Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis

References

• Abraham D. (2008). Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc? Rheumatology (Oxford) 47 (Suppl 5):8–9.
   PubMedGoogle Scholar
• Abreu JG, Ketpura NI, Reversade B, De Robertis EM. (2002). Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 4:599–604.
   PubMed Web of Science ®Google Scholar
• Ahmed MS, Øie E, Vinge LE, Yndestad A, Øystein Andersen G, Andersson Y, Attramadal T, Attramadal H. (2004). Connective tissue growth factor—a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats. J Mol Cell Cardiol 36:393–404.
   PubMed Web of Science ®Google Scholar
• Allen JT, Knight RA, Bloor CA, Spiteri MA. (1999). Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Cell Mol Biol 21:693–700.
   PubMed Web of Science ®Google Scholar
• Andersen S, van Nieuwenhoven FA, Tarnow L, Rossing P, Rossing K, Wieten L, Goldschmeding R, Parving HH. (2005). Reduction of urinary connective tissue growth factor by losartan in type 1 patients with diabetic nephropathy. Kidney Int 67:2325–2329.
   PubMed Web of Science ®Google Scholar
• Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M. (2009). N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan. Biochem J 420:413–420.
   PubMed Web of Science ®Google Scholar
• Bao J, Tu Z, Wang J, Ye F, Sun H, Qin M, Shi Y, Bu H, Li YP. (2008). A novel accurate rapid ELISA for detection of urinary connective tissue growth factor, a biomarker of chronic allograft nephropathy. Transplant Proc 40:2361–2364.
   PubMed Web of Science ®Google Scholar
• Bergestuen DS, Gravning J, Haugaa KH, Sahakyan LG, Aakhus S, Thiis-Evensen E, Øie E, Aukrust P, Attramadal H, Edvardsen T. (2010). Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors. BMC Cancer 10:6.
   PubMed Web of Science ®Google Scholar
• Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR, Harding PA. (1997). Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J Biol Chem 272:20275–20282.
   PubMedGoogle Scholar
• Chen CC, Lau LF. (2009). Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41:771–783.
   PubMed Web of Science ®Google Scholar
• Cheng O, Thuillier R, Sampson E, Schultz G, Ruiz P, Zhang X, Yuen PS, Mannon RB. (2006). Connective growth factor is a biomarker and mediator of kidney allograft fibrosis. Am J Transplant 6:2292–2306.
   PubMed Web of Science ®Google Scholar
• Cicha I, Garlichs CD, Daniel WG, Goppelt-Struebe M. (2004). Activated human platelets release connective tissue growth factor. Thromb Haemost 91:755–760.
   PubMed Web of Science ®Google Scholar
• Cicha I, Goppelt-Struebe M. (2009). Connective tissue growth factor: context-dependent functions and mechanisms of regulation. Biofactors 35:200–208.
   PubMed Web of Science ®Google Scholar
• Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock DR, Daniel WG, Goppelt-Struebe M, Garlichs CD. (2005). Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler Thromb Vasc Biol 25:1008–1013.
   PubMed Web of Science ®Google Scholar
• Dziadzio M, Usinger W, Leask A, Abraham D, Black CM, Denton C, Stratton R. (2005). N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma. QJM 98:485–492.
   PubMed Web of Science ®Google Scholar
• Fletcher JT, Nankivell BJ, Alexander SI. (2009). Chronic allograft nephropathy. Pediatr Nephrol 24:1465–1471.
   PubMed Web of Science ®Google Scholar
• Fonseca C, Lindahl GE, Ponticos M, Sestini P, Renzoni EA, Holmes AM, Spagnolo P, Pantelidis P, Leoni P, McHugh N, Stock CJ, Shi-Wen X, Denton CP, Black CM, Welsh KI, du Bois RM, Abraham DJ. (2007). A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med 357:1210–1220.
   PubMed Web of Science ®Google Scholar
• Gao R, Brigstock DR. (2004). Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J Biol Chem 279:8848–8855.
   PubMed Web of Science ®Google Scholar
• Gao R, Brigstock DR. (2003). Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 27:214–220.
