108
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Nuclear factor κB1/RelA mediates the inflammation and/or survival of human airway exposed to sulfur mustard

, , , , , & show all
Pages 367-373 | Received 19 Jun 2011, Accepted 29 Jun 2011, Published online: 19 Sep 2011

References

  • Paromov V, Suntres Z, Smith M, Stone WL. Sulfur mustard toxicity following dermal exposure: Role of oxidative stress, and antioxidant therapy. J Burns Wounds 2007, 7, e7.
  • Han S, Espinoza LA, Liao H, Boulares AH, Smulson ME. Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analog 2-chloroethylethyl sulphide (CEES) in Jurkat T cells and normal human lymphocytes. Br J Pharmacol 2004, 141, 795–802.
  • Dillman JF 3rd, Phillips CS, Dorsch LM, Croxton MD, Hege AI, Sylvester AJ, Moran TS, Sciuto AM. Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure. Chem Res Toxicol 2005, 18, 28–34.
  • Ghanei M, Panahi Y, Mojtahedzadeh M, Khalili AR, Aslani J. Effect of γ interferon on lung function of mustard gas exposed patients, after 15 years. Pulm Pharmacol Ther 2006, 19, 148–153.
  • Balali-Mood M, Hefazi M. Comparison of early and late toxic effects of sulfur mustard in Iranian veterans. Basic Clin Pharmacol Toxicol 2006, 99, 273–282.
  • Beheshti J, Mark EJ, Akbaei HM, Aslani J, Ghanei M. Mustard lung secrets: Long term clinicopathological study following mustard gas exposure. Pathol Res Pract 2006, 202, 739–744.
  • Ghanei M, Khalili AR, Arab MJ, Mojtahedzadeh M, Aslani J, Lessan-Pezeshki M, Panahi Y, Alaeddini F. Diagnostic and therapeutic value of short-term corticosteroid therapy in exacerbation of mustard gas-induced chronic bronchitis. Basic Clin Pharmacol Toxicol 2005, 97, 302–305.
  • Emad A, Emad Y. Increased in CD8 T lymphocytes in the BAL fluid of patients with sulfur mustard gas-induced pulmonary fibrosis. Respir Med 2007, 101, 786–792.
  • Ghanei M, Shohrati M, Jafari M, Ghaderi S, Alaeddini F, Aslani J. N-acetylcysteine improves the clinical conditions of mustard gas-exposed patients with normal pulmonary function test. Basic Clin Pharmacol Toxicol 2008, 103, 428–432.
  • Ebrahimi M, Roudkenar MH, Imani Fooladi AA, Halabian R, Ghanei M, Kondo H, Nourani MR. Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard. J Biomed Biotechnol 2010, 2010, 823131.
  • Nourani MR, Yazdani S, Roudkenar MH, Ebrahimi M, Halabian R, Mirbagheri L, Ghanei M, Fooladi AA. HO1 mRNA and Protein do not Change in Parallel in Bronchial Biopsies of Patients After Long Term Exposure to Sulfur Mustard. Gene Regul Syst Bio 2009, 4, 83–90.
  • Smith KJ, Fan LL. Insights into post-infectious bronchiolitis obliterans in children. Thorax 2006, 61, 462–463.
  • Ghanei M, Mokhtari M, Mohammad MM, Aslani J. Bronchiolitis obliterans following exposure to sulfur mustard: Chest high resolution computed tomography. Eur J Radiol 2004, 52, 164–169.
  • Imanifooladi AA, Yazdani S, Nourani MR. The role of nuclear factor-κB in inflammatory lung disease. Inflamm Allergy Drug Targets 2010, 9, 197–205.
  • Haddad JJ. Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: Role for nuclear factor-κB. Crit Care 2002, 6, 481–490.
  • Jacque E, Tchenio T, Piton G, Romeo PH, Baud V. RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proc Natl Acad Sci USA 2005, 102, 14635–14640.
  • García-Román R, Pérez-Carreón JI, Márquez-Quiñones A, Salcido-Neyoy ME, Villa-Treviño S. Persistent activation of NF-κB related to IκB’s degradation profiles during early chemical hepatocarcinogenesis. J Carcinog 2007, 6, 5.
  • Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell 2008, 132, 344–362.
