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Pharmaceutical Development and Technology Volume 1, 1996 - Issue 2
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Research Article

Dissolution Enhancement of an Insoluble Drug by Physical Mixture with a Superdisintegrant: Optimization with a Simplex Lattice Design

Franca Ferrari Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
,
Moreno Bertoni Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
,
Cristina M. Bonferoni Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
,
Silvia Rossi Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
,
Carla Caramella Department of Pharmaceutical Chemistry, University of Pavia, Pavia, ItalyCorrespondence[email protected]
&
Gerard K. Bolhuis Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands
Pages 159-164 | Received 16 Jan 1996, Accepted 26 Feb 1996, Published online: 27 Sep 2008

References

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  • Bolhuis G. K., Duineveld C. A. A., De Boer J. H., Coenegracht P. M. J. Simultaneous optimization of multiple criteria in tablet formulation: Part I. Pharm. Tech. Eur. 1995; 7(6)42–50
  • Draper N. R., Smith H. Applied Regression Analysis. Wiley & Sons, New York 1981; 412–419
  • Caramella C., Ferrari F., Ronchi M., Smilde A. K. An integrated computer-aided approach for modeling disintegration related phenomena. Acta Pharm. Technol. 1990; 36: 249–253
  • van Kamp H. V., Bolhuis G. K., Kussendrager K. D., Lerk C. F. Studies on tabletting properties of lactose. IV. Dissolution and disintegration properties of different types of crystalline lactose. Int. J. Pharm. 1986; 28: 229–238

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