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Journal of Receptor Research Volume 4, 1984 - Issue 1-6
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Research Article

Effects of Temperature and Allosteric Modulators on [3H]Nitrendipine Binding: Methods for Detecting Potential Ca2+ Channel Blockers

M. Holck Pharmaceutical Research Department, F. Hoffmann-La Roche and Co., Ltd., CH-4002, Basel, Switzerland
,
W. Fischli Pharmaceutical Research Department, F. Hoffmann-La Roche and Co., Ltd., CH-4002, Basel, Switzerland
&
U. Hengartner Pharmaceutical Research Department, F. Hoffmann-La Roche and Co., Ltd., CH-4002, Basel, Switzerland
Pages 557-569 | Published online: 26 Sep 2008

References

  • Holck M., Thorens S., Haeusler G. Characterization of[3H]nifedipine binding sites in rabbit myocardium, Eur. J. Pharmacol. 1982; 85: 305–315
  • Holck M., Thorens S., Haeusler G. Does [3H]nifedipine label the calcium channel in rabbit myocardium?. J. Receptor Res. 1983; 3: 191–198
  • Bellemann P., Ferry D., Lübbecke F., Glossmann H. [3H] Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes. Arzneim.-Forsch. 1981; 31: 2064–2067
  • Ehlert F. J., Roeske W. R., Itoga E., Yamamura H. I. The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats. Life Sci. 1982; 30: 2192–2202
  • Ferry D. R., Glossmann H. Identification of putative calcium channels in skeletal muscle microsomes. FEBS Lett. 1982; 148: 331–337
  • Murphy K. M.M., Gould R. J., Largent B. L., Snyder S. H. A unitary mechanism of calcium antagonist drug action. Proc. Natl. Acad. Sci. USA 1983; 80: 860–864
  • Marsh J. D., Loh E., Lachance D., Barry W. H., Smith T. W. Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells, Circ. Res. 1983; 53: 539–543
  • Schramm M., Thomas G., Towart R., Franckowiak G. Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature 1983; 303: 535–537
  • Morita T., Yoshino K., Kanazawa T., Ito K., Nose T. Vasodilator action of KB-944, a new calcium antagonist. Arzneim -Forsch. 1982; 32: 1037–1042
  • De Pover A., Matlib M. A., Lee S. W., Dube G. P., Grupp I. L., Grupp G., Schwartz A. Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem, Biochem. Biophys. Res. Comm. 1982; 108: 110–117
  • Weiland G. A., Minneman K. P., Molinoff P. B. Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor. Nature 1979; 281: 114–117
  • Yamamura H. I., Schoemaker H., Boles R. G., Roeske W. R. Diltiazem enhancement of [3H]nitrendipine binding to calcium channel associated drug receptor sites in rat brain synapto-somes, Biochem. Biophys. Res. Comm. 1982; 108: 640–646

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