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Research Article

Characterization of Human Striatal A2-Adenosine Receptors Using Radioligand Binding and Photoaffinity Labeling

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Pages 149-169 | Published online: 26 Sep 2008

References

  • Lohse M. J., Elger B., Lindenborn-Fotinos J., Klotz K.-N., Schwabe U. Separation of solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA binding sites by gel filtration. Naunyn-Schmiedeberg's Arch. Pharmacol. 1988; 337: 64–68
  • Olsson R. A., Pearson J. D. Cardiovascular purinoceptors. Physiol. Rev. 1990; 70: 761–845
  • Hutchison A. J., Webb R. L., Oei H. H., Ghai G. R., Williams M. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther. 1989; 251: 47–55
  • Phillis J. W. Purines in Cellular Signalling: Targets for New Drugs, K. Jacobson, J. Daly, V. Manganiello. Springer-Verlag, New York, NY 1990; 41–47
  • Jarvis M. F., Jackson R. H., Williams M. Autoradiographic characterization of high affinity adenosine A2 receptors in the rat brain. Brain Res. 1989; 484: 111–118
  • Nikodijevic O., Daly J. W., Jacobson K. A. Characterization of the locomotor depression produced by an A2-selective adenosine agonist. FEBS Letters 1990; 261: 67–70
  • Barrington W. W., Jacobson K. A., Williams M., Hutchison A. J., Stiles G. L. Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking. Proc. Nat. Acad. Sci. USA 1989; 86: 6572–6576
  • Barrington W. W., Jacobson K. A., Stiles G. L. The glycoprotein nature of the A2 adenosine receptor binding subunit. Mol. Pharmacol. 1990; 38: 177–183
  • Nanoff C., Jacobson K. A., Stiles G. L. The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis. Mol. Pharmacol. 1991; 39: 130–135
  • Maenhaut C., van Sande J., Libert F., Abramowicz M., Parmentier M., Vanderhaegen J.-J., Dumont J. E., Vassart G., Schiffmann S. RDC8 codes for an adenosine A2 receptor with physiological constitutive activity. Biochem. Biophys. Res. Comm. 1990; 173: 1169–1178
  • Jacobson K. A., Kirk K. L., Padgett W. L., Daly J. W. Functionalized congeners of adenosine: Preparation of analogues with high affinity for adenosine receptors. J. Med. Chem. 1985; 28: 1341–1346
  • Jacobson K. A., Barrington W. W., Pannell L. K., Jarvis M. F., Ji X.-D., Williams M., Hutchison A. J., Stiles G. L. Agonist-derived molecular probes for A2-adenosine receptors. J. Mol. Recognition 1989; 2: 170–178
  • Bruns R. F., Fergus J. H., Badger E. W., Bristol J. A., Santay L. A., Hays S. J. PD 115 199: an antagonist ligand for adenosine A2 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 1987; 335: 64–69
  • Bruns R. F. Purines in Cellular Signalling: Targets for New Drugs, K. Jacobson, J. Daly, V. Manganiello. Springer-Verlag, New York, NY 1990; 126–135
  • Williams M., Francis J. E., Ghai G. R., Braunwalder A., Psychyos S., Stone G. A., Cash W. D. Biochemical characterization of the triazoloquinazoline, CGS 15943 a novel non-xanthine adenosine antagonist. J. Pharmacol. Exp. Ther. 1987; 241: 415–420
  • Sarges R., Howard H. R., Browne R. G., Lebel L. A., Seymour P. A., Koe B. K. 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines – a novel class of potent adenosine receptor antagonists and potential rapid onset anti-depressants. J. Med. Chem. 1990; 33: 2240–2254
  • Jarvis M. F., Schutz R., Hutchison A. J., Do E., Sills M. A., Williams M. [3H]CGS 21680 an A2 selective adenosine receptor agonist directly labels A2 receptors in rat brain tissue. J. Pharmacol. Exp. Ther. 1989; 251: 888–893
  • Jacobson K. A., Ukena D., Kirk K. L., Daly J. W. [3H]Xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors. Proc. Natl. Acad. Sci. U. S. A. 1986; 83: 4089–4093
  • Ukena D., Jacobson K. A., Kirk K. L., Daly J. W. A [3H]amine congener of 1,3-dipropyl-8-phenyl xanthine – a new radioligand for A2 adenosine receptors of human platelets. FEBS Lett. 1986; 199: 269–274
  • Ji X.-D., Stiles G. L., Jacobson K. A. [3H]XAC (xanthine amine congener) is a radioligand for A2-adenosine receptors in rabbit striatum. Neurochem. Internat. 1991; 18: 207–213
  • Cheng Y.-C., Prusoff W. H. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzyme reaction. Biochem. Pharmacol. 1973; 22: 3099–3108
  • Ramkumar V., Barrington W. W., Jacobson K. A., Stiles G. L. Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells. Mol. Pharmacol. 1990; 37: 149–156
  • Bruns R. F., Lu G. H., Pugsley T. A. Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes. Mol. Pharmacol. 1986; 29: 331–346
  • Deckert J., Morgan P. F., Bisserbe J. C., Jacobson K. A., Kirk K. L., Daly J. W., Marangos P. J. Autoradiographic localization of mouse brain adenosine receptors with an antagonist ([3H]xanthine amine congener) ligand probe. Neurosci. Lett. 1988; 86: 121–126
  • Reynaud D., Gharib A., Lagarde M., Sarda M. Characterization of A-2 receptors in postmortem human pineal gland. J. Neurochem. 1990; 55: 1316–1321
  • Wan W., Sutherland G. R., Geiger J. D. Binding of the adenosine A2 receptor ligand [3H]CGS21680 to human and rat brain: Evidence for multiple affinity sites. J. Neurochem 1990; 55: 1763–1771
  • Stone G. A., Jarvis M. F., Sills M. A., Weeks B., Snowhill E. W., Williams M. Species differences in high-affinity adenosine A2 binding sites in striatal membranes from mammalian brain. Drug Devel. Res. 1988; 15: 31–46
  • Ferkany J. W., Valentine H. L., Stone G. A., Williams M. Adenosine A1 receptors in mammalian brain: species differences in their interactions with agonists and antagonists. Drug Dev. Res. 1986; 9: 85–93
  • Nakata H. Purification of the A1-adenosine receptor from rat brain membranes. J. Biol. Chem. 1989; 264: 16545–16551
  • Olah M. E., Jacobson K. A., Stiles G. L. Purification and characterization of bovine cerebral cortex A1 adenosine receptor. Arch. Biochem. Biophys. 1991; 283: 440–446
  • Bridges A. J., Bruns R. F., Ortwine D. G., Pribe S. R., Szotek D. L., Trivedi B. K. N6-[2(3,5-dimethoxyphenyl)-2-(2-methylphenyl)-ethyl]-adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. J. Med. Chem. 1988; 31: 1282–1285
  • Lohse M. J., Klotz K.-N., Schwabe U., Cristalli G., Vittori S., Grifantini M. 2-Chloro-N6-Cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 1988; 337: 687–689
  • Cooper D. M. F. Adenosine Receptors, D. Cooper, C. Londos. Alan R. Liss, Inc., New York, NY 1987; 63–74

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