72
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Evidence for cytochrome P450 2B1/2B2 isoenzymes in freshly prepared peripheral blood lymphocytes

&
Pages 649-656 | Received 23 Jun 2011, Accepted 07 Sep 2011, Published online: 11 Oct 2011

References

  • Anzenbacher P, Anzenbacherová E. (2001). Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 58:737–747.
  • Baldwin SJ, Bramhall JL, Ashby CA, Yue L, Murdock PR, Hood SR, Ayrton AD, Clarke SE. (2006). Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan). Drug Metab Dispos 34:1063–1069.
  • Baron JM, Zwadlo-Klarwasser G, Jugert F, Hamann W, Rübben A, Mukhtar H, Merk HF. (1998). Cytochrome P450 1B1: A major P450 isoenzyme in human blood monocytes and macrophage subsets. Biochem Pharmacol 56:1105–1110.
  • Boccia S, Sayed-Tabatabaei FA, Persiani R, Gianfagna F, Rausei S, Arzani D, La Greca A, D’Ugo D, La Torre G, van Duijn CM, Ricciardi G. (2007). Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: A case-control study in an Italian population. BMC Cancer 7:206.
  • Cederbaum A. (2009). Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opin Drug Metab Toxicol 5:1223–1244.
  • Czekaj P. (2000). Phenobarbital-induced expression of cytochrome P450 genes. Acta Biochim Pol 47:1093–1105.
  • Dey A, Dhawan A, Kishore Seth P, Parmar D. (2005). Evidence for cytochrome P450 2E1 catalytic activity and expression in rat blood lymphocytes. Life Sci 77:1082–1093.
  • Dey A, Parmar D, Dayal M, Dhawan A, Seth PK. (2001). Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression. Life Sci 69:383–393.
  • Dey A, Parmar D, Dhawan A, Dash D, Seth PK. (2002). Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes. Life Sci 71:2509–2519.
  • Dey A, Yadav S, Dhawan A, Seth PK, Parmar D. (2006). Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes. Life Sci 79:1729–1735.
  • Finnström N, Thörn M, Lööf L, Rane A. (2001). Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease. Eur J Clin Pharmacol 57:403–409.
  • Furukawa M, Nishimura M, Ogino D, Chiba R, Ikai I, Ueda N, Naito S, Kuribayashi S, Moustafa MA, Uchida T, Sawada H, Kamataki T, Funae Y, Fukumoto M. (2004). Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci 95:520–529.
  • Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T. (2001). Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics 5:161–170.
  • Haas CE, Brazeau D, Cloen D, Booker BM, Frerichs V, Zaranek C, Frye RF, Kufel T. (2005). Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction. Eur J Clin Pharmacol 61:583–593.
  • Hamadeh HK, Bushel PR, Jayadev S, Martin K, DiSorbo O, Sieber S, Bennett L, Tennant R, Stoll R, Barrett JC, Blanchard K, Paules RS, Afshari CA. (2002). Gene expression analysis reveals chemical-specific profiles. Toxicol Sci 67:219–231.
  • Hanna IH, Reed JR, Guengerich FP, Hollenberg PF. (2000). Expression of human cytochrome P450 2B6 in Escherichia coli: Characterization of catalytic activity and expression levels in human liver. Arch Biochem Biophys 376:206–216.
  • Hannon-Fletcher MP, Barnett YA. (2008). Lymphocyte cytochrome P450 expression: inducibility studies in male Wistar rats. Br J Biomed Sci 65:1–6.
  • Harris CC. (1989). Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair. Carcinogenesis 10:1563–1566.
  • Hesse LM, He P, Krishnaswamy S, Hao Q, Hogan K, von Moltke LL, Greenblatt DJ, Court MH. (2004). Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes. Pharmacogenetics 14:225–238.
  • Hukkanen J, Hakkola J, Anttila S, Piipari R, Karjalainen A, Pelkonen O, Raunio H. (1997). Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. Mol Carcinog 20:224–230.
  • Ingelman-Sundberg M. (2002). Polymorphism of cytochrome P450 and xenobiotic toxicity. Toxicology 181-182:447–452.
  • Khan AJ, Sharma A, Choudhuri G, Parmar D. (2011). Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. Alcohol 45:81–87.
  • Krovat BC, Tracy JH, Omiecinski CJ. (2000). Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci 55:352–360.
  • Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, Fackenthal JD, Rogan PK, Ring B, Wrighton SA, Schuetz EG. (2003). Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 307:906–922.
