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Research Article

Use of Chitosan in Compressed Tablets of Diclofenac Sodium: Inhibition of Drug Release in an Acidic Environment

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Pages 243-255 | Received 01 Jul 1996, Accepted 13 Feb 1997, Published online: 27 Sep 2008

References

  • O'Brien W. M. Adverse reactions to nonsteroidal anti-inflammatory drugs: Diclofenac compared with other nonsteroidal anti-inflammatory drugs. Am. J. Med. 1986; 80(suppl. 4B)70–80
  • Brogden R. N., Heel R. C., Pakes G. E., Speight T. M., Avery G. S. Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. Drugs 1980; 20: 24–48
  • Sawayanagi Y., Nambu N., Nagai T. Directly compressed tablets containing chitin or chitosan in addition to lactose or potato starch. Chem. Pharm. Bull. 1982; 30: 2935–2940
  • Acartürk F. Preparation of a prolonged-release tablet formulation of diclofenac sodium, part 1: using chitosan. Pharmazie 1989; 44: 547–547
  • Nigalaye A., Adusumilli P., Bolton S. Investigation of prolonged drug release from matrix formulations of chitosan. Drug Dev. Ind. Pharm. 1990; 16: 449–467
  • Knapczyk J. Excipient ability of chitosan for direct tableting. Int. J. Pharm. 1993; 89: 1–7
  • Al-Angary A. A. Effects of molecular weight and particle size of chitosan on chlorpheniramine maleate release from compressed tablets. Saudi Pharm. J. 1994; 2: 157–162
  • Austin P. R., Brine C. J. Chitin powder and process for making it, U. S. patent #. 4,286,087, August 25, 1981
  • Dunn H. J., Farr M. P. Microcrystalline chitin, U. S. patent #. 3,847,897, November 12, 1974
  • Shiraishi S., Arahira M., Imai T., Otagiri M. Enhancement of dissolution rates of several drugs by low-molecular chitosan and alginate. Chem. Pharm. Bull. 1990; 38: 185–187
  • Imai T., Shiraishi S., Saitô H., Otagiri M. Interaction of indomethacin with low molecular weight chitosan, and improvements of some pharmaceutical properties of indomethacin by low molecular weight chitosans. Int. J. Pharm. 1991; 67: 11–20
  • Errington N., Harding S. E., Varum K. M., Illum L. Hydrodynamic characterization of chitosans varying in degree of acetylation. Int. J. Biol. Macromol. 1993; 15: 113–117
  • Sabnis S. S., Block L. H., to be published
  • Sabnis S. S. Development of modified chitosans as excipients for use in drug delivery systems. Ph.D. dissertation, Duquesne University. 1996; 63–72, cf. S. S. Sabnis and L. H. Block, Evaluation of the degree of N-deacetylation of chitosan using UV/VIS. IR, and NIR spectroscopic techniques, Pharm. Res. 1994, 11 (supp. 10) 31
  • Block L. H., Patel R. N. Solubility and dissolution of triamcinolone acetonide. J. Pharm. Sci. 1973; 62: 617–621
  • Aiba S. Studies on chitosan: 3. Evidence for the presence of random and block copolymer structures in partially N-deacetylated chitosans. Int. J. Biol. Macromol. 1991; 13: 40–44
  • Hasegawa M., Isogai A., Onabe F., Usuda M., Atalla R. H. Characterization of cellulose-chitosan blend films. J. Appl. Polym. Sci. 1992; 45: 1873–1879
  • 1986; 367, File no. 26–921. Powder Diffraction File, JCPDS-Inter-national Center for Diffraction Data, Pennsylvania
  • Fini A., Zecchi V., Tartarini A. Dissolution profiles of NSAID carboxylic acids and their salts with different counterions. Pharm. Acta Helv. 1985; 60: 58–62
  • Larsen C., Bundgaard H. Kinetics of the acid-catalyzed cyclization of diclofenac to an indolinone in aqueous solution. Arch. Pharm. Chemi. Sci. Ed. 1980; 8: 100–108
  • Gordon R. E., Rosanske T. W., Fornner D. E., Anderson N. R., Banker G. S. Granulation technology and tablet characterization. Pharmaceutical Dosage Forms: Tablets, H. A. Liebermann, L. Lachman, J. B. Schwartz. Marcel Dekker, Inc., New York 1990; vol. 2: 245–348
  • Hariharan D., Peppas N. A. Modelling of water transport and solute release in physiologically sensitive gels. J. Control. Rel. 1993; 23: 123–136

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