83
Views
14
CrossRef citations to date
0
Altmetric
Research Article

β2-Adrenoceptor confers cardioprotection against hypoxia in isolated ventricular myocytes and the effects depend on estrogenic environment

, , , , , , & show all
Pages 255-261 | Received 05 Apr 2010, Accepted 20 Apr 2010, Published online: 05 Jul 2010

References

  • Xiao RP, Zhu W, Zheng M, et al. Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications. Trends Pharmacol Sci 2004, 25, 358–365.
  • Chesley A, Lundberg MS, Asai T, et al. The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase. Circ Res 2000, 87, 1172–1179.
  • Zheng M, Zhu W, Han Q, et al. Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling. Pharmacol Ther 2005, 108, 257–268.
  • Zhu W, Zeng X, Zheng M, et al. The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly. Circ Res. 2005, 97, 507–509.
  • Xiao RP, Zhu W, Zheng M, et al. Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci 2006, 27, 330–337.
  • Persad S, Panagia V, Dhalla NS. Role of H2O2 in changing beta-adrenoceptor and adenylyl cyclase in ischemia–reperfused hearts. Mol Cell Biochem 1998, 186, 99–106.
  • Wang X, Wang J, Takeda S, et al. Alterations of cardiac β-adrenoceptor mechanisms due to calcium depletion and repletion. Mol Cell Biochem 2002, 232, 63–73.
  • Saini HK, Dhalla NS. Defective calcium handling in cardiomyocytes isolated from hearts subjected to ischemia–reperfusion. Am J Physiol Heart Circ Physiol 2005, 288, H2260–H2270.
  • Grodstein F, Stampfer M. The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiovasc Dis 1995, 38, 199–210.
  • Hale SL, Birnbaum Y, Kloner RA. Estradiol, administered acutely, protects ischemic myocardium in both female and male rabbits. J Cardiovasc Pharmacol Ther 1997, 2, 47–52.
  • Murphy E, Steenbergen C. Cardioprotection in females: a role for nitric oxide and altered gene expression. Heart Fail Rev 2007, 12, 293–300.
  • Sullivan JM, Vander Zwaag R, Lemp GF, et al. Postmenopausal estrogen use and coronary atherosclerosis. Ann Intern Med 1988, 108, 358–363.
  • Wu Q, Zhao Z, Sun H, et al. Estrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia–reperfusion. Exp Physiol 2008, 93, 1034–1043.
  • Patten RD, Pourati I, Aronovitz MJ, et al. 17Beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circ Res 2004, 95, 692–699.
  • Tune JD, Gorman MW, Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 2004, 97, 404–415.
  • Nayler WG, Poole-Wilson PA, Williams A. Hypoxia and calcium. J Mol Cell Cardiol 1979, 11, 683–706.
  • Camici PG. Hibernation and heart failure. Heart 2004, 90, 141–143.
  • Sun H, Zhou F, Wang Y, et al. Effects of beta-adrenoceptors overexpression on cell survival are mediated by Bax/Bcl-2 pathway in rat cardiac myocytes. Pharmacology 2006, 78, 98–104.
  • Hao Y, Sun Y, Xu C, et al. Improvement of contractile function in isolated cardiomyocytes from ischemia–reperfusion rats by ginkgolide B pretreatment. J Cardiovasc Pharmacol 2009, 54, 3–9.
  • Alekseev AE, Markevich NI, Korystova AF, et al. Comparative analysis of the kinetic characteristics of L-type calcium channels in cardiac cells of hibernators. Biophys J 1996, 70, 786–797.
  • Gong H, Adamson DL, Ranu HK, et al. The effect of Gi-protein inactivation on basal, and β1- and β2AR-stimulated contraction of myocytes from transgenic mice overexpressing the β2-adrenoceptor. Br J Pharmacol 2000, 131, 594–600.
  • Harding SE, Vescovo G, Kirby M, et al. Contractile responses of isolated adult rat and rabbit cardiac myocytes to isoproterenol and calcium. J Mol Cell Cardiol 1988, 20, 635–647.
  • Zhou JJ, Pei JM, Wang GY, et al. Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 2001, 281, H40–H47.
  • Penson PE, Ford WR, Kidd EJ, et al. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn Schmiedebergs Arch Pharmacol 2004, 378, 589–597.
  • Penna C, Abbadessa G, Mancardi D, et al. Synergistic effects against post-ischemic cardiac dysfunction by sub-chronic nandrolone pretreatment and postconditioning: role of beta2-adrenoceptor. J Physiol Pharmacol 2005, 59, 645–659.
  • Camici PG, Prasad SK, Rimoldi OE. Stunning, hibernation, and assessment of myocardial viability. Circulation 2008, 117, 103–114.
  • Stumpe T, Schrader J. Short-term hibernation in adult cardiomyocytes is PO2 dependent and Ca2+ mediated. Am J Physiol Heart Circ Physiol 2001, 49, H42–H50.
  • Murphy E, Steenbergen C. Gender-based differences in mechanisms of protection in myocardial ischemia–reperfusion injury. Cardiovasc Res 2007, 75, 478–486.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.