   PubMed Web of Science ®Google Scholar
• Gerritsen KG, Peters HP, Nguyen TQ, Koeners MP, Wetzels JF, Joles JA, Christensen EI, Verroust PJ, Li D, Oliver N, Xu L, Kok RJ, Goldschmeding R. (2010). Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion. Am J Physiol Renal Physiol 298:F1457–F1464.
   PubMed Web of Science ®Google Scholar
• Gilbert RE, Akdeniz A, Weitz S, Usinger WR, Molineaux C, Jones SE, Langham RG, Jerums G. (2003). Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy. Diabetes Care 26:2632–2636.
   PubMed Web of Science ®Google Scholar
• Granel B, Argiro L, Hachulla E, Fajardy I, Weiller PJ, Durand JM, Frances Y, Dombey AM, Marquet S, Lesavre N, Disdier P, Bernard F, Hatron PY, Chevillard C. (2010). Association between a CTGF gene polymorphism and systemic sclerosis in a French population. J Rheumatol 37:351–358.
   PubMed Web of Science ®Google Scholar
• Gressner AM, Yagmur E, Lahme B, Gressner O, Stanzel S. (2006). Connective tissue growth factor in serum as a new candidate test for assessment of hepatic fibrosis. Clin Chem 52:1815–1817.
   PubMed Web of Science ®Google Scholar
• Grotendorst GR, Duncan MR. (2005). Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J 19:729–738.
   PubMed Web of Science ®Google Scholar
• Guo-Qiu W, Nai-Feng L, Xiao-Bo V, Linxian L, Chen Z, Lixia G, Zhao L. (2010). The level of connective tissue growth factor in sera of patients with hepatitis B virus strongly correlates with stage of hepatic fibrosis. Viral Immunol 23:71–78.
   PubMed Web of Science ®Google Scholar
• Heng EC, Huang Y, Black SA Jr, Trackman PC. (2006). CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem 98:409–420.
   PubMed Web of Science ®Google Scholar
• Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. (2004). Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol 287:F1223–F1232.
   PubMed Web of Science ®Google Scholar
• Higley H, Persichitte K, Chu S, Waegell W, Vancheeswaran R, Black C. (1994). Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud’s phenomenon. Arthritis Rheum 37:278–288.
   PubMedGoogle Scholar
• Hinton DR, Spee C, He S, Weitz S, Usinger W, LaBree L, Oliver N, Lim JI. (2004). Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care 27:758–764.
   PubMed Web of Science ®Google Scholar
• Hoshijima M, Hattori T, Inoue M, Araki D, Hanagata H, Miyauchi A, Takigawa M. (2006). CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett 580:1376–1382.
   PubMed Web of Science ®Google Scholar
• Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, Grotendorst GR, Takehara K. (1996). Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 106:729–733.
   PubMed Web of Science ®Google Scholar
• Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y. (2002). Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16:219–221.
   PubMedGoogle Scholar
• Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R. (1998). Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 53:853–861.
   PubMed Web of Science ®Google Scholar
• Ito Y, Aten J, Nguyen TQ, Joles JA, Matsuo S, Weening JJ, Goldschmeding R. (2010). Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. Nephron Exp Nephrol 117:e9–20.
   PubMedGoogle Scholar
• Iwanciw D, Rehm M, Porst M, Goppelt-Struebe M. (2003). Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways. Arterioscler Thromb Vasc Biol 23:1782–1787.
   PubMed Web of Science ®Google Scholar
• Jaffa AA, Usinger W, McHenry MB, Jaffa MA, Lipstiz SR, Lackland D, Lopes–Virella M, Luttrell LM, Wilson PW. (2008). Connective tissue growth factor and susceptibility to renal and vascular risk in type 1 diabetes. J Clin Endocrinol Metab 93:1893–1900.
   PubMed Web of Science ®Google Scholar
• Kawaguchi Y, Ota Y, Kawamoto M, Ito I, Tsuchiya N, Sugiura T, Katsumata Y, Soejima M, Sato S, Hasegawa M, Fujimoto M, Takehara K, Kuwana M, Yamanaka H, Hara M. (2008). Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. Ann Rheum Dis 68:1921–1924.
