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Research Article

Novel topical formulation for ischemic chronic wounds. Technological design, quality control and safety evaluation

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Pages 399-404 | Received 16 Sep 2014, Accepted 17 Jan 2015, Published online: 17 Feb 2015

References

  • Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet 2003;361:1545–1551
  • Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 1994;130:489–493
  • Harding KG, Morris HL, Patel GK. Healing chronic wounds. Br Med J 2002;324:160–163
  • Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 1998;176:26S–38S
  • James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Rep Reg 2008;16:37–44
  • Thomsen TR, Aasholm MS, Rudkjobing VB, et al. The bacteriology of chronic venous leg ulcer examined by culture-independent molecular methods. Wound Rep Regen 2010;18:38–49
  • Edwards R, Harding KG. Bacteria and wound healing. Curr Opp Infect Dis 2004;17:91–96
  • Ramos AN, Peral MC, Valdez JC. Differences between Pseudomonas aeruginosa in a clinical sample and in a colony isolated from it: comparison of virulence capacity and susceptibility of biofilm to inhibitors. Comp Immunol Microbiol Infect Dis 2010;33:267–275
  • Bjarnsholt T, Kirketerp-Moller K, Jensen PO, et al. Why chronic wounds will not heal: a novel hypothesis. Wound Rep Reg 2008;16:2–10
  • Valdez JC, Peral M, Rachid M, et al. Interference of Lactobacillus plantarum on Pseudomonas aeruginosa in vitro and in infected burns. The potential use of probiotic in wound treatment. Clin Microbiol Infect 2005;11:472–479
  • Ramos AN, Sesto Cabral ME, Noseda D, et al. Antipathogenic properties of Lactobacillus plantarum on Pseudomonas aeruginosa: the potential use of its supernatants in the treatment of infected chronic wounds. Wound Rep Regen 2012;20:552–562
  • Ramos AN, Gobbato N, Rachid M, et al. Effect of Lactobacillus plantarum and Pseudomonas aeruginosa culture supernatants on polymorphonuclear damage and inflammatory response. Int Immunopharmacol 2010;10:247–251
  • Valdez JC, Ramos AN, Fernández D, et al. Probiotics and their potential use in wound treatment. In: Alvarez S, ed. Probiotics: inmunobiotics and inmunogenics. Florida: Science publishers/CRC; 2013:296–333
  • Ramos AN, Sesto Cabral ME, Arena ME, et al. Compounds from Lactobacillus plantarum culture supernatants with potential pro-healing and anti-pathogenic properties in skin chronic wounds. Pharm Biol 2015;53:350–358
  • Vijaya Bhanu P, Shanmugam V, Lakshmi PK. Development and evaluation of Diclofenac Emulgel for topical drug delivery. Pharmacie Globale IJCP 2011;9:1–4
  • Soldevilla J, Torra JE, Bou I. Atención Integral de las heridas crónicas. SPA ed. Madrid 2004;2:98–99
  • Neves J, Bahia MF. Gels as vaginal drug delivery systems. Int J Pharmaceut 2006;318:1–14
  • Sesto Cabral ME, Ramos AN, Cabrera CA, et al. Equipment and method for in vitro release measurements on topical dosage forms. Pharm Dev Technol 2015;20:619–625
  • Sesto Cabral ME, Ramos AN, Macedo AJ, et al. Formulation and quality control of semi-solid containing harmless bacteria by-products: chronic wounds pro-healing activity. Pharm Dev Technol. 2015;20:911–919
  • Pathan AK, Rahul T, Rukhsana AR. Formulation development and evaluation of silymarin gel for psoriasis treatment. J Inn Pharm Biol Sci 2014;1:21–26
  • Matousek JL, Campbell KL. A comparative review of cutaneous pH. Veter Dermatol 2002;13:293–300
  • Percival SL, McCarty S, Hunt JA, Woods EJ. The effects of pH on wound healing, biofilms, and antimicrobial efficacy. Wound Rep Reg 2014;22:174–186
  • Riccia EJ, Lunardib LO, Nanclaresb DMA, Marchetti JM. Sustained release of lidocaine from Poloxamer 407 gels. Int J Pharmaceut 2005;288:235–244
  • Shah SNH, Hussain T, Khan IU, et al. Formulation study of topically applied lotion: in vitro and in vivo evaluation. BI 2013;3:11–19
  • Wester R, Maibach H. Percutaneous absorption of drugs. Clin Pharmacokinet 1992;23:253–266

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