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Research Article

Design and characterization of chitosan-alginate microspheres for ocular delivery of azelastine

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Pages 813-823 | Received 04 Apr 2013, Accepted 27 Jul 2013, Published online: 13 Sep 2013

References

  • Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Adv Drug Deliver Rev 2005;57:1595–1639
  • Gaudana R, Jwala J, Boddu SHS, Mitra AK. Recent perspectives in ocular drug delivery. Pharm Res 2009;26:1197–1216
  • Barar J, Javadzadeh AR, Omidi Y. Ocular novel drug delivery: impacts of membranes and barriers. Expert Opin Drug Deliv 2008;5:567–581
  • Duvvuri S, Majumdar S, Mitra AK. Role of metabolism in ocular drug delivery. Curr Drug Metab 2004;5:507–515
  • Macha S, Hughes P, Mitra AK. Overview of ocular drug delivery. In: Mitra AK, ed. Ophthalmic drug delivery systems. New York: Marcel Dekker; 2003:1–12
  • Urtti A, Salminen L. Minimizing systemic absorption of topically administered ophthalmic drugs. Surv Ophthalmol 1993;37:435–456
  • Araújo J, Vega E, Lopes C, et al. Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres. Colloid Surface B 2009;72:48–56
  • Joshi A. Microparticulates for ophthalmic drug delivery. J Ocul Pharmacol Th 1994;10:29–45
  • Nagda C, Chotai NP, Patel U, et al. Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac. Drug Dev Ind Pharm 2009;35:1155–1166
  • Henriksen I, Green KL, Smart JD, et al. Bioadhesion of hydrated chitosans: an in vitro and in vivo study. Int J Pharm 1996;145:231–240
  • Sogias IA, Williams AC, Khutoryanskiy VV. Why is chitosan mucoadhesive? Biomacromolecules 2008;9:1837–1842
  • Van der Merwe SM, Verhoef JC, Verheijden JHM, et al. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur J Pharm Biopharm 2004;58:225–235
  • Mucha M. Rheological characteristics of semi dilute chitosan solutions. Macromol Chem Physic 1997;198:471–484
  • Singh KH, Shinde UA. Development and evaluation of novel polymeric nanoparticles of brimonidine tartrate. Curr Drug Del 2010;7:244–251
  • Lee KY, Park WH, Ha WS. Polyelectrolyte complexes of sodium alginate with chitosan or its derivatives for microcapsules. J Appl Polym Sci 1997;63:425–432
  • Motwani SK, Chopra S, Talegaonkar S, et al. Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation. Eur J Pharm Biopharm 2008;68:513–525
  • Liu W, Griffith M, Li F. Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation. J Mater Sci-Mater M 2008;19:3365–3371
  • Mi FL, Sung HW, Shyu SS. Drug release from chitosan-alginate complex beads reinforced by a naturally occurring cross-linking agent. Carbohyd Res 2002;48:61–72
  • Chellat F, Tabrizian M, Dumitriu S, et al. In vitro and in vivo biocompatibility of chitosan xanthan polyionic complex. J Biomed Mater Res 2000;51:107–116
  • Ma Y, Pacan JC, Wang Q, Xu Y, et al. Microencapsulation of bacteriophage felix O1 into chitosan-alginate microspheres for oral delivery. Appl Environ Microb 2008;74:4799–4805
  • Sanchis-Merino ME, Montero JA, Ruiz-Moreno JM, et al. Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis. Exp Eye Res 2008;86:791–797
  • Sinha VR, Singla AK, Wadhawan S, et al. Chitosan microspheres as a potential carrier for drugs. Int J Pharm 2004;274:1–33
  • Dhaliwal S, Jain S, Singh HP, Tiwary AK. Mucoadhesive microspheres for gastroretentive delivery of acyclovir: in vitro and in vivo evaluation. AAPS J 2008;10:322–330
  • Carvalho FC, Bruschi ML, Evangelista RC, Gremião MPD. Mucoadhesive drug delivery systems. Braz J Pharm Sci 2010;46:1–17
  • Karavas E, Georgarakis E, Bikiaris D. Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics. Eur J Pharm Biopharm 2006;64:115–126
  • Owen CG, Shah A, Henshaw K, et al. Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness. Brit J Gen Pract 2004;54:451–456
  • Groneberg DA, Bielory L, Fischer A, et al. Animal models of allergic and inflammatory conjunctivitis. Allergy 2003;58:1101–1113
  • Calonge MC, Pastor JC, Herreras JM, Gonzalez JL. Pharmacologic modulation of vascular permeability in ocular allergy in the rat. Invest Ophthalmol Vis Sci 1990;31:176–180
  • Minami K, Kamei C. A chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int Immunopharmacol 2004;4:101–108
  • Das S, Suresh PK, Desmukh R. Design of Eudragit RL 100 nanoparticles by nanoprecipitation method for ocular drug delivery. Nanomedicine 2010;6:318–323
  • Douglas KL, Tabrizian M. Effect of experimental parameters on the formation of alginate-chitosan nanoparticles and evaluation of their potential application as DNA carrier. J Biomater Sci Polym Ed 2005;16:43–56
  • KH Singh, UA Shinde. Chitosan nanoparticles for controlled delivery of brimonidine tartrate to the ocular membrane. Die Pharmazie 2011;66:594–599
  • Ribeiro AJ, Silva C, Ferreira D, Veiga F. Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique. Eur J Pharm Biopharm 2005;25:31–40
  • Yanni JM, Stephens DJ, Parnell DW, Spellman JM. Preclinical efficacy of emedastine, a potent, selective histamine H1 antagonist for topical ocular use. J Ocul Pharmacol Th 1994;10:665–675
  • Gazori T, Khoshayand MR, Azizi E, et al. Evaluation of Alginate/Chitosan nanoparticles as antisense delivery vector: formulation, optimization and in vitro characterization. Carbohyd Polym 2009;77:599–606
  • El-Kamel A, Sokar M, Naggar V, Al Gamal S. Chitosan and sodium alginate – based bioadhesive vaginal tablets. AAPS PharmSci 2002;4:224--230
  • Gohel MC, Amin AF. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. J Control Release 1998;51:115–122
  • Shinde UA, Shete JN, Nair HA, Singh KH. Eudragit RL 100 Based microspheres for ocular administration of azelastine hydrochloride. J Microencapsul 2012;29:511–519

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