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Journal of Receptors and Signal Transduction Volume 15, 1995 - Issue 1-4
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Research Article

In Vitro Receptor Binding Characteristics of the New Dopamine D2 Antagonist [125I]NCO-298: Methodological Considerations of High Affinity Binding

E. Jerning Department of Neuropharmacology, CNS Preclinical R & D, Astra Arcus AB, S-151 85, Södertälje, Sweden
,
Å. Malmberg Department of Neuropharmacology, CNS Preclinical R & D, Astra Arcus AB, S-151 85, Södertälje, Sweden
&
N. Mohell Department of Neuropharmacology, CNS Preclinical R & D, Astra Arcus AB, S-151 85, Södertälje, Sweden
Pages 503-515 | Published online: 26 Sep 2008

References

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  • Malmberg Å.H., Jackson D. M., Hacksell U., Johansson A. M., Eriksson A-M., Mohell N. A. Pharmacological characterization of human dopamine D2A, D2B and D3 receptors. Soc. Neurosci. Abstr. 1992; 18: 1171
  • Högberg T., Ström P., Hall H., Köhler C., Halldin C., Farde L. Synthesis of [123I]-, [125I]- and unlabelled (S)-3-iodo-5,6-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]salicylamide (NCQ 298). selective ligands for the study of dopamine D-2 receptors. Acta Pharm. Nord. 1990; 2: 53–60
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  • Neve K. A., Henningsen R. A., Kinzie J. M., De Paulis T., Schmidt D. E., Kessler R. M., Janowsky A. Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride. a high-affinity substituted benzamide ligand. J. Pharmacol. Exp. Ther. 1990; 252: 1108–1116
  • Niznik H. B., Grigoriadis D. E., Pri-Bar I., Buchman O., Seeman P. Dopamine D2 receptors selectively labeled by a benzamide neuroleptic: [3H]-YM-09151-2. Naunyn-Schmiedeberg's Arch. Pharmacol. 1985; 329: 333–343
  • Hulme E. C., Birdsall N. J.M. Receptor-Ligand Interactions: A Practical Approach, E. C. Hulme. Oxford University Press, New York 1992

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