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Review Article

The application of antitumor drug-targeting models on liver cancer

, , &
Pages 1667-1675 | Received 27 May 2015, Accepted 16 Jun 2015, Published online: 12 Aug 2015

References

  • Abuin A, Hansen GM, Zambrowicz B. (2007). Gene trap mutagenesis. Handb Exp Pharmacol 178:129–47
  • Adams JM, Cory S. (1991). Transgenic models of tumor development. Science 254:1161–7
  • Antonio RJ, Angela C, Antonio R. (2015). Pharmacokinetic and pharmacodynamic evaluation of telaprevir for the treatment of hepatitis C. Drug Metab Toxicol 11:1157–65
  • Arap W, Pasqualini R, Ruoslahti E. (1998). Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279:377–80
  • Asahi M, Wang X, Mori T, et al. (2001). Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood–brain barrier and white matter components after cerebral ischemia. J Neurosci 21:7724–32
  • Babbs CF. (1990). Free radicals and the etiology of colon cancer. Free Radic Biol Med 8:191–200
  • Bishayee A, Politis T, Darvesh AS. (2010). Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev 36:43–53
  • Blakey DC, Westwood FR, Walker M, et al. (2002). Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models. Clin Cancer Res 8:1974–83
  • Brannon-Peppas L, Blanchette JO. (2012). Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 64: 206–12
  • Brillet PY, Gazeau F, Luciani A, et al. (2005). Evaluation of tumoral enhancement by superparamagnetic iron oxide particles: comparative studies with ferumoxtran and anionic iron oxide nanoparticles. Eur. Radiol 15:1369–77
  • Brinster RL, Palmiter RD. (1984). Transgenic mice containing growth hormone fusion genes. Philos Trans R Soc Lond B Biol Sci 307:309–12
  • Cai SR, Garbow JR, Culverhouse R, et al. (2005). A mouse model for developing treatment for secondary liver tumors. Int J Oncol 27:113–20
  • Callegari E, Gramantieri L, Domenicali M, et al. (2014). MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ 22:46–57
  • Capecchi MR. (1989). The new mouse genetics: altering the genome by gene targeting. Trends Genet 5:70–6
  • Chen X, Calvisi DF. (2014). Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol 184:912–23
  • Chen Y, Hu W, Lu Y, et al. (2014). A TALEN-based specific transcript knock-down of PIWIL2 suppresses cell growth in HepG2 tumor cell. Cell Prolif 7:448–56
  • Dawson LA, Normolle D, Balter JM, et al. (2002). Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 53:810–21
  • De Carvalho DD, Binato R, Pereira WO, et al. (2010). BCR–ABL-mediated upregulation of PRAME is responsible for knocking down TRAIL in CML patients. Oncogene 30:223–33
  • Denzler R, Agarwal V, Stefano J, et al. (2014). Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol cell 54:766–76
  • Ellinwood NM, Vite CH, Haskins ME. (2005). Gene therapy for lysosomal storage diseases: the lessons and promise of animal models. J Gene Med 6:481–506
  • Feray C, Zignego AL, Samuel D, et al. (1990). Persistent hepatitis B virus infection of mononuclear blood cells without concomitant liver infection: the liver transplantation model. Transplantation 49:1155–7
  • Ferrari M. (2005). Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5:161–71
  • Fisher PB, Weinstein IB, Eisenberg D, et al. (1978). Interactions between adenovirus, a tumor promoter, and chemical carcinogens in transformation of rat embryo cell cultures. Proc Natl Acad Sci USA 75:2311–14
  • Flatmark K, Mælandsmo GM, Martinsen M, et al. (2004). Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice. Eur J Cancer 40:1593–8
  • Freise CE, Ferrell L, Liu T, et al. (1999). Effect of systemic cyclosporine on tumor recurrence after liver transplantation in a model of hepatocellular carcinoma1. Transplantation 67:510–13
  • Fujiki H. (2014). Gist of Dr. Katsusaburo Yamagiwa’s papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports). Cancer Sci 105:143–49
  • Fülöp AK, Földes A, Buzás E, et al. (2003). Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Endocrinology 144:4306–14
