Cell signaling and receptors in toxicity of advanced glycation end products (AGEs): α-dicarbonyls, radicals, oxidative stress and antioxidants

References

• Kovacic P, Somanathan R. Advanced glycation endproducts (AGEs): mechanism, toxicity, reactive oxygen species, electron transfer. In: Systems biology of free radicals and anti-oxidants. Laher I. (ed.). Springer-Verlag, New York, 2011, in press.
   Google Scholar
• Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet β cells in diabetes. J Biol Chem 2004, 279, 42351–42354.
   PubMed Web of Science ®Google Scholar
• Nakayama T, Terazawa K, Kawakishi S. Role of active oxygen species in the toxic effects of glucosone on mammalian cells. J Nutr Sci Vitaminol 1992, 38, 593–601.
   PubMedGoogle Scholar
• Fumitaka H. Autoxidation of reducing sugars and Maillard reaction. Production and scavenging of reactive oxygen species. Kassel Sanso Furi Rajikaru 1993, 4, 271–278.
   Google Scholar
• Usui T, Shizuuchi S, Watanabe H, Hayase F. Cytotoxicity and oxidative stress induced by the glyceraldehyde-related Maillard reaction products for HL-60 cells. Biosci Biotechnol Biochem 2004, 68, 333–340.
   PubMed Web of Science ®Google Scholar
• Schalkwijk CG, Vermeer MA, Verzijl N, Stenhouwer CDA, te Koppele J, Hans MG, Van Hinsbergh VWM. Modification of low-density lipoprotein by methylglyoxal alters its physiochemical and biological properties. Special Publication Royal Society of Chemistry 1998, 223, 285–290.
   Google Scholar
• Yim MB, Kang SO, Chock PB. Enzyme-like activity of glycated cross-linked proteins in free radical generation. Ann N Y Acad Sci 2000, 899, 168–181.
   PubMedGoogle Scholar
• Shangari N, Bruce WR, Poon R, O’Brien PJ. Toxicity of glyoxals–role of oxidative stress, metabolic detoxification and thiamine deficiency. Biochem Soc Trans 2003, 31, 1390–1393.
   PubMed Web of Science ®Google Scholar
• Shangari N, O’Brien PJ. The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem Pharmacol 2004, 68, 1433–1442.
   PubMed Web of Science ®Google Scholar
• Miyata T, Ishikawa N, van Ypersele de Strihou C. Carbonyl stress and diabetic complications. Clin Chem Lab Med 2003, 41, 1150–1158.
   PubMed Web of Science ®Google Scholar
• Niiya Y, Abumiya T, Shichinohe H, Kuroda S, Kikuchi S, Ieko M, Yamagishi S, Takeuchi M, Sato T, Iwasaki Y. Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species. Brain Res 2006, 1108, 179–187.
   PubMedGoogle Scholar
• Wautier JL, Schmidt AM. Protein glycation: a firm link to endothelial cell dysfunction. Circ Res 2004, 95, 233–238.
   PubMed Web of Science ®Google Scholar
• Kikuchi S, Shinpo K, Takeuchi M, Yamagishi S, Makita Z, Sasaki N, Tashiro K. Glycation–a sweet tempter for neuronal death. Brain Res Brain Res Rev 2003, 41, 306–323.
   PubMed Web of Science ®Google Scholar
• Srivivasan A, Menon VP, Periaswamy V, Rajasekaran KN. Protection of pancreatic β-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes. J Pharm Pharm Sci 2003, 6, 327–333.
   PubMed Web of Science ®Google Scholar
• Muscat S, Pelka J, Hegele J, Weigle B, Münch G, Pischetsrieder M. Coffee and Maillard products activate NF-κB in macrophages via H2O2 production. Mol Nutr Food Res 2007, 51, 525–535.
   PubMed Web of Science ®Google Scholar
• Masaki H, Okano Y, Sakurai H. Generation of active oxygen species from advanced glycation end-products (AGEs) during ultraviolet light A (UVA) irradiation and a possible mechanism for cell damaging. Biochim Biophys Acta 1999, 1428, 45–56.
