2,080
Views
7
CrossRef citations to date
0
Altmetric
Review Article

Analysis of V/Q-matching—a safety “biomarker” in pulmonary drug development?

, &
Pages S5-S10 | Received 13 Dec 2010, Accepted 28 Apr 2011, Published online: 28 Jun 2011

References

  • Agustí AG, Barberà JA. (1994). Contribution of multiple inert gas elimination technique to pulmonary medicine. 2. Chronic pulmonary diseases: chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Thorax 49:924–932.
  • Agustí AG, Rodriguez-Roisin R. (1993). Effect of pulmonary hypertension on gas exchange. Eur Respir J 6:1371–1377.
  • Bajc M, Neilly B, Miniati M, Mortensen J, Jonson B. (2010). Methodology for ventilation/perfusion SPECT. Semin Nucl Med 40:415–425.
  • Ballester E, Reyes A, Roca J, Guitart R, Wagner PD, Rodriguez-Roisin R. (1989). Ventilation–perfusion mismatching in acute severe asthma: effects of salbutamol and 100% oxygen. Thorax 44:258–267.
  • Barberà JA, Blanco I. (2009). Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management. Drugs 69:1153–1171.
  • Barberá JA, Reyes A, Roca J, Montserrat JM, Wagner PD, Rodríguez-Roisin R. (1992). Effect of intravenously administered aminophylline on ventilation/perfusion inequality during recovery from exacerbations of chronic obstructive pulmonary disease. Am Rev Respir Dis 145:1328–1333.
  • Barberà JA, Roger N, Roca J, Rovira I, Higenbottam TW, Rodriguez-Roisin R. (1996). Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 347:436–440.
  • Bauman G, Puderbach M, Deimling M, Jellus V, Chefd’hotel C, Dinkel J, Hintze C, Kauczor HU, Schad LR. (2009). Non-contrast-enhanced perfusion and ventilation assessment of the human lung by means of Fourier decomposition in proton MRI. Magn Reson Med 62:656–664.
  • Behr J, Ryu JH. (2008). Pulmonary hypertension in interstitial lung disease. Eur Respir J 31:1357–1367.
  • Blanco I, Gimeno E, Munoz PA, Pizarro S, Gistau C, Rodriguez-Roisin R, Roca J, Barberà JA. (2010). Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Am J Respir Crit Care Med 181:270–278.
  • Cornet AD, Hofstra JJ, Swart EL, Girbes AR, Juffermans NP. (2010). Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS. Intensive Care Med 36:758–764.
  • Dantzker DR, Bower JS. (1981). Pulmonary vascular tone improves VA/Q matching in obliterative pulmonary hypertension. J Appl Physiol 51:607–613.
  • Dartevelle P, Fadel E, Mussot S, Chapelier A, Hervé P, de Perrot M, Cerrina J, Ladurie FL, Lehouerou D, Humbert M, Sitbon O, Simonneau G. (2004). Chronic thromboembolic pulmonary hypertension. Eur Respir J 23:637–648.
  • de Gray L, Rush EM, Jones JG. (1997). A noninvasive method for evaluating the effect of thoracotomy on shunt and ventilation perfusion inequality. Anaesthesia 52:630–635.
  • Elliott CG. (1992). Pulmonary physiology during pulmonary embolism. Chest 101:163S–171S.
  • Günther A, Enke B, Markart P, Hammerl P, Morr H, Behr J, Stähler G, Seeger W, Grimminger F, Leconte I, Roux S, Ghofrani HA. (2007). Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study. Eur Respir J 29:713–719.
  • Hoeper MM, Barberà JA, Channick RN, Hassoun PM, Lang IM, Manes A, Martinez FJ, Naeije R, Olschewski H, Pepke-Zaba J, Redfield MM, Robbins IM, Souza R, Torbicki A, McGoon M. (2009). Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol 54:S85–S96.
  • Hope DA, Jenkins BJ, Willis N, Maddock H, Mapleson WW. (1995). Non-invasive estimation of venous admixture: validation of a new formula. Br J Anaesth 74:538–543.
  • Khoukaz G, Gross NJ. (1999). Effects of salmeterol on arterial blood gases in patients with stable chronic obstructive pulmonary disease. Comparison with albuterol and ipratropium. Am J Respir Crit Care Med 160:1028–1030.