  • Furukawa T, Fu X, Kubota T, et al. (1993). Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. Cancer Res 53:1204–08
  • Gao Y, Xie J, Chen H, et al. (2014). Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnol Adv 32:761–77
  • Gerin JL. (1990). Experimental WHV infection of woodchucks: an animal model of hepadnavirus-induced liver cancer. Gastroenterol Jpn 25:38–42
  • Gerlai R. (2003). Zebra fish: an uncharted behavior genetic model. Behav Genet 33:461–8
  • Ghoshal AK, Farber E. (1984). The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis 5:1367–70
  • Gingrich JR, Barrios RJ, Morton RA, et al. (1996). Metastatic prostate cancer in a transgenic mouse. Cancer Res 56:4096–102
  • Goldstein NI, Prewett M, Zuklys K, et al. (1995). Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1:1311–18
  • Gossler A, Joyner AL, Rossant J, et al. (1989). Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244:463–5
  • Guy CT, Cardiff RD, Muller WJ. (1992). Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12:954–61
  • Hamilton A, Huang SL, Warnick D, et al. (2002). Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes studies in a new experimental model. Circulation 105:2772–8
  • Hansen K, Khanna C. (2004). Spontaneous and genetically engineered animal models: use in preclinical cancer drug development. Eur J Cancer 40:858–80
  • Hasegawa H, Shimada M, Yonemitsu Y, et al. (2001). Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase. Cancer Gene Ther 8:252–8
  • Hirano T, Kaneko S, Kaneda Y, et al. (2001). HVJ-liposome-mediated transfection of HSVtk gene driven by AFP promoter inhibits hepatic tumor growth of hepatocellular carcinoma in SCID mice. Gene Ther 8:80–3
  • Ho RJ, Chien J. (2014). Trends in translational medicine and drug targeting and delivery: new insights on an old concept-targeted drug delivery with antibody–drug conjugates for cancers. J Pharm Sci 103:71–7
  • Hogan B, Lyons K. (1988). Gene targeting: getting nearer the mark. Nature 336:304–5
  • Huang S, Armstrong EA, Benavente S, et al. (2004). Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR) combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res 64:5355–62
  • Jackson NSH, Gallin JI, Holland SM. (1995). The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med 182:751–8
  • Kapadia RD, Stroup GB, Badger AM, et al. (1998). Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis. Technol Health Car 6:361–72
  • Kaplan-Lefko PJ, Chen TM, Ittmann MM, et al. (2003). Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model. Prostate 55:219–37
  • Keffer J, Probert L, Cazlaris H, et al. (1991). Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. J EMBO 10:4025–31
  • Kennedy GD, Nukaya M, Moran SM, et al. (2014). Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. Toxicol Sci 140:135–43
  • Khanna C, Hunter K. (2005). Modeling metastasis in vivo. Carcinogenesis 26:513–23
  • Kim CM, Koike K, Saito I, et al. (1991). HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317–20
  • Ko YH, Pedersen PL, Geschwind JF. (2001). Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett 173:83–91
  • Kota J, Chivukula RR, O’Donnell KA, et al. (2009). Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137:1005–17
  • Kothary R, Clapoff S, Brown A, et al. (1988). A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube. Nature 335:435–7
  • Kubota T. (1994). Metastatic models of human cancer xenografted in the nude mouse: the importance of orthotopic transplantation. J Cell Biochem 56:4–8
  • Kuhn R, Schwenk F, Aguet M, et al. (1995). Inducible gene targeting in mice. Science 269:1427–9
  • Kukowska-Latallo JF, Candido KA, Cao Z, et al. (2005). Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res 65:5317–24
  • Lampson LA. (2001). New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns. J Neuro-Oncol 53:275–87
  • Leenders MW, Nijkamp MW, Rinkes IHB. (2008). Mouse models in liver cancer research: a review of current literature. World J Gastroenterol 14:6915–23
