346
Views
2
CrossRef citations to date
0
Altmetric
Review Article

The signaling pathway of uromodulin and its role in kidney diseases

, &
Pages 440-444 | Received 15 Mar 2014, Accepted 28 Apr 2014, Published online: 22 May 2014

References

  • Serafini-Cessi F, Malagolini N, Cavallone D. Tamm–Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 2003;42:658–76
  • Hoyer JR, Sisson SP, Vernier RL. Tamm-Horsfall glycoprotein: ultrastructural immunoperoxidase localization in rat kidney. Lab Invest 1979;41:168–73
  • Pennica D, Kohr WJ, Kuang WJ, et al. Identification of human uromodulin as the Tamm–Horsfall urinary glycoprotein. Science 1987;236:83–8
  • Wei X, Xu R, Yang Z, et al. Novel uromodulin mutation in familial juvenile hyperuricemic nephropathy. Am J Nephrol 2012;36:114–20
  • Han J, Liu Y, Rao F, et al. Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Kidney Int 2013;83:733–40
  • Köttgen A, Hwang SJ, Larson MG, et al. Uromodulin levels associate with a common UMOD variant and risk for incident CKD. J Am Soc Nephrol 2010;21:337–44
  • Torffvit O, Kamper AL, Strandgaard S. Tamm–Horsfall protein in urine after uninephrectomy/transplantation in kidney donors and their recipients. Scand J Urol Nephrol 1997;31:555–9
  • Sejdiu I, Torffvit O. Decreased urinary concentration of Tamm–Horsfall protein is associated with development of renal failure and cardiovascular death within 20 years in type 1 but not in type 2 diabetic patients. Scand J Urol Nephrol 2008;42:168–74
  • Campanello M, Herlitz H, Hultberg B, et al. Serum levels of IgG antibodies against Tamm–Horsfall protein and urinary excretion of NAG and alpha-1-microglobulin as possible markers for tubular damage in patients with a continent ileal reservoir for urinary diversion. Scand J Urol Nephrol 1997;31:237–43
  • Bates JM, Raffi HM, Prasadan K, et al. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 2004;65:791–7
  • Zhou TB, Qin YH. The potential mechanism for the different expressions of gelatinases induced by all-trans retinoic acid in different cells. J Recept Signal Transduct Res 2012;32:129–33
  • Zhou TB. Signaling pathways of PAX2 and its role in renal interstitial fibrosis and glomerulosclerosis. J Recept Signal Transduct Res 2012;32:285–9
  • Lhotta K. Uromodulin and chronic kidney disease. Kidney Blood Press Res 2010;33:39–398
  • Wu CH, Li KJ, Siao SC, et al. The binding affinity and molecular basis of the structure–binding relationship between urinary Tamm–Horsfall glycoprotein and tumor necrosis factor-α. Molecules 2012;17:11978–89
  • Muchmore AV. Uromodulin: an immunoregulatory glycoprotein isolated from pregnancy urine that binds to and regulates the activity of interleukin 1. Am J Reprod Immunol Microbiol 1986;11:89–93
  • Lambert C, Brealey R, Steele J, et al. The interaction of Tamm–Horsfall protein with the extracellular matrix. Immunology 1993;79:203–10
  • Shen HL, Xu ZG, Huang LY, et al. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. Mol Cell Biochem 2009;321:73–83
  • Mutig K, Kahl T, Saritas T, et al. Activation of the bumetanide-sensitive Na+, K+, 2Cl− cotransporter (NKCC2) is facilitated by Tamm–Horsfall protein in a chloride-sensitive manner. J Biol Chem 2011;286:30200–10
  • Gokhale JA, McKee MD, Khan SR. Immunocytochemical localization of Tamm–Horsfall protein in the kidneys of normal and nephrolithic rats. Urol Res 1996;24:201–9
  • Rhodes DC, Hinsman EJ, Rhodes JA. Tamm–Horsfall glycoprotein binds IgG with high affinity. Kidney Int 1993;44:1014–21
  • Renigunta A, Renigunta V, Saritas T, et al. Tamm–Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. J Biol Chem 2011;286:2224–35
  • Menozzi FD, Debrie AS, Tissier JP, et al. Interaction of human Tamm–Horsfall glycoprotein with Bordetella pertussis toxin. Microbiology 2002;148:1193–201
  • Rhodes DC. Importance of carbohydrate in the interaction of Tamm–Horsfall protein with complement 1q and inhibition of classical complement activation. Immunol Cell Biol 2006;84:357–65
  • Dulawa J, Rambausek M, Jann K, et al. Abnormal radiofurosemide binding by Tamm Horsfall glycoprotein of diabetic patients. Diabetologia 1985;28:827–30
  • Guidi E, Giglioni A, Cozzi MG, et al. Which urinary proteins are decreased after angiotensin converting – enzyme inhibition? Ren Fail 1998;20:243–8
  • Huang HS, Chen J, Chen CF, et al. Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors. Kidney Int 2006;70:699–710
  • Srivastava R, Micanovic R, El-Achkar TM, et al. An intricate network of conserved DNA upstream motifs and associated transcription factors regulate the expression of uromodulin gene. J Urol 2014. [Epub ahead of print]. doi:10.1016/j.juro.2014.02.095
  • El-Achkar TM, Huang X, Plotkin Z, et al. Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney. Am J Physiol Renal Physiol 2006;290:1034–43
  • Chen YS, Hu QH, Zhang X, et al. Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. Pharmacology 2013;92:75–83
  • Darisipudi MN, Thomasova D, Mulay SR, et al. Uromodulin triggers IL-1β-dependent innate immunity via the NLRP3 inflammasome. J Am Soc Nephrol 2012;23:1783–9