   PubMed Web of Science ®Google Scholar
• Zhang M, Kho AL, Anilkumar N, Chibber R, Pagano PJ, Shah AM, Cave AC. Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase. Circulation 2006, 113, 1235–1243.
   PubMed Web of Science ®Google Scholar
• Alikhani M, Maclellan CM, Raptis M, Vora S, Trackman PC, Graves DT. Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor. Am J Physiol, Cell Physiol 2007, 292, C850–C856.
   PubMedGoogle Scholar
• Ha H, Lee HB. Reactive oxygen species and matrix remodeling in diabetic kidney. J Am Soc Nephrol 2003, 14, S246–S249.
   PubMed Web of Science ®Google Scholar
• Ha H, Lee HB. Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney. Nephrology (Carlton) 2005, 10 Suppl, S7–10.
   Google Scholar
• Iida T, Yoshiki Y, Someya S, Okubo K. Generation of reactive oxygen species and photon emission from a browned product. Biosci Biotechnol Biochem 2002, 66, 1641–1645.
   PubMed Web of Science ®Google Scholar
• Matsuoka T, Kajimoto Y, Watada H, Kaneto H, Kishimoto M, Umayahara Y, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest 1997, 99, 144–150.
   PubMed Web of Science ®Google Scholar
• Baynes JW. From life to death–the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage. Biogerontology 2000, 1, 235–246.
   PubMedGoogle Scholar
• Traverso N, Menini S, Cottalasso D, Odetti P, Marinari UM, Pronzato MA. Mutual interaction between glycation and oxidation during non-enzymatic protein modification. Biochim Biophys Acta 1997, 1336, 409–418.
   PubMed Web of Science ®Google Scholar
• Wallace KB, ed. Free Radical Toxicology. Taylor & Francis, Washington, 1997, pp. 79–81.
   Google Scholar
• Tsukahara H, Sekine K, Uchiyama M, Kawakami H, Hata I, Todoroki Y, Hiraoka M, Kaji M, Yorifuji T, Momoi T, Yoshihara K, Beppu M, Mayumi M. Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes. Pediatr Res 2003, 54, 419–424.
   PubMedGoogle Scholar
• Yan HD, Li XZ, Xie JM, Li M. Effects of advanced glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells. Chin Med J 2007, 120, 787–793.
   PubMed Web of Science ®Google Scholar
• Aronson D, Rayfield EJ. How hyperglycemia promotes atherosclerosis: molecular mechanisms. Cardiovasc Diabetol 2002, 1, 1.
   PubMed Web of Science ®Google Scholar
• Jay D, Hitomi H, Griendling KK. Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med 2006, 40, 183–192.
   PubMedGoogle Scholar
• Scivittaro V, Ganz MB, Weiss MF. AGEs induce oxidative stress and activate protein kinase C-β(II) in neonatal mesangial cells. Am J Physiol Renal Physiol 2000, 278, F676–F683.
   PubMed Web of Science ®Google Scholar
• Coughlan MT, Mibus AL, Forbes JM. Oxidative stress and advanced glycation in diabetic nephropathy. Ann N Y Acad Sci 2008, 1126, 190–193.
   PubMed Web of Science ®Google Scholar
• Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr 2000, 71, 621S–629S.
   PubMed Web of Science ®Google Scholar
• Yamagishi S, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S. Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications. Expert Opin Investig Drugs 2008, 17, 983–996.
   PubMed Web of Science ®Google Scholar
• Baynes JW. The role of AGEs in aging: causation or correlation. Exp Gerontol 2001, 36, 1527–1537.
   PubMed Web of Science ®Google Scholar
• Baynes JW, Thorpe SR. Glycoxidation and lipoxidation in atherogenesis. Free Radic Biol Med 2000, 28, 1708–1716.
   PubMed Web of Science ®Google Scholar
• Thorpe SR, Baynes JW. Maillard reaction products in tissue proteins: new products and new perspectives. Amino Acids 2003, 25, 275–281.