   PubMed Web of Science ®Google Scholar
• Kemp TJ, Aggeli IK, Sugden PH, Clerk A. (2004). Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes. J Mol Cell Cardiol 37:603–606.
   PubMed Web of Science ®Google Scholar
• Kim HS, Nagalla SR, Oh Y, Wilson E, Roberts CT Jr, Rosenfeld RG. (1997). Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc Natl Acad Sci USA 94:12981–12986.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Hayashi N, Hayashi K, Yamataka A, Lane GJ, Miyano T. (2005). Connective tissue growth factor and progressive fibrosis in biliary atresia. Pediatr Surg Int 21:12–16.
   PubMed Web of Science ®Google Scholar
• Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, Kurabayashi M. (2007). Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis. Hypertension 49:1120–1127.
   PubMed Web of Science ®Google Scholar
• Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, Kurabayashi M. (2008). Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure. Eur J Heart Fail 10:373–379.
   PubMed Web of Science ®Google Scholar
• Kono M, Nakamura Y, Suda T, Kaida Y, Kato M, Hashimoto D, Inui N, Miyazaki O, Kurasita S, Fukamachi L, Endo K, Ng P, Takehara K, Hamada E, Maekawa M, Chida K. (2010). N-terminal connective tissue growth factor (CTGF) is a potential biomarker of idiopathic interstitial pneumonias (IIPs) (Abstract). Am J Respir Crit Care Med 181:A1106.
   PubMed Web of Science ®Google Scholar
• Kovalenko E, Tacke F, Gressner OA, Zimmermann HW, Lahme B, Janetzko A, Wiederholt T, Berg T, Müller T, Trautwein C, Gressner AM, Weiskirchen R. (2009). Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. J Viral Hepat 16:612–620.
   PubMed Web of Science ®Google Scholar
• Kubota S, Kawata K, Yanagita T, Doi H, Kitoh T, Takigawa M. (2004). Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. J Biochem 136:279–282.
   PubMed Web of Science ®Google Scholar
• Kuiper EJ, de Smet MD, van Meurs JC, Tan HS, Tanck MW, Oliver N, van Nieuwenhoven FA, Goldschmeding R, Schlingemann RO. (2006). Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye. Arch Ophthalmol 124:1457–1462.
   PubMed Web of Science ®Google Scholar
• Kuiper EJ, Van Nieuwenhoven FA, de Smet MD, van Meurs JC, Tanck MW, Oliver N, Klaassen I, van Noorden CJF, Goldschmeding R, Schlingemann RO. (2008). The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. Plosone 3:e2675.
   PubMed Web of Science ®Google Scholar
• Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, Athas G, Lungarella G, Brody A, Friedman M. (1998). Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol 275:L365–L371.
   PubMed Web of Science ®Google Scholar
• Leask A, Abraham DJ. (2006). All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 119:4803–4810.
   PubMed Web of Science ®Google Scholar
• Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T, Takigawa M. (2009). CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem 145:207–216.
   PubMed Web of Science ®Google Scholar
• Mercurio S, Latinkic B, Itasaki N, Krumlauf R, Smith JC. (2004). Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 131:2137–2147.
   PubMed Web of Science ®Google Scholar
• Miyazaki O, Kurashita S, Fukamachi I, Endo K, Ng PS, Takehara K. (2010). Subtraction method for determination of N-terminal connective tissue growth factor. Ann Clin Biochem 47:205–211.
   PubMed Web of Science ®Google Scholar
• Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S. (2010). Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. Am J Physiol Renal Physiol 298:F721–F733.
   PubMed Web of Science ®Google Scholar
• Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K. (1999). Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol 181:153–159.
   PubMed Web of Science ®Google Scholar
• Morikawa H, Tamori A, Nishiguchi S, Enomoto M, Habu D, Kawada N, Shiomi S. (2007). Expression of connective tissue growth factor in the human liver with idiopathic portal hypertension. Mol Med 13:240–245.
   PubMed Web of Science ®Google Scholar
• Narkewicz MR, Kasaragod A, Lucia MS, Pflummer S, Sokol RJ, Stenmark KR. (2005). Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia. J Pediatr Surg 40:1721–1725.
