering crosstalk between a Wnt signaling pathway and an adherens junction via EGR-1. Mol Biosyst 11:859–68
   PubMed Web of Science ®Google Scholar
• Chiang IT, Liu YC, Hsu FT, et al. (2014). Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity. Oncol Rep 31:1729–37
   PubMed Web of Science ®Google Scholar
• Choi JY, Cho HJ, Hwang SG, et al. (2014). Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway. Biomed Pharmacother 70:111–18
   Web of Science ®Google Scholar
• Durazo SA, Kompella UB. (2012). Functionalized nanosystems for targeted mitochondrial delivery. Mitochondrion 12:190–201
   PubMed Web of Science ®Google Scholar
• El-Bahr SM. (2015). Effect of curcumin on hepatic antioxidant enzymes activities and gene expressions in rats intoxicated with aflatoxin B1. Phytother Res 29:134–40
   PubMed Web of Science ®Google Scholar
• Gokce EH, Korkmaz E, Dellera E, et al. (2012). Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomedicine 7:1841–50
   PubMed Web of Science ®Google Scholar
• Gong C, Wu Q, Wang Y, et al. (2013). A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 34:6377–87
   PubMed Web of Science ®Google Scholar
• Guo Y, Shu L, Zhang C, et al. (2015). Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem Pharmacol 94:69–78
   PubMed Web of Science ®Google Scholar
• Heller A, Brockhoff G, Goepferich A. (2012). Targeting drugs to mitochondria. Eur J Pharm Biopharm 82:1–18
   PubMed Web of Science ®Google Scholar
• Jia T, Zhang L, Duan Y, et al. (2014). The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway. Cancer Cell Int 14:126. doi:10.1186/s12935-014-0126-4
   PubMed Web of Science ®Google Scholar
• Lin H, Gao X, Chen G, et al. (2015). Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway. Biochem Biophys Res Commun 460:422–7
   Google Scholar
• Liu Q, Li J, Pu G, Zhang F, et al. (2015). Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy. Drug Deliv 15:1–5
   Google Scholar
• Madane RG, Mahajan HS. (2014). Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study. Drug Deliv 4:1–9
   Google Scholar
• Mayol L, Serri C, Menale C, et al. (2015). Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells. Eur J Pharm Biopharm 93:37–45
   Google Scholar
• Mohankumar K, Pajaniradje S, Sridharan S, et al. (2014). Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin – an in vitro and in silico approach. Chem Biol Interact 210:51–63
   PubMed Web of Science ®Google Scholar
• Ng WK, Saiful Yazan L, Yap LH, et al. (2015). Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa). Biomed Res Int 2015:263131
   PubMed Web of Science ®Google Scholar
• Park W, Amin AR, Chen ZG, Shin DM. (2013). New perspectives of curcumin in cancer prevention. Cancer Prev Res (Phila) 6:387–400
   PubMed Web of Science ®Google Scholar
• Sarin H. (2010). Overcoming the challenges in the effective delivery of chemotherapies to CNS solid tumors. Ther Deliv 1:289–305
   PubMedGoogle Scholar
• Shanmugam MK, Rane G, Kanchi MM, et al. (2015). The multifaceted role of curcumin in cancer prevention and treatment. Molecules 20:2728–69
   PubMed Web of Science ®Google Scholar
• Shao Z, Shao J, Tan B, et al. (2015). Targeted lung cancer therapy: preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA. Int J Nanomedicine 10:1223–33
   PubMed Web of Science ®Google Scholar
• Shelma R, Sharma CP. (2013). In vitro and in vivo evaluation of curcumin loaded lauroyl sulphated chitosan for enhancing oral bioavailability. Carbohydr Polym 95:441–8
   PubMed Web of Science ®Google Scholar
• Stander XX, Stander BA, Joubert AM. (2015). Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways. Cell Physiol Biochem 35:1499–526
   PubMed Web of Science ®Google Scholar
• Su CC, Chen GW, Lin JG, et al. (2006a). Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. Anticancer Res 26:1281–8
   PubMed Web of Science ®Google Scholar
• Su CC, Lin JG, Li TM, et al. (2006b). Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res 26:4379–89
   PubMed Web of Science ®Google Scholar
• Van Tellingen O, Yetkin-Arik B, de Gooijer MC, et al. (2015). Overcoming the blood-brain tumor barrier for effective glioblastoma treatment. Drug Resist Update 19:1–12
   Google Scholar
• Vecchi Brumatti L, Marcuzzi A, Tricarico PM, et al. (2014). Curcumin and inflammatory bowel disease: potential and limits of innovative treatments. Molecules 19:21127–53
   PubMed Web of Science ®Google Scholar
• Venur VA, Peereboom DM, Ahluwalia MS. (2015). Current medical treatment of glioblastoma. Cancer Treat Res 163:103–15
   PubMedGoogle Scholar
• Wang X, Wang Q, Ives KL, Evers BM. (2006). Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res 12:5346–55
   PubMed Web of Science ®Google Scholar
• Wang P, Zhang L, Peng H, et al. (2013). The formulation and delivery of curcumin with solid lipid nanoparticles for the treatment of on non-small cell lung cancer both in vitro and in vivo. Mater Sci Eng C Mater Biol Appl 33:4802–8
   PubMed Web of Science ®Google Scholar
• Zhang W, Liu J, Zhang Q, et al. (2014). Enhanced cellular uptake and anti-proliferating effect of chitosan hydrochlorides modified genistein loaded NLC on human lens epithelial cells. Int J Pharm 471:118–26
   PubMed Web of Science ®Google Scholar