   PubMed Web of Science ®Google Scholar
• Miyata T, Kurokawa K, van Ypersele de Strihou C. Relevance of oxidative and carbonyl stress to long-term uremic complications. Kidney Int Suppl 2000, 76, S120–S125.
   Google Scholar
• Gasic-Milenkovic J, Loske C, Münch G. Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y. J Alzheimers Dis 2003, 5, 25–30.
   PubMed Web of Science ®Google Scholar
• Murthy UM, Sun WQ. Protein modification by Amadori and Maillard reactions during seed storage: roles of sugar hydrolysis and lipid peroxidation. J Exp Bot 2000, 51, 1221–1228.
   PubMed Web of Science ®Google Scholar
• Kalousová M, Skrha J, Zima T. Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus. Physiol Res 2002, 51, 597–604.
   PubMed Web of Science ®Google Scholar
• Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab 2000, 26, 163–176.
   PubMed Web of Science ®Google Scholar
• Baragetti I, Furiani S, Vettoretti S, Raselli S, Maggi FM, Galli F, Catapano AL, Buccianti G. Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: a pilot study. Blood Purif 2006, 24, 369–376.
   PubMedGoogle Scholar
• Lal MA, Brismar H, Eklöf AC, Aperia A. Role of oxidative stress in advanced glycation end product-induced mesangial cell activation. Kidney Int 2002, 61, 2006–2014.
   PubMed Web of Science ®Google Scholar
• Mamputu JC, Renier G. Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor-induced ICAM-1 expression: inhibitory effect of antioxidants. J Leukoc Biol 2004, 75, 1062–1069.
   PubMed Web of Science ®Google Scholar
• Kiho T, Usui S, Hirano K, Aizawa K, Inakuma T. Tomato paste fraction inhibiting the formation of advanced glycation end-products. Biosci Biotechnol Biochem 2004, 68, 200–205.
   PubMed Web of Science ®Google Scholar
• Reddy VP, Garrett MR, Perry G, Smith MA. Carnosine: a versatile antioxidant and antiglycating agent. Sci Aging Knowledge Environ 2005, 2005, pe12.
   PubMedGoogle Scholar
• Bengmark S. Advanced glycation and lipoxidation end products–amplifiers of inflammation: the role of food. JPEN J Parenter Enteral Nutr 2007, 31, 430–440.
   PubMed Web of Science ®Google Scholar
• Osawa T, Kato Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann N Y Acad Sci 2005, 1043, 440–451.
   PubMed Web of Science ®Google Scholar
• Sajithlal GB, Chithra P, Chandrakasan G. Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats. Biochem Pharmacol 1998, 56, 1607–1614.
   PubMed Web of Science ®Google Scholar
• Lapolla A, Piarulli F, Sartore G, Ceriello A, Ragazzi E, Reitano R, Baccarin L, Laverda B, Fedele D. Advanced glycation end products and antioxidant status in type 2 diabetic patients with and without peripheral artery disease. Diabetes Care 2007, 30, 670–676.
   PubMedGoogle Scholar
• Gupta M, Chari S. Proxidant and antioxidant status in patients of type II diabetes mellitus with IHD. Indian J Clinc Biochem 2006, 21, 118–122.
   PubMedGoogle Scholar
• Zhou H, Tan KCB, Shiu AWM, Wong Y. Increased serum advanced glycation end products is associated with impairment in HDL antioxidative capacity in diabetic nephropathy. Nephrol Dial Transplant 2007, 0, 1–7.
   Google Scholar
• Koya D, Hayashi K, Kitada M, Kashiwagi A, Kikkawa R, Haneda M. Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol 2003, 14, S250–S253.
   PubMed Web of Science ®Google Scholar
• Manzocco L, Calligaris S, Mastrocola D, Nicoli MC, Lerici CR. Review of non-enzymatic browning and antioxidant capacity in processed foods. Trends Food Sci Technol 2001, 11, 340–346.
   Web of Science ®Google Scholar
• Lingnert H, Waller GR. Stability of antioxidants formed from histidine and glucose by the Maillard reaction. J Agric Food Chem 1983, 31, 27–30.
