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Original Research Article

Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices

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Pages 856-867 | Received 23 Jun 2013, Accepted 06 Aug 2013, Published online: 13 Sep 2013

References

  • Lee KY, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci 2012;37:106–126
  • Nagarwal RC, Kumar R, Pandit JK. Chitosan coated sodium alginate–chitosan nanoparticles loaded with 5-FU for ocular delivery: in vitro characterization and in vivo study in rabbit eye. Eur J Pharm Sci 2012;47:678–685
  • Nograles N, Abdullah S, Shamsudin MN, et al. Formation and characterization of pDNA-loaded alginate microspheres for oral administration in mice. J Biosci Bioeng 2012;113:133–140
  • Pillay V, Fassihi R. In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract I. Comparison of pH-responsive drug release and associated kinetics. J Control Release 1999;59:229–242
  • Pillay V, Fassihi R. In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract II. Physicochemical characterization of calcium-alginate, calcium-pectinate and calcium-alginate-pectinate pellets. J Control Release 1999;59:243–256
  • Möbus K, Siepmann J, Bodmeir R. Zinc–alginate microparticles for controlled pulmonary delivery of proteins prepared by spray-drying. Eur J Pharm Biopharm 2012;81:121–130
  • Joshi A, Solanki S, Chaudhari R, et al. Multifunctional alginate microspheres for biosensing, drug delivery and magnetic resonance imaging. Acta Biomater 2011;7:3955–3963
  • Chang H, Park H, Kelly P, Robinson J. Bioadhesive polymers as platforms for oral controlled drug delivery. Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J Pharm Sci 1985;74:399–405
  • George M, Abraham TE. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review. J Control Release 2006;114:1–14
  • Schnürch AB, Kast CE, Richter MF. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J Control Release 2001;71:277–285
  • Taha MO, Nasser W, Ardakani A, AlKhatib H. Sodium lauryl sulfate impedes drug release from zinc-crosslinked alginate beads: switching from enteric coating release into biphasic profile. Int J Pharm 2008;350:291–300
  • Nokhodchi A, Tailor A. In situ crosslinking of sodium alginate with calcium and aluminum ions to sustain the release of theophylline from polymeric matrices. Farmaco 2004;59:999–1004
  • Kikuchi A, Kawabuchi M, Sugihara M, et al. Pulsed dextran release from calcium-alginate gel beads. J Control Release 1997;47:21–29
  • Ostberg T, Lund EM, Graffner C. Calcium alginate matrixes for oral multiple unit administration: IV. Release characteristics in different media. Int J Pharm 1994;112:241–248
  • Taha MO, Aiedeh K. Synthesis of iron-crosslinked hydroxamated alginic acid and its in vitro evaluation as a potential matrix material for oral sustained-release beads. Pharmazie 2000;55:663–667
  • Taha MO, Aiedeh KM, Al-Hiari Y, Al-Khatib H. Synthesis of zinc-crosslinked thiolated alginic acid beads and their in vitro evaluation as potential enteric delivery system utilizing folic acid as model drug. Pharmazie 2005;60:736–742
  • Younes IR, Stamatakis MK, Callery PS, Meyer-Stout P. Influence of pH on the dissolution of folic acid supplements. Int J Pharm 2009;367:97–102
  • AlKhatib HS, Taha MO, Aideh KM, et al. Synthesis and in vitro behavior of iron-crosslinked N-methyl and N-benzyl hydroxamated derivatives of alginic acid as controlled release carriers. Eur Polym J 2006;42:2464–2474
  • Bajpai SK, Sharma S. Investigation of swelling/degradation behaviour of alginate beads crosslinked with Ca2+ and Ba2+ ions. React Funct Polym 2004;59:129–140
  • Aiedeh K, Taha MO. Synthesis of iron-crosslinked chitosan succinate and iron crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads. Eur J Pharm Sci 2001;13:159–168
  • Williams DH, Fleming L. Spectroscopic methods in organic chemistry. 5th ed. London: McGraw-Hill; 1997
  • Olea AF. Hydrophobic polyelectrolytes. Chap. 7. Ciferri A, Perico A, eds. Hoboken (NJ): John Wiley & Sons, Inc; 2012:211–233
  • Pasparakis G, Bouropoulos N. Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate–chitosan beads. Int J Pharm 2006;323:34–42
  • Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev 2002;43:3–12
  • Rodriguez-Douton MJ, Cornia A, Sessoli R, et al. Introduction of ester and amido functions in tetrairon(III) single-molecule magnets: synthesis and physical characterization. Dalton Trans 2010;39:5851–5859
  • Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv 1985;60:110–111
  • Peppas NA, Korsmeyer RW. Dynamically swelling hydrogels in controlled release applications. In: Peppas NA, ed. Hydrogels in medicine and pharmacy. Vol. 3. Boca Raton: CRC Press; 1986:109–136
  • Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 2001;48:139–157

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