  • Leighton PA, Van de Lavoir MC, Diamond JH, et al. (2008). Genetic modification of primordial germ cells by gene trapping, gene targeting, and фC31 integrase. Mol Reprod Dev 75:1163–75
  • Leong-Poi H, Christiansen J, Klibanov AL, et al. (2003). Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to αv-integrins. Circulation 107:455–60
  • Liu Y, Miyoshi H, Nakamura M. (2007). Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int J Cancer 120:2527–37
  • Lu B, Xiong SB, Yang H, et al. (2006). Mitoxantrone-loaded BSA nanospheres and chitosan nanospheres for local injection against breast cancer and its lymph node metastases. II. Tissue distribution and pharmacodynamics. Int J Pharm 307:175–81
  • Mahfoozur R, Sohail A, Javed A, et al. (2015). Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy. Drug Deliv 12:635–52
  • Mak TW. (2007). Gene targeting in embryonic stem cells scores a knockout in Stockholm. Cell 131:1027–31
  • Makino S. (1956). Further evidence favoring the concept of the stem cell in ascites tumors of rats. Ann NY Acad Sci 63:818–30
  • Mansour SL, Thomas KR, Capecchi MR. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348–52
  • Matalon R, Rady PL, Platt KA, et al. (2000). Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. J Gene Med 2:165–75
  • Morris SM, Carter KT, Baek JY, et al. (2014). TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Oncogene 34:3273–82
  • Murali MR, Jackson DD, Jebasingh D, et al. (2015). Anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in male albino Wistar rats. Drug Deliv 53:1133–40
  • Nakatani T, Roy G, Fujimoto N, et al. (2001). Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin. Jpn J Cancer Res 92:249–56
  • Nasongkla N, Bey E, Ren J, et al. (2006). Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett 6:2427–30
  • Naugler WE, Sakurai T, Kim S, et al. (2007). Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317:121–4
  • Ornstein DK, Englert C, Gillespie JW, et al. (2000). Characterization of intracellular prostate-specific antigen from laser capture microdissected benign and malignant prostatic epithelium. Clin Cancer Res 6:353–6
  • Peer D, Karp JM, Hong S, et al. (2007). Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2:751–60
  • Peer D, Margalit R. (2004). Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models. Int J Cancer 108:780–9
  • Peterson DL, Sheridan PJ, Brown Jr WE. (1994). Animal models for brain tumors: historical perspectives and future directions. J Neurosurg 80:865–76
  • Qian X, Peng XH, Ansari DO, et al. (2007). In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat Biotechnol 26:83–90
  • Ren W, Qiao Z, Wang H, et al. (2003). Flavonoids: promising anticancer agents. Med Res Rev 23:519–34
  • Ristevski S. (2005). Making better transgenic models. Mol Biotechnol 29:153–63
  • Rosol TJ, Tannehill-Gregg SH, LeRoy BE, et al. (2003). Animal models of bone metastasis. Cancer 97:748–57
  • Rygaard J, Povlsen CO. (1969). Heterotransplantation of a human malignant tumor to “Nude” mice. Acta Pathol Microbiol Scand 77:758–60
  • Sakai D, Mochida J, Iwashina T, et al. (2005). Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration. Spine 30:2379–87
  • Sell S, Leffert HL. (1982). An evaluation of cellular lineages in the pathogenesis of experimental hepatocellular carcinoma. Hepatology 2:77S–86S
  • Semenza GL. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721–32
  • Serra R, Villani M, Semeria A. (2004). Genetic network models and statistical properties of gene expression data in knock-out experiments. J Theor Biol 227:149–57
  • Seymour LW, Ferry DR, Anderson D, et al. (2002). Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin. J Clin Oncol 20:1668–76
  • Sharpless NE, DePinho RA. (2006). The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5:741–54
  • Silveira ER, Naves MMV, Vannucchi H, et al. (2001). Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats. Nutr Cancer 39:244–51