   Web of Science ®Google Scholar
• Yilmaz Y, Toledo R. Antioxidant activity of water-soluble Maillard reaction products. Food Chem 2005, 9, 273–278.
   Google Scholar
• Mastrocola D, Munari M. Progress of the Maillard reaction and antioxidant action of Maillard reaction products in preheated model systems during storage. J Agric Food Chem 2005, 48, 3555–3559.
   Google Scholar
• Yoshimura Y, Iijima T, Watanabe T, Nakazawa H. Antioxidant effect of Maillard reaction products using glucose-glycine model system. J Agric Food Chem 1997, 45, 4106–4109.
   Web of Science ®Google Scholar
• Wijewickreme AN, Kitts DD. Oxidative reactions of model Maillard reaction products and α-tocopherol in a flour-lipid mixture. J Food Sci 1998, 63, 466–471.
   Google Scholar
• Jing H, Kitts DD. Antioxidant activity of sugar-lysine Maillard reaction products in cell free and cell culture systems. Arch Biochem Biophys 2004, 429, 154–163.
   PubMed Web of Science ®Google Scholar
• Ide N, Lau BH, Ryu K, Matsuura H, Itakura Y. Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract. J Nutr Biochem 1999, 10, 372–376.
   PubMed Web of Science ®Google Scholar
• Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara H. Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression. Am J Pathol 2007, 170, 1893–1902.
   PubMed Web of Science ®Google Scholar
• Pamplona R, Portero-Otín M, Requena J, Gredilla R, Barja G. Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls. Mech Ageing Dev 2002, 123, 1437–1446.
   PubMed Web of Science ®Google Scholar
• Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 2005, 15, 16R–28R.
   PubMed Web of Science ®Google Scholar
• Bierhaus A, Humpert PM, Morcos M, Wendt T, Chavakis T, Arnold B, Stern DM, Nawroth PP. Understanding RAGE, the receptor for advanced glycation end products. J Mol Med 2005, 83, 876–886.
   PubMed Web of Science ®Google Scholar
• Basta G, Lazzerini G, Del Turco S, Ratto GM, Schmidt AM, De Caterina R. At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products. Arterioscler Thromb Vasc Biol 2005, 25, 1401–1407.
   PubMed Web of Science ®Google Scholar
• Schupp N, Schinzel R, Heidland A, Stopper H. Genotoxicity of advanced glycation end products: involvement of oxidative stress and of angiotensin II type 1 receptors. Ann N Y Acad Sci 2005, 1043, 685–695.
   PubMed Web of Science ®Google Scholar
• Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem 1997, 272, 17810–17814.
   PubMed Web of Science ®Google Scholar
• Alves M, Cunha DA, Calegari VC, Saad MJ, Boschero AC, Velloso LA, Rocha EM. Nuclear factor-κB and advanced glycation end-products expression in lacrimal glands of aging rats. J Endocrinol 2005, 187, 159–166.
   PubMedGoogle Scholar
• Haslbeck KM, Neundörfer B, Schlötzer-Schrehardtt U, Bierhaus A, Schleicher E, Pauli E, Haslbeck M, Hecht M, Nawroth P, Heuss D. Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies? Neurol Res 2007, 29, 103–110.
   PubMed Web of Science ®Google Scholar
• Ihara Y, Egashira K, Nakano K, Ohtani K, Kubo M, Koga J, Iwai M, Horiuchi M, Gang Z, Yamagishi S, Sunagawa K. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol 2007, 43, 455–464.
   PubMed Web of Science ®Google Scholar
• Li JH, Huang XR, Zhu HJ, Oldfield M, Cooper M, Truong LD, Johnson RJ, Lan HY. Advanced glycation end products activate Smad signaling via TGF-β-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J 2004, 18, 176–178.
   PubMed Web of Science ®Google Scholar
• Fukami K, Ueda S, Yamagishi S, Kato S, Inagaki Y, Takeuchi M, Motomiya Y, Bucala R, Iida S, Tamaki K, Imaizumi T, Cooper ME, Okuda S. AGEs activate mesangial TGF-β-Smad signaling via an angiotensin II type I receptor interaction. Kidney Int 2004, 66, 2137–2147.
