Computer-aided design of dry powder inhalers using computational fluid dynamics to assess performance

References

• Balducci AG, Cagnani S, Sonvico F, et al. Pure insulin highly respirable powders for inhalation. Eur J Pharm Sci. 2014;51:110–117
   PubMed Web of Science ®Google Scholar
• Finlay WH. The mechanics of inhaled pharmaceutical aerosols. London: Academic Press; 2001
   Google Scholar
• Telko MJ, Hickey AJ. Dry powder inhaler formulation. Resp Care 2005;50:1209–1227
   PubMedGoogle Scholar
• Steckel H, Markefka P, teWierik H, Kammelar R. Effect of milling and sieving on functionality of dry powder inhalation products. Int J Pharm 2006;309:51–19
   PubMed Web of Science ®Google Scholar
• Frijlink H, De-Boer A. Dry powder inhalers for pulmonary drug delivery. Exprt Opin Drug Deliv 2004;1:67–86
   PubMedGoogle Scholar
• Mitchell JP, Nagel MW. Improved laboratory test methods for orally inhaled products. Ther Deliv 2013;4:1003–1026
   PubMedGoogle Scholar
• United States Pharmacopeia Convention. <601> Aerosol, nasal sprays, metered-dose inhalers, and dry powder inhalers. United States Pharmacopeia and National Formulary (USP 34-NF 29). 1. Rockville, MD: United States Pharmacopeia Convention; 2011:219–39
   Google Scholar
• Daniher DI, Zhu J. Dry powder platform for pulmonary drug delivery. Particuology 2008;6:225–238
   Web of Science ®Google Scholar
• Islam N, Gladki E. Dry powder inhalers (DPIs)—a review of device reliability and innovation. Int J Pharm 2008;360:1–11
   PubMed Web of Science ®Google Scholar
• Islam N, Cleary MJ. Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery – a review for multidisciplinary researchers. Med Eng Phys 2012;34:409–427
   PubMed Web of Science ®Google Scholar
• Desai SS, Aher AA, Kadaskar PT. Methods for reduction of cohesive forces between carrier and drug in DPI formulation. Drug Dev Ind Pharm 2013;39:1589–1598
   PubMed Web of Science ®Google Scholar
• Coates MS, Chan H-K, Fletcher DF, Raper JA. Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharm Res 2005;22:1445–1453
   PubMed Web of Science ®Google Scholar
• Zhou QT, Tang P, Leung SSY, et al. Emerging inhalation aerosol devices and strategies: where are we headed? Adv Drug Deliv Rev 2014;75:3–17
   PubMed Web of Science ®Google Scholar
• Coates MS, Chan HK, Fletcher DF, Chiou H. Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler. Pharm Res 2007;24:1450–1456
   PubMed Web of Science ®Google Scholar
• Coates MS, Chan HK, Fletcher DF, Raper JA. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: air inlet size. J Pharm Sci 2006;95:1382–1392
   PubMed Web of Science ®Google Scholar
• Coates MS, Fletcher DF, Chan HK, Raper JA. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: grid structure and mouthpiece length. J Pharm Sci 2004;93:2863–2876
   PubMed Web of Science ®Google Scholar
• Wong W, Fletcher DF, Traini D, et al. Particle aerosolisation and break-up in dry powder inhalers 1: evaluation and modelling of venturi effects for agglomerated systems. Pharm Res 2010;27:1367–1376
   PubMed Web of Science ®Google Scholar
• Smith IJ, Parry-Billings M. The inhalers of the future? A review of dry powder devices on the market today. Pulm Pharmacol Ther 2003;16:79–95
   PubMed Web of Science ®Google Scholar
• Srichana T, Martin GP, Marriott C. Dry powder inhalers: the influence of device resistance and powder formulation on drug and lactose deposition in vitro. Eur J Pharm Sci 1998;7:73–80
   PubMed Web of Science ®Google Scholar
• Elkins MR, Robinson P, Anderson SD, et al. Inspiratory flows and volumes in subjects with cystic fibrosis using a new dry powder inhaler device. Open Resp Med J 2014;8:1–7
   PubMedGoogle Scholar
• Chew N, Chan H. In vitro aerosol performance and dose uniformity between the Foradile Aerolizer and the Oxis Turbuhaler. J Aerosol Med 2001;14:495–501
   PubMedGoogle Scholar
• Zainudin B, Biddiscombe M, Tolfree S, et al. Comparison of bronchodilator responses and deposition patterns of salbutamol inhaled from a pressurised metered dose inhaler, as a dry powder, and as a nebulised solution. Thorax 1990;45:469–473
   PubMed Web of Science ®Google Scholar
• Richards R, Dickson C, Renwick A, et al. Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique. J Pharmacol Exp Ther 1987;241:1028–1032
   PubMed Web of Science ®Google Scholar
• Borgstrom L, Newman S, Weisz A, Moren F. Pulmonary deposition of inhaled terbutaline: comparison of scanning gamma camera and urinary excretion methods. J Pharm Sci 1992;81:753–755
   PubMed Web of Science ®Google Scholar
• Thornton C, Liu L. How do agglomerates break. Powder Technol 2004;143–144:110–116
   Web of Science ®Google Scholar
• Guo Y, Kafui KD, Wu C-Y, et al. A coupled DEM/CFD analysis of the effect of air on powder flow during die filling. AIChE J 2003;55:49–62
   Web of Science ®Google Scholar
• Tong Z, Zheng B, Yang R, et al. CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers. Powder Technol 2013;240:19–24
   Web of Science ®Google Scholar
• Hoppentocht M, Hagedoorn P, Frijlink HW, Boer AHd. Technological and practical challenges of dry powder inhalers and formulations. Adv Drug Deliv Rev 2014;75:18–31
   PubMed Web of Science ®Google Scholar
• Oliveira RF, Teixeira SFCF, Silva LF, et al. Development of new spacer device geometry: a CFD study (Part I). Comput Method Biomech 2012;15:825–833
   PubMed Web of Science ®Google Scholar
• Vogel L, Peukert W. Breakage behaviour of different materials—construction of a mastercurve for the breakage probability. Powder Technol 2002;129:101–111
   Web of Science ®Google Scholar
• Adams WP, Lee SL, Plourde R, et al. Effects of device and formulation on in vitro performance of dry powder inhalers. AAPS J 2012;14:400–409
   PubMed Web of Science ®Google Scholar
• Vidgren M, Paronen P, Vidgren P, et al. In vivo evaluation of the new multiple dose powder inhaler and the Rotahaler using the gamma scintigraphy. Acta Pharm Nordica 1990;2:3–10
   PubMedGoogle Scholar
• Pavkov R, Mueller S, Fiebich K, et al. Characteristics of a capsule based dry powder inhaler for the delivery of indacaterol. Curr Med Res Opin 2010;26:2527–2533
   PubMed Web of Science ®Google Scholar
• Selroos O. Dry-powder inhalers in acute asthma. Ther Deliv 2014;5:69–81
   PubMedGoogle Scholar
• Ruzycki CA, Javaheri E, Finlay WH. The use of computational fluid dynamics in inhaler design. Expert Opin Drug Deliv 2013;10:307–333
   PubMed Web of Science ®Google Scholar
• Parisini I, Cheng SJ, Symons DD, Murnane D. Potential of a cyclone prototype spacer to improve in vitro dry powder delivery. Pharm Res 2014;31:1133–1145
   PubMed Web of Science ®Google Scholar
• Voss A, Finlay WH. Deagglomeration of dry powder pharmaceutical aerosols. Int J Pharm 2002;248:39–50
   PubMed Web of Science ®Google Scholar