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Journal of Receptors and Signal Transduction Volume 15, 1995 - Issue 1-4
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Research Article

Pharmacological and Functional Characterisation of the Wild—Type and Site—Directed Mutants of the Human H1 Histamine Receptor Stably Expressed in CHO Cells

N. Moguilevsky Laboratory of Applied Genetics, Université Libre de Bruxelles, 24 rue de l'Industrie, B 1400, Nivelles, Belgium
,
F. Varsalona Laboratory of Applied Genetics, Université Libre de Bruxelles, 24 rue de l'Industrie, B 1400, Nivelles, Belgium
,
J.-P. Guillaume Laboratory of Applied Genetics, Université Libre de Bruxelles, 24 rue de l'Industrie, B 1400, Nivelles, Belgium
,
M. Noyer UCB S.A. Pharma Sector, chemin du Foriest, B 1420, Braine-l'Alleud, Belgium
,
M. Gillard UCB S.A. Pharma Sector, chemin du Foriest, B 1420, Braine-l'Alleud, Belgium
,
J. Daliers UCB S.A. Pharma Sector, chemin du Foriest, B 1420, Braine-l'Alleud, Belgium
,
J.-P. Hénichart UCB S.A. Pharma Sector, chemin du Foriest, B 1420, Braine-l'Alleud, Belgium
&
A. Bollen Laboratory of Applied Genetics, Université Libre de Bruxelles, 24 rue de l'Industrie, B 1400, Nivelles, Belgium
 show all
Pages 91-102 | Published online: 26 Sep 2008

References

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  • Moguilevsky N., Varsalona F., Noyer M., Gillard M., Guillaume J.-P., Garcia L., Szpirer C., Szpirer J., Bollen A. Stable expression of human H1 histamine receptor cDNA in Chinese hamster ovary cells: pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. Eur. J. Biochem., in press
  • Chang R. S. L., Tran V. T., Snyder S. H. Heterogeneity of histamine H1- receptors: species variations in [3H]mepyramine binding of brain membranes. J. Neurochem. 1979; 32: 1653–1663
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  • Beaven A., Moore J. P., Smith G. A., Hesketh T. R., Metcalfe J. C. The Calcium Signal and Phosphatidylinositol Breakdown in 2H3 Cells. J. Biol. Chem. 1984; 259: 7137–7142
  • Gantz I., DelValle J., Wang L., Tashiro T., Munzert G., Guo Y., Konda Y., Yamada T. Molecular Basis for Interaction of Histamine with the Histamine H2 Receptor. J. Biol. Chem. 1992; 267: 20840–20843
  • Hibert M., Trumpp-Kallmeyer S., Bruivels A., Hoflack J. Three Dimensional Models of Neurotransmitter G-binding Protein-Coupled Receptors. Mol. Pharmacol. 1991; 40: 8–15
  • De Backer M. D., Gommeren W., Moereels H., Nobels G., Van Gompel P., Leysen J. E., Luyten W. H. M. L. Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. Biochem. Biophys. Res. Comm. 1993; 197: 1601–1608

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