   PubMed Web of Science ®Google Scholar
• Nguyen TQ, Goldschmeding R. (2008). Bone morphogenetic protein-7 and connective tissue growth factor: novel targets for treatment of renal fibrosis? Pharm Res 25:2416–2426.
   PubMed Web of Science ®Google Scholar
• Nguyen TQ, Tarnow L, Andersen S, Hovind P, Parving HH, Goldschmeding R, van Nieuwenhoven FA. (2006). Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy. Diabetes Care 29:83–88.
   PubMed Web of Science ®Google Scholar
• Nguyen TQ, Tarnow L, Jorsal A, Oliver N, Roestenberg P, Ito Y, Parving HH, Rossing P, van Nieuwenhoven FA, Goldschmeding R. (2008). Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care 31:1177–1182.
   PubMed Web of Science ®Google Scholar
• Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AM. (2004). Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 101:14895–14900.
   PubMed Web of Science ®Google Scholar
• Nishioka M, Ogawa E, Kinose D, Haruna A, Ohara T, Ito I, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Hirai T, Muro S, Mishima M. (2010). Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells. Respirology 15:669–676.
   PubMed Web of Science ®Google Scholar
• Pan LH, Yamauchi K, Uzuki M, Nakanishi T, Takigawa M, Inoue H, Sawai T. (2001). Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. Eur Respir J 17:1220–1227.
   PubMed Web of Science ®Google Scholar
• Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, Gauthier JM, Ba N, Sobesky R, Ratziu V, Bedossa P. (1999). Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30:968–976.
   PubMed Web of Science ®Google Scholar
• Perbal B. (2004). CCN proteins: multifunctional signalling regulators. Lancet 363:62–64.
   PubMed Web of Science ®Google Scholar
• Phanish MK, Winn SK, Dockrell ME. (2010). Connective tissue growth factor-(CTGF, CCN2)—a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 114:e83–e92.
   PubMed Web of Science ®Google Scholar
• Riser BL, Cortes P, DeNichilo M, Deshmukh PV, Chahal PS, Mohammed AK, Yee J, Kahkonen D. (2003). Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report. Kidney Int 64:451–458.
   PubMed Web of Science ®Google Scholar
• Roach JP, Bruny JL. (2008). Advances in the understanding and treatment of biliary atresia. Curr Opin Pediatr 20:315–319.
   PubMed Web of Science ®Google Scholar
• Roestenberg P, van Nieuwenhoven FA, Joles JA, Trischberger C, Martens PP, Oliver N, Aten J, Höppener JW, Goldschmeding R. (2006). Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice. Am J Physiol Renal Physiol 290:F1344–F1354.
   PubMed Web of Science ®Google Scholar
• Roestenberg P, van Nieuwenhoven FA, Wieten L, Boer P, Diekman T, Tiller AM, Wiersinga WM, Oliver N, Usinger W, Weitz S, Schlingemann RO, Goldschmeding R. (2004). Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy. Diabetes Care 27:1164–1170.
   PubMed Web of Science ®Google Scholar
• Sánchez-López E, Rayego S, Rodrigues-Díez R, Rodriguez JS, Rodrigues-Díez R, Rodríguez-Vita J, Carvajal G, Aroeira LS, Selgas R, Mezzano SA, Ortiz A, Egido J, Ruiz-Ortega M. (2009). CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB. J Am Soc Nephrol 20:1513–1526.
   PubMed Web of Science ®Google Scholar
• Sato S, Nagaoka T, Hasegawa M, Tamatani T, Nakanishi T, Takigawa M, Takehara K. (2000). Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. J Rheumatol 27:149–154.
   PubMed Web of Science ®Google Scholar
• Schieren G, Gambichler T, Skrygan M, Burkert B, Altmeyer P, Rump LC, Kreuter A. (2010). Balance of profibrotic and antifibrotic [corrected] signaling in nephrogenic systemic fibrosis skin lesions. Am J Kidney Dis 55:1040–1049.
   PubMed Web of Science ®Google Scholar
• Segarini PR, Nesbitt JE, Li D, Hays LG, Yates JR 3rd, Carmichael DF. (2001). The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. J Biol Chem 276:40659–40667.
