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- , For each of n ligands there are m! potential orderings of its potency for the m sites, or altogether, (m!)n orderings. This number must be reduced by the m! permutations of the m binding sites. Thus, there are (m!)n-1 distinct patterns for n ligands, based only on the order of potency. Consistent patterns with many ligands become highly unlikely, unless the true multiple binding site model has been observed