Differential effects of Akt pathway inhibitors on IL-1β-induced protein phosphorylation in human fibroblast-like synoviocytes

References

• Huber LC, Distler O, Tarner I, Gay RE, Gay S, Pap T. Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford) 2006, 45, 669–675.
   PubMed Web of Science ®Google Scholar
• Feldmann M. Pathogenesis of arthritis: Recent research progress. Nat Immunol 2001, 2, 771–773.
   PubMed Web of Science ®Google Scholar
• Okamoto T. NF-κB and rheumatic diseases. Endocr Metab Immune Disord Drug Targets 2006, 6, 359–372.
   PubMedGoogle Scholar
• Tsuji F, Oki K, Senda T, Horiuchi M, Mita S. Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells. Immunol Lett 1999, 68, 275–279.
   PubMed Web of Science ®Google Scholar
• Dunne A, O’Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense. Sci STKE (2003), 171, re3.
   Google Scholar
• Tsuji F, Seki I, Aono H, Odani N, Mizutani K, Okamoto M, Sasano M. Bucillamine mechanism inhibiting IL-1β-induced VEGF production from fibroblast-like synoviocytes. Int Immunopharmacol 2007, 7, 1569–1576.
   PubMed Web of Science ®Google Scholar
• Zhang HG, Wang Y, Xie JF, Liang X, Liu D, Yang P, Hsu HC, Ray RB, Mountz JD. Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis Rheum 2001, 44, 1555–1567.
   PubMed Web of Science ®Google Scholar
• Hashiramoto A, Sakai C, Yoshida K, Tsumiyama K, Miura Y, Shiozawa K, Nose M, Komai K, Shiozawa S. Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt. Arthritis Rheum 2007, 56, 2170–2179.
   PubMed Web of Science ®Google Scholar
• Chergui F, Chrétien AS, Bouali S, Ramacci C, Rouyer M, Bastogne T, Genin P, Leroux A, Merlin JL. Validation of a phosphoprotein array assay for characterization of human tyrosine kinase receptor downstream signaling in breast cancer. Clin Chem 2009, 55, 1327–1336.
   PubMed Web of Science ®Google Scholar
• Concannon CG, Gorman AM, Samali A. On the role of Hsp27 in regulating apoptosis. Apoptosis 2003, 8, 61–70.
   PubMed Web of Science ®Google Scholar
• Lavoie JN, Lambert H, Hickey E, Weber LA, Landry J. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol Cell Biol 1995, 15, 505–516.
   PubMedGoogle Scholar
• Stokoe D, Engel K, Campbell DG, Cohen P, Gaestel M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett 1992, 313, 307–313.
   PubMed Web of Science ®Google Scholar
• Ludwig S, Engel K, Hoffmeyer A, Sithanandam G, Neufeld B, Palm D, Gaestel M, Rapp UR. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Mol Cell Biol 1996, 16, 6687–6697.
   PubMed Web of Science ®Google Scholar
• Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 1994, 78, 1039–1049.
   PubMed Web of Science ®Google Scholar
• Maizels ET, Peters CA, Kline M, Cutler RE Jr, Shanmugam M, Hunzicker-Dunn M. Heat-shock protein-25/27 phosphorylation by the delta isoform of protein kinase C. Biochem J 1998, 332 (Pt 3), 703–712.
   PubMed Web of Science ®Google Scholar
• Kato K, Ito H, Iwamoto I, Lida K, Inaguma Y. Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. Cell Stress Chaperones 2001, 6, 16–20.
   PubMed Web of Science ®Google Scholar
• Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378, 785–789.
   PubMed Web of Science ®Google Scholar
• Dugo L, Collin M, Allen DA, Patel NS, Bauer I, Mervaala EM, Louhelainen M, Foster SJ, Yaqoob MM, Thiemermann C. GSK-3β inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Crit Care Med 2005, 33, 1903–1912.
   PubMed Web of Science ®Google Scholar
• Etienne-Manneville S, Hall A. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 2003, 421, 753–756.
   PubMed Web of Science ®Google Scholar
• Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S. I κ B-β regulates the persistent response in a biphasic activation of NF-κ B. Cell 1995, 80, 573–582.
   PubMed Web of Science ®Google Scholar
• Schmidt C, Peng B, Li Z, Sclabas GM, Fujioka S, Niu J, Schmidt-Supprian M, Evans DB, Abbruzzese JL, Chiao PJ. Mechanisms of proinflammatory cytokine-induced biphasic NF-κB activation. Mol Cell 2003, 12, 1287–1300.
   PubMed Web of Science ®Google Scholar
• Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X. Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFκB activation pathways bifurcate at IL-1 receptor-associated kinase modification. J Biol Chem 2007, 282, 6075–6089.
   PubMed Web of Science ®Google Scholar
• Ramachandiran S, Huang Q, Dong J, Lau SS, Monks TJ. Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem Res Toxicol 2002, 15, 1635–1642.
   PubMed Web of Science ®Google Scholar
• Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol 2009, 83, 11665–11672.
   PubMed Web of Science ®Google Scholar
• Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 2003, 4, 463–476.
   PubMed Web of Science ®Google Scholar
• Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL. IκB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci USA 2011, 108, 6474–6479.
   PubMed Web of Science ®Google Scholar
• Oki K, Tsuji F, Ohashi K, Kageyama M, Aono H, Sasano M. The investigation of synovial genomic targets of bucillamine with microarray technique. Inflamm Res 2009, 58, 571–584.
   PubMed Web of Science ®Google Scholar