  • Liu Y, El-Achkar TM, Wu XR. Tamm–Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap. J Biol Chem 2012;287:16365–78
  • Siao SC, Li KJ, Hsieh SC, et al. Tamm–Horsfall glycoprotein enhances PMN phagocytosis by binding to cell surface-expressed lactoferrin and cathepsin G that activates MAP kinase pathway. Molecules 2011;16:2119–34
  • Säemann MD, Weichhart T, Zeyda M, et al. Tamm–Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005;115:468–75
  • Yu CL, Tsai CY, Lin WM, et al. Tamm–Horsfall urinary glycoprotein enhances monokine release and augments lymphocyte proliferation. Immunopharmacology 1993;26:249–58
  • Wolf MT, Wu XR, Huang CL. Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis. Kidney Int 2013;84:130–7
  • Wang W, Tang Y, Ni L, et al. Overexpression of uromodulin-like 1 accelerates follicle depletion and subsequent ovarian degeneration. Cell Death Dis 2012;3:e433
  • Han J, Liu Y, Rao F, et al. Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Kidney Int 2013;83:733–40
  • Takiue Y, Hosoyamada M, Kimura M, et al. Enhancement of androgen action in the kidneys of transgenic mice harboring the mutant human UMOD gene. J Pharmacol Sci 2011;115:383–9
  • Viswanathan P, Rimer JD, Kolbach AM, et al. Calcium oxalate monohydrate aggregation induced by aggregation of desialylated Tamm–Horsfall protein. Urol Res 2011;39:269–82
  • Schmid M, Prajczer S, Gruber LN, et al. Uromodulin facilitates neutrophil migration across renal epithelial monolayers. Cell Physiol Biochem 2010;26:311–8
  • El-Achkar TM, Wu XR, Rauchman M, et al. Tamm–Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression. Am J Physiol Renal Physiol 2008;295:F534–44
  • Pfistershammer K, Klauser C, Leitner J, et al. Identification of the scavenger receptors SREC-I, Cla-1 (SR-BI), and SR-AI as cellular receptors for Tamm–Horsfall protein. J Leukoc Biol 2008;83:131–8
  • Serafini-Cessi F, Monti A, Cavallone D. N-Glycans carried by Tamm–Horsfall glycoprotein have a crucial role in the defense against urinary tract diseases. Glycoconj J 2005;22:383–94
  • Stein P, Rajasekaran M, Parsons CL. Tamm–Horsfall protein protects urothelial permeability barrier. Urology 2005;66:903–7
  • Raffi HS, Bates JM Jr, Laszik Z, et al. Tamm–Horsfall protein acts as a general host-defense factor against bacterial cystitis. Am J Nephrol 2005;25:570–8
  • Kreft B, Jabs WJ, Laskay T, et al. Polarized expression of Tamm–Horsfall protein by renal tubular epithelial cells activates human granulocytes. Infect Immun 2002;70:2650–6
  • Zbikowska HM, Soukhareva N, Behnam R, et al. Uromodulin promoter directs high-level expression of biologically active human alpha1-antitrypsin into mouse urine. Biochem J 2002;365:7–11
  • Renigunta A, Renigunta V, Saritas T, et al. Tamm–Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. J Biol Chem 2011;286:2224–35
  • Fletcher AP, Neuberger A, Ratcliffe WA, et al. Tamm–Horsfall urinary glycoprotein. The chemical composition. Biochem J 1970;120:417–24
  • Edyvane KA, Hibberd CM, Harnett RM, et al. Macromolecules inhibit calcium oxalate crystal growth and aggregation in whole human urine. Clin Chim Acta 1987;167:329–38
  • Yoshida T, Kurella M, Beato F, et al. Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Kidney Int 2002;61:1646–54
  • Bachmann S, Mutig K, Bates J, et al. Renal effects of Tamm–Horsfall protein (uromodulin) deficiency in mice. Am J Physiol Renal Physiol 2005;288:559–67
  • El-Achkar TM, McCracken R, Liu Y, et al. Tamm–Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury. Am J Physiol Renal Physiol 2013;304:1066–75
  • Srichai MB, Hao C, Davis L, et al. Apoptosis of the thick ascending limb results in acute kidney injury. J Am Soc Nephrol 2008;19:1538–46
  • Mo L, Liaw L, Evan AP, et al. Renal calcinosis and stone formation in mice lacking osteopontin, Tamm–Horsfall protein, or both. Am J Physiol Renal Physiol 2007;293:1935–43
  • Raffi H, Bates J, Kumar S, et al. Tamm–Horsfall protein knockout mice have increased stress induced micturition. Neurourol Urodyn 2009;28:469–78
  • Qu Y, Du E, Zhang Y, et al. Changes in the expression of bone morphogenetic protein 7 and Tamm–Horsfall protein in the early stages of diabetic nephropathy. Nephrourol Mon 2012;4:466–9
  • Prajczer S, Heidenreich U, Pfaller W, et al. Evidence for a role of uromodulin in chronic kidney disease progression. Nephrol Dial Transplant 2010;25:1896–903
  • Trudu M, Janas S, Lanzani C, et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med 2013;19:1655–60
  • Kemter E, Rathkolb B, Rozman J, et al. Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol 2009;297:1391–8
  • Turner JJ, Stacey JM, Harding B, et al. Uromodulin mutations cause familial juvenile hyperuricemic nephropathy. J Clin Endocrinol Metab 2003;88:1398–401
  • Sato K, Oguchi H, Yoshie T, et al. Tubulointerstitial nephritis induced by Tamm–Horsfall protein sensitization in guinea pigs. Virchows Arch B Cell Pathol Incl Mol Pathol 1990;58:357–63

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.