  • Lipscomb JC, Barton HA, Tornero-Velez R, Evans MV, Alcasey S, Snawder JE, Laskey J. (2004). The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. J Toxicol Environ Health Part A 67:537–553.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275.
  • Lucier GW, Thompson CL. (1987). Issues in biochemical applications to risk assessment: When can lymphocytes be used as surrogate markers? Environ Health Perspect 76:187–191.
  • Manceau S, Giraud C, Declèves X, Batteux F, Chouzenoux S, Tang R, Dauchy S, Scherrmann JM, Weill B, Morini JP, Perrot JY, Tréluyer JM. (2010). Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes. Int J Pharm 395:98–103.
  • Miller MC 3rd, Mohrenweiser HW, Bell DA. (2001). Genetic variability in susceptibility and response to toxicants. Toxicol Lett 120:269–280.
  • Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. (1996). P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6:1–42.
  • Nguyen LT, Ramanathan M, Weinstock-Guttman B, Dole K, Miller C, Planter M, Patrick K, Brownscheidle C, Jacobs LD. (2000). Detection of cytochrome P450 and other drug-metabolizing enzyme mRNAs in peripheral blood mononuclear cells using DNA arrays. Drug Metab Dispos 28:987–993.
  • Omiecinski CJ, Remmel RP, Hosagrahara VP. (1999). Concise review of the cytochrome P450s and their roles in toxicology. Toxicol Sci 48:151–156.
  • Parmar D, Dhawan A, Dayal M, Seth PK. (1998). Immunochemical and biochemical evidence for expression of Phenobarbital and 3-Methylcholanthrene-inducible isoenzymes of Cytochrome P450 in rat brain. Int J Toxicol 17:619–630.
  • Qin G, Meng Z. (2006). The expressions of protooncogenes and CYP1A in lungs of rats exposed to sulfur dioxide and benzo(a)pyrene. Regul Toxicol Pharmacol 45:36–43.
  • Raucy JL, Schultz ED, Kearins MC, Arora S, Johnston DE, Omdahl JL, Eckmann L, Carpenter SP. (1999). CYP2E1 expression in human lymphocytes from various ethnic populations. Alcohol Clin Exp Res 23:1868–1874.
  • Raucy JL, Schultz ED, Wester MR, Arora S, Johnston DE, Omdahl JL, Carpenter SP. (1997). Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity. Drug Metab Dispos 25:1429–1435.
  • Rumsby PC, Yardley-Jones A, Anderson D, Phillimore HE, Davies MJ. (1996). Detection of CYP1A1 mRNA levels and CYP1A1 Msp polymorphisms as possible biomarkers of exposure and susceptibility in smokers and non-smokers. Teratog, Carcinog Mutagen 16:65–74.
  • Saurabh K, Sharma A, Yadav S, Parmar D. (2010). Polycyclic aromatic hydrocarbon metabolizing cytochrome P450s in freshly prepared uncultured rat blood lymphocytes. Biochem Pharmacol 79:1182–1188.
  • Shah PP, Saurabh K, Pant MC, Mathur N, Parmar D. (2009). Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. Mutat Res 670:74–78.
  • Shimada T. (2006). Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab Pharmacokinet 21:257–276.
  • Siest G, Jeannesson E, Marteau JB, Samara A, Marie B, Pfister M, Visvikis-Siest S. (2008). Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. Drug Metab Dispos 36:182–189.
  • Thier R, Brüning T, Roos PH, Rihs HP, Golka K, Ko Y, Bolt HM. (2003). Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes. Int J Hyg Environ Health 206:149–171.
  • Vanden Heuvel JP, Clark GC, Thompson CL, McCoy Z, Miller CR, Lucier GW, Bell DA. (1993). CYP1A1 mRNA levels as a human exposure biomarker: Use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis 14:2003–2006.
  • Vineis P. (2002). The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer. Toxicology 181-182:457–462.
  • Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. (2004). Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem 279:29295–29301.
  • Waxman DJ, Azaroff L. (1992). Phenobarbital induction of cytochrome P-450 gene expression. Biochem J 281 (Pt 3):577–592.
  • Wu D, Cederbaum AI. (2005). Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol 207:70–76.
  • Wyde ME, Kirwan SE, Zhang F, Laughter A, Hoffman HB, Bartolucci-Page E, Gaido KW, Yan B, You L. (2005). Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses. Toxicol Sci 86:281–290.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.