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Biomarkers Volume 16, 2011 - Issue 5
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Research Article

HPLC/MS/MS methodology for sensitive quantitation of monic acid A, the metabolic product of the antibiotic mupirocin

Elizabeth A.C. HaidarMedical Microbiology, Centre for Infection, Division of Clinical Sciences, St George’s - University of London, Cranmer Terrace, London SW17 0RE, UK
,
Terence D. LeeDivision of Cardiac and Vascular Sciences, St George’s – University of London SW17 0RE, UK
,
Jonathan D. BartonChemistry Department, Imperial College London, London SW7 2AZ, UK
,
Anthony R.M. CoatesMedical Microbiology, Centre for Infection, Division of Clinical Sciences, St George’s - University of London, Cranmer Terrace, London SW17 0RE, UK
&
Peter G. MantleCentre for Environmental Policy, Imperial College London, London SW7 2AZ, UKCorrespondence[email protected]
Pages 422-425 | Received 14 Mar 2011, Accepted 14 Apr 2011, Published online: 20 May 2011

References

  • Chain EB, Mellows G. (1977). Pseudomonic acid. Part 1. The structure of pseudomonic acid A, a novel antibiotic produced by Pseudomonas fluorescens. J Chem Soc Perkin Trans 1 3:294–309.
  • Clayton JP, Luk K, Rogers NH. (1979). The chemistry of pseudomonic acid. Part 2. The conversion of pseudomonic acid A into monic acid A and its esters. J Chem Soc Perkin Trans 1 308–313.
  • Feline TC, Jones RB, Mellows G, Phillips L. (1977). Pseudomonic acid. Part 2. Biosynthesis of pseudomonic acid A. J Chem Soc Perkin Trans 1 3:309–318.
  • Fuller AT, Mellows G, Woolford M, Banks GT, Barrow KD, Chain EB. (1971). Pseudomonic acid: An antibiotic produced by Pseudomonas fluorescens. Nature 234:416–417.
  • Hughes J, Mellows G, Soughton S. (1980). How does Pseudomonas fluorescens, the producing organism of the antibiotic pseudomonic acid A, avoid suicide? FEBS Lett 122:322–324.
  • Mantle PG, Macgeorge KM. (1990). The role of monic acid A in pseudomonic acid A biosynthesis in Pseudomonas fluorescens. Appl Microbiol Biotechnol 33:709–711.
  • Mantle PG, de Langen M, Teo VK. (2001). Differentiating the biosynthesis of pseudomonic acids A and B. J Antibiot 54:166–174.
  • Thomas CM, Hothersall J, Willis CL, Simpson TJ. (2010). Resistance to and synthesis of the antibiotic mupirocin. Nat Rev Microbiol 8:281–289.

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