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Amyloid
The Journal of Protein Folding Disorders
Volume 2, 1995 - Issue 2
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Original Article

Transgenic mice expressing the amyloid β protein-containing carboxyl-terminal fragment of the Alzheimer amyloid precursor protein

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Pages 100-106 | Received 14 Feb 1994, Accepted 20 Dec 1994, Published online: 06 Jul 2009

References

  • Glenner G G, Wong C W. Alzheimer's diesease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984; 120: 885–890
  • Masters C L, Simms G, Weinman N A, Multhaup G, McDonald B L, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82: 4245–4249
  • Kang J, Lemaire H G, Unterbeck A, Salbaum J M, Masters C L, Grzeschik K H, Multhaup G, Beyreuther K, Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325: 733–736
  • Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature 1988; 331: 530–532
  • Palmert M R, Podlisny M B, Witker D S, Oltersdorf T, Younkin L H, Selkoe D J, Younkin S G. The β-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci USA 1989; 86: 6338–6342
  • Sisodia S S, Koo E H, Beyreuther K, Unterbeck A, Price D L. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990; 248: 492–495
  • Estus S, Golde T E, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu X, Tabira T, Greenberg B D, Younkin S G. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science 1992; 255: 726–728
  • Kaass C, Koo E H, Mellon A, Hung A Y, Selkoe D J. Targeting of cell surface B-amyloid protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 1992; 357: 500–503
  • Haass C, Schlossmacher M G, Hung A Y, Vigo-Pelfrey C, Mellon A, Ostaszewski B L, Lieberburg I, Koo E H, Schenk D, Teplow D B, Selkoe D J. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 1992; 359: 322–325
  • Shoji M, Golde T E, Ghiso J, Cheung T T, Estus S, Shaffer L M, Cai X D, McKay D M, Tintner R, Frangione B, Younkin S G. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Scienc 1992; 258: 126–129
  • Dyrks T, Weidemann A, Multhaup G, Salbaum J M, Lemaire H G, Kang J, Muller-Hill B, Masters C L, Beyreuther K. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J 1988; 7: 949–957
  • Yankner B A, Dawes L R, Fisher S, Villa-Komaroff L, Oster-Granite M L, Neve R L. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 1989; 245: 417–420
  • Maruyama K, Terakado K, Usami M, Yoshikawa K. Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature 1990; 347: 566–569
  • Fukuchi K, Kamino K, Deeb S S, Smith A C, Dang T, Martin G M. Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem Biophys Res Commun 1992; 182: 165–173
  • Goate A, Chartier-Harlin M C, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton R, Rooke K, Roques P., Talbot C, Pericak-Vance M, Roses A, Williamsor R, Rossor M, Owen M, Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familiar Alzheimer's disease. Nature 1991; 349: 704–706
  • Kunkel T A. Rapid and efficient site-specific mutagenesis without phenotype selection. Proc Natl Acad Sci USA 1985; 82: 488–492
  • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 1987; 162: 156–159
  • Yamaguchi H, Ishiguro K, Shoji M, Yamazaki T, Nakazato Y, Ihara Y, Hirai S. Amyloid β/A4 protein precursor is bound to neurof ibrillary tangles in Alzheimer-type dementia. Brain Res 1990; 537: 318–322
  • Yamaguchi H, Yamazaki T, Ishiguro K, Shoji M, Nakazato Y, Hirai S. Ultrastructurar localization of Alzheimer amyloid β/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes. Acta Neuropathol 1992; 85: 15–22
  • Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Ihara Y. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by Aβ protein immunostaining. Acta Neuropathol 1988; 76: 541–549
  • Yamaguchi H, Nakazato Y, Kawarabayashi T, Ishiguro K, Ihara Y, Morimatsu M, Hirai S. Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia. Acta Neuropathol 1991; 81: 603–609
  • Forss-Petter S, Danielson P E, Catsicas S, Battenberg E, Price J, Nerenberg M, Sutcliffe J G. Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 1990; 5: 187–197
  • Quon D, Wang Y, Catalano R, Scardina J M, Murakami K, Cordell B. Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 1991; 352: 239–241
  • Wirak D O, Bayney R, Ramabhadran T V, Fracasso R R, Hart J T, Hauer P E, Hsiau R, Pekar S K, Scangos G A, Trapp B D, Unterbeck A J. Deposits of amyloid β protein in the central nervous of transgenic mice. Science 1991; 253: 323–325
  • Sandhu F A, Salim M, Zain S B. Expression of the human β-amyioid protein of Alzheimer's disease specifically in the brains of transgenic mice. J Biol Chem 1991; 266: 21331–21334
  • Kammesheidt A, Boyce F M, Spanoyannis A F, Cummings B J, Ortegon M, Cotman C, Vaught J L, Neve R L. Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci USA 1992; 89: 10857–10861
  • Lamb B T, Sisodia S S, Lawler A M, Slunt H H, Kitt C A, Kearns W G, Pearson R L, Price D L, Gearhart J D. Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice. Nature Genet 1993; 5: 22–29
  • Schellenberg G D, Bird T D, Wijsman E M, Orr H T, Anderson L, Nemens E, White J A, Bonnycastle L, Weber J L, Alonso M E, Potter H, Heston L L, Martin J. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258: 668–67
  • Strittmatter W J, Saunders A M, Schmechel D, Pericak-Vance M, Enghild J, Salvesen G S, Roses A D. Apolipoprotein E: high avidity binding to β-amyioid and increased frequency of type4 aliele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993; 90: 1977–1981

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