Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption

Reference

• Altman DG. (1991). Practical statistics for medical research. London, Chapman and Hall.
   Google Scholar
• Bergmark E. (1997). Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers. Chem. Res. Toxicol. 10, 78–84.
   PubMed Web of Science ®Google Scholar
• Bramer SL and Kallungal BA. (2003). Clinical considerations in study designs that use cotinine as a biomarker. Biomarkers 8, 187–203.
   PubMed Web of Science ®Google Scholar
• Burns DM, Dybing E, Gray N, Hecht S, Anderson C, Sanner T, O’Connor R, Djordjevic M, Dresler C, Hainaut P, Jarvis M, Opperhuizen A, and Straif K. (2008). Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tob. Control 17, 132–141.
   PubMed Web of Science ®Google Scholar
• Dong JZ, Glass JN, and Moldoveanu SC. (2000). A Simple GC-MS Technique for the Analysis of Vapour Phase Mainstream Cigarette Smoke. J. Microcolumn Separations 12, 142–152.
   Google Scholar
• FDA. Food and Drug Administration (FDA) (2001): Guidance for Industry - Bioanalytical Method Validation 1–22.
   Google Scholar
• Fennell TR, Kedderis GL, and Sumner SC. (1991). Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy. Chem. Res. Toxicol. 4, 678–687.
   PubMed Web of Science ®Google Scholar
• Fennell TR, MacNeela JP, Morris RW, Watson M, Thompson CL, and Bell DA. (2000). Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes. Cancer Epidemiol. Biomarkers Prev. 9, 705–712.
   PubMed Web of Science ®Google Scholar
• IARC. International, Agency for Research on Cancer (1979). Acrylonitrile, acrylic and modacrylic fibres, and acrylonitrile-butadiene-styrene and styrene-acrylonitrile copolymers. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 19, 73–113.
   Google Scholar
• IARC. International, Agency for Research on Cancer (1999). Acrylonitrile. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 71, 43–108.
   PubMedGoogle Scholar
• IARC. International, Agency for Research on Cancer (2004). Tobacco smoke and involuntary smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 83, 1–1438.
   PubMedGoogle Scholar
• International Conference on Harmonization (1996). Harmonized tripartite guidelines for good clinical practice. Directive 91/507/EEC. The rules governing medicinal products in the European Community.
   Google Scholar
• International Organization for Standardization (2000). ISO Standard 3308, in Routine Analytical Cigarette-smoking Machine-definitions and standard conditions. 4.
   Google Scholar
• IOM (2001). Institute of Medicine. Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction.
   Google Scholar
• Jakubowski M, Linhart I, Pielas G, and Kopecky J. (1987). 2-Cyanoethylmercapturic acid (CEMA) in the urine as a possible indicator of exposure to acrylonitrile. Br. J. Ind. Med. 44, 834–840.
   PubMedGoogle Scholar
• Jenkins RA, Guerin MR, Tomkins BA. (2000). The chemistry of environmental tobacco smoke: composition and measurement. 2nd ed. Boca Raton: Lewis Publishers.
   Google Scholar
• Lambotte-Vandepaer M, Duverger-van BM, and Rollmann B. (1985). Metabolism and mutagenicity of acrylonitrile: an in vivo study. Environ. Mutagen. 7, 655–662.
   PubMedGoogle Scholar
• Leonard A, Gerber GB, Stecca C, Rueff J, Borba H, Farmer PB, Sram RJ, Czeizel AE, and Kalina I. (1999). Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile. Mutat. Res. 436, 263–283.
   PubMed Web of Science ®Google Scholar
• Massachusetts General Law (1997) Ch. 94Sect. 307B, 105 Code of Massachusetts Regulation 660.000.
   Google Scholar
• Miller SL, Branoff S, and Nazaroff WW. (1998). Exposure to toxic air contaminants in environmental tobacco smoke: an assessment for California based on personal monitoring data. J. Expo. Anal. Environ. Epidemiol. 8, 287–311.
   PubMedGoogle Scholar
• Scherer G, Engl J, Urban M, Gilch G, Janket D, and Riedel K. (2007). Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany. Regul. Toxicol. Pharmacol. 47, 171–183.
   PubMed Web of Science ®Google Scholar
• Scherer G, Urban M, Hagedorna H-W, Serafin R, Feng S, Kapurb S, Muhammad R, Jin Y, Sarkarb M, Roethig H-J. (2010). Determination of methyl-, 2-hydroxyethyl- and 2-cyanoethylmercapturic acids as biomarkers of exposure to alkylating agents in cigarette smoke. J. Chromatography B. 878, 2520–2528.
   PubMed Web of Science ®Google Scholar
• Schettgen T, Broding HC, Angerer J, and Drexler H. (2002). Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine. Toxicol. Lett. 134, 65–70.
   PubMed Web of Science ®Google Scholar
• Schettgen T, Musiol A, Alt A, Ochsmann E, and Kraus T. (2009). A method for the quantification of biomarkers of exposure to acrylonitrile and 1,3-butadiene in human urine by column-switching liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 393, 969–981.
   PubMed Web of Science ®Google Scholar
• Shepperd CJ, St Charles FK, Lien M, and Dixon M. (2006) Validation of Methods for Determining Consumer Smoked Cigarette Yields from Cigarette Filter Analysis. Beitrage zur Tabakforschung International 22, 176–184.
   Google Scholar
• Shepperd CJ, Eldridge AC, Mariner DC, McEwan M, Errington G, and Dixon M. (2009). A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure. Regul. Toxicol. Pharmacol. 55, 97–109.
   PubMed Web of Science ®Google Scholar
• St Charles FK, Krautter GR, Dixon M, and Mariner DC. (2006). A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites. Psychopharmacology (Berl) 189, 345–354.
   PubMed Web of Science ®Google Scholar
• Sumner SC, Selvaraj L, Nauhaus SK, and Fennell TR. (1997). Urinary metabolites from F344 rats and B6C3F1 mice coadministered acrylamide and acrylonitrile for 1 or 5 days. Chem. Res. Toxicol. 10, 1152–1160.
   PubMed Web of Science ®Google Scholar
• Thier R, Lewalter J, and Bolt HM. (2000). Species differences in acrylonitrile metabolism and toxicity between experimental animals and humans based on observations in human accidental poisonings. Arch. Toxicol. 74, 184–189.
   PubMed Web of Science ®Google Scholar
• World Medical Association. Declaration of Helsinki - Recommendations guiding physicians in biomedical research involving human subjects. Adopted 1964, amended 1975, 1983, 1989, 1996, 2000, 2002, and 2004.
   Google Scholar
• Xu X, Iba MM, and Weisel CP. (2004). Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry. Clin. Chem. 50, 2323–2330.
   PubMed Web of Science ®Google Scholar