  • Aggarwal BB, Takada Y, Shishodia S, Gutierrez AM, Oommen OV, Ichikawa H, Baba Y, Kumar A. Nuclear transcription factor NF-κB: Role in biology and medicine. Indian J Exp Biol 2004, 42, 341–353.
  • George PA. NF-κB: A Novel Therapeutic Target for Cancer. Vol. 1, January 2005: pp. 4–5.
  • Choudhary S, Boldogh S, Garofalo R, Jamaluddin M, Brasier AR. Respiratory syncytial virus influences NF-κB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-κB2. J Virol 2005, 79, 8948–8959.
  • Chabot-Fletcher M. A role for transcription factor NF-κB in inflammation. Inflamm Res 1997, 46, 1–2.
  • Weichert W, Boehm M, Gekeler V, Bahra M, Langrehr J, Neuhaus P, Denkert C, Imre G, Weller C, Hofmann HP, Niesporek S, Jacob J, Dietel M, Scheidereit C, Kristiansen G. High expression of RelA/p65 is associated with activation of nuclear factor-κB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis. Br J Cancer 2007, 97, 523–530.
  • Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS. Nerve growth factor-dependent activation of NF-κB contributes to survival of sympathetic neurons. J Neurosci 1998, 18, 10356–10365.
  • Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-κB transcription factors: Structural views. Oncogene 1999, 18, 6845–6852.
  • Collins T, Cybulsky MI. NF-κB: Pivotal mediator or innocent bystander in atherogenesis? J Clin Invest 2001, 107, 255–264.
  • Brown KD, Claudio E, Siebenlist U. The roles of the classical and alternative nuclear factor-κB pathways: Potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res Ther 2008, 10, 212.
  • Haeberle HA, Nesti F, Dieterich HJ, Gatalica Z, Garofalo RP. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-κB activation. Am J Respir Crit Care Med 2002, 165, 1433–1438.
  • Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNA-mediated reduction of inhibitor of nuclear factor-κB kinase prevents tumor necrosis factor-α-induced insulin resistance in human skeletal muscle. Diabetes 2008, 57, 2066–2073.
  • Napolitano M, Zei D, Centonze D, Palermo R, Bernardi G, Vacca A, Calabresi P, Gulino A. NF-κB/NOS cross-talk induced by mitochondrial complex II inhibition: Implications for Huntington’s disease. Neurosci Lett 2008, 434, 241–246.
  • Basak S, Kim H, Kearns JD, Tergaonkar V, O’Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. A fourth IκB protein within the NF-κB signaling module. Cell 2007, 128, 369–381.
  • Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. Evidence that reactive oxygen species do not mediate NF-κB activation. EMBO J 2003, 22, 3356–3366.
  • Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, Mische S, Li J, Marcu KB. IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB-mediated inflammatory response program. J Biol Chem 2002, 277, 45129–45140.
  • Garg A, Aggarwal BB. Nuclear transcription factor-κB as a target for cancer drug development. Leukemia 2002, 16, 1053–1068.
  • Karin M. The IκB kinase - a bridge between inflammation and cancer. Cell Res 2008, 18, 334–342.
  • Lucas PC, McAllister-Lucas LM, Nunez G. NF-κB signaling in lymphocytes: A new cast of characters. J Cell Sci 2004, 117, 31–39.
  • Yao H, Yang SR, Kode A, Rajendrasozhan S, Caito S, Adenuga D, Henry R, Edirisinghe I, Rahman I. Redox regulation of lung inflammation: Role of NADPH oxidase and NF-κB signalling. Biochem Soc Trans 2007, 35, 1151–1155.
  • Hiscott J, Kwon H, Génin P. Hostile takeovers: Viral appropriation of the NF-κB pathway. J Clin Invest 2001, 107, 143–151.
  • Karin M. The beginning of the end: IκB kinase (IKK) and NF-κB activation. J Biol Chem 1999, 274, 27339–27342.
  • Sachdev S, Hoffmann A, Hannink M. Nuclear localization of IκBα is mediated by the second ankyrin repeat: The IκBα ankyrin repeats define a novel class of cis-acting nuclear import sequences. Mol Cell Biol 1998, 18, 2524–2534.
  • Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IκBβ x NF-κB p65 homodimer complex. J Biol Chem 2003, 278, 23094–23100.
  • Sosne G, Qiu P, Christopherson PL, Wheater MK. Thymosin β 4 suppression of corneal NFκB: A potential anti-inflammatory pathway. Exp Eye Res 2007, 84, 663–669.
  • Ward C, Walker A, Dransfield I, Haslett C, Rossi AG. Regulation of granulocyte apoptosis by NF-κB. Biochem Soc Trans 2004, 32, 465–467.
  • Beinke S, Ley SC. Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem J 2004, 382, 393–409.
  • Basak S, Shih VF, Hoffmann A. Generation and activation of multiple dimeric transcription factors within the NF-κB signaling system. Mol Cell Biol 2008, 28, 3139–3150.
  • Nuñez C, Cansino JR, Bethencourt F, Pérez-Utrilla M, Fraile B, Martínez-Onsurbe P, Olmedilla G, Paniagua R, Royuela M. TNF/IL-1/NIK/NF-κB transduction pathway: A comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma). Histopathology 2008, 53, 166–176.
  • Gao Z, Chiao P, Zhang X, Zhang X, Lazar MA, Seto E, Young HA, Ye J. Coactivators and corepressors of NF-κB in IκBα gene promoter. J Biol Chem 2005, 280, 21091–21098.
  • Cousins DJ, McDonald J, Lee TH. Therapeutic approaches for control of transcription factors in allergic disease. J Allergy Clin Immunol 2008, 121, 803–9; quiz 810.
  • Christman JW, Sadikot RT, Blackwell TS. The role of nuclear factor-κB in pulmonary diseases. Chest 2000, 117, 1482–1487.
  • Poynter ME, Cloots R, van Woerkom T, Butnor KJ, Vacek P, Taatjes DJ, Irvin CG, Janssen-Heininger YM. NF-κB activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol 2004, 173, 7003–7009.
  • Pourazar J, Blomberg A, Kelly FJ, Davies DE, Wilson SJ, Holgate ST, Sandström T. Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium. Part Fibre Toxicol 2008, 5, 8.
  • Janssen YM, Barchowsky A, Treadwell M, Driscoll KE, Mossman BT. Asbestos induces nuclear factor κB (NF-κB) DNA-binding activity and NF-κB-dependent gene expression in tracheal epithelial cells. Proc Natl Acad Sci USA 1995, 92, 8458–8462.
  • Gius D, Botero A, Shah S, Curry HA. Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1. Toxicol Lett 1999, 106, 93–106.
  • Janssen YM, Driscoll KE, Howard B, Quinlan TR, Treadwell M, Barchowsky A, Mossman BT. Asbestos causes translocation of p65 protein and increases NF-κB DNA binding activity in rat lung epithelial and pleural mesothelial cells. Am J Pathol 1997, 151, 389–401.
  • Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, Bubici C, Mossman BT, Pass HI, Testa JR, Franzoso G, Carbone M. TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci USA 2006, 103, 10397–10402.
  • Fang C, Corrigan CJ, Ying S. The treatment targets of asthma: From laboratory to clinic. Inflamm Allergy Drug Targets 2008, 7, 119–128.
  • Di Stefano A, Caramori G, Ricciardolo FL, Capelli A, Adcock IM, Donner CF. Cellular and molecular mechanisms in chronic obstructive pulmonary disease: An overview. Clin Exp Allergy 2004, 34, 1156–1167.
  • Bracke KR, Demedts IK, Joos GF, Brusselle GG. CC-chemokine receptors in chronic obstructive pulmonary disease. Inflamm Allergy Drug Targets 2007, 6, 75–79.
  • Szulakowski P, Crowther AJ, Jiménez LA, Donaldson K, Mayer R, Leonard TB, MacNee W, Drost EM. The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006, 174, 41–50.
  • Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O. Enhanced IL-1β-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-κB signaling. Biochem Biophys Res Commun 2007, 357, 402–407.
  • Nourani MR, Owada Y, Kitanaka NSA, Iwasa H, Sakagami H, Spener F and Kondo H. Localization of epidermal-type fatty acid binding protein in macrophages in advanced atretic follicles of adult mice. J Mol His 2005, 36, 6–7, 391–400.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.