Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5′UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in Alzheimer's Disease

References

• Abecasis, G. R., Cookson, W. O. (2000). GOLD–graphical overview of linkage disequilibrium. Bioinformatics, 16(2):182–183.
   PubMed Web of Science ®Google Scholar
• Agbas, A., Zaidi, A., Michaelis, E. K. (2005). Decreased activity and increased aggregation of brain calcineurin during aging. Brain Research, 1059(1):59–71.
   PubMedGoogle Scholar
• Biala, G., Betancur, C., Mansuy, I. M., Giros, B. (2005). The reinforcing effects of chronic D-amphetamine and morphine are impaired in a line of memory-deficient mice overexpressing calcineurin. European Journal of Neuroscience, 21(11):3,089–3,096.
   Google Scholar
• Brion, J. P., Couck, A. M., Conreur, J. L. (1995). Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease. Neurodegeneration, 4(1):13–21.
   PubMedGoogle Scholar
• Celsi, F., (2007). Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress. Neurobiology of Disease, 26(2):342–352.
   PubMedGoogle Scholar
• Gerber, D. J., (2003). Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proceedings of the National Academy of Sciences of the United States of America, 100(15):8,993–8,998.
   Google Scholar
• Gerdjikov, T. V., Beninger, R. J. (2005). Differential effects of calcineurin inhibition and protein kinase A activation on nucleus accumbens amphetamine-produced conditioned place preference in rats. European Journal of Neuroscience, 22(3):697–705.
   PubMedGoogle Scholar
• Gong, C. X., Liu, F., Grundke-Iqbal, I., Iqbal, K. (2006). Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target. Journal of Biomedical and Biotechnology, 2006(3):31,825.
   Google Scholar
• Guerini, D., Klee, C. B. (1989). Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. Proceedings of the National Academy of Sciences of the United States of America, 86(23):9,183–9,187.
   Google Scholar
• Johnson, C. (2006). Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. American Journal of Medical Genetics Part B: Neuropsychiatry Genetics, 141B(8):844–853.
   Google Scholar
• Kincaid, R. L., (1990). Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. Journal of Biological Chemistry, 265(19):11,312–11,319.
   Google Scholar
• Klee, C. B., Crouch, T. H., Krinks, M. H. (1979). Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proceedings of the National Academy of Sciences of the United States of America, 76(12):6,270–6,273.
   Google Scholar
• Lian, Q., Ladner, C. J., Magnuson, D., Lee, J. M. (2001). Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex. Experimental Neurology, 167(1):158–165.
   PubMedGoogle Scholar
• Liu, F., Grundke-Iqbal, I., Iqbal, K., Oda, Y., Tomizawa, K., Gong, C. X. (2005a). Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. Journal of Biological Chemistry, 280(45):37,755–37,762.
   Google Scholar
• Liu, Q. R., (2005b). Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. Proceedings of the National Academy of Sciences of the United States of America, 102(33):11,864–11,869.
   Google Scholar
• Liu, Q. R., Lu, L., Zhu, X. G., Gong, J. P., Shaham, Y., Uhl, G. R. (2006). Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Research, 1067(1):1–12.
   PubMed Web of Science ®Google Scholar
• Malleret, G., (2001). Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell, 104(5):675–686.
   PubMed Web of Science ®Google Scholar
• Mansuy, I. M., Mayford, M., Jacob, B., Kandel, E. R., Bach, M. E. (1998). Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell, 92(1):39–49.
   PubMed Web of Science ®Google Scholar
• Norris, C. M., (2005). Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. Journal of Neuroscience, 25(18):4,649–4,658.
   Google Scholar
• Reuter, A., Mi, J., Sehrsam, I., Ludolph, A. C., Volkel, H. (2001). A novel calcineurin splice variant that modifies calcineurin activity. European Journal of Biochemistry, 268(22):5,955–5,960.
   Google Scholar
• Stephens, M., Donnelly, P. (2003). A comparison of Bayesian methods for haplotype reconstruction from population genotype data. American Journal of Human Genetics, 73(5):1,162–1,169.
   Google Scholar
• Stephens, M., Smith, N. J., Donnelly, P. (2001). A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics, 68(4):978–989.
   PubMed Web of Science ®Google Scholar
• Uhl, G. R., Liu, Q. R., Walther, D., Hess, J., Naiman, D. (2001). Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. American Journal of Human Genetics, 69(6):1,290–1,300.
   Google Scholar
• Winder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M., Kandel, E. R. (1998). Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell, 92(1):25–37.
   PubMedGoogle Scholar
• Yakel, J. L. (1997). Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription. Trends in Pharmacological Sciences, 18(4):124–34.
   PubMedGoogle Scholar