Overexpression of multiple myeloma SET domain (MMSET) is associated with advanced tumor aggressiveness and poor prognosis in serous ovarian carcinoma

References

• Brito JL, Walker B, Jenner M, et al. (2009). MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells. Haematologica 94:78–86
   PubMed Web of Science ®Google Scholar
• Chesi M, Nardini E, Lim RS, et al. (1998). The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 92:3025–34
   PubMed Web of Science ®Google Scholar
• Crum CP, Drapkin R, Miron A, et al. (2007). The distal fallopian tube: a new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol 9:304–14
   Google Scholar
• Ezponda T, Popovic R, Shah MY, et al. (2012). The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene, Jul 16. doi: 10.1038/onc.2012.297 [Epub ahead of print]
   Google Scholar
• Garlisi CG, Uss AS, Xiao H, et al. (2001). A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription. Am J Respir Cell Mol Biol 24:90–8
   PubMed Web of Science ®Google Scholar
• Ge YZ, Pu MT, Gowher H, et al. (2004). Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. J Biol Chem 279:25447–54
   PubMedGoogle Scholar
• Hart WR. (2005). Borderline epithelial tumors of the ovary. Mod Pathol 18:S33–50
   PubMed Web of Science ®Google Scholar
• Heintz AP, Odicino F, Maisonneuve P, et al. (2006). Carcinoma of the ovary. FIGO 6th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet 95:S161–92
   PubMedGoogle Scholar
• Hudlebusch HR, Santoni-Rugiu E, Simon R, et al. (2011a). The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res 17:2919–33
   PubMed Web of Science ®Google Scholar
• Hudlebusch HR, Skotte J, Santoni-Rugiu E, et al. (2011b). MMSET is highly expressed and associated with aggressiveness in neuroblastoma. Cancer Res 71:4226–35
   PubMed Web of Science ®Google Scholar
• Jemal A, Bray F, Center MM, et al. (2011). Global cancer statistics. CA Cancer J Clin 61:69–90
   PubMed Web of Science ®Google Scholar
• Katso RM, Manek S, Ganjavi H, et al. (2000). Overexpression of H-Ryk in epithelial ovarian cancer: prognostic significance of receptor expression. Clin Cancer Res 6:3271–81
   Google Scholar
• Keats JJ, Reiman T, Maxwell CA, et al. (2003). In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood 101:1520–9
   PubMed Web of Science ®Google Scholar
• Kim JY, Kee HJ, Choe NW, et al. (2008). Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity. Mol Cell Biol 28:2023–34
   PubMed Web of Science ®Google Scholar
• Kurman RJ, Shih Ie M. (2010). The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol 34:433–43
   PubMed Web of Science ®Google Scholar
• Lauring J, Abukhdeir AM, Konishi H, et al. (2008). The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood 111:856–64
   PubMed Web of Science ®Google Scholar
• Li Y, Trojer P, Xu CF, et al. (2009). The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem 284:34283–95
   PubMed Web of Science ®Google Scholar
• Love JJ, Li X, Chung J, et al. (2004). The LEF-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA. Biochemistry 43:8725–34
   PubMedGoogle Scholar
• Marango J, Shimoyama M, Nishio H, et al. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood 111:3145–54
   PubMed Web of Science ®Google Scholar
• Marquez RT, Baggerly KA, Patterson AP, et al. (2005). Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res 11:6116–26
   PubMedGoogle Scholar
• Rauh-Hain JA, Krivak TC, Del Carmen MG, Olawaiye AB. (2011). Ovarian cancer screening and early detection in the general population. Rev Obstet Gynecol 4:15–21
   PubMedGoogle Scholar
• Seidman JD, Russell P, Kurman RJ. (2002). Surface epithelial tumors of the ovary. In: Kurman RJ, TeLinde RW, eds. Blaustein's pathology of the female genital tract. 5th ed. New York: Springer, 791–804
   Google Scholar
• Shi X, Hong T, Walter KL, et al. (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442:96–9
   PubMed Web of Science ®Google Scholar
• Silverberg SG. (2000). Histopathologic grading of ovarian carcinoma: a review and proposal. Int J Gynecol Pathol 19:7–15
   PubMed Web of Science ®Google Scholar
• Stec I, Wright TJ, van Ommen GJ, et al. (1998). WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf--Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma. Hum Mol Genet 7:1071–82
   PubMed Web of Science ®Google Scholar
• Wang M, He Y, Shi L, Shi C. (2011). Multivariate analysis by Cox proportional hazard model on prognosis of patient with epithelial ovarian cancer. Eur J Gynaecol Oncol 32:171–7
   Google Scholar
• Wysocka J, Swig ut T, Xiao H, et al. (2006). A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 442:86–90
   PubMed Web of Science ®Google Scholar
• Xiao M, Yang S, Chen J, et al. (2013). Overexpression of MMSET in endometrial cancer: a clinicopathologic study. J Surg Oncol 107:428–32
   PubMed Web of Science ®Google Scholar
• Yang P, Guo L, Duan ZJ, et al. (2012). Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol 32:3121–31
   PubMed Web of Science ®Google Scholar
• Zhou P, Wu LL, Wu KM, et al. (2012). Overexpression of MMSET is correlation with poor prognosis in hepatocellular carcinoma. Pathol Oncol Res, Dec 8 [Epub ahead of print]
   Google Scholar