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Research Article

Continuous granulation with a twin-screw extruder: Impact of material throughput

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Pages 518-525 | Received 15 Jun 2009, Accepted 07 Oct 2009, Published online: 18 Nov 2009

References

  • Leuenberger H. New trends in the production of pharmaceutical granules: Batch versus continuous processing. Eur J Pharm Biopharm 2001;52:289–296.
  • Vervaet C, Remon JP. Continuous granulation in the pharmaceutical industry. Chem Eng Sci 2005;60:3949–3957.
  • Gamlen MJ, Eardley C. Continuous extrusion using a Baker Perkins MP50 (multipurpose) extruder. Drug Dev Ind Pharm 1986;12:1701–1713.
  • Lindberg NO, Tufvesson C, Holm P, Olbjer L. Extrusion of an effervescent ranulation with a twin screw extruder, Baker Perkins MPF 50D – influence on intragranular porosity and liquid saturation. Drug Dev Ind Pharm 1988;14:1791–1798.
  • Schroeder R, Steffens KJ. A new system for continuous wet granulation. Pharm Ind 2002;64:283–288.
  • Ghebre-Sellasie I, Plains M, Mollan MJ, Pathak N, Lodaya M, Fessehaie M. Continuous production of pharmaceutical granulation. [US 6,499, 984 B1], 2002.
  • Keleb EI, Vermeire A, Vervaet C, Remon JP. Continuous twin screw extrusion for the wet granulation of lactose. Int J Pharm 2002;239:69–80.
  • Van Melkebeke B, Vermeulen B, Vervaet C, Remon JP. Melt granulation using a twin-screw extruder: A case study. Int J Pharm 2006;326:89–93.
  • Van Melkebeke B, Vervaet C, Remon JP. Validation of a continuous granulation process using a twin-screw extruder. Int J Pharm 2008;356:224–230.
  • Djuric D, Kleinebudde P. Impact of screw elements on continuous granulation with a twin-screw extruder. J Pharm Sci 2008;97:4934–4942.
  • Djuric D, Van Melkebeke B, Kleinebudde P, Remon JP, Vervaet C. Comparison of two twin-screw extruders for continuous granulation. Eur J Pharm Biopharm 2009:155–160.
  • Hunter, B. Friability test for granules. J Pharmacol Pharm 1973;25(Suppl.):111P.
  • Jenike AW. Storage and flow of solids. Bulletin of the University of Utah No. 123. 1964; Salt Lake City, Engineering Experiment Station, University of Utah.
  • Schulze D, Wittmaier A. Flow properties of highly dispersed powders at very small consolidation stresses. Chem Eng Technol 2003;26:133–137.
  • Albers J, Knop K, Kleinebudde P. Brand-to-brand and batch-to-batch uniformity of microcrystalline cellulose in direct tableting with a pneumohydraulic tablet press. Pharm Ind 2006;68:1420–1428.
  • Adolfsson A, Nyström CH. Tablet strength, porosity, elasticity and solid state structure of tablets compressed at high loads. Int J Pharm 1996;132:95–106.
  • Fell JT, Newton JM. Determination of tablet strength by diametral-compression test. J Pharm Sci 1970;59:688–691.
  • Becker D, Rigassi T, Bauer-Brandl A. Effectiveness of binders in wet granulation: A comparison using model formulations of different tabletability. Drug Dev Ind Pharm 1997;23:791–808.
  • Kristensen HG, Schaefer T. Granulation – a review of pharmaceutical wet-granulation. Drug Dev Ind Pharm 1987;13:803–872.
  • Holm P, Jungersen O, Schaefer T, Kristensen HG. Granulation in high speed mixers. Part 2: Effects of process variables during kneading. Pharm Ind 1984;46:97–100.
  • Jivraj M, Martini LG, Thomson CM. An overview of the different excipients useful for the direct compression of tablets. PSTT 2000;3:58–63.

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