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Research Article

Discrepancies in the Specific Activity of 3H-N-Methylscopolamine as Determined by Mass Spectrometry and Radioreceptor Assay due to Racemisation

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Pages 871-883 | Published online: 26 Sep 2008

References

  • Munson P. J., Rodbard D. LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 1980; 107: 220–239
  • Brown J. H., Goldstein D. Analysis of cardiac muscarinic receptors recognized selectively by nonquaternary but not by quaternary ligands. J. Pharmacol. Exp. Ther. 1986; 238: 580–586
  • Ensing K., In't Hout W. G., De Zeeuw R. A. Lyophilised receptor preparation for a radioreceptor assay for anticholinergics. Anal. Letters 1987; 20: 489–502
  • El-Fakahany E. E., Ramkumar V., Lai W. S. Multiple binding sites of N-methyl scopolamine to brain muscarinic acetylcholine receptors: Differentiation from M and M2 receptor subtypes. J. Pharmacol. Exp. Ther. 1986; 238: 554–563
  • Burgisser E. Methods for the determination of the specific radioactivity of radioligands. J. Rec. Res. 1984; 4: 357–369
  • Cheng Y.-C., Prusoff W. H. Relation between the inhibition constant (Ki) and the concentration of inhibition which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 1973; 22: 3099–3108
  • van der Greef J., Nibbering N. M.M. Detection of unimolecular gas phase decompositions of ions, generated upon field desorption, in the time range of 10-11 - 10-9 s. Int. J. Mass Spectrom. 1977; 25: 357–359
  • Rabrenovic M., Ast M., Kramer V. Alternative organic substances for generation of carbon emitters for field desorption mass spectrometry. Int. J. Mass Spectrom. Ion Phys. 1981; 37: 297–307
  • Beckey H. D., Heindrichs A., Winkler H. U. Some new field desorption techniques. Int. J. Mass Spectrom. Ion Phys. 1970; 3: 9–11
  • Barlow R. B., Franks F. M., Pearson J. D.M. Studies on the stereospecificity of closely related compounds which blocked postganglionic acetylcholine receptors in the guinea-pig ileum. J. Med. Chem. 1973; 16: 439–446
  • Hulme E. C., Birdsall N. J.M., Burgen A. S.V., Mehta P. The binding of antagonists to brain muscarinic receptors. Mol. Pharmacol. 1978; 14: 737–750

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