  • Lang IM, Klepetko W. (2008). Chronic thromboembolic pulmonary hypertension: an updated review. Curr Opin Cardiol 23:555–559.
  • Montserrat JM, Barberà JA, Viegas C, Roca J, Rodriguez-Roisin R. (1995). Gas exchange response to intravenous aminophylline in patients with a severe exacerbation of asthma. Eur Respir J 8:28–33.
  • Musch G, Venegas JG. (2005). Positron emission tomography imaging of regional pulmonary perfusion and ventilation. Proc Am Thorac Soc 2:522–7, 508.
  • Polverino E, Gómez FP, Manrique H, Soler N, Roca J, Barberà JA, Rodríguez-Roisin R. (2007). Gas exchange response to short-acting beta2-agonists in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med 176:350–355.
  • Preston IR. (2007). Clinical perspective of hypoxia-mediated pulmonary hypertension. Antioxid Redox Signal 9:711–721.
  • Reinartz P, Wildberger JE, Schaefer W, Nowak B, Mahnken AH, Buell U. (2004). Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V/Q lung scintigraphy in SPECT technique and multislice spiral CT. J Nucl Med 45:1501–1508.
  • Ryu JH, Krowka MJ, Pellikka PA, Swanson KL, McGoon MD. (2007). Pulmonary hypertension in patients with interstitial lung diseases. Mayo Clin Proc 82:342–350.
  • Stolz D, Rasch H, Linka A, Di Valentino M, Meyer A, Brutsche M, Tamm M. (2008). A randomised, controlled trial of bosentan in severe COPD. Eur Respir J 32:619–628.
  • Thieme SF, Hoegl S, Nikolaou K, Fisahn J, Irlbeck M, Maxien D, Reiser MF, Becker CR, Johnson TR. (2010). Pulmonary ventilation and perfusion imaging with dual-energy CT. Eur Radiol 20:2882–2889.
  • Truebel H, Hahn G, Becker E, Dittmar J, Just A, Hellige G. (2010). The assessment of ventilation–perfusion ratios by electrical impedance tomography in experimental ALI. Am J Respir Crit Care Med 181:A1705.
  • Tunnicliffe B, Shah S. (2008). Oxygenation. In: Mackenzie I, editor. Core Topics in Mechanical Ventilation. Cambridge, UK: Cambridge University Press, pp. 115–141.
  • Viegas CA, Ferrer A, Montserrat JM, Barberà JA, Roca J, Rodriguez-Roisin R. (1996). Ventilation–perfusion response after fenoterol in hypoxemic patients with stable COPD. Chest 110:71–77.
  • Wagner PD, Dantzker DR, Dueck R, Clausen JL, West JB. (1977). Ventilation–perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest 59:203–216.
  • Wagner PD, Laravuso RB, Uhl RR, West JB. (1974). Distributions of ventilation–perfusion ratios in acute respiratory failure. Chest 65:Suppl:32S–Suppl:35S.
  • Walmrath D, Schermuly R, Pilch J, Grimminger F, Seeger W. (1997). Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension. Eur Respir J 10:1084–1092.
  • Ware LB, Matthay MA. (2000). The acute respiratory distress syndrome. N Engl J Med 342:1334–1349.
  • Weir EK, Olschewski A. (2006). Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia. Cardiovasc Res 71:630–641.
  • Weissmann N, Grimminger F, Olschewski A, Seeger W. (2001). Hypoxic pulmonary vasoconstriction: a multifactorial response? Am J Physiol Lung Cell Mol Physiol 281:L314–L317.
  • Weissmann N, Sommer N, Schermuly RT, Ghofrani HA, Seeger W, Grimminger F. (2006). Oxygen sensors in hypoxic pulmonary vasoconstriction. Cardiovasc Res 71:620–629.
  • West JB. (1962). Regional differences in gas exchange in the lung of erect man. J Appl Physiol 17:893–898.
  • West JB. (1995). Respiratory Physiology—The Essentials, 5th edition. Baltimore, USA: Williams & Wilkins.
  • West JB. (1996). Respiratory Physiology—People and Ideas. Oxford, UK: Oxford University Press.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.