   PubMed Web of Science ®Google Scholar
• Brizzi MF, Dentelli P, Rosso A, Calvi C, Gambino R, Cassader M, Salvidio G, Deferrari G, Camussi G, Pegoraro L, Pagano G, Cavallo-Perin P. RAGE- and TGF-β receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy. FASEB J 2004, 18, 1249–1251.
   PubMedGoogle Scholar
• Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D. Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb 1994, 14, 1521–1528.
   PubMed Web of Science ®Google Scholar
• Khechai F, Ollivier V, Bridey F, Amar M, Hakim J, de Prost D. Effect of advanced glycation end product-modified albumin on tissue factor expression by monocytes. Role of oxidant stress and protein tyrosine kinase activation. Arterioscler Thromb Vasc Biol 1997, 17, 2885–2890.
   PubMedGoogle Scholar
• Riboulet-Chavey A, Pierron A, Durand I, Murdaca J, Giudicelli J, Van Obberghen E. Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species. Diabetes 2006, 55, 1289–1299.
   PubMed Web of Science ®Google Scholar
• Kani S, Nakayama E, Yoda A, Onishi N, Sougawa N, Hazaka Y, Umeda T, Takeda K, Ichijo H, Hamada Y, Minami Y. Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling. Genes Cells 2007, 12, 919–928.
   PubMed Web of Science ®Google Scholar
• Onyango IG, Tuttle JB, Bennett JP Jr. Altered intracellular signaling and reduced viability of Alzheimer’s disease neuronal cybrids is reproduced by β-amyloid peptide acting through receptor for advanced glycation end products (RAGE). Mol Cell Neurosci 2005, 29, 333–343.
   PubMedGoogle Scholar
• Huttunen HJ, Kuja-Panula J, Rauvala H. Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation. J Biol Chem 2002, 277, 38635–38646.
   PubMedGoogle Scholar
• Schmidt A, Kuhla B, Bigl K, Münch G, Arendt T. Cell cycle related signaling in Neuro2a cells proceeds via the receptor for advanced glycation end products. J Neural Transm 2007, 114, 1413–1424.
   PubMedGoogle Scholar
• Huttunen HJ, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 1999, 274, 19919–19924.
   PubMed Web of Science ®Google Scholar
• Pichiule P, Chavez JC, Schmidt AM, Vannucci SJ. Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia. J Biol Chem 2007, 282, 36220–36340.
   Google Scholar
• Rodríguez-Ayala E, Anderstam B, Suliman ME, Seeberger A, Heimbürger O, Lindholm B, Stenvinkel P. Enhanced RAGE-mediated NFκB stimulation in inflamed hemodialysis patients. Atherosclerosis 2005, 180, 33–340.
   Google Scholar
• Guh JY, Huang JS, Chen HC, Hung WC, Lai YH, Chuang LY. Advanced glycation end product-induced proliferation in NRK-49F cells is dependent on the JAK2/STAT5 pathway and cyclin D1. Am J Kidney Dis 2001, 38, 1096–1104.
   PubMed Web of Science ®Google Scholar
• Vincent AM, Perrone L, Sullivan KA, Backus C, Sastry AM, Lastoskie C, Feldman EL. Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress. Endocrinology 2007, 148, 548–558.
   PubMed Web of Science ®Google Scholar
• Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H. AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation. Am J Physiol, Cell Physiol 2008, 294, C145–C152.
   PubMed Web of Science ®Google Scholar
• Mukherjee TK, Mukhopadhyay S, Hoidal JR. The role of reactive oxygen species in TNFα-dependent expression of the receptor for advanced glycation end products in human umbilical vein endothelial cells. Biochim Biophys Acta 2005, 1744, 213–223.
   PubMed Web of Science ®Google Scholar
• Mamputu JC, Renier G. Signalling pathways involved in retinal endothelial cell proliferation induced by advanced glycation end products: inhibitory effect of gliclazide. Diabetes Obes Metab 2004, 6, 95–103.