  • Stephen LC, Anthony WC, Winnie Y. (2015). Novel therapeutic targets and predictive markers for hepatocellular carcinoma. Therapeutic Targets 19:973–83
  • Sundaresan V, Springer P, Volpe T, et al. (1995). Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements. Gene Dev 9:1797–810
  • Sudimack J, Lee RJ. (2000). Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev 41:147–62
  • Sun Y. (1990). Free radicals, antioxidant enzymes, and carcinogenesis. Free Radic Biol Med 8:583–99
  • Takeuchi T. (1997). A gene trap approach to identify genes that control development. Dev Growth Differ 39:127–34
  • Talmadge JE, Singh RK, Fidler IJ, et al. (2007). Murine models to evaluate novel and conventional therapeutic strategies for cancer. J Am Pathol 170:793–804
  • Tardi P, Choice E, Masin D, et al. (2000). Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models. Cancer Res 60:3389–93
  • Tian Y, Guo B, Jia H, et al. (2012). Targeted therapy via oral administration of attenuated Salmonella expression plasmid-vectored Stat3-shRNA cures orthotopically transplanted mouse HCC. Cancer Gene Ther 19:393–401
  • Thomas KR, Capecchi MR. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503–12
  • Thorpe PE. (2004). Vascular targeting agents as cancer therapeutics. Clin Cancer Res 10:415–27
  • Toyokuni S. (1999). Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49:91–102
  • Tsuruo T, Naito M, Tomida A, et al. (2003). Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci 94:15–21
  • Uehara K, Ichida T, Sugahara S, et al. (2002). Systemic administration of liposome-encapsulated OK-432 prolongs the survival of rats with hepatocellular carcinoma through the induction of IFN-gamma-producing hepatic lymphocytes. J Gastroen Hepatol 17:81–90
  • Van der Spoel TI, Agostoni P, Van Belle E, et al. (2011). Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease. Cardiovasc Res 91:649–58
  • Van Dyke T, Jacks T. (2002). Cancer modeling in the modern era: progress and challenges. Cell 108:135–44
  • Verhaegh W, Van Ooijen H, Inda MA, et al. (2014). Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways. Cancer Res 74:2936–45
  • Waxman S, Anderson KC. (2001). History of the development of arsenic derivatives in cancer therapy. Oncologist 6:3–10
  • Weigelt B, Lo AT, Park C, et al. (2010). HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat 122:35–43
  • Weinstein IB, Joe AK. (2006). Mechanisms of disease: oncogene addiction – a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 3:448–57
  • Wiesner RH, McDiarmid SV, Kamath PS, et al. (2001). MELD and PELD: application of survival models to liver allocation. Liver Transplant 7:567–80
  • Williams GM. (1980). The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochem Biophys Acta 605:167–89
  • Wu M, Frieboes HB, McDougall SR., et al. (2013). The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems. J Theor Biol 320:131–51
  • Yang JA, Kong WH, Sung DK, et al. (2014). Hyaluronic acid – tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis. Acta Biomater 7061:444–9
  • Yang R, Rescorla FJ, Reilly CR, et al. (1992). A reproducible rat liver cancer model for experimental therapy: introducing a technique of intrahepatic tumor implantation. J Surg Res 52:193–8
  • Yao FY, Ferrell L, Bass NM, et al. (2001). Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 33:1394–403
  • Yao Z, Lu R, Jia J, et al. (2006). The effect of tripeptide tyroserleutide (YSL) on animal models of hepatocarcinoma. Peptides 27:1167–72
  • Zambrowicz BP, Friedrich GA. (1998). Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse. Int J Dev Biol 42:1025–36
  • Zhang J, Schweers B, Dyer MA. (2004). The first knockout mouse model of retinoblastoma. Cell Cycle 3:952–9
  • Zheng H, Liu J, Choo KH, et al. (1996). Metallothionein-I and –II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53. Toxicol Appl Pharmacol 136:229–35
  • Zheng H, Matte-Martone C, Li H, et al. (2008). Effector memory CD4 + T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood 111:2476–84

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