   PubMed Web of Science ®Google Scholar
• Shi Y, Tu Z, Bao J, Sun H, Wang W, Luo G, Li S, Li Y, Bu H. (2009). Urinary connective tissue growth factor increases far earlier than histopathological damage and functional deterioration in early chronic renal allograft injury. Scand J Urol Nephrol 43:390–399.
   PubMed Web of Science ®Google Scholar
• Slagman MCJ, Nguyen TQ, Waanders F, Vogt L, Hemmelder MH, Oliver N, Navis GJ, Goldschmeding R, Laverman GD. (2009). Sodium restriction, losartan, and hydrochlorothiazide reduce elevated urinary CTGF/CCN-2 levels in patients with non-diabetic proteinuria (Abstract). J Am Soc Nephrol 20:A620.
   Google Scholar
• Tam FW, Riser BL, Meeran K, Rambow J, Pusey CD, Frankel AH. (2009). Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Cytokine 47:37–42.
   PubMed Web of Science ®Google Scholar
• Tamatani T, Kobayashi H, Tezuka K, Sakamoto S, Suzuki K, Nakanishi T, Takigawa M, Miyano T. (1998). Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Biochem Biophys Res Commun 251:748–752.
   PubMed Web of Science ®Google Scholar
• Tong ZY, Brigstock DR. (2006). Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor. J Endocrinol 188:R1–R8.
   PubMed Web of Science ®Google Scholar
• Wahab NA, Weston BS, Mason RM. (2005). Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 16:340–351.
   PubMed Web of Science ®Google Scholar
• Weitz SL, Usinger WR. (2003). Methods of assaying connective tissue growth factor. US patent (online) available at http://ip.com/patapp/US20030113816.
   Google Scholar
• Wynn TA. (2008). Cellular and molecular mechanisms of fibrosis. J Pathol 214:199–210.
   PubMed Web of Science ®Google Scholar
• Yilmaz S, McLaughlin K, Paavonen T, Taskinen E, Monroy M, Aavik E, Vamvakopoulos J, Häyry P. (2007). Clinical predictors of renal allograft histopathology: a comparative study of single-lesion histology versus a composite, quantitative scoring system. Transplantation 83:671–676.
   PubMed Web of Science ®Google Scholar
• Yokoi H, Mukoyama M, Sugawara A, Mori K, Nagae T, Makino H, Suganami T, Yahata K, Fujinaga Y, Tanaka I, Nakao K. (2002). Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol 282:F933–F942.
   PubMed Web of Science ®Google Scholar
• Yoon PO, Lee MA, Cha H, Jeong MH, Kim J, Jang SP, Choi BY, Jeong D, Yang DK, Hajjar RJ, Park WJ. (2010). The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis. J Mol Cell Cardiol 49:294–303.
   PubMed Web of Science ®Google Scholar
• Yoshisue H, Suzuki K, Kawabata A, Ohya T, Zhao H, Sakurada K, Taba Y, Sasaguri T, Sakai N, Yamashita S, Matsuzawa Y, Nojima H. (2002). Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library. Atherosclerosis 162:323–334.
   PubMed Web of Science ®Google Scholar
• Yue L, Xia Q, Luo GH, Lu YP. (2010). Urinary connective tissue growth factor is a biomarker in a rat model of chronic nephropathy. Transplant Proc 42:1875–1880.
   PubMed Web of Science ®Google Scholar
• Zarrinkalam KH, Stanley JM, Gray J, Oliver N, Faull RJ. (2003). Connective tissue growth factor and its regulation in the peritoneal cavity of peritoneal dialysis patients. Kidney Int 64:331–338.
   PubMed Web of Science ®Google Scholar
• Zhang D, Wang NY, Yang CB, Fang GX, Liu W, Wen J, Luo C. (2009). The clinical value of serum connective tissue growth factor in the assessment of liver fibrosis. Dig Dis Sci 55:767–774.
   PubMed Web of Science ®Google Scholar
• Zhang P, Shi M, Wei Q, Wang K, Li X, Li H, Bu H. (2008). Increased expression of connective tissue growth factor in patients with urethral stricture. Tohoku J Exp Med 215:199–206.
   PubMed Web of Science ®Google Scholar