   PubMedGoogle Scholar
• Basta G, Lazzerini G, Massaro M, Simoncini T, Tanganelli P, Fu C, Kislinger T, Stern DM, Schmidt AM, De Caterina R. Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses. Circulation 2002, 105, 816–822.
   PubMed Web of Science ®Google Scholar
• Treins C, Giorgetti-Peraldi S, Murdaca J, Van Obberghen E. Regulation of vascular endothelial growth factor expression by advanced glycation end products. J Biol Chem 2001, 276, 43836–43841.
   PubMed Web of Science ®Google Scholar
• Li JH, Wang W, Huang XR, Oldfield M, Schmidt AM, Cooper ME, Lan HY. Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway. Am J Pathol 2004, 164, 1389–1397.
   PubMed Web of Science ®Google Scholar
• Miyata T, Hori O, Zhang J, Yan SD, Ferran L, Iida Y, Schmidt AM. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-β2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis. J Clin Invest 1996, 98, 1088–1094.
   PubMed Web of Science ®Google Scholar
• Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK. Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-α in human osteoarthritic chondrocytes. FEBS Lett 2007, 581, 1928–1932.
   PubMed Web of Science ®Google Scholar
• Chuang PY, Yu Q, Fang W, Uribarri J, He JC. Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor. Kidney Int 2007, 72, 965–976.
   PubMed Web of Science ®Google Scholar
• Alikhani M, Alikhani Z, Boyd C, MacLellan CM, Raptis M, Liu R, Pischon N, Trackman PC, Gerstenfeld L, Graves DT. Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways. Bone 2007, 40, 345–353.
   PubMed Web of Science ®Google Scholar
• Chen BH, Jiang DY, Tang LS. Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes. Life Sci 2006, 79, 1040–1048.
   PubMed Web of Science ®Google Scholar
• Wang AL, Yu AC, He QH, Zhu X, Tso MO. AGEs mediated expression and secretion of TNF α in rat retinal microglia. Exp Eye Res 2007, 84, 905–913.
   PubMed Web of Science ®Google Scholar
• Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, Song F, Bakr S, Szabolcs M, D’Agati V, Liu R, Homma S, Schmidt AM, Yan SF, Ramasamy R. RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol 2008, 294, H1823–H1832.
   Google Scholar
• Gebhardt C, Riehl A, Durchdewald M, Németh J, Fürstenberger G, Müller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med 2008, 205, 275–285.
   PubMed Web of Science ®Google Scholar
• Guo Z, Hou F, Zhang X, Liu Z, Wang L. [Advanced glycation end products inhibit production of nitric oxide by human endothelial cells through activation of the p38 signal pathway]. Zhonghua Yi Xue Za Zhi 2002, 82, 1328–1331.
   PubMedGoogle Scholar
• Nah SS, Choi IY, Lee CK, Oh JS, Kim YG, Moon HB, Yoo B. Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes. Rheumatology (Oxford) 2008, 47, 425–431.
   PubMed Web of Science ®Google Scholar
• Cai W, He JC, Zhu L, Lu C, Vlassara H. Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor. Proc Natl Acad Sci USA 2006, 103, 13801–13806.
   PubMed Web of Science ®Google Scholar
• Kovacic P, Pozos RS. Cell signaling (mechanism and reproductive toxicity): redox chains, radicals, electrons, relays, conduit, electrochemistry, and other medical implications. Birth Defects Res C Embryo Today 2006, 78, 333–344.
   PubMedGoogle Scholar
• Sheriar GH, Mikhail AF, Georgia M, Hannah M, Roberto B. Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks. Biochim Biophys Acta 2004, 1662, 113–137.
   PubMedGoogle Scholar
• Hancock GT. Cell Signaling, Oxford University Press, New York, 2005, pp. 1–296.
   Google Scholar
• Forman HG, Cadenas E, eds. Oxidative stress and signal transduction. Chapman and Hall, New York, 1997, pp.1–475.
   Google Scholar
• Demple B. Oxidative stress and signal transduction. In Handbook of Cell Signaling 2004, 78, 293–307.
   Google Scholar
• Hansen JM. Oxidative stress as a mechanism of teratogenesis. Birth Defects Res C Embryo Today 2006, 78, 293–307.
   PubMedGoogle Scholar
• Jones DP. Redefining oxidative stress. Antioxid Redox Signal 2006, 8, 1865–1879.
   PubMed Web of Science ®Google Scholar
• Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005, 106, 852–859.
   PubMed Web of Science ®Google Scholar
• Miller AA, Drummond GR, Sobey CG. Reactive oxygen species in the cerebral circulation: are they all bad? Antioxid Redox Signal 2006, 8, 1113–1120.
   PubMed Web of Science ®Google Scholar
• Bunik VI, Schloss JV, Pinto JT, Gibson GE, Cooper AJ. Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases. Neurochem Res 2007, 32, 871–891.
   PubMedGoogle Scholar
• Liu LZ, Hu XW, Xia C, He J, Zhou Q, Shi X, Fang J, Jiang BH. Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1α expression through activation of AKT and P70S6K1 in human ovarian cancer cells. Free Radic Biol Med 2006, 41, 1521–1533.
   PubMed Web of Science ®Google Scholar
• Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. Understanding Ras: ‘it ain’t over ‘til it’s over’. Trends Cell Biol 2000, 10, 147–154.
   PubMed Web of Science ®Google Scholar
• Kovacic P. Unifying mechanism for bacterial cell signalers (4,5-dihydroxy-2,3-pentanedione, lactones and oligopeptides): electron transfer and reactive oxygen species. Practical medical features. Med Hypotheses 2007, 69, 1105–1110.
   PubMedGoogle Scholar
• Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Meijler MM, Moss JA, Clapham B, Brogan AP, Dickerson TJ, Janda KD. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci USA 2005, 102, 309–314.
   PubMed Web of Science ®Google Scholar
• Diggle SP, Matthijs S, Wright VJ, Fletcher MP, Chhabra SR, Lamont IL, Kong X, Hider RC, Cornelis P, Cámara M, Williams P. The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol 2007, 14, 87–96.
   PubMed Web of Science ®Google Scholar
• Bredenbruch F, Geffers R, Mimtz M, Buer J, Haussler S. The Pseudomonas aerugenosa quinolone signal (PQS) has an iron-chelating activity. Environ Microbiol 2006. doi:10.1111/j.1462–2920.2006.0125.x.
   PubMedGoogle Scholar
• Chung AC, Zhang H, Kong YZ, Tan JJ, Huang XR, Kopp JB, Lan HY. Advanced glycation end-products induce tubular CTGF via TGF-β-independent Smad3 signaling. J Am Soc Nephrol 2010, 21, 249–260.
   PubMed Web of Science ®Google Scholar
• Lue LF, Walker DG, Jacobson S, Sabbagh M. Receptor for advanced glycation end products: its role in Alzheimer’s disease and other neurological diseases. Future Neurol 2009, 4, 167–177.
   PubMedGoogle Scholar
• Riehl A, Németh J, Angel P, Hess J. The receptor RAGE: Bridging inflammation and cancer. Cell Commun Signal 2009, 7, 12.
   PubMed Web of Science ®Google Scholar
• Origlia N, Bonadonna C, Rosellini A, Leznik E, Arancio O, Yan SS, Domenici L. Microglial receptor for advanced glycation end product-dependent signal pathway drives β-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex. J Neurosci 2010, 30, 11414–11425.
   PubMedGoogle Scholar
• Zong H, Madden A, Ward M, Mooney MH, Elliott CT, Stitt AW. Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction. J Biol Chem 2010, 285, 23137–23146.
   PubMed Web of Science ®Google Scholar
• Ichikawa M, Williams R, Wang L, Vogl T, Srikrishna G. S100A8/A9 activate key genes and pathways in colon tumor progression. Mol Cancer Res 2011, 9, 133–148.
   PubMed Web of Science ®Google Scholar
• Hirose A, Tanikawa T, Mori H, Okada Y, Tanaka Y. Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway. FEBS Lett 2010, 584, 61–66.
   PubMed Web